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Book ; Online: Faculty Opinions recommendation of An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation.

Cox, Daniel

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

2020

Keywords	covid19
Publisher	Faculty Opinions Ltd
Publishing country	uk
Document type	Book ; Online
DOI	10.3410/f.738470337.793577860
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The role of the therapeutic bond when working with clients in suicidal crisis.

Cox, Daniel W / Deptuck, Halina M / Fischer, Olivia / Wojcik, Katharine D

Journal of counseling psychology

2024 Volume 71, Issue 2, Page(s) 115–125

Abstract: The desire to die by suicide has been linked with interpersonal difficulties and impeded clinical outcomes. Despite the emphasis on the therapeutic relationship in clinical guidelines for working with suicidal clients, little is known about how suicidal ... ...

Abstract	The desire to die by suicide has been linked with interpersonal difficulties and impeded clinical outcomes. Despite the emphasis on the therapeutic relationship in clinical guidelines for working with suicidal clients, little is known about how suicidal clients' interpersonal difficulties manifest in clinical contexts. Additionally, there is limited understanding of the therapeutic relationship in single-session suicidal crisis contexts. Our aim was to examine the trajectory of the therapeutic bond in mediating clients' suicidal desire and outcome in single-session suicidal crisis intervention. Single-session online text-based crisis intervention sessions (
MeSH term(s)	Female ; Humans ; Adult ; Male ; Suicidal Ideation ; Suicide ; Databases, Factual ; Latent Class Analysis
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2066555-6
ISSN	1939-2168 ; 0022-0167
ISSN (online)	1939-2168
ISSN	0022-0167
DOI	10.1037/cou0000724
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bridging the multicultural orientation framework with sexual and gender minority psychotherapy: A mixed studies systematic review.

Fischer, Olivia / Cox, Daniel W / Mickelson, Johanna M / Lyons, Kelly

Psychotherapy (Chicago, Ill.)

2024 Volume 61, Issue 1, Page(s) 1–30

Abstract: Sexual and gender minorities (SGM) experience higher rates of psychological distress and seek psychotherapy at higher rates compared to their heterosexual and cisgender counterparts. However, few therapists are trained on how to provide effective ... ...

Abstract	Sexual and gender minorities (SGM) experience higher rates of psychological distress and seek psychotherapy at higher rates compared to their heterosexual and cisgender counterparts. However, few therapists are trained on how to provide effective psychotherapy with SGM clients. The multicultural orientation (MCO) framework, which has been linked to improved therapeutic processes and outcomes, may be a valuable tool for working with SGM clients. The primary aim of this systematic review was to link the MCO framework to existing empirical psychotherapy research with SGM clients. A secondary aim was to examine how MCO constructs that we identified within the SGM literature have been associated with therapeutic processes and outcomes with SGM clients. A systematic search of five databases yielded 61 studies that were included in the review. Framework analysis was used to extract data and identify themes and subthemes related to MCO constructs from included studies. Results of the review demonstrate how the MCO framework can be used to conceptualize psychotherapy with SGM clients and-using the MCO framework-highlight potential beneficial and harmful therapist qualities and actions when working with SGM clients. Implications for future research and psychotherapy practice with SGM clients are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Humans ; Cultural Diversity ; Sexual and Gender Minorities ; Psychotherapy
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	281564-3
ISSN	1939-1536 ; 0033-3204
ISSN (online)	1939-1536
ISSN	0033-3204
DOI	10.1037/pst0000518
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Article ; Online: A Randomized, Phase 3, Double-Blind, Crossover Comparison of Multilayer, Extended-Release Methylphenidate (PRC-063), and Lisdexamfetamine in the Driving Performance of Young Adults With ADHD.

Madaan, Vishal / Bhaskar, Sailaja / Donnelly, Graeme A E / Cox, Daniel J

Journal of attention disorders

2024 Volume 28, Issue 6, Page(s) 947–956

Abstract: Objective: To compare PRC-063 (multilayer-release methylphenidate) and lisdexamfetamine dimesylate (LDX) on the driving performance of young adults with attention deficit hyperactivity disorder (ADHD) in a randomized, double-blind, crossover study.: ... ...

Abstract	Objective: To compare PRC-063 (multilayer-release methylphenidate) and lisdexamfetamine dimesylate (LDX) on the driving performance of young adults with attention deficit hyperactivity disorder (ADHD) in a randomized, double-blind, crossover study. Method: Following up to 21 days of each treatment in each treatment course (PRC-063/LDX or LDX/PRC-063), subjects completed a 15-hour driving simulator laboratory assessment. The primary outcome measure was the Tactical Driving Quotient (TDQ) and the Clinical Global Impressions-Improvement (CGI-I) scale was a secondary outcome measure. Results: Forty-four subjects completed the study. PRC-063 and LDX had equivalent effects on driving performance through a 15-hour time period (least square mean difference -0.3 [standard error 1.08], 95% confidence interval [-2.4, 1.8], Conclusions: PRC-063 and LDX had comparable effects on driving performance, from 1 through 15 hours, the last time point measured.
MeSH term(s)	Humans ; Young Adult ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/chemically induced ; Central Nervous System Stimulants/therapeutic use ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Lisdexamfetamine Dimesylate/therapeutic use ; Methylphenidate/therapeutic use ; Treatment Outcome
Chemical Substances	Central Nervous System Stimulants ; Lisdexamfetamine Dimesylate (SJT761GEGS) ; Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	2024-02-25
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/10870547241226634
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Article ; Online: The Effect of Cognitive Fusion on Change in PTSD and Depression Symptom Severity in Veterans Engaged in Group Psychotherapy.

Wojcik, Katharine D / Cox, Daniel W / Kealy, David / Zumbo, Bruno

Journal of cognitive psychotherapy

2024 Volume 38, Issue 2, Page(s) 169–184

Abstract: Cognitive fusion occurs when people experience their thoughts as literally true and allow them to dictate behavior. Fusion has been shown to be associated with increased symptoms of post-traumatic stress disorder (PTSD) and depression; however, the ... ...

Abstract	Cognitive fusion occurs when people experience their thoughts as literally true and allow them to dictate behavior. Fusion has been shown to be associated with increased symptoms of post-traumatic stress disorder (PTSD) and depression; however, the association between change in cognitive fusion, PTSD, and depression symptoms has been relatively uninvestigated. Our study aims to examine the associations between PTSD, depression symptoms, and cognitive fusion in Canadian veterans from pre- to post-treatment. Clients (
MeSH term(s)	Humans ; Veterans/psychology ; Depression ; Stress Disorders, Post-Traumatic/psychology ; Canada ; Psychotherapy, Group/methods ; Cognition
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	639096-1
ISSN	1938-887X ; 0889-8391
ISSN (online)	1938-887X
ISSN	0889-8391
DOI	10.1891/JCP-2022-0035
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Article: Neural substrates of cold nociception in

Patel, Atit A / Cardona, Albert / Cox, Daniel N

bioRxiv : the preprint server for biology

2023

Abstract: Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node in a neural network that computes stimulus specific behaviors to either navigate ... ...

Abstract	Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node in a neural network that computes stimulus specific behaviors to either navigate away from injury-causing conditions or to perform protective behaviors that mitigate extensive injury. The ability of an animal to detect and respond to various sensory stimuli depends upon molecular diversity in the primary sensors and the underlying neural circuitry responsible for the relevant behavioral action selection. Recent studies in
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.31.551339
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Article ; Online: Diel niche variation in mammalian declines in the Anthropocene.

Cox, Daniel T C / Gardner, Alexandra S / Gaston, Kevin J

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1031

Abstract: Biodiversity is being eroded worldwide. Many human pressures are most forcefully exerted or have greatest effect during a particular period of the day. Therefore when species are physically active (their diel niche) may influence their risk of population ...

Abstract	Biodiversity is being eroded worldwide. Many human pressures are most forcefully exerted or have greatest effect during a particular period of the day. Therefore when species are physically active (their diel niche) may influence their risk of population decline. We grouped 5032 terrestrial extant mammals by their dominant activity pattern (nocturnal, crepuscular, cathemeral and diurnal), and determine variation in population decline across diel niches. We find an increased risk of population decline in diurnal (52.1% of species), compared to nocturnal (40.1% of species), crepuscular (39.1% of species) and cathemeral (43.0% of species) species, associated with the larger proportion of diurnal mammals that are primates. Those species with declining populations whose activity predominantly coincides with that of humans (cathemeral, diurnal) face an increased number of anthropogenic threats than those principally active at night, with diurnal species more likely to be declining from harvesting. Across much of the land surface habitat loss is the predominant driver of population decline, however, harvesting is a greater threat to day-active species in sub-Saharan Africa and mainland tropical Asia, associated with declines in megafauna and arboreal foragers. Deepening understanding of diel variation in anthropogenic pressures and resulting population declines will help target conservation actions.
MeSH term(s)	Humans ; Animals ; Mammals ; Ecosystem ; Biodiversity ; Asia
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28104-2
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Article ; Online: Global erosion of terrestrial environmental space by artificial light at night.

Cox, Daniel T C / Gaston, Kevin J

The Science of the total environment

2023 Volume 904, Page(s) 166701

Abstract: Artificial light at night (ALAN) disrupts natural light cycles, with biological impacts that span from behaviour of individual organisms to ecosystem functions, and across bacteria, fungi, plants and animals. Global consequences have almost invariably ... ...

Abstract	Artificial light at night (ALAN) disrupts natural light cycles, with biological impacts that span from behaviour of individual organisms to ecosystem functions, and across bacteria, fungi, plants and animals. Global consequences have almost invariably been inferred from the geographic distribution of ALAN. How ALAN is distributed in environmental space, and the extent to which combinations of environmental conditions with natural light cycles have been lost, is also key. Globally (between 60°N and 56°S), we ordinated four bioclimatic variables at 1.61 * 1.21 km resolution to map the position and density of terrestrial pixels within nighttime environmental space. We then used the Black Marble Nighttime Lights product to determine where direct ALAN emissions were present in environmental space in 2012 and how these had expanded in environmental space by 2022. Finally, we used the World Atlas of Artificial Sky Brightness to determine the proportion of environmental space that is unaffected by ALAN across its spatial distribution. We found that by 2012 direct ALAN emissions occurred across 71.9 % of possible nighttime terrestrial environmental conditions, with temperate nighttime environments and highly modified habitats disproportionately impacted. From 2012 to 2022 direct ALAN emissions primarily grew within 34.4 % of environmental space where it was already present, with this growth concentrated in tropical environments. Additionally considering skyglow, just 13.2 % of environmental space now only experiences natural light cycles throughout its distribution. With opportunities to maintain much of environmental space under such cycles fast disappearing, the removal, reduction and amelioration of ALAN from areas of environmental space in which it is already widespread is critical.
Language	English
Publishing date	2023-08-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.166701
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Article: Anthropogenic changes to the nighttime environment.

Gaston, Kevin J / Gardner, Alexandra S / Cox, Daniel T C

Bioscience

2023 Volume 73, Issue 4, Page(s) 280–290

Abstract: How the relative impacts of anthropogenic pressures on the natural environment vary between different taxonomic groups, habitats, and geographic regions is increasingly well established. By contrast, the times of day at which those pressures are most ... ...

Abstract	How the relative impacts of anthropogenic pressures on the natural environment vary between different taxonomic groups, habitats, and geographic regions is increasingly well established. By contrast, the times of day at which those pressures are most forcefully exerted or have greatest influence are not well understood. The impact on the nighttime environment bears particular scrutiny, given that for practical reasons (e.g., researchers themselves belong to a diurnal species), most studies on the impacts of anthropogenic pressures are conducted during the daytime on organisms that are predominantly day active or in ways that do not differentiate between daytime and nighttime. In the present article, we synthesize the current state of knowledge of impacts of anthropogenic pressures on the nighttime environment, highlighting key findings and examples. The evidence available suggests that the nighttime environment is under intense stress across increasing areas of the world, especially from nighttime pollution, climate change, and overexploitation of resources.
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	280313-6
ISSN	0006-3568
ISSN	0006-3568
DOI	10.1093/biosci/biad017
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Article ; Online: Cathemerality: a key temporal niche.

Cox, Daniel T C / Gaston, Kevin J

Biological reviews of the Cambridge Philosophical Society

2023 Volume 99, Issue 2, Page(s) 329–347

Abstract: Given the marked variation in abiotic and biotic conditions between day and night, many species specialise their physical activity to being diurnal or nocturnal, and it was long thought that these strategies were commonly fairly fixed and invariant. The ... ...

Abstract	Given the marked variation in abiotic and biotic conditions between day and night, many species specialise their physical activity to being diurnal or nocturnal, and it was long thought that these strategies were commonly fairly fixed and invariant. The term 'cathemeral', was coined in 1987, when Tattersall noted activity in a Madagascan primate during the hours of both daylight and darkness. Initially thought to be rare, cathemerality is now known to be a quite widespread form of time partitioning amongst arthropods, fish, birds, and mammals. Herein we provide a synthesis of present understanding of cathemeral behaviour, arguing that it should routinely be included alongside diurnal and nocturnal strategies in schemes that distinguish and categorise species across taxa according to temporal niche. This synthesis is particularly timely because (i) the study of animal activity patterns is being revolutionised by new and improved technologies; (ii) it is becoming apparent that cathemerality covers a diverse range of obligate to facultative forms, each with their own common sets of functional traits, geographic ranges and evolutionary history; (iii) daytime and nighttime activity likely plays an important but currently neglected role in temporal niche partitioning and ecosystem functioning; and (iv) cathemerality may have an important role in the ability of species to adapt to human-mediated pressures.
MeSH term(s)	Animals ; Humans ; Ecosystem ; Circadian Rhythm ; Mammals ; Biological Evolution ; Adaptation, Physiological
Language	English
Publishing date	2023-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1423558-4
ISSN	1469-185X ; 0006-3231 ; 1464-7931
ISSN (online)	1469-185X
ISSN	0006-3231 ; 1464-7931
DOI	10.1111/brv.13024
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