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  1. AU="Cox, Stephen V"
  2. AU="Theile, Marianne"
  3. AU="Rif, Maria"
  4. AU="Chamakuri, Srinivas"
  5. AU=Oswin Henry P AU=Oswin Henry P
  6. AU=Sandvig Kirsten AU=Sandvig Kirsten
  7. AU="Mohanaruban, Aruchuna"
  8. AU="McDowell, Cliona"
  9. AU="Boehncke, Heiner"
  10. AU=Chan Rebecca J
  11. AU="Glare, T.R."
  12. AU="Dubose, Thomas D"
  13. AU="Hirano, Toru"
  14. AU="Kong, Rebekah"
  15. AU="Karen de Jager"
  16. AU=Peters A
  17. AU="Xiaofang Li"
  18. AU="Campbell, John D"
  19. AU="Emara, Yasmine"
  20. AU="Orbe, Paul"
  21. AU="Karel J van Erpecum"
  22. AU=Oltean Mihai
  23. AU="Relph, Katharine A"
  24. AU=Li Jifen AU=Li Jifen
  25. AU="Diamant, Eran"
  26. AU="Kyoung, Henry" AU="Kyoung, Henry"
  27. AU=al-Gazali L I
  28. AU="Maillet, Jean-Michel"
  29. AU="Enlong Liu"
  30. AU="Afria, Dikshant"
  31. AU="Duggal, M. S."
  32. AU="Narcisa G. Pricope"
  33. AU="Kunisada, Toshiyuki"
  34. AU="Barvkar, Vitthal"

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  1. Artikel ; Online: Plaster pipes and crystalized graphite: Open transventricular transcatheter aortic valve replacement for failed mechanical aortic valve prostheses in the porcelain aorta.

    Yong, Matthew S / Camuglia, Anthony C / Cox, Stephen V / Cole, Christopher M

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2021  Band 98, Heft 3, Seite(n) E471–E474

    Abstract: Patients with a true porcelain aorta and a failed mechanical aortic valve prosthesis have limited treatment options. Using a hybrid of an open trans-ventricular approach with peripheral cardiopulmonary bypass and integration of transcatheter techniques ... ...

    Abstract Patients with a true porcelain aorta and a failed mechanical aortic valve prosthesis have limited treatment options. Using a hybrid of an open trans-ventricular approach with peripheral cardiopulmonary bypass and integration of transcatheter techniques this challenge can be overcome. Trans-ventricular mechanical valve extraction (with transcatheter endovascular occlusion and cardioplegia) followed by direct ante-grade transcatheter heart valve implantation offers a potential solution to this conundrum. The procedure described is a novel technique that allows for the effective treatment of patients with failed mechanical surgical aortic valve prostheses in the setting of an inoperable porcelain aorta. In addition, a collaborative integrated multi-disciplinary heart team environment is required for the management of these complex patients.
    Mesh-Begriff(e) Aorta/surgery ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Dental Porcelain ; Graphite ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Chemische Substanzen Dental Porcelain (12001-21-7) ; Graphite (7782-42-5)
    Sprache Englisch
    Erscheinungsdatum 2021-02-06
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.29465
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  2. Artikel ; Online: Third-Generation Transcatheter Aortic Heart Valve with Reverse Parachute Sealing Cuff in Patients with Aortic Valve Disease.

    Malhotra, Ganeev / Cole, Chris M W / Cox, Stephen V / Ross, Jordan D W / Dooris, Mark / Moore, Peter T / Chong, Adrian A / Dahiya, Arun / Korver, Kellee / Hayman, Sam M / Camuglia, Anthony C

    Heart, lung & circulation

    2024  Band 33, Heft 3, Seite(n) 324–331

    Abstract: Background: The Navitor (Abbott Inc, IL, USA) transcatheter heart valve is a novel third-generation self-expanding bioprosthesis with specific features to mitigate paravalvular regurgitation (PVR). Owing to its novelty, there is a paucity of data on its ...

    Abstract Background: The Navitor (Abbott Inc, IL, USA) transcatheter heart valve is a novel third-generation self-expanding bioprosthesis with specific features to mitigate paravalvular regurgitation (PVR). Owing to its novelty, there is a paucity of data on its application in clinical practice.
    Methods: Consecutive cohort analysis of the use of the Navitor system in an as-treated clinical setting at a quaternary heart hospital.
    Results: Sixty consecutive non-clinical trial patients treated with Navitor were identified. All patients underwent a successful procedure. The mean age was 79.3 years (±SD 7.82), 56.67% (n=34) were female, and the mean STS score was 4.87 (±SD 5.70). At 30 days post-procedure, all patients were alive with no readmissions for heart failure. One patient had a major vascular complication (1.7%). Four patients (7.14% of patients without a pre-existing pacemaker) received a new permanent pacemaker. Two patients (3.4%) had a non-disabling stroke. PVR at 30 days was trivial or none in 75% of patients, and no patient had worse than mild PVR.
    Conclusions: The Navitor system in this as-treated cohort was associated with favourable clinical, haemodynamic, and safety outcomes.
    Mesh-Begriff(e) Humans ; Female ; Aged ; Male ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Transcatheter Aortic Valve Replacement/adverse effects ; Heart Valve Prosthesis ; Treatment Outcome ; Aortic Valve Disease/etiology ; Prosthesis Design ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2024-01-05
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.11.019
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  3. Artikel ; Online: Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial.

    Cox, Emily R / Gajanand, Trishan / Keating, Shelley E / Hordern, Matthew D / Burton, Nicola W / Green, Daniel J / Ramos, Joyce S / Ramos, Maximiano V / Fassett, Robert G / Cox, Stephen V / Coombes, Jeff S / Bailey, Tom G

    European journal of applied physiology

    2024  

    Abstract: Purpose: We compared the effects of low-volume combined aerobic and resistance high-intensity interval training (C-HIIT), combined moderate-intensity continuous training (C-MICT) and waitlist control (CON) on vascular health after 8-weeks of supervised ... ...

    Abstract Purpose: We compared the effects of low-volume combined aerobic and resistance high-intensity interval training (C-HIIT), combined moderate-intensity continuous training (C-MICT) and waitlist control (CON) on vascular health after 8-weeks of supervised training, and an additional 10-months of self-directed training, in adults with type 2 diabetes (T2D).
    Methods: Sixty-nine low active adults with T2D were randomised to 8-weeks of supervised C-HIIT (3 times/week, 78-min/week), C-MICT (current exercise guidelines, 4 times/week, 210-min/week) or CON. CON underwent usual care for 8-weeks before being re-randomised to C-HIIT or C-MICT. This was followed by 10-months of self-directed training for participants in C-HIIT and C-MICT. Vascular outcomes were evaluated at baseline, 8-weeks, and 12-months.
    Results: After 8-weeks, supervised C-HIIT significantly improved relative flow-mediated dilation (FMD) compared with CON (mean difference [MD] 0.8% [0.1, 1.4], p = 0.025). Although not significantly different from CON, the magnitude of change in relative FMD following 8-weeks of supervised C-MICT was similar (MD 0.8% [-0.1, 1.7], p = 0.080). There were no differences in haemodynamic indices, carotid-femoral pulse wave velocity (cfPWV), or aortic reservoir pressure between groups at 8-weeks. After 12-months, there was a significant reduction in haemodynamic indices (time effect, p < 0.05) for both C-HIIT and C-MICT, with no between-group difference. The reduction in cfPWV over 12-months was significantly greater in C-MICT than C-HIIT (group × time effect, p = 0.018). There was no difference in FMD over time or between groups at 12-months.
    Conclusions: Short-term supervised C-HIIT and C-MICT both increased brachial artery FMD compared with CON. Long-term C-HIIT and C-MICT were beneficial for improving haemodynamic indices, but not brachial artery FMD. C-MICT was superior to C-HIIT for improving cfPWV at 12-months.
    Trial registration: Australian New Zealand Clinical Trials Registry Identifier ACTRN12615000475549.
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-024-05473-8
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  4. Artikel ; Online: Effects of fitness and fatness on age-related arterial stiffening in people with type 2 diabetes.

    Cox, Emily R / Brown, Wendy J / Gajanand, Trishan / Bailey, Tom G / Gomersall, Sjaan R / Chachay, Veronique S / Burton, Nicola W / Fassett, Robert G / Cox, Stephen V / Coombes, Jeff S / Keating, Shelley E

    Clinical obesity

    2022  Band 12, Heft 3, Seite(n) e12519

    Abstract: People with type 2 diabetes (T2D) are at a greater risk of cardiovascular disease than the general population. Both non-modifiable (age) and modifiable (low aerobic fitness, high body fatness) factors are separately predictive of cardiovascular risk, ... ...

    Abstract People with type 2 diabetes (T2D) are at a greater risk of cardiovascular disease than the general population. Both non-modifiable (age) and modifiable (low aerobic fitness, high body fatness) factors are separately predictive of cardiovascular risk, although they often occur concomitantly. This study aimed to examine the (1) association between age and arterial stiffness, a subclinical marker of cardiovascular risk; and (2) effects of body fatness and aerobic fitness on age-related increases in arterial stiffness in people with T2D. Data from 64 individuals with T2D (age 59.8 ± 8.7 years, 40% female, HbA
    Mesh-Begriff(e) Aged ; Child ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Pulse Wave Analysis ; Risk Factors ; Vascular Stiffness
    Sprache Englisch
    Erscheinungsdatum 2022-03-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2625816-X
    ISSN 1758-8111 ; 1758-8103
    ISSN (online) 1758-8111
    ISSN 1758-8103
    DOI 10.1111/cob.12519
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  5. Artikel ; Online: 30-Day Outcomes With the Portico Transcatheter Heart Valve: Insights From a Multi-Centre Australian Observational Study.

    Camuglia, Anthony C / Cole, Christopher M W / Boyne, Nicholas / Hayman, Sam M / Cox, Stephen V / Moore, Peter T / Lau, Jerrett K / Delacroix, Sinny / Williamson, Anna Emilie / Duong, MyNgan / Schwarz, Nisha / Montarello, Joseph K / Worthley, Stephen G

    Heart, lung & circulation

    2022  Band 32, Heft 2, Seite(n) 224–231

    Abstract: Background: Transcatheter aortic valve implantation (TAVI) is an established therapy for the treatment of aortic valve disease in appropriately selected patients. Previous studies using the self-expanding Portico transcatheter heart valve (THV), (Abbott ...

    Abstract Background: Transcatheter aortic valve implantation (TAVI) is an established therapy for the treatment of aortic valve disease in appropriately selected patients. Previous studies using the self-expanding Portico transcatheter heart valve (THV), (Abbott Structural Heart, St Paul, MN, USA) have demonstrated the technical feasibility of this system albeit in the hands of relatively inexperienced Portico users. The objective of this study was to assess the real-world safety and efficacy of the Portico THV (with and without the FlexNav delivery system, Abbott Structural Heart) at the 30-day timepoint in an Australian cohort.
    Methods and results: This study was a retrospective real-world cohort analysis of 269 consecutive patients with severe aortic valve disease who underwent TAVI at multiple centres within Australia between February 2015 and April 2021. Of the 269 patients, 51.7% were female, mean Society of Thoracic Surgeons (STS) score was 5.2 (±6.8) and 98.5% had successful implantations. Thirty (30)-day post-implantation all-cause mortality was observed in one (0.4%) patient, major vascular complications in two (0.7%) patients, more-than-mild paravalvular leak in six (2.2%) patients and requirement for new permanent pacemaker implantation in 27 (10.2%) patients. Haemodynamic parameters at 30 days included mean effective orifice area (EOA) of 2.3 (±0.9) cm
    Conclusion: This analysis of the Portico THV in a real-world setting suggested that the system is associated with satisfactory safety and efficacy parameters. Previously published datasets may not have found similar findings owing to lower operator experience with the Portico THV system.
    Mesh-Begriff(e) Humans ; Female ; Male ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Retrospective Studies ; Treatment Outcome ; Heart Valve Prosthesis ; Australia/epidemiology ; Transcatheter Aortic Valve Replacement/methods ; Aortic Valve Disease/surgery ; Prosthesis Design
    Sprache Englisch
    Erscheinungsdatum 2022-11-04
    Erscheinungsland Australia
    Dokumenttyp Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2022.09.012
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    Zs.A 4988: Hefte anzeigen Standort:
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  6. Artikel ; Online: Percutaneous closure of an aortic prosthetic paravalvar leak: an Australian first.

    Fanning, Jonathon P / Cox, Stephen V / Scalia, Gregory M

    Heart, lung & circulation

    2012  Band 21, Heft 3, Seite(n) 174–177

    Abstract: Percutaneous intervention is becoming an increasingly recognised modality for the management of prosthetic paravalvar leaks (PVLs) with particular utility in severely symptomatic non-surgical candidates. To date, application of this intervention has ... ...

    Abstract Percutaneous intervention is becoming an increasingly recognised modality for the management of prosthetic paravalvar leaks (PVLs) with particular utility in severely symptomatic non-surgical candidates. To date, application of this intervention has predominantly involved closure of mitral valve PVLs. Consequently, current literature on its application to aortic PVLs is limited. This article describes what we believe to be the first percutaneous closure of an aortic prosthetic PVL in Australia.
    Mesh-Begriff(e) Aged, 80 and over ; Angioplasty/instrumentation ; Angioplasty/methods ; Animals ; Aorta/pathology ; Aorta/surgery ; Aortic Valve/pathology ; Aortic Valve/surgery ; Aortic Valve Insufficiency/surgery ; Aortic Valve Insufficiency/therapy ; Australia ; Coronary Angiography ; Heart Valve Prosthesis Implantation/instrumentation ; Heart Valve Prosthesis Implantation/methods ; Humans ; Male ; Prosthesis Failure ; Swine
    Sprache Englisch
    Erscheinungsdatum 2012-03
    Erscheinungsland Australia
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2011.09.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4988: Hefte anzeigen Standort:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel: The Cone Flare Crush Modified-T (CFCT) stenting technique for coronary artery bifurcation lesions.

    Peverill, William T / Incani, Alexander / Worthley, Stephen G / Singbal, Yash / Garrahy, Paul J / McCann, Andrew B / Cox, Stephen V / Moore, Peter T / Lim, Richard Y Y / Fetahovic, Taufik / Connors, Gerard W / Hall, Cindy / Sieg, Charmaine / Camuglia, Anthony C

    International journal of cardiology. Heart & vasculature

    2020  Band 30, Seite(n) 100643

    Abstract: Background: The present study is a prospective observational single arm clinical investigation, with parallel bench test interrogation, aimed at investigating the technical feasibility, safety and clinical outcomes with the cone flare crush modified-T ( ... ...

    Abstract Background: The present study is a prospective observational single arm clinical investigation, with parallel bench test interrogation, aimed at investigating the technical feasibility, safety and clinical outcomes with the cone flare crush modified-T (CFCT) bifurcation stenting technique. Bifurcation percutaneous coronary intervention (PCI) remains an area of ongoing procedural evolution. More widely applicable and reproducible techniques are required.
    Methods: From April 2018 until March 2019, 20 consecutive patients underwent bifurcation PCI using the CFCT technique with a Pt-Cr everolimus drug-eluting stent with a bioresorbable polymer. Exercise stress echocardiography was performed at 12-month follow-up. The primary outcome was a composite of cardiac related mortality, myocardial infarction, target lesion/vessel revascularization and stroke. Safety secondary endpoints included bleeding, all-cause mortality and stent thrombosis.
    Results: All patients underwent a successful CFCT bifurcation procedure with no complications to 30-day follow-up. One patient met the primary endpoint requiring target lesion revascularization at 9 months for stable angina. There were no other primary or secondary outcome events in the cohort. There were no strokes, deaths, stent thrombosis or myocardial infarction during the follow-up period. The mean CCS score improved from 2.25 to 0.25 (p < 0.0001). Optical coherence tomography (OCT) and bench test findings indicated optimal side branch ostial coverage and minimal redundant strut material crowding the neo-carina.
    Conclusions: The CFCT technique appears to be a safe, efficacious and feasible strategy for managing coronary artery bifurcation disease. Expanded and randomized datasets with longer term follow-up are required to further explore confirm this feasibility data. (ANZCTR ID: ACTRN12618001145291).
    Sprache Englisch
    Erscheinungsdatum 2020-09-25
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2020.100643
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