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Article ; Online: Short-term Reactions Among Pregnant and Lactating Individuals in the First Wave of the COVID-19 Vaccine Rollout.

Kachikis, Alisa / Englund, Janet A / Singleton, Michael / Covelli, Isabela / Drake, Alison L / Eckert, Linda O

JAMA network open

2021 Volume 4, Issue 8, Page(s) e2121310

MeSH term(s)	Adult ; COVID-19/prevention & control ; COVID-19 Vaccines ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; Humans ; Lactation/drug effects ; Pregnancy ; Pregnancy Complications/chemically induced ; Pregnancy Complications/epidemiology ; Pregnancy Complications, Infectious/prevention & control ; Pregnancy Complications, Infectious/virology ; Prospective Studies ; SARS-CoV-2 ; United States/epidemiology
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2021.21310
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Article ; Online: Influence of gender and sexual identity on adolescent skin health.

Covelli, Isabela / Ahrens, Kym / Onchiri, Frankline M / Inwards-Breland, David / Boos, Markus D

Pediatric dermatology

2021 Volume 38 Suppl 2, Page(s) 65–72

Abstract: Background/objective: Studies have identified dermatologic conditions and relevant skin-related behaviors that distinctly or disproportionately impact sexual and gender minority (SGM) adults compared with their cisgender/heterosexual counterparts, but ... ...

Abstract	Background/objective: Studies have identified dermatologic conditions and relevant skin-related behaviors that distinctly or disproportionately impact sexual and gender minority (SGM) adults compared with their cisgender/heterosexual counterparts, but whether these observations apply to SGM adolescents remains unknown. We aimed to describe the nature and frequency of skin conditions in SGM youth relative to their cisgender/heterosexual peers and explore adolescents' attitudes toward their skin health and accessing dermatologic care. Methods: SGM and cisgender/heterosexual youth aged 13-21 years seen at Seattle Children's Hospital Adolescent Medicine and Gender clinics from June to December 2019 were invited to participate in this cross-sectional survey study, with subsequent statistical analysis. Results: One-hundred and eighteen subjects were included in the study. Sexual orientation did not affect how participants personally felt about and cared for their skin, though gender identity did influence this relationship. (P = .012) Both sexual and gender minority youth demonstrated a preference for a dermatologist who identified as SGM and would be more likely to actively seek care from these providers. (P < .001) There was no difference in the reported prevalence of most dermatologic conditions among groups based on sexual orientation or gender identity. Conclusion: Dermatologists should inquire with adolescent and young adult patients how their sexual orientation and gender identities influence how they view their skin, in an effort to guide counseling and demonstrate holistic support for adolescents. Therapeutic alliances with SGM youth may be strengthened by providers who openly identify as SGM.
MeSH term(s)	Adolescent ; Child ; Cross-Sectional Studies ; Female ; Gender Identity ; Heterosexuality ; Humans ; Male ; Sexual Behavior ; Sexual and Gender Minorities ; Young Adult
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	605539-4
ISSN	1525-1470 ; 0736-8046
ISSN (online)	1525-1470
ISSN	0736-8046
DOI	10.1111/pde.14686
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Article ; Online: Analysis of Vaccine Reactions After COVID-19 Vaccine Booster Doses Among Pregnant and Lactating Individuals.

Kachikis, Alisa / Englund, Janet A / Covelli, Isabela / Frank, Yael / Haghighi, Candace / Singleton, Michael / Drake, Alison L / Eckert, Linda O

JAMA network open

2022 Volume 5, Issue 9, Page(s) e2230495

Abstract: Importance: COVID-19 vaccine boosters or third doses are recommended for adolescents and adults who completed their initial COVID-19 vaccine course more than 5 months prior. Minimal data are available on COVID-19 vaccine booster or third dose ... ...

Abstract	Importance: COVID-19 vaccine boosters or third doses are recommended for adolescents and adults who completed their initial COVID-19 vaccine course more than 5 months prior. Minimal data are available on COVID-19 vaccine booster or third dose reactogenicity among pregnant and lactating individuals. Objective: To describe the reactions to the booster or third dose of the COVID-19 vaccine and vaccine experiences among pregnant and lactating individuals. Design, setting, and participants: Beginning in October 2021, a follow-up Research Electronic Data Capture (REDCap) survey regarding a COVID-19 vaccine booster or third dose was sent to 17 504 participants in an ongoing online prospective cohort study on COVID-19 vaccines among pregnant and lactating individuals. A convenience sample of adults enrolled in the online prospective study who were pregnant, lactating, or neither pregnant nor lactating at the time of their booster or third dose was eligible for this follow-up survey; 17 014 (97.2%) completed the follow-up survey. Exposure: Receipt of a booster or third dose of the COVID-19 vaccine. Main outcomes and measures: Self-reported vaccine reactions less than 24 hours after the dose. Results: As of April 4, 2022, 17 014 eligible participants (mean [SD] age, 33.3 [3.5] years) responded to the booster or third dose survey; of these, 2009 (11.8%) were pregnant at the time of their booster or third dose, 10 279 (60.4%) were lactating, and 4726 (27.8%) were neither pregnant nor lactating. After a COVID-19 booster or third dose, most individuals (14 074 of 17 005 [82.8%]) reported a local reaction, and 11 542 of 17 005 (67.9%) reported at least 1 systemic symptom. Compared with individuals who were neither pregnant nor lactating, pregnant participants were more likely to report any local reaction to a COVID-19 booster or third dose (adjusted odds ratio [aOR], 1.2; 95% CI, 1.0-1.4; P = .01) but less likely to report any systemic reaction (aOR, 0.7; 95% CI, 0.6-0.8; P < .001). Most pregnant (1961 of 2009 [97.6%]) and lactating (9866 of 10 277 [96.0%]) individuals reported no obstetric or lactation concerns after vaccination. Conclusions and relevance: This study suggests that COVID-19 vaccine boosters or third doses were well tolerated among pregnant and lactating individuals. Data to evaluate tolerability of boosters or additional doses among pregnant and lactating individuals will be important as they are considered for these populations.
MeSH term(s)	Adolescent ; Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Immunization, Secondary/adverse effects ; Lactation ; Pregnancy ; Pregnancy Complications, Infectious/prevention & control ; Prospective Studies ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.30495
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Article ; Online: Clinical characteristics of infantile hemangiomas with aggressive, persistent, and destructive ulceration.

Gautam, Ayushi / Frieden, Ilona J / Shah, Sonal D / Witman, Patricia M / Harfmann, Katya / Bradley, Flora / Blei, Francine / Pope, Elena / Alsumait, Anwar / Gupta, Deepti / Covelli, Isabela / Streicher, Jenna L / Cotton, Colleen / Tollefson, Megha / Nguyen, Henry / Hunt, Raegan / Buros, Amy / Fernández Faith, Esteban

Pediatric dermatology

2023 Volume 40, Issue 6, Page(s) 996–1002

Abstract: Background/objectives: Ulceration is a common complication of infantile hemangioma (IH). Severe, persistent ulceration occurs in a minority of patients. This study aims to characterize the clinical features of IH with aggressive ulceration (AU).: ... ...

Abstract	Background/objectives: Ulceration is a common complication of infantile hemangioma (IH). Severe, persistent ulceration occurs in a minority of patients. This study aims to characterize the clinical features of IH with aggressive ulceration (AU). Methods: Multicenter retrospective study of clinical features of IH with AU. Results: Thirty-five patients with AU were identified and included in the study. The majority of AU occurred in segmental IH (23/35, 65%). Segmental IH with AU were large (≥10 cm Conclusions: IH resulting in AU differ in clinical features by anatomic site. Those in the diaper area are nearly always segmental with thin superficial component, whereas other sites tend to be localized, mixed, with thick superficial component. These distinct phenotypes may prove useful in the clinical setting for physicians to identify patterns of IH ulceration with increased risk of aggressive, persistent ulceration.
MeSH term(s)	Humans ; Infant ; Retrospective Studies ; Hemangioma, Capillary/complications ; Hemangioma/complications ; Hemangioma/diagnosis ; Upper Extremity ; Skin ; Skin Neoplasms/complications ; Skin Neoplasms/diagnosis
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	605539-4
ISSN	1525-1470 ; 0736-8046
ISSN (online)	1525-1470
ISSN	0736-8046
DOI	10.1111/pde.15444
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Article ; Online: Clinical Features, Prognostic Factors, and Treatment Interventions for Ulceration in Patients With Infantile Hemangioma.

Fernández Faith, Esteban / Shah, Sonal / Witman, Patricia M / Harfmann, Katya / Bradley, Flora / Blei, Francine / Pope, Elena / Alsumait, Anwar / Gupta, Deepti / Covelli, Isabela / Streicher, Jenna L / Cotton, Colleen / Tollefson, Megha / Nguyen, Henry / Hunt, Raegan / Moore-Clingenpeel, Melissa / Frieden, Ilona J

JAMA dermatology

2021 Volume 157, Issue 5, Page(s) 566–572

Abstract: Importance: Ulceration is a common complication of infantile hemangioma (IH), which leads to substantial morbidity. Ulceration in IH has not been systematically studied since the advent of β-blocker therapy for IH.: Objectives: To examine treatment ... ...

Abstract	Importance: Ulceration is a common complication of infantile hemangioma (IH), which leads to substantial morbidity. Ulceration in IH has not been systematically studied since the advent of β-blocker therapy for IH. Objectives: To examine treatment interventions used for ulceration in IH and identify clinical prognostic indicators of healing time. Design, setting, and participants: A retrospective, multicenter cohort study was conducted on 436 consecutive patients with a clinical diagnosis of ulcerated IH and available clinical photographs. Patients receiving care at tertiary referral centers evaluated between 2012 and 2016 were included; statistical and data analysis were performed from February 7 to April 27, 2020. Exposures: Clinical characteristics, treatment interventions, course, complications, and resource use were analyzed. Treatment interventions for ulceration in IH included local (wound care, topical), systemic (β-blocker, corticosteroids), and procedural (pulsed-dye laser). Main outcomes and measures: The primary end point was time to complete or nearly complete ulceration healing. Clinical characteristics were analyzed to determine the responses to most common interventions and prognostic factors for healing of ulceration. Results: Of the 436 patients included in the study, 327 were girls (75.0%); median age at ulceration was 13.7 weeks (interquartile range, 8.86-21.30 weeks). The median heal time was 4.79 weeks (95% CI, 3.71-5.86 weeks) with wound care alone, 5.14 weeks (95% CI, 4.57-6.00 weeks) with timolol, 6.36 weeks (95% CI, 5.57-8.00 weeks) with a systemic β-blocker, and 7.71 weeks (95% CI, 6.71-10.14 weeks) with multimodal therapy. After adjusting for IH size, a dose of propranolol less than or equal to 1 mg/kg/d was associated with shorter healing time compared with higher propranolol doses (hazard ratio, 2.04; 95% CI, 1.11 to 3.73; P = .02). Size of the IH was identified as a significant prognostic factor for healing time in multivariable analysis. Increasing size of IH portends a proportionately longer time to heal of the ulceration. Conclusions and relevance: Despite the use of β-blockers, this cohort study found that a subset of patients with IH ulceration continued to experience prolonged IH healing times. Larger IH size appears to be a poor prognostic factor for time to heal. For patients requiring systemic therapy, initiation of propranolol at lower doses (≤1 mg/kg/d) should be considered.
MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Age Factors ; Bandages ; Combined Modality Therapy ; Female ; Hemangioma, Capillary/complications ; Hemangioma, Capillary/pathology ; Hemangioma, Capillary/therapy ; Humans ; Infant ; Lasers, Dye/therapeutic use ; Low-Level Light Therapy ; Male ; Prognosis ; Retrospective Studies ; Skin Neoplasms/complications ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Skin Ulcer/diagnosis ; Skin Ulcer/etiology ; Skin Ulcer/therapy ; Timolol/therapeutic use ; Treatment Outcome ; Wound Healing
Chemical Substances	Adrenergic beta-Antagonists ; Timolol (817W3C6175)
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2021.0469
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Article ; Online: Preliminary summary and reclassification of cases from the Pediatric Research of Management in Stevens-Johnson syndrome and Epidermonecrolysis (PROMISE) study: A North American, multisite retrospective cohort.

Martinez-Cabriales, Sylvia / Coulombe, Jerome / Aaron, Michelle / Hussain, Sadaf H / Linggonegoro, Danny / Lara-Corrales, Irene / Barootes, Hailey / Brandling-Bennett, Heather / Covelli, Isabela / Kirkorian, Anna Yasmine / Shah, Nidhi / Castelo-Soccio, Leslie / McKenzie, Paige / Arkin, Lisa M / Heinze, Adam / Liy-Wong, Carmen / Travis, Nicole / Rieder, Michael / Del Pozzo-Magana, Blanca R /

Schoch, Jennifer J / Monir, Reesa / Glick, Sharon A / Uwakwe, Laura / Skillman, Sarah / Hekman, Dan P / Lethebe, Brendan C / Ramien, Michele L

Journal of the American Academy of Dermatology

2023 Volume 90, Issue 3, Page(s) 635–637

MeSH term(s)	Child ; Humans ; Retrospective Studies ; Stevens-Johnson Syndrome/therapy ; Research ; North America
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.08.112
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Article ; Online: Isothermal strand displacement amplification (iSDA): a rapid and sensitive method of nucleic acid amplification for point-of-care diagnosis.

Toley, Bhushan J / Covelli, Isabela / Belousov, Yevgeniy / Ramachandran, Sujatha / Kline, Enos / Scarr, Noah / Vermeulen, Nic / Mahoney, Walt / Lutz, Barry R / Yager, Paul

The Analyst

2015 Volume 140, Issue 22, Page(s) 7540–7549

Abstract: We present a method of rapid isothermal amplification of DNA without initial heat denaturation of the template, and methods and probes for (a) real-time fluorescence detection and (b) lateral flow detection of amplicons. Isothermal strand displacement ... ...

Abstract	We present a method of rapid isothermal amplification of DNA without initial heat denaturation of the template, and methods and probes for (a) real-time fluorescence detection and (b) lateral flow detection of amplicons. Isothermal strand displacement amplification (iSDA) can achieve >10(9)-fold amplification of the target sequence in <20 minutes at 49 °C, which makes it one of the fastest existing isothermal DNA amplification methods. iSDA initiates at sites where DNA base pairs spontaneously open or transiently convert into Hoogsteen pairs, i.e. "breathe", and proceeds to exponential amplification by repeated nicking, extension, and displacement of single strands. We demonstrate successful iSDA amplification and lateral flow detection of 10 copies of a Staphylococcus aureus gene, NO.-inducible l-lactate dehydrogenase (ldh1) (Richardson, Libby, and Fang, Science, 2008, 319, 1672-1676), in a clean sample and 50 copies in the presence of high concentrations of genomic DNA and mucins in <30 minutes. We also present a simple kinetic model of iSDA that incorporates competition between target and primer-dimer amplification. This is the first model that quantitates the effects of primer-dimer products in isothermal amplification reactions. Finally, we demonstrate the multiplexing capability of iSDA by the simultaneous amplification of the target gene and an engineered internal control sequence. The speed, sensitivity, and specificity of iSDA make it a powerful method for point-of-care molecular diagnosis.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; Humans ; Isoenzymes/genetics ; Isoenzymes/isolation & purification ; L-Lactate Dehydrogenase/genetics ; L-Lactate Dehydrogenase/isolation & purification ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Nucleic Acid Amplification Techniques/economics ; Nucleic Acid Amplification Techniques/methods ; Point-of-Care Systems/economics ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/microbiology ; Time Factors
Chemical Substances	Bacterial Proteins ; DNA, Bacterial ; Isoenzymes ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; lactate dehydrogenase 1 (EC 1.1.1.27.-)
Language	English
Publishing date	2015-11-21
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/c5an01632k
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Article ; Online: Short-term Reactions Among Pregnant and Lactating Individuals in the First Wave of the COVID-19 Vaccine Rollout.

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Article ; Online: Influence of gender and sexual identity on adolescent skin health.

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Article ; Online: Analysis of Vaccine Reactions After COVID-19 Vaccine Booster Doses Among Pregnant and Lactating Individuals.

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Article ; Online: Clinical characteristics of infantile hemangiomas with aggressive, persistent, and destructive ulceration.

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Article ; Online: Clinical Features, Prognostic Factors, and Treatment Interventions for Ulceration in Patients With Infantile Hemangioma.

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Article ; Online: Preliminary summary and reclassification of cases from the Pediatric Research of Management in Stevens-Johnson syndrome and Epidermonecrolysis (PROMISE) study: A North American, multisite retrospective cohort.

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Article ; Online: Isothermal strand displacement amplification (iSDA): a rapid and sensitive method of nucleic acid amplification for point-of-care diagnosis.

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