Article ; Online: Depleting transforming growth factor beta receptor 2 signalling in the cartilage of
Osteoarthritis and cartilage open
2023 Volume 5, Issue 4, Page(s) 100399
Abstract: Objectives: Integrin α1β1 protects against osteoarthritis (OA) when it is upregulated in the superficial zone of cartilage in the early stages of disease. However, the mechanism behind this protection is unknown. Integrin α1β1 moderates transforming ... ...
| Abstract | Objectives: Integrin α1β1 protects against osteoarthritis (OA) when it is upregulated in the superficial zone of cartilage in the early stages of disease. However, the mechanism behind this protection is unknown. Integrin α1β1 moderates transforming growth factor β receptor II (TGFBR2) signalling, a critical regulator of chondrocyte anabolic activity. To this end, mice lacking integrin α1β1 have increased baseline activation of TGFBR2 signalling and overall fibrosis. The purpose of this study was to evaluate the interplay between integrin α1β1 and TGFBR2 in the development of spontaneous OA. We hypothesized that dampening TGFBR2 signalling in the cartilage of Methods: Behavioural and histological manifestations of spontaneous knee OA were measured at 4, 8, 12 and 16 months in mice with and without a ubiquitous Results: Knee cartilage degeneration, collateral ligament ossification and pain responses increased with age. Conclusion: Intact TGFBR2 signalling drives early and worse knee OA in |
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| Language | English |
| Publishing date | 2023-08-12 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2665-9131 |
| ISSN (online) | 2665-9131 |
| DOI | 10.1016/j.ocarto.2023.100399 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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