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  1. Article ; Online: Sepsis - it is all about the platelets.

    Cox, Dermot

    Frontiers in immunology

    2023  Volume 14, Page(s) 1210219

    Abstract: Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the ... ...

    Abstract Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause sepsis also directly activate platelets, which suggests that pathogen-induced platelet activation leads to systemic thrombosis and drives the multi-organ failure of DIC. In this paper we review the mechanisms of platelet activation by pathogens and the evidence for a role for anti-platelet agents in the management of sepsis.
    MeSH term(s) Humans ; Blood Platelets ; Disseminated Intravascular Coagulation/etiology ; Thrombocytopenia/etiology ; Blood Coagulation Disorders/etiology ; Sepsis/complications ; Anemia
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1210219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What do we know about covid-19 vaccines in under 5s?

    Cox, David

    BMJ (Clinical research ed.)

    2022  Volume 378, Page(s) o1892

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o1892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: What will happen to the orphans of covid-19?

    Cox, David

    BMJ (Clinical research ed.)

    2022  Volume 379, Page(s) o2838

    MeSH term(s) Humans ; Child, Orphaned ; COVID-19
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o2838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How overturning Roe

    Cox, David

    BMJ (Clinical research ed.)

    2022  Volume 378, Page(s) o2075

    MeSH term(s) Abortion, Induced ; Civil Rights ; Female ; Fetus ; Humans ; Jurisprudence ; Personal Autonomy ; Pregnancy ; Pregnant Women ; Privacy ; Supreme Court Decisions ; United States
    Language English
    Publishing date 2022-08-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o2075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Case of a Lady at New York, North America, as Mentioned in Letter to a Friend, Dated May 23, 1801.

    Cox, D

    The Medical and physical journal

    2018  Volume 6, Issue 33, Page(s) 393–394

    Language English
    Publishing date 2018-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2535269-6
    ISSN 0267-0100
    ISSN 0267-0100
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  6. Article: Targeting SARS-CoV-2-Platelet Interactions in COVID-19 and Vaccine-Related Thrombosis.

    Cox, Dermot

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 708665

    Abstract: It is clear that COVID-19 is more than a pneumonia and is associated with a coagulopathy and multi-organ failure. While the use of anti-coagulants does reduce the incidence of pulmonary emboli, it does not help with survival. This suggests that the ... ...

    Abstract It is clear that COVID-19 is more than a pneumonia and is associated with a coagulopathy and multi-organ failure. While the use of anti-coagulants does reduce the incidence of pulmonary emboli, it does not help with survival. This suggests that the coagulopathy is more likely to be platelet-driven rather than thrombin-driven. There is significant evidence to suggest that SARS-CoV-2 virions directly interact with platelets to trigger activation leading to thrombocytopenia and thrombosis. I propose a model of multiple interactions between SARS-CoV-2 and platelets that has many similarities to that with
    Language English
    Publishing date 2021-07-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.708665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Investigating the Implications of Sexual Assaults with Ride-Sharing: A Call for Research.

    Tillewein, Heather / Cox, Destiny

    Journal of interpersonal violence

    2024  , Page(s) 8862605241237170

    Abstract: Sexual assault rates are increasing with ride-shares. Sexual violence data are often underestimated due to sexual violence cases going unreported and can lead to negative health outcomes. There is no research on the phenomenon of sexual assaults among ... ...

    Abstract Sexual assault rates are increasing with ride-shares. Sexual violence data are often underestimated due to sexual violence cases going unreported and can lead to negative health outcomes. There is no research on the phenomenon of sexual assaults among ride-share users. This manuscript investigates sexual assaults from two ride-share companies and the policies/procedures in place to prevent sexual assaults. The data from two ride-share companies' previous Safety Reports were compared to see an increase in sexual assaults. The researchers looked at policies and regulations that ride-share companies have to prevent sexual assault. There is a call for research to investigate more in-depth the sexual assaults that have occurred including demographic data, geographic location, global positioning system failure, and the effectiveness of the criminal background checks.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2028900-5
    ISSN 1552-6518 ; 0886-2605
    ISSN (online) 1552-6518
    ISSN 0886-2605
    DOI 10.1177/08862605241237170
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  8. Article ; Online: How not to discover a drug - integrins.

    Cox, Dermot

    Expert opinion on drug discovery

    2020  Volume 16, Issue 2, Page(s) 197–211

    Abstract: Introduction: Integrins are a family of 24 cell adhesion receptors that play a role in the biggest unmet needs in medicine - cardiovascular disease, immunology and cancer. Their discovery promised huge potential for the pharmaceutical industry. Areas ... ...

    Abstract Introduction: Integrins are a family of 24 cell adhesion receptors that play a role in the biggest unmet needs in medicine - cardiovascular disease, immunology and cancer. Their discovery promised huge potential for the pharmaceutical industry. Areas covered. Over 35-years since their discovery, there is little to show for the hundreds of billions of dollars of investment in anti-integrin drug discovery programmes. In this review the author discusses the reasons for the failure of this promising class of drugs and the future for this class of drugs. Expert opinion. Within 10-years, there was a plethora of potent, specific anti-integrin molecules and since their discovery, many of these agents have entered clinical trials. The success in discovering these agents was due to recently discovered monoclonal antibody technology. The integrin-recognition domain Arg-Gly-Asp (RGD) provided the basis for discovering small molecule inhibitors to integrins - both cyclic peptides and peptidomimetics. Most agents failed in the Phase III clinical trials and those agents that did make it to the market were plagued with issues of toxicity and limited efficacy and were soon replaced with non-integrin targeting agents. Their failure was due to a combination of poor pharmacokinetics and pharmacodynamics, complicated by the complex pathophysiology of integrins.
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Drug Development/methods ; Drug Discovery/methods ; Drug Industry ; Humans ; Integrins/antagonists & inhibitors ; Integrins/metabolism ; Molecular Targeted Therapy ; Peptides, Cyclic/pharmacology ; Peptidomimetics/pharmacology
    Chemical Substances Antibodies, Monoclonal ; Integrins ; Peptides, Cyclic ; Peptidomimetics
    Language English
    Publishing date 2020-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2020.1819234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Alarm bells ring for patient data and privacy in the covid-19 goldrush.

    Cox, David

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m1925

    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Regression Reconstruction from a Retrospective Sample.

    Kartsonaki, Christiana / Cox, D R

    Econometrics and statistics

    2023  Volume 25, Page(s) 87–92

    Abstract: The simplest form of retrospective study allows the reconstruction of the dependence between a binary outcome, ...

    Abstract The simplest form of retrospective study allows the reconstruction of the dependence between a binary outcome,
    Language English
    Publishing date 2023-01-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0389
    ISSN 2468-0389
    DOI 10.1016/j.ecosta.2020.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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