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  1. Book ; Online ; E-Book: Pubertal suppression in transgender youth

    Finlayson, Courtney

    2019  

    Author's details Courtney Finlayson, MD
    Language English
    Size 1 Online-Ressource (viii, 106 Seiten)
    Publisher Elsevier
    Publishing place St. Louis
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019810879
    ISBN 978-0-323-56964-4 ; 9780323569637 ; 0-323-56964-1 ; 0323569633
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Generalised eruptive keratoacanthomas of Grzybowski.

    Courtney, Ashling / Su, John C

    BMJ case reports

    2024  Volume 17, Issue 3

    MeSH term(s) Humans ; Keratoacanthoma/diagnosis ; Skin
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2024-260007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The dorsomedial prefrontal cortex prioritizes social learning during rest.

    Jimenez, Courtney A / Meyer, Meghan L

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 12, Page(s) e2309232121

    Abstract: Sociality is a defining feature of the human experience: We rely on others to ensure survival and cooperate in complex social networks to thrive. Are there brain mechanisms that help ensure we quickly learn about our social world to optimally navigate it? ...

    Abstract Sociality is a defining feature of the human experience: We rely on others to ensure survival and cooperate in complex social networks to thrive. Are there brain mechanisms that help ensure we quickly learn about our social world to optimally navigate it? We tested whether portions of the brain's default network engage "by default" to quickly prioritize social learning during the memory consolidation process. To test this possibility, participants underwent functional MRI (fMRI) while viewing scenes from the documentary film,
    MeSH term(s) Humans ; Brain Mapping ; Prefrontal Cortex/diagnostic imaging ; Brain ; Cognition ; Social Learning ; Rest ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2309232121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  4. Article: The Psychology of Atopic Dermatitis.

    Courtney, Ashling / Su, John C

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterised by pruritus and recurrent eczematous patches and plaques. It impacts sleep and its visibility can lead to stigmatisation, low self-esteem, social withdrawal, reduced ... ...

    Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterised by pruritus and recurrent eczematous patches and plaques. It impacts sleep and its visibility can lead to stigmatisation, low self-esteem, social withdrawal, reduced quality of life (QOL), and psychological burden. This study explores the relationship between AD and mental health, including possible causation pathways. A literature review was conducted in PubMed without using limiters. AD carries higher odds of suicidality and an increased risk of depression, anxiety, alexithymia, and obsessive-compulsive disorder (OCD) across all severities. While some studies report an association of AD with attention deficit hyperactivity disorder (ADHD), and possibly autism spectrum disorder (ASD), others do not. There is increasing evidence that AD contributes to chronic low-grade inflammation and cognitive impairment (CI). Causative factors for mental health complications of AD likely include both psychosocial and biological variables. AD is associated with higher levels of cutaneous and circulating proinflammatory cytokines; these can breach the blood-brain barrier and trigger central nervous system events, including oxidative stress, neurotransmitter breakdown, altered serotonin metabolism, and reduced neurogenesis in several brain regions. Excessive inflammation in AD may thus contribute to CI, depression, and suicidality. AD providers should be vigilant about mental health.
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting the cytoskeleton as a therapeutic approach to substance use disorders.

    Pandey, Surya / Miller, Courtney A

    Pharmacological research

    2024  Volume 202, Page(s) 107143

    Abstract: Substance use disorders (SUD) are chronic relapsing disorders governed by continually shifting cycles of positive drug reward experiences and drug withdrawal-induced negative experiences. A large body of research points to plasticity within systems ... ...

    Abstract Substance use disorders (SUD) are chronic relapsing disorders governed by continually shifting cycles of positive drug reward experiences and drug withdrawal-induced negative experiences. A large body of research points to plasticity within systems regulating emotional, motivational, and cognitive processes as drivers of continued compulsive pursuit and consumption of substances despite negative consequences. This plasticity is observed at all levels of analysis from molecules to networks, providing multiple avenues for intervention in SUD. The cytoskeleton and its regulatory proteins within neurons and glia are fundamental to the structural and functional integrity of brain processes and are potentially the major drivers of the morphological and behavioral plasticity associated with substance use. In this review, we discuss preclinical studies that provide support for targeting the brain cytoskeleton as a therapeutic approach to SUD. We focus on the interplay between actin cytoskeleton dynamics and exposure to cocaine, methamphetamine, alcohol, opioids, and nicotine and highlight preclinical studies pointing to a wide range of potential therapeutic targets, such as nonmuscle myosin II, Rac1, cofilin, prosapip 1, and drebrin. These studies broaden our understanding of substance-induced plasticity driving behaviors associated with SUD and provide new research directions for the development of SUD therapeutics.
    MeSH term(s) Humans ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/metabolism ; Cytoskeleton ; Actin Cytoskeleton/metabolism ; Brain ; Substance Withdrawal Syndrome/metabolism
    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2024.107143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
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  6. Article ; Online: Interprofessional education: considering long-term outcomes in course design.

    Simpkins, Courtney A

    Currents in pharmacy teaching & learning

    2021  Volume 13, Issue 6, Page(s) 736–737

    MeSH term(s) Education, Pharmacy ; Humans ; Interprofessional Education ; Students, Pharmacy
    Language English
    Publishing date 2021-02-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2515217-8
    ISSN 1877-1300 ; 1877-1297
    ISSN (online) 1877-1300
    ISSN 1877-1297
    DOI 10.1016/j.cptl.2021.01.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic ethics and mtDNA replacement techniques.

    Brenner, Courtney A

    The New bioethics : a multidisciplinary journal of biotechnology and the body

    2021  Volume 27, Issue 1, Page(s) 3–18

    Abstract: The United Kingdom parliament made history in 2015 when they voted to allow the use of mitochondrial (mtDNA) replacement techniques. Mitochondrial diseases are genetically inherited and currently, the only known cure is replacement therapies. However, ... ...

    Abstract The United Kingdom parliament made history in 2015 when they voted to allow the use of mitochondrial (mtDNA) replacement techniques. Mitochondrial diseases are genetically inherited and currently, the only known cure is replacement therapies. However, most other countries have been slow to adopt policy changes that allow for mtDNA replacement due to the ethical challenges of the techniques. While there are ethical challenges concerning mtDNA replacement, there is a need to address these challenges and allow these techniques in the US to provide treatment for individuals affected. This paper first addresses mitochondrial diseases and replacement techniques currently used and analyzes ethical challenges related to the interventions, such as safety, efficacy, and contributed genetic material from three individuals. This paper then addresses how the ethical principles, beneficence, nonmaleficence, autonomy and justice support mtDNA replacement. Suggestions on how the US can allow mtDNA replacement by adopting similar policy changes to the UK are provided, as well as additional measures to protect patients. Given the rate of individuals affected, severity of mitochondrial diseases, and lack of treatment options available, it's important to address how to overcome ethical challenges and policy barriers.
    MeSH term(s) Beneficence ; DNA, Mitochondrial/genetics ; Humans ; Mitochondria/genetics ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/therapy ; Social Justice
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2021-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2727428-7
    ISSN 2050-2885 ; 2050-2877
    ISSN (online) 2050-2885
    ISSN 2050-2877
    DOI 10.1080/20502877.2021.1876204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4431: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Performance of Strawberry Varieties Developed for Perennial Matted-Row Production in Annual Plasticulture in a Cold Climate Region

    Courtney A. Weber

    Agronomy, Vol 11, Iss 1407, p

    2021  Volume 1407

    Abstract: Annual plasticulture production of strawberries promises superior weed control, fruit quality and yields. However, strawberry varieties adapted for perennial, matted-row production and local markets in cold climate regions have not been widely tested for ...

    Abstract Annual plasticulture production of strawberries promises superior weed control, fruit quality and yields. However, strawberry varieties adapted for perennial, matted-row production and local markets in cold climate regions have not been widely tested for adaptation to an annual production cycle. Productivity of seven short-day varieties developed for matted-row and/or annual production was examined in an annual plasticulture system in two consecutive trials in central NY (lat. 42.87° N, long. 76.99° W) harvested in 2013 and 2014. ‘Flavorfest’ demonstrated good performance in Trial 1 with high yield (390 g/plant) and large fruit size (13.9 g mean berry weight). ‘Jewel’ was shown to be well adapted to the annual plasticulture system with consistently high yields (330 and 390 g/plant) that equaled or surpassed other varieties and had moderate fruit size. ‘Chandler’ performed similarly to previous trials conducted in warmer regions with yield (340 g/plant) and fruit size (9.8 g mean berry weight) similar to ‘Jewel’. ‘Clancy’ yielded less but was consistent from year to year. The late season varieties Seneca and Ovation showed marked variability between years, possibly due to drastically different temperatures during flowering and fruit development in Trial 1 compared to Trial 2. High temperatures in Trial 1 likely caused higher early fruit yield, a compressed season and a precipitous decline in fruit size in the later season, thus reducing yield in the late season. Survival after a second dormant period was poor resulting in a small second harvest and reduced fruit size. Overall, the system demonstrated many of the expected benefits but may be more sensitive to weather conditions in the region. While many varieties developed for matted-row production may work well in an annual plasticulture system, not all varieties are equally adapted. Performance of each variety should be determined independently before large scale adoption by growers.
    Keywords annual hill production ; perennial production ; variety trial ; Agriculture ; S
    Subject code 571
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Developing Codes to Capture Post-Operative Care

    Mehrotra, Ateev / Gidengil, Courtney A / Hilborne, Lee H / Kranz, Ashley M / Stratos, Stephanie

    2016  

    Keywords Health systems & services ; Medicolegal issues ; Medical profession ; Health Sciences
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030611178
    ISBN 9780833096296 ; 083309629X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Current Issues in the Management of Patients With Newly Diagnosed Advanced-Stage High-Grade Serous Carcinoma of the Ovary.

    Penn, Courtney A / Alvarez, Ronald D

    JCO oncology practice

    2023  Volume 19, Issue 3, Page(s) 116–122

    Abstract: Ovarian cancer is the most common cause of mortality in patients with gynecologic malignancies. Advanced-stage high-grade serous carcinoma accounts for most ovarian cancer cases. Current issues in the management of patients with newly diagnosed advanced- ... ...

    Abstract Ovarian cancer is the most common cause of mortality in patients with gynecologic malignancies. Advanced-stage high-grade serous carcinoma accounts for most ovarian cancer cases. Current issues in the management of patients with newly diagnosed advanced-stage high-grade serous ovarian cancer include decisions on primary versus interval cytoreduction, hyperthermic intraperitoneal chemotherapy, maintenance therapy, incorporation of bevacizumab, and germline and somatic genetic testing. Evidence and guidelines regarding these topics are addressed in this review.
    MeSH term(s) Humans ; Female ; Chemotherapy, Adjuvant ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/genetics
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7198: Show issues Location:
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