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Artikel ; Online: Being "False Positive": An "Inconvenience"? Debates and Questions Regarding the Notion of Vaccine-Induced Seropositivity (VISP) in the Recruitment of Healthy Volunteers for a Preventive Anti-HIV Vaccine Trial.

Couderc, Mathilde

Journal of acquired immune deficiency syndromes (1999)

2018 Band 79 Suppl 1, Seite(n) S20–S29

Abstract: This article considers a stage in the clinical trial process seldom documented in social sciences: recruitment of healthy volunteers for an HIV preventive vaccine trial through a media campaign. It analyzes one of the consequences of participating in ... ...

Abstract	This article considers a stage in the clinical trial process seldom documented in social sciences: recruitment of healthy volunteers for an HIV preventive vaccine trial through a media campaign. It analyzes one of the consequences of participating in such a clinical trial: the development of vaccine-induced seropositivity (VISP) and how this biomedical notion is mobilized both in recruitment procedures' normative discourses and from the volunteers' points of view, and its consequences on their decision to participate. The interpretations of VISP by volunteers depend on several factors: socialization, itinerary into the recruitment procedure, sexuality, etc., and generates diverse feelings such as indifference, doubt, or even fear. Fear of VISP represents the principal refusal reason for those who interrupted their participating step, just before inclusion stage. Addressing VISP phenomenon is important because it represents a major challenge for the information and the communication procedures for the next anti-HIV prophylactic trials recruitment campaigns.
Mesh-Begriff(e)	AIDS Vaccines/administration & dosage ; Clinical Trials as Topic ; False Positive Reactions ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; Healthy Volunteers/psychology ; Humans ; Seroconversion/physiology
Chemische Substanzen	AIDS Vaccines
Sprache	Englisch
Erscheinungsdatum	2018-09-17
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000001814
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Complete chloroplast genome of two nutmeg species,

Kusuma, Jakty / Couderc, Marie / Scarcelli, Nora / Duminil, Jérôme

Mitochondrial DNA. Part B, Resources

2023 Band 8, Heft 7, Seite(n) 751–755

Abstract: Myristica ... ...

Abstract	Myristica argentea
Sprache	Englisch
Erscheinungsdatum	2023-07-19
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2023.2233154
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Haptoglobin blood assay to assess treatment compliance in rheumatoid arthitis patients treated with tocilizumab.

Montagnon, Pierre-Yves / Beauger, Marine / Couderc, Marion / Tournadre, Anne / Soubrier, Martin / Mathieu, Sylvain

Clinical and experimental rheumatology

2024

Sprache	Englisch
Erscheinungsdatum	2024-05-01
Erscheinungsland	Italy
Dokumenttyp	Letter
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/ua2zfc
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Response to: 'Ultrasonographic salivary gland evaluation in systemic sclerosis: is sicca syndrome secondary to an authentic overlap syndrome or another specific fibrotic manifestation of the disease?' by Coiffier

Couderc, Marion / Dubost, Jean-Jacques

Annals of the rheumatic diseases

2019 Band 79, Heft 12, Seite(n) e161

Mesh-Begriff(e)	Autoimmune Diseases ; Connective Tissue Diseases ; Humans ; Salivary Glands/diagnostic imaging ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnostic imaging ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnostic imaging
Sprache	Englisch
Erscheinungsdatum	2019-08-07
Erscheinungsland	England
Dokumenttyp	Journal Article ; Comment
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2019-215991
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: De l'information des patients à l'engagement associatif des personnes vivant avec le VIH participant à une recherche médicale au Sénégal - cohorte ANRS 1215.

Couderc, M / Desclaux Sall, C

Bulletin de la Societe de pathologie exotique (1990)

2014 Band 107, Heft 4, Seite(n) 286–291

Abstract: Based on work in anthropology and the experience of the implementation of a project on ethics, this article describes the contributions of the ANRS 1215 cohort to information of participants and community involvement in research. It draws a parallel ... ...

Titelübersetzung	Moving from patient information to involvement in associations for people living with HIV participating in a medical study in Senegal - ANRS cohort 1215.
Abstract	Based on work in anthropology and the experience of the implementation of a project on ethics, this article describes the contributions of the ANRS 1215 cohort to information of participants and community involvement in research. It draws a parallel between the development of information methods and the roles gradually held by PLWA individually or collectively. From 1998 to 2011, the PLWA have diversified theirs activities (psycho-social support, administrative tasks, ethical watch function) and have contributed to improve the information of participants. This involvement of PLWHIV in ethics, which belongs to a long-term process, is analyzed through social, political, economical and ethical evolutions, both at national and international level.
Mesh-Begriff(e)	Biomedical Research ; Clinical Trials as Topic ; Cohort Studies ; Community Health Services/manpower ; HIV Infections/epidemiology ; HIV-1 ; Health Behavior ; Humans ; Information Seeking Behavior ; Patient Education as Topic/manpower ; Patient Participation/statistics & numerical data ; Senegal/epidemiology ; Social Support
Sprache	Französisch
Erscheinungsdatum	2014-10
Erscheinungsland	France
Dokumenttyp	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	419158-4
ISSN	1961-9049 ; 0037-9085
ISSN (online)	1961-9049
ISSN	0037-9085
DOI	10.1007/s13149-014-0377-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Performance of a diagnostic score for gouty arthritis: results from a cohort of acute arthritis suspected of being septic.

Lafforgue, Aurore / Lambert, Céline / Dubost, Jean-Jacques / Tournadre, Anne / Soubrier, Martin / Couderc, Marion

Rheumatology international

2022 Band 43, Heft 1, Seite(n) 119–124

Abstract: Septic arthritis (SA) and gout are the main suspected etiologies of acute monoarthritis. Differentiating them is essential because SA is an emergency. The performance of a gout diagnostic score developed by Janssens et al. was investigated in a cohort of ...

Abstract	Septic arthritis (SA) and gout are the main suspected etiologies of acute monoarthritis. Differentiating them is essential because SA is an emergency. The performance of a gout diagnostic score developed by Janssens et al. was investigated in a cohort of patients with acute arthritis suspected of being septic. This was an ancillary study of a single-center cohort of patients with suspected SA. Patients were classified into three groups according to the final diagnosis (gout, SA or other diagnosis). We assessed the performance of the score (sensitivity [Se], specificity [Sp], positive and negative predictive value [PPV, NPV], area under the receiver operating characteristic [ROC] curve) for the diagnosis of gouty arthritis. In total, 138 patients were included: 28 (20.3%) had gout, 42 (30.4%) SA, and 68 (49.3%) another diagnosis. The median diagnostic score was 7.0 [4.5; 8.8] for patients with gout, 3.5 [2.5; 6.0] for those with SA and 3.0 [2.0-5.0] for those with another diagnosis. With a score threshold of ≥ 8, the Se for a diagnosis of gout was 28.6%, Sp 96.4%, PPV 66.7%, and NPV 84.1%. With a threshold of ≤ 4, the Se was 82.1%, Sp 64.5%, PPV 37.1%, and NPV 93.4%. The area under the ROC for the diagnostic score was 0.79. The performance of the clinico-biological score of Janssens et al. for a diagnosis of gout applied to a cohort of patients with acute arthritis and suspected of being septic was poor. Joint aspiration remains necessary to differentiate SA from another etiology.
Mesh-Begriff(e)	Humans ; Arthritis, Gouty/diagnosis ; Gout ; Arthritis, Infectious/diagnosis ; Predictive Value of Tests ; ROC Curve
Sprache	Englisch
Erscheinungsdatum	2022-10-23
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-022-05216-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Genomic introgressions from African rice (Oryza glaberrima) in Asian rice (O. sativa) lead to the identification of key QTLs for panicle architecture.

Adam, Hélène / Gutiérrez, Andrés / Couderc, Marie / Sabot, François / Ntakirutimana, Fabrice / Serret, Julien / Orjuela, Julie / Tregear, James / Jouannic, Stefan / Lorieux, Mathias

BMC genomics

2023 Band 24, Heft 1, Seite(n) 587

Abstract: Background: Developing high yielding varieties is a major challenge for breeders tackling the challenges of climate change in agriculture. The panicle (inflorescence) architecture of rice is one of the key components of yield potential and displays high ...

Abstract	Background: Developing high yielding varieties is a major challenge for breeders tackling the challenges of climate change in agriculture. The panicle (inflorescence) architecture of rice is one of the key components of yield potential and displays high inter- and intra-specific variability. The genus Oryza features two different crop species: Asian rice (Oryza sativa L.) and the African rice (O. glaberrima Steud.). One of the main morphological differences between the two independently domesticated species is the structure (or complexity) of the panicle, with O. sativa displaying a highly branched panicle, which in turn produces a larger number of grains than that of O. glaberrima. The gene regulatory network that governs intra- and interspecific panicle diversity is still under-studied. Results: To identify genetic factors linked to panicle architecture diversity in the two species, we used a set of 60 Chromosome Segment Substitution Lines (CSSLs) issued from third generation backcross (BC Conclusion: Our analysis led to the detection of genomic variations between O. sativa cv. Caiapó and O. glaberrima cv. MG12 in regions associated with enhanced panicle traits in specific CSSLs. These regions contain a number of key genes that regulate panicle development in O. sativa and their interspecific genomic variations may explain the phenotypic effects observed.
Mesh-Begriff(e)	Oryza ; Genetic Introgression ; Quantitative Trait Loci ; Phenotype ; Genomics
Sprache	Englisch
Erscheinungsdatum	2023-10-04
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09695-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparison of the cardiovascular risk profile of rheumatoid arthritis versus hand osteoarthritis patients.

Mathieu, Sylvain / Lambert, C / Fayet, Françoise / Couderc, Marion / Beauger, Marine / Malochet, Sandrine / Pickering, Marie-Eva / Tournadre, Anne / Soubrier, Martin

Rheumatology international

2023 Band 43, Heft 11, Seite(n) 2065–2072

Abstract: It is clear that there is an increased cardiovascular (CV) risk in rheumatoid arthritis (RA) as a result of systemic inflammation. Hand osteoarthritis (HOA) patients, also have an increased CV risk, but the causes are still debated. Our objective was to ... ...

Abstract	It is clear that there is an increased cardiovascular (CV) risk in rheumatoid arthritis (RA) as a result of systemic inflammation. Hand osteoarthritis (HOA) patients, also have an increased CV risk, but the causes are still debated. Our objective was to compare CV risk factors and risk scores between HOA and RA patients. Thirty-five HOA patients were matched by age (< 3 years) and sex to 35 RA patients in a case-control study. We compared their CV risk profiles and their risk of occurrence of CV events at 10 years using the risk equations SCORE1, SCORE2, and QRISK3. There was a significant increase in SCORE1, SCORE2, but not in QRISK3 in the RA group compared to the HOA group, provided that the multiplication coefficient for RA was applied. This increase was found to no longer be significant for SCORE1 when RA patients have low disease activity (DAS28 ≤ 3.2; n = 8). There was no difference between groups in the frequency of metabolic syndrome, blood pressure, abdominal circumference, body mass index, uricemia, triglyceridemia, HDL cholesterolemia, or pain intensity. Conversely, HOA patients had higher LDL cholesterol and fasting blood glucose levels, in the main analysis and in the subgroup of moderate/high RA activity patients (DAS28 > 3.2; n = 26). We found a higher CV risk in RA compared to HOA patients with moderate/high disease activity. The increased CV risk reported in OA remains to be confirmed in HOA, but these patients appear to have a pro-atherogenic lipid and glycemic profile.
Mesh-Begriff(e)	Humans ; Child, Preschool ; Osteoarthritis ; Risk Factors ; Case-Control Studies ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Heart Disease Risk Factors
Sprache	Englisch
Erscheinungsdatum	2023-08-11
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-023-05405-3
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Haitian coffee agroforestry systems harbor complex arabica variety mixtures and under-recognized genetic diversity.

Millet, Claude Patrick / Allinne, Clémentine / Vi, Tram / Marraccini, Pierre / Verleysen, Lauren / Couderc, Marie / Ruttink, Tom / Zhang, Dapeng / Sanchéz, William Solano / Tranchant-Dubreuil, Christine / Jeune, Wesly / Poncet, Valérie

PloS one

2024 Band 19, Heft 4, Seite(n) e0299493

Abstract: Though facing significant challenges, coffee (Coffea arabica) grown in Haitian agroforestry systems are important contributors to rural livelihoods and provide several ecosystem services. However, little is known about their genetic diversity and the ... ...

Abstract	Though facing significant challenges, coffee (Coffea arabica) grown in Haitian agroforestry systems are important contributors to rural livelihoods and provide several ecosystem services. However, little is known about their genetic diversity and the variety mixtures used. In light of this, there is a need to characterize Haitian coffee diversity to help inform revitalization of this sector. We sampled 28 diverse farms in historically important coffee growing regions of northern and southern Haiti. We performed KASP-genotyping of SNP markers and HiPlex multiplex amplicon sequencing for haplotype calling on our samples, as well as several Ethiopian and commercial accessions from international collections. This allowed us to assign Haitian samples to varietal groups. Our analyses revealed considerable genetic diversity in Haitian farms, higher in fact than many farmers realized. Notably, genetic structure analyses revealed the presence of clusters related to Typica, Bourbon, and Catimor groups, another group that was not represented in our reference accession panel, and several admixed individuals. Across the study areas, we found both mixed-variety farms and monovarietal farms with the historical and traditional Typica variety. This study is, to our knowledge, the first to genetically characterize Haitian C. arabica variety mixtures, and report the limited cultivation of C. canephora (Robusta coffee) in the study area. Our results show that some coffee farms are repositories of historical, widely-abandoned varieties while others are generators of new diversity through genetic mixing.
Mesh-Begriff(e)	Humans ; Coffee ; Haiti ; Ecosystem ; Coffea/genetics ; Genetic Variation
Chemische Substanzen	Coffee
Sprache	Englisch
Erscheinungsdatum	2024-04-16
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299493
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Cardiovascular profile in osteoarthritis: a meta-analysis of cardiovascular events and risk factors.

Mathieu, Sylvain / Couderc, Marion / Tournadre, Anne / Soubrier, Martin

Joint bone spine

2019 Band 86, Heft 6, Seite(n) 679–684

Abstract: Introduction: Higher cardiovascular risk found in rheumatoid arthritis or psoriatic arthritis is largely due to systemic inflammation. In osteoarthritis (OA), occurrence of systemic inflammation has already been sometimes reported, but the possible ... ...

Abstract	Introduction: Higher cardiovascular risk found in rheumatoid arthritis or psoriatic arthritis is largely due to systemic inflammation. In osteoarthritis (OA), occurrence of systemic inflammation has already been sometimes reported, but the possible association between OA and increased cardiovascular risk remains unclear. In this meta-analysis, we aimed to assess the incidences of myocardial infarction (MI) and stroke, and the cardiovascular risk factors in OA patients. Methods: We searched PubMed, EMBase, and the Cochrane Library to find references of interest up to June 2018. MI and stroke incidence were calculated using meta-proportion analysis. Differences in cardiovascular risk factors between OA patients and controls were expressed as standardized mean differences using the inverse of variance method. Results: The reviewed studies reported 227 MIs in 3550 OA patients (incidence, 7.5%; 95% CI: 3.0-13.8%) and 616 MIs among 12,444 control subjects (incidence, 6.0%; 95% CI: 2.8-10.3%). Meta-analysis of the three longitudinal studies revealed a significantly increased MI risk among OA patients (RR=1.22; 95% CI: 1.02-1.45). We also found a significantly increased stroke risk in OA patients (RR=1.43; 95% CI: 1.38-1.48). Concerning cardiovascular risk factors, OA patients exhibited a pro-atherogenic lipid and glycemic profile including high levels of fasting glucose, total cholesterol, and LDL cholesterol and a high body mass index. Concerning atherosclerosis markers, OA patients exhibited a higher risk of metabolic syndrome, and increased pulse wave velocity. Conclusion: Our meta-analysis results revealed higher cardiovascular risk in OA patients. This highlights the importance of cardiovascular risk factor management in OA.
Mesh-Begriff(e)	Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Case-Control Studies ; Comorbidity ; Female ; France ; Humans ; Longitudinal Studies ; Male ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Osteoarthritis/diagnosis ; Osteoarthritis/epidemiology ; Prevalence ; Prognosis ; Risk Assessment ; Stroke/diagnosis ; Stroke/epidemiology ; Survival Analysis
Sprache	Englisch
Erscheinungsdatum	2019-07-16
Erscheinungsland	France
Dokumenttyp	Journal Article ; Meta-Analysis
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2019.06.013
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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