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  1. Article: Analysis of Intervention Employability in Pharmacy-Related Medication Safety Reports at a Tertiary Medical Center.

    Crozier, Nick / Robinson, Elisa / Murtagh, Nicole C / Coyne, Briana D

    Hospital pharmacy

    2023  Volume 59, Issue 2, Page(s) 210–216

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787231207995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1758: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 21: Show issues

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  2. Article ; Online: Cross-sectional study of the association of social relationship resources with Staphylococcus aureus colonization in naturally occurring social groups along the US/Mexico border.

    Barger, Steven D / Lininger, Monica R / Trotter, Robert T / Mbegbu, Mimi / Kyman, Shari / Tucker-Morgan, Kara / Wood, Colin / Coyne, Briana / Russakoff, Benjamin / Ceniceros, Kathya / Padilla, Cristina / Maltinsky, Sara / Pearson, Talima

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0284400

    Abstract: Asymptomatic carriage of Staphylococcus aureus is a major risk factor for subsequent clinical infection. Diminishing returns from mitigation efforts emphasize the need to better understand colonization, spread, and transmission of this opportunistic ... ...

    Abstract Asymptomatic carriage of Staphylococcus aureus is a major risk factor for subsequent clinical infection. Diminishing returns from mitigation efforts emphasize the need to better understand colonization, spread, and transmission of this opportunistic pathogen. While contact with other people presents opportunities for pathogen exposure and transmission, diversity of social connections may be protective against pathogens such as the common cold. This study examined whether social relationship resources, including the amount and diversity of social contacts, are associated with S. aureus colonization. Participants were community members (N = 443; 68% Hispanic) in naturally occurring social groups in southwestern Arizona. Four types of social relationships and loneliness were assessed, and samples from the skin, nose and throat were obtained to ascertain S. aureus colonization. Overall S. aureus prevalence was 64.8%. Neither the amount nor the diversity of social contacts were associated with S. aureus colonization. The concurrent validity of the social relationship assessments was supported by their moderate intercorrelations and by their positive association with self-rated health. The results suggest that the association of social network diversity and susceptibility to the common cold does not extend to S. aureus colonization. Conversely, colonization prevalence was not higher among those with more social contacts. The latter pattern suggests that social transmission may be relatively infrequent or that more intimate forms of social interaction may drive transmission and colonization resulting in high community prevalence of S. aureus colonization. These data inform communicable disease control efforts.
    MeSH term(s) Humans ; Staphylococcus aureus ; Cross-Sectional Studies ; Common Cold ; Social Group ; Mexico/epidemiology ; Staphylococcal Infections/epidemiology ; Social Interaction ; Methicillin-Resistant Staphylococcus aureus ; Carrier State/epidemiology
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SaQuant: a real-time PCR assay for quantitative assessment of Staphylococcus aureus.

    Wood, Colin / Sahl, Jason / Maltinsky, Sara / Coyne, Briana / Russakoff, Benjamin / Yagüe, David Panisello / Bowers, Jolene / Pearson, Talima

    BMC microbiology

    2021  Volume 21, Issue 1, Page(s) 174

    Abstract: Background: Molecular assays are important tools for pathogen detection but need to be periodically re-evaluated with the discovery of additional genetic diversity that may cause assays to exclude target taxa or include non-target taxa. A single well- ... ...

    Abstract Background: Molecular assays are important tools for pathogen detection but need to be periodically re-evaluated with the discovery of additional genetic diversity that may cause assays to exclude target taxa or include non-target taxa. A single well-developed assay can find broad application across research, clinical, and industrial settings. Pathogen prevalence within a population is estimated using such assays and accurate results are critical for formulating effective public health policies and guiding future research. A variety of assays for the detection of Staphylococcus aureus are currently available. The utility of commercial assays for research is limited, given proprietary signatures and lack of transparent validation.
    Results: In silico testing of existing peer-reviewed assays show that most suffer from a lack of sensitivity and specificity. We found no assays that were specifically designed and validated for quantitative use. Here we present a qPCR assay, SaQuant, for the detection and quantification of S. aureus as might be collected on sampling swabs. Sensitivity and specificity of the assay was 95.6 and 99.9 %, respectively, with a limit of detection of between 3 and 5 genome equivalents and a limit of quantification of 8.27 genome equivalents. The presence of DNA from non-target species likely to be found in a swab sample, did not impact qualitative or quantitative abilities of the assay.
    Conclusions: This assay has the potential to serve as a valuable tool for the accurate detection and quantification of S. aureus collected from human body sites in order to better understand the dynamics of prevalence and transmission in community settings.
    MeSH term(s) DNA, Bacterial/genetics ; Humans ; Real-Time Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1471-2180
    ISSN (online) 1471-2180
    DOI 10.1186/s12866-021-02247-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Quantitative Assessment of Staphylococcus aureus Community Carriage in Yuma, Arizona.

    Russakoff, Benjamin / Wood, Colin / Lininger, Monica R / Barger, Steven D / Trotter, Robert T / Maltinsky, Sara / Mbegbu, Mimi / Coyne, Briana / Panisello Yagüe, David / Kyman, Shari / Tucker-Morgan, Kara / Ceniceros, Kathya / Padilla, Cristina / Hurtado, Kevin / Menard, Ashley / Villa, Francisco / Wayment, Heidi A / Hepp, Crystal / Furstenau, Tara /
    Fofanov, Viacheslav / Liu, Cindy M / Pearson, Talima R

    The Journal of infectious diseases

    2022  Volume 227, Issue 9, Page(s) 1031–1041

    Abstract: Background: Disease control relies on pathogen identification and understanding reservoirs. Staphylococcus aureus infection prevention is based upon decades of research on colonization and infection, but diminishing returns from mitigation efforts ... ...

    Abstract Background: Disease control relies on pathogen identification and understanding reservoirs. Staphylococcus aureus infection prevention is based upon decades of research on colonization and infection, but diminishing returns from mitigation efforts suggest significant knowledge gaps. Existing knowledge and mitigation protocols are founded upon culture-based detection, with almost no information about pathogen quantities.
    Methods: We used culture and a quantitative polymerase chain reaction assay on samples from 3 body sites to characterize colonization more comprehensively than previous studies by describing both prevalence and pathogen quantity.
    Results: We show a much higher overall prevalence (65.9%) than previously documented, with higher quantities and prevalence associated with the nares, non-Hispanic males (86.9%), and correlating with colonization in other body sites. These results suggest that research and clinical practices likely misclassify over half of colonized persons, limiting mitigation measures and their impact.
    Conclusions: This work begins the process of rebuilding foundational knowledge of S aureus carriage with more accurate and wholistic approaches.
    MeSH term(s) Male ; Humans ; Staphylococcus aureus/genetics ; Arizona/epidemiology ; Carrier State/epidemiology ; Carrier State/diagnosis ; Staphylococcal Infections/epidemiology ; Nasal Cavity ; Prevalence ; Methicillin-Resistant Staphylococcus aureus
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    Zs.MO 445: Show issues

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