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  1. Artikel: Neural substrates of cold nociception in

    Patel, Atit A / Cardona, Albert / Cox, Daniel N

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node in a neural network that computes stimulus specific behaviors to either navigate ... ...

    Abstract Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node in a neural network that computes stimulus specific behaviors to either navigate away from injury-causing conditions or to perform protective behaviors that mitigate extensive injury. The ability of an animal to detect and respond to various sensory stimuli depends upon molecular diversity in the primary sensors and the underlying neural circuitry responsible for the relevant behavioral action selection. Recent studies in
    Sprache Englisch
    Erscheinungsdatum 2023-08-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.07.31.551339
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Local Microtubule and F-Actin Distributions Fully Constrain the Spatial Geometry of

    Nanda, Sumit / Bhattacharjee, Shatabdi / Cox, Daniel N / Ascoli, Giorgio A

    International journal of molecular sciences

    2023  Band 24, Heft 7

    Abstract: Dendritic morphology underlies the source and processing of neuronal signal inputs. Morphology can be broadly described by two types of geometric characteristics. The first is dendrogram topology, defined by the length and frequency of the arbor branches; ...

    Abstract Dendritic morphology underlies the source and processing of neuronal signal inputs. Morphology can be broadly described by two types of geometric characteristics. The first is dendrogram topology, defined by the length and frequency of the arbor branches; the second is spatial embedding, mainly determined by branch angles and straightness. We have previously demonstrated that microtubules and actin filaments are associated with arbor elongation and branching, fully constraining dendrogram topology. Here, we relate the local distribution of these two primary cytoskeletal components with dendritic spatial embedding. We first reconstruct and analyze 167 sensory neurons from the
    Mesh-Begriff(e) Animals ; Drosophila/metabolism ; Actins/metabolism ; Drosophila Proteins/metabolism ; Dendrites/metabolism ; Microtubules/metabolism ; Sensory Receptor Cells/metabolism ; Actin Cytoskeleton/metabolism
    Chemische Substanzen Actins ; Drosophila Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-04-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076741
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Cold-Temperature Coding with Bursting and Spiking Based on TRP Channel Dynamics in

    Maksymchuk, Natalia / Sakurai, Akira / Cox, Daniel N / Cymbalyuk, Gennady S

    International journal of molecular sciences

    2023  Band 24, Heft 19

    Abstract: Temperature sensation involves thermosensitive TRP (thermoTRP) and non-TRP channels. ...

    Abstract Temperature sensation involves thermosensitive TRP (thermoTRP) and non-TRP channels.
    Mesh-Begriff(e) Animals ; Larva ; Drosophila ; Cold Temperature ; Temperature ; Sensory Receptor Cells/physiology ; Action Potentials/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-09-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914638
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Local microtubule and F-actin distributions fully determine the spatial geometry of

    Nanda, Sumit / Bhattacharjee, Shatabdi / Cox, Daniel N / Ascoli, Giorgio A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Dendritic morphology underlies the source and processing of neuronal signal inputs. Morphology can be broadly described by two types of geometric characteristics. The first is dendrogram topology, defined by the length and frequency of the arbor branches; ...

    Abstract Dendritic morphology underlies the source and processing of neuronal signal inputs. Morphology can be broadly described by two types of geometric characteristics. The first is dendrogram topology, defined by the length and frequency of the arbor branches; the second is spatial embedding, mainly determined by branch angles and tortuosity. We have previously demonstrated that microtubules and actin filaments are associated with arbor elongation and branching, fully constraining dendrogram topology. Here we relate the local distribution of these two primary cytoskeletal components with dendritic spatial embedding. We first reconstruct and analyze 167 sensory neurons from the
    Sprache Englisch
    Erscheinungsdatum 2023-02-27
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.02.24.529978
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Homeostatic Roles of the Proteostasis Network in Dendrites.

    Lottes, Erin N / Cox, Daniel N

    Frontiers in cellular neuroscience

    2020  Band 14, Seite(n) 264

    Abstract: Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally complex and diverse multipolar projection morphologies that can ... ...

    Abstract Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally complex and diverse multipolar projection morphologies that can span great distances. These properties present unique demands on proteostatic machinery to dynamically regulate the neuronal proteome in both space and time. Proteostasis is regulated by a distributed network of cellular processes, the proteostasis network (PN), which ensures precise control of protein synthesis, native conformational folding and maintenance, and protein turnover and degradation, collectively safeguarding proteome integrity both under homeostatic conditions and in the contexts of cellular stress, aging, and disease. Dendrites are equipped with distributed cellular machinery for protein synthesis and turnover, including dendritically trafficked ribosomes, chaperones, and autophagosomes. The PN can be subdivided into an adaptive network of three major functional pathways that synergistically govern protein quality control through the action of (1) protein synthesis machinery; (2) maintenance mechanisms including molecular chaperones involved in protein folding; and (3) degradative pathways (
    Sprache Englisch
    Erscheinungsdatum 2020-08-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2020.00264
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature.

    Himmel, Nathaniel J / Cox, Daniel N

    Proceedings. Biological sciences

    2020  Band 287, Heft 1933, Seite(n) 20201309

    Abstract: The transient receptor potential superfamily of ion channels (TRP channels) is widely recognized for the roles its members play in sensory nervous systems. However, the incredible diversity within the TRP superfamily, and the wide range of sensory ... ...

    Abstract The transient receptor potential superfamily of ion channels (TRP channels) is widely recognized for the roles its members play in sensory nervous systems. However, the incredible diversity within the TRP superfamily, and the wide range of sensory capacities found therein, has also allowed TRP channels to function beyond sensing an organism's external environment, and TRP channels have thus become broadly critical to (at least) animal life. TRP channels were originally discovered in
    Mesh-Begriff(e) Animals ; Drosophila ; Evolution, Molecular ; Phylogeny ; Transient Receptor Potential Channels
    Chemische Substanzen Transient Receptor Potential Channels
    Sprache Englisch
    Erscheinungsdatum 2020-08-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2020.1309
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception.

    Patel, Atit A / Sakurai, Akira / Himmel, Nathaniel J / Cox, Daniel N

    Frontiers in molecular neuroscience

    2022  Band 15, Seite(n) 942548

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    Sprache Englisch
    Erscheinungsdatum 2022-09-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.942548
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Transient and Steady-State Properties of

    Maksymchuk, Natalia / Sakurai, Akira / Cox, Daniel N / Cymbalyuk, Gennady

    Frontiers in cellular neuroscience

    2022  Band 16, Seite(n) 831803

    Abstract: Coding noxious cold signals, such as the magnitude and rate of temperature change, play essential roles in the survival of organisms. We combined electrophysiological and computational neuroscience methods to investigate the neural dynamics ... ...

    Abstract Coding noxious cold signals, such as the magnitude and rate of temperature change, play essential roles in the survival of organisms. We combined electrophysiological and computational neuroscience methods to investigate the neural dynamics of
    Sprache Englisch
    Erscheinungsdatum 2022-07-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.831803
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Protocols for measuring cold-evoked neural activity and cold tolerance in Drosophila larvae following fictive cold acclimation.

    Himmel, Nathaniel J / Sakurai, Akira / Donaldson, Kevin J / Cox, Daniel N

    STAR protocols

    2022  Band 3, Heft 3, Seite(n) 101510

    Abstract: Here, we outline protocols to study cold acclimation in Drosophila from a neurobiological perspective, starting with fictive cold acclimation using a custom-built optogenetics-housing apparatus we call the OptoBox. We also provide detailed steps for ... ...

    Abstract Here, we outline protocols to study cold acclimation in Drosophila from a neurobiological perspective, starting with fictive cold acclimation using a custom-built optogenetics-housing apparatus we call the OptoBox. We also provide detailed steps for single-unit electrophysiological recordings from larval cold nociceptors and a high-throughput cold-tolerance assay. These protocols expand the toolkit for the study of insect cold acclimation and nociception. For complete details on the use and execution of this protocol, please refer to Himmel et al. (2021).
    Mesh-Begriff(e) Acclimatization/physiology ; Animals ; Drosophila/physiology ; Larva/physiology
    Sprache Englisch
    Erscheinungsdatum 2022-06-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101510
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Changes in neuropeptide large dense core vesicle trafficking dynamics contribute to adaptive responses to a systemic homeostatic challenge.

    Kirchner, Matthew K / Althammer, Ferdinand / Donaldson, Kevin J / Cox, Daniel N / Stern, Javier E

    iScience

    2023  Band 26, Heft 11, Seite(n) 108243

    Abstract: Neuropeptides are packed into large dense core vesicles (LDCVs) that are transported from the soma out into their processes. Limited information exists regarding mechanisms regulating LDCV trafficking, particularly during challenges to bodily homeostasis. ...

    Abstract Neuropeptides are packed into large dense core vesicles (LDCVs) that are transported from the soma out into their processes. Limited information exists regarding mechanisms regulating LDCV trafficking, particularly during challenges to bodily homeostasis. Addressing this gap, we used 2-photon imaging in an
    Sprache Englisch
    Erscheinungsdatum 2023-10-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108243
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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