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  1. AU="Couto Souza, Paulo Henrique"
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  1. Artikel: Panoramic imaged carotid atheromas are associated with increased neutrophil count: both validated, independent predictors of near-term myocardial infarction.

    Chang, Tina I / Wu, Xiuju / Boström, Kristina I / Tran, Hoang-Anh / Couto-Souza, Paulo Henrique / Friedlander, Arthur H

    Dento maxillo facial radiology

    2021  Band 50, Heft 8, Seite(n) 20210045

    Abstract: Objectives: Panoramic images (PXs) demonstrating calcified carotid artery atheromas (CCAAs) are associated with heightened risk of near-term myocardial infarction (MI). Elevated neutrophil counts (NC) within normal range 2,500-6,000 per mm: Methods: ... ...

    Abstract Objectives: Panoramic images (PXs) demonstrating calcified carotid artery atheromas (CCAAs) are associated with heightened risk of near-term myocardial infarction (MI). Elevated neutrophil counts (NC) within normal range 2,500-6,000 per mm
    Methods: Investigators implemented a retrospective study of PXs and accompanying medical records of white males ≥ 65 years treated by a VA dental service. Two groups (
    Results: The study group of (CCAA+) (mean age 75.9; range 69-91 years) demonstrated a mean NC of 4,843 per mm
    Conclusions: CCAAs on PXs of elderly white males are associated with elevated NC; amplifying need for medical consultation prior to invasive dental procedures.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Carotid Arteries ; Carotid Artery Diseases/diagnostic imaging ; Humans ; Male ; Myocardial Infarction/diagnostic imaging ; Neutrophils ; Plaque, Atherosclerotic ; Radiography, Panoramic ; Retrospective Studies ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2021-06-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 221323-0
    ISSN 1476-542X ; 0250-832X ; 0349-490X
    ISSN (online) 1476-542X
    ISSN 0250-832X ; 0349-490X
    DOI 10.1259/dmfr.20210045
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  2. Artikel ; Online: Periodontitis in individuals with few remaining teeth and a high gingival bleeding index increases the probability of dyslipidemia.

    Gomes-Filho, Isaac Suzart / Freitas, Taciane Oliveira Bet / Cruz, Simone Seixas da / Trindade, Soraya Castro / Figueiredo, Ana Claudia Morais Godoy / Couto Souza, Paulo Henrique / Cerqueira, Eneida de Moraes Marcílio / Hintz, Alexandre Marcelo / Carneiro, Daline Oliveira / Lacerda, Juliana Andrade de / Seymour, Gregory John / Scannapieco, Frank Andrew / Loomer, Peter Michael / Passos-Soares, Johelle de Santana

    Journal of periodontology

    2023  Band 94, Heft 10, Seite(n) 1243–1253

    Abstract: Background: Dyslipidemia, a silent multifactorial condition, is characterized by changes in blood lipid levels, affecting all socioeconomic strata, increasing the risk for atherosclerotic diseases. This study investigated whether there is an association ...

    Abstract Background: Dyslipidemia, a silent multifactorial condition, is characterized by changes in blood lipid levels, affecting all socioeconomic strata, increasing the risk for atherosclerotic diseases. This study investigated whether there is an association between dyslipidemia and the combined exposure of periodontitis plus the number of remaining teeth, gingival bleeding, or caries.
    Methods: A two-center cross-sectional study was conducted involving 1270 individuals, with a minimum age of 18 years. Socioeconomic and demographic data, health conditions, lifestyle parameters, and anthropometric, biochemical, and oral clinical examinations were performed. The exposures considered were the presence of periodontitis, dental caries, number of remaining teeth, and gingival bleeding. The outcome was dyslipidemia as defined by the Brazilian Guidelines on Dyslipidemia and Prevention of Atherosclerosis. The combined associations between periodontitis plus other oral health conditions and dyslipidemia were estimated using confounder-adjusted prevalence ratios (PR
    Results: The occurrence of dyslipidemia was 70.1% and periodontitis was 84.1%. A positive association between periodontitis and dyslipidemia existed: PR
    Conclusion: Periodontitis combined with fewer than 11 teeth doubled the likelihood of being diagnosed with dyslipidemia.
    Mesh-Begriff(e) Humans ; Adolescent ; Dental Caries ; Cross-Sectional Studies ; Periodontitis/complications ; Periodontitis/epidemiology ; Mouth Diseases ; Probability
    Sprache Englisch
    Erscheinungsdatum 2023-06-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390921-9
    ISSN 1943-3670 ; 0022-3492 ; 1049-8885 ; 0095-960X
    ISSN (online) 1943-3670
    ISSN 0022-3492 ; 1049-8885 ; 0095-960X
    DOI 10.1002/JPER.23-0091
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  3. Artikel ; Online: Marsupialization of a Large Radicular Cyst with Extensive Maxillary Tooth Displacement: Eight-Year Follow-Up.

    Tanaka, Orlando Motohiro / Meira, Thiago Martins / Batista Rodrigues, Aline Cristina / Willems, Guy / Baggio, Gabriela Leite / Couto Souza, Paulo Henrique

    Journal of dentistry for children (Chicago, Ill.)

    2019  Band 86, Heft 1, Seite(n) 64–68

    Abstract: Radicular cysts arising from primary teeth are uncommon and, when present as large lesions, may adversely affect the underlying permanent teeth. The purpose of this paper is to describe the management of a very large atypical radicular cyst involving the ...

    Abstract Radicular cysts arising from primary teeth are uncommon and, when present as large lesions, may adversely affect the underlying permanent teeth. The purpose of this paper is to describe the management of a very large atypical radicular cyst involving the primary dentition of a nine-year-old boy and causing extensive tooth displacement with transposition of the permanent maxillary left canine between the bicuspids. The root apex of the canine was close to the median level of the lateral border of the nasal cavity and showed incomplete root formation and signs of dilacerations in its apical third. Marsupialization was successfully performed, followed by long-term orthodontic treatment. This interdisciplinary management facilitated the lesion resolution for repositioning of the canine into functional occlusion.
    Mesh-Begriff(e) Bicuspid ; Child ; Follow-Up Studies ; Humans ; Male ; Malocclusion/etiology ; Malocclusion/therapy ; Radicular Cyst/complications ; Radicular Cyst/therapy ; Tooth Movement Techniques ; Tooth, Deciduous
    Sprache Englisch
    Erscheinungsdatum 2019-04-13
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 390120-8
    ISSN 1935-5068 ; 1551-8949 ; 0022-0353
    ISSN (online) 1935-5068
    ISSN 1551-8949 ; 0022-0353
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  4. Artikel ; Online: Inflammatory cytologic alterations in the oral epithelium associated with HIV pre-exposure prophylaxis: a preliminary study.

    Baggio, Gabriela Leite / Macedo, Nayara Flores / Merlin, Julio Cezar / Anghebem, Mauren Isfer / Santos, Juliane Cardoso Villela / Ignácio, Sérgio Aparecido / Rubira-Bullen, Izabel Regina Fischer / Azevedo Alanis, Luciana Reis / Couto Souza, Paulo Henrique

    Oral surgery, oral medicine, oral pathology and oral radiology

    2021  Band 131, Heft 5, Seite(n) 534–539

    Abstract: Objective: The objective of this study was to assess inflammatory cytologic alterations in the oral epithelium of patients on human immunodeficiency virus pre-exposure prophylaxis (PrEP).: Material and methods: Epithelial cells from the buccal mucosa ...

    Abstract Objective: The objective of this study was to assess inflammatory cytologic alterations in the oral epithelium of patients on human immunodeficiency virus pre-exposure prophylaxis (PrEP).
    Material and methods: Epithelial cells from the buccal mucosa of 30 patients were collected by exfoliative cytology and were evaluated according to inflammatory cellular alterations: karyomegaly, bi- or multinucleation, karyopyknosis, karyorrhexis, perinuclear halo formation, metachromasia, cytoplasmic vacuolization, indistinct cytoplasmic border, keratinization, and atrophy. Epithelial cells were collected initially before PrEP onset (T1) and then after 30 days of PrEP use (T2). Two experienced cytopathologists independently analyzed the slides.
    Results: The nonparametric Wilcoxon test showed that there was a statistically significant increase in the number of cells with karyomegaly at T2 compared to T1 (P = .033). The other cellular alterations did not present with statistically significant differences between the 2 moments of evaluation (P > .05).
    Conclusion: The increased number of oral epithelial cells with karyomegaly after 30 days of using PrEP suggests the presence of inflammatory alterations at this site.
    Mesh-Begriff(e) Epithelial Cells ; Epithelium ; HIV Infections/prevention & control ; Humans ; Mouth Mucosa
    Sprache Englisch
    Erscheinungsdatum 2021-01-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2021.01.010
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  5. Artikel ; Online: Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents.

    Penteado, Carlos Antonio Schaffer / Batista, Thiago Beltrami Dias / Chaiben, Cassiano Lima / Bonacin, Bruna Guedes / Ventura, Talita M O / Dionizio, Aline / Couto Souza, Paulo Henrique / Buzalaf, Marília Afonso Rabelo / Azevedo-Alanis, Luciana Reis

    Oral diseases

    2020  Band 26, Heft 6, Seite(n) 1200–1208

    Abstract: Objectives: To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders.: Subjects and methods: Thirty-three male volunteers were evaluated for alcohol abuse ... ...

    Abstract Objectives: To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders.
    Subjects and methods: Thirty-three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non-stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was generated from the database and manually revised, obtaining the total number of candidate biomarkers for oral disorders.
    Results: The mean age (n = 33) was 42.94 ± 8.61 years. Fourteen (42.4%) subjects presented with 23 oral mucosa changes, and 31 (94%) had dental plaque. A total of 282 proteins were found in saliva (n = 9), of which 26 were identified as candidates for biomarkers of oral disorders. After manual review, 21 proteins were selected. The highest number of candidates for biomarkers was associated with carcinoma of head and neck (n = 10), nasopharyngeal carcinoma (n = 6), and periodontal disease (n = 6).
    Conclusion: Alcohol and tobacco dependents showed gingival inflammation, and less than half of them showed oral mucosa changes. Twenty-one protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease.
    Sprache Englisch
    Erscheinungsdatum 2020-04-14
    Erscheinungsland Denmark
    Dokumenttyp Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13337
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  6. Artikel ; Online: Periodontitis is a factor associated with dyslipidemia.

    Gomes-Filho, Isaac Suzart / Oliveira, Michelle Teixeira / Cruz, Simone Seixas da / Cerqueira, Eneida de Moraes Marcílio / Trindade, Soraya Castro / Vieira, Graciete Oliveira / Couto Souza, Paulo Henrique / Adan, Luis Fernando Fernandes / Hintz, Alexandre Marcelo / Passos-Soares, Johelle de Santana / Scannapieco, Frank Andrew / Loomer, Peter Michael / Seymour, Gregory John / Figueiredo, Ana Claudia Morais Godoy

    Oral diseases

    2021  Band 28, Heft 3, Seite(n) 813–823

    Abstract: Objective: To investigate the association between the severity of periodontitis (exposure) and dyslipidemia (outcome).: Methods: This was a cross-sectional study of users of public health services. Periodontitis was defined using the Center for ... ...

    Abstract Objective: To investigate the association between the severity of periodontitis (exposure) and dyslipidemia (outcome).
    Methods: This was a cross-sectional study of users of public health services. Periodontitis was defined using the Center for Disease Prevention and Control and the American Academy of Periodontology criteria. Lipid evaluation used data on systemic biomarkers. Dyslipidemia diagnosis was based on the Guidelines of total cardiovascular risk of the World Health Organization. Weight, height, waist circumference, and blood pressure were measured, and socioeconomic-demographic, lifestyle behavior factors, general and oral health conditions of the participants were collected. Hierarchical and logistic regression analyzes were used to determine the association between the exposures and the outcome. Odds Ratios, unadjusted and adjusted, and 95% confidence intervals were estimated.
    Results: Of 1,011 individuals examined, 75.17% had dyslipidemia, and 84.17% had periodontitis, 0.2% with mild, 48.56% moderate, and 35.41% severe disease. The association between periodontitis and dyslipidemia was maintained through hierarchical analysis and in the multiple regression modeling, showing that the occurrences of dyslipidemia in the group with periodontitis, and its moderate and severe levels, were, respectively, 14%, 30%, and 16% higher compared with those without periodontitis.
    Conclusions: The results showed a positive association between moderate and severe periodontitis and dyslipidemia.
    Mesh-Begriff(e) Cross-Sectional Studies ; Dyslipidemias/complications ; Dyslipidemias/epidemiology ; Humans ; Periodontitis/complications ; Risk Factors ; Waist Circumference
    Sprache Englisch
    Erscheinungsdatum 2021-02-11
    Erscheinungsland Denmark
    Dokumenttyp Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13779
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  7. Artikel: Association of calcified carotid artery plaque in panoramic images and diagonal earlobe crease.

    Couto Souza, Paulo Henrique / Berti-Couto, Soraya de Azambuja / Majewski, Cassiana Nathalie Machado / da Silva, Isteicy Cortez / Donaduzzi, Liziane Cattelan / Silva, Isabela Maria Vasconcelos / Lisboa, Maria do Carmo / Lee, Urie K / Friedlander, Ida K / Friedlander, Arthur H

    Dento maxillo facial radiology

    2018  Band 48, Heft 2, Seite(n) 20170256

    Abstract: Objectives:: Brazilians who are free of traditional atherogenic risk factors frequently suffer myocardial infarctions (MI). Calcified carotid artery plaque (CCAP) on panoramic images (PIs) has been shown to be a validated "risk indicator" of future MIs. ...

    Abstract Objectives:: Brazilians who are free of traditional atherogenic risk factors frequently suffer myocardial infarctions (MI). Calcified carotid artery plaque (CCAP) on panoramic images (PIs) has been shown to be a validated "risk indicator" of future MIs. The diagonal earlobe crease (DELC) is likewise a validated "risk indicator" of future MI. We sought to determine the prevalence of DELC+ among patients having CCAP+ on their PIs.
    Methods:: In a masked cross-sectional study, three dentists evaluated PIs of patients (N = 481) over age 55 for presence of CCAP+. Among the CCAP+ cohort, the presence of DELC+ was determined by two additional dentists masked to the presence of CCAP+ on PIs. A control group (CCAP-) comprised of individuals with PIs devoid of plaque was similarly evaluated for evidence of DELC+.
    Results:: A mixed-gender group (8.6%) of patients (N = 41; mean age 67.5 ± 6.8) evidenced CCAP+ on their PIs and approximately 88% of these individuals (N = 36) had concomitant DELC+. Among members of the control group (N = 41), 17 patients were DELC+. Our results demonstrated that among the full mixed-gender cohort (N = 82), the association between CCAP+ and DELC+ was statistically significant (p = 0.0001). However, when adjusting for gender, only the CCAP+ men were significantly (p = 0.00011) more likely to evidence DELC+ on clinical examination.
    Conclusions:: Males with atherosclerosis of their carotid arteries as evidenced by PIs displaying calcified atheromas are significantly more likely to evidence a DELC+ than those without an imaged atheroma.
    Mesh-Begriff(e) Aged ; Carotid Artery Diseases/diagnostic imaging ; Carotid Stenosis/diagnostic imaging ; Cross-Sectional Studies ; Humans ; Male ; Middle Aged ; Plaque, Atherosclerotic/diagnostic imaging ; Prevalence ; Radiography, Panoramic ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2018-08-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 221323-0
    ISSN 1476-542X ; 0250-832X ; 0349-490X
    ISSN (online) 1476-542X
    ISSN 0250-832X ; 0349-490X
    DOI 10.1259/dmfr.20170256
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  8. Artikel ; Online: Immunohistochemical detection of NANOG in oral leukoplakia.

    Kitahara, Aldini Beuting Pereira / Michels, Arieli Carini / Luiz, Suelen Teixeira / Nagashima, Seigo / Camargo Martins, Ana Paula / de Azevedo, Marina Luise Viola / Azevedo Alanis, Luciana Reis / Couto Souza, Paulo Henrique / Ignácio, Sérgio Aparecido / de Noronha, Lucia / Bettega, Patrícia Vida Cassi / Tyski, Maria Carolina Albini / Quispe, Edinson Manuel Pérez / Mozzer, Izabela / Souto, Giovanna Ribeiro / Aguiar, Maria Cássia Ferreira / Modolo, Filipe / Scariot, Rafaela / Jham, Bruno Correia /
    Hardy, Ana Maria Trindade Grégio / Johann, Aline Cristina Batista Rodrigues

    Oral diseases

    2021  Band 29, Heft 2, Seite(n) 376–379

    Mesh-Begriff(e) Humans ; Leukoplakia, Oral/diagnosis ; Mouth Neoplasms/diagnosis ; Nanog Homeobox Protein
    Chemische Substanzen Nanog Homeobox Protein ; NANOG protein, human
    Sprache Englisch
    Erscheinungsdatum 2021-05-10
    Erscheinungsland Denmark
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
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  9. Artikel: Massive Submandibular Sialolith: Complete Radiographic Registration and Biochemical Analysis through X-Ray Diffraction.

    Franco, Ademir / de Carvalho Mattos, Mayara Jessica / Ferrari, Francine / Dos Reis Neto, José Manoel / Carta Gambus, Luiz Carlos / Couto Souza, Paulo Henrique / Berti-Couto, Soraya de Azambuja

    Case reports in surgery

    2014  Band 2014, Seite(n) 659270

    Abstract: Sialolithiasis is a pathologic condition that affects 60 million people per year, which is caused by the presence of calcified structures, named sialoliths, inside the salivary glands and their salivary ducts. Despite the large incidence of ... ...

    Abstract Sialolithiasis is a pathologic condition that affects 60 million people per year, which is caused by the presence of calcified structures, named sialoliths, inside the salivary glands and their salivary ducts. Despite the large incidence of sialolithiasis, its etiology is still unknown. In the present case report, a 47-year-old female patient, presenting with local pain and hampered mouth opening, underwent a surgical approach for the removal of a 20 mm sialolith, which was further analyzed through X-ray diffraction. In parallel, a radiographic registration of 8 years, covering all the period for sialolith formation, is presented along the case report.
    Sprache Englisch
    Erscheinungsdatum 2014-09-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2657697-1
    ISSN 2090-6919 ; 2090-6900
    ISSN (online) 2090-6919
    ISSN 2090-6900
    DOI 10.1155/2014/659270
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  10. Artikel ; Online: Spontaneous eruption of a canine after marsupialization of an infected dentigerous cyst.

    Berti, Soraya de Azambuja / Pompermayer, Adriane Bastos / Couto Souza, Paulo Henrique / Tanaka, Orlando Motohiro / Westphalen, Vânia Portela Ditzel / Westphalen, Fernando Henrique

    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

    2010  Band 137, Heft 5, Seite(n) 690–693

    Abstract: A dentigerous cyst is the most common developmental odontogenic cyst. It is a benign and asymptomatic intraosseous lesion that affects the bones of the maxillofacial complex, interfering with tooth eruption. This article reports the spontaneous eruption ... ...

    Abstract A dentigerous cyst is the most common developmental odontogenic cyst. It is a benign and asymptomatic intraosseous lesion that affects the bones of the maxillofacial complex, interfering with tooth eruption. This article reports the spontaneous eruption of a canine after marsupialization of an infected dentigerous cyst and extraction of the deciduous teeth. A radiograph showed a large cyst with a radiolucent area involving the mandibular left deciduous canine and first molar, and the permanent canine and first premolar. Although enucleation is the treatment of choice, marsupialization is the best option for large cysts involving an unerupted permanent tooth, as in this case. The patient was followed for 1 year, and eruption of the permanent canine and first premolar and gradual reduction of the radiolucent area were observed.
    Mesh-Begriff(e) Bicuspid/physiology ; Child ; Cuspid/physiology ; Cyst Fluid ; Dentigerous Cyst/surgery ; Follow-Up Studies ; Humans ; Male ; Mandibular Diseases/surgery ; Molar/surgery ; Tooth Eruption/physiology ; Tooth Extraction ; Tooth, Deciduous/surgery ; Tooth, Unerupted/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2010-05
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 356699-7
    ISSN 1097-6752 ; 0889-5406 ; 0002-9416
    ISSN (online) 1097-6752
    ISSN 0889-5406 ; 0002-9416
    DOI 10.1016/j.ajodo.2009.10.023
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