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  1. Book ; Online ; E-Book: Enteroviruses

    Jackson, William T. / Coyne, Carolyn B.

    omics, molecular biology, and control

    2018  

    Author's details edited by William T. Jackson and Carolyn B. Coyne
    Keywords Enteroviruses ; Enteroviruses / Pathogenicity
    Language English
    Size 1 Online-Ressource (viii, 157 Seiten), Illustrationen
    Publisher Caister Academic Press
    Publishing place Norfolk, UK
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020212349
    ISBN 978-1-910190-74-6 ; 9781910190739 ; 1-910190-74-8 ; 191019073X
    DOI 10.21775/9781910190739
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Pregnancy-associated morbidity and mortality during pandemics: Looking to the past in order to prepare for the future.

    Caldwell, Allyson / Coyne, Carolyn B

    Cell host & microbe

    2023  Volume 31, Issue 6, Page(s) 847–850

    Abstract: Pregnant women are at high risk of adverse outcomes in the setting of viral-associated outbreaks and pandemics. In this forum, we discuss the impact of past and current pandemics on pregnant women and make recommendations to protect this vulnerable ... ...

    Abstract Pregnant women are at high risk of adverse outcomes in the setting of viral-associated outbreaks and pandemics. In this forum, we discuss the impact of past and current pandemics on pregnant women and make recommendations to protect this vulnerable population.
    MeSH term(s) Pregnancy ; Female ; Humans ; Pandemics ; Pregnancy Complications, Infectious/epidemiology ; Morbidity
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An

    Wells, Alexandra I / Coyne, Carolyn B

    Journal of virology

    2022  Volume 96, Issue 13, Page(s) e0033022

    Abstract: Echoviruses are among the most common worldwide causes of aseptic meningitis, which can cause long-term sequelae and death, particularly in neonates. However, the mechanisms by which these viruses induce meningeal inflammation are poorly understood, ... ...

    Abstract Echoviruses are among the most common worldwide causes of aseptic meningitis, which can cause long-term sequelae and death, particularly in neonates. However, the mechanisms by which these viruses induce meningeal inflammation are poorly understood, owing at least in part to the lack of
    MeSH term(s) Animals ; Central Nervous System Infections/physiopathology ; Central Nervous System Infections/virology ; Echovirus Infections/complications ; Echovirus Infections/physiopathology ; Echovirus Infections/virology ; Enterovirus B, Human/physiology ; Humans ; Inflammation ; Interferon Type I/metabolism ; Interferons ; Meningitis, Aseptic/etiology ; Meningitis, Aseptic/physiopathology ; Meningitis, Aseptic/virology ; Mice ; Interferon Lambda
    Chemical Substances Interferon Type I ; Interferons (9008-11-1) ; Interferon Lambda
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00330-22
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    Zs.A 609: Show issues Location:
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  4. Article ; Online: Horsepox: Framing a dual use research of concern debate.

    Coyne, Carolyn B

    PLoS pathogens

    2018  Volume 14, Issue 10, Page(s) e1007344

    MeSH term(s) Biohazard Release/prevention & control ; Dual Use Research ; Humans ; Orthopoxvirus ; Poxviridae Infections/prevention & control ; Poxviridae Infections/virology
    Language English
    Publishing date 2018-10-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1007344
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  5. Article ; Online: STING'ing Zika virus in neurons.

    Coyne, Carolyn B

    Nature microbiology

    2018  Volume 3, Issue 9, Page(s) 975–976

    MeSH term(s) Animals ; Autophagy/immunology ; Brain/immunology ; Brain/pathology ; Brain/virology ; Disease Models, Animal ; Drosophila Proteins/immunology ; Drosophila melanogaster/immunology ; Drosophila melanogaster/virology ; Humans ; Membrane Proteins/immunology ; Zika Virus/immunology ; Zika Virus Infection/immunology ; Zika Virus Infection/pathology ; Zika Virus Infection/prevention & control
    Chemical Substances Drosophila Proteins ; Membrane Proteins ; Sting protein, Drosophila
    Language English
    Publishing date 2018-08-14
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-018-0232-5
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  6. Article ; Online: Uterine NK cell education: Learning the ropes in pregnancy.

    Wells, Alexandra I / Coyne, Carolyn B

    Immunity

    2021  Volume 54, Issue 6, Page(s) 1102–1104

    Abstract: The impact of inhibitory receptor NKG2A-mediated education on uterine NK (uNK) cell responsiveness to vascular remodeling on pregnancy outcomes has remained unclear. In this issue of Immunity, Shreeve et al. show that loss of ... ...

    Abstract The impact of inhibitory receptor NKG2A-mediated education on uterine NK (uNK) cell responsiveness to vascular remodeling on pregnancy outcomes has remained unclear. In this issue of Immunity, Shreeve et al. show that loss of NKG2A
    MeSH term(s) Female ; Humans ; Killer Cells, Natural ; Neovascularization, Pathologic ; Pregnancy ; Uterus ; Vascular Remodeling
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.05.009
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  7. Article ; Online: Infections at the maternal-fetal interface: an overview of pathogenesis and defence.

    Megli, Christina J / Coyne, Carolyn B

    Nature reviews. Microbiology

    2021  Volume 20, Issue 2, Page(s) 67–82

    Abstract: Infections are a major threat to human reproductive health, and infections in pregnancy can cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to congenital infection and severe disease. The acronym 'TORCH' (Toxoplasma ...

    Abstract Infections are a major threat to human reproductive health, and infections in pregnancy can cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to congenital infection and severe disease. The acronym 'TORCH' (Toxoplasma gondii, other, rubella virus, cytomegalovirus, herpes simplex virus) refers to pathogens directly associated with the development of congenital disease and includes diverse bacteria, viruses and parasites. The placenta restricts vertical transmission during pregnancy and has evolved robust mechanisms of microbial defence. However, microorganisms that cause congenital disease have likely evolved diverse mechanisms to bypass these defences. In this Review, we discuss how TORCH pathogens access the intra-amniotic space and overcome the placental defences that protect against microbial vertical transmission.
    MeSH term(s) Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/pathology ; Cytomegalovirus Infections/transmission ; Female ; Fetal Diseases/etiology ; Fetal Diseases/microbiology ; Fetal Diseases/parasitology ; Fetal Diseases/virology ; Herpes Simplex/congenital ; Herpes Simplex/pathology ; Herpes Simplex/transmission ; Humans ; Infectious Disease Transmission, Vertical ; Placenta/microbiology ; Placenta/virology ; Pregnancy ; Rubella/congenital ; Rubella/pathology ; Rubella/transmission ; Toxoplasma/pathogenicity ; Toxoplasmosis, Congenital/pathology
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-021-00610-y
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  8. Article ; Online: Gatekeepers of the fetus: Characterization of placental macrophages.

    Megli, Christina / Coyne, Carolyn B

    The Journal of experimental medicine

    2021  Volume 218, Issue 1

    Abstract: In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide elegant technological and conceptual advances that further our understanding of the immune cells enriched at the maternal-fetal interface. Using new isolation strategies ... ...

    Abstract In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide elegant technological and conceptual advances that further our understanding of the immune cells enriched at the maternal-fetal interface. Using new isolation strategies to better separate maternal- and fetal-derived cells, the authors identify previously undefined maternal-derived immune cells associated with the fetal-derived placenta and provide an in-depth analysis of the markers and characteristics of placental Hofbauer cells.
    MeSH term(s) Female ; Fetus ; Humans ; Macrophages ; Placenta ; Pregnancy
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20202071
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  9. Article ; Online: Innate immune defenses at the maternal-fetal interface.

    Semmes, Eleanor C / Coyne, Carolyn B

    Current opinion in immunology

    2021  Volume 74, Page(s) 60–67

    Abstract: The human maternal-fetal interface is an immunologically complex environment that must balance the divergent demands of tolerance towards the developing fetus with anti-pathogen defense. The innate immune responses at the maternal-fetal interface that ... ...

    Abstract The human maternal-fetal interface is an immunologically complex environment that must balance the divergent demands of tolerance towards the developing fetus with anti-pathogen defense. The innate immune responses at the maternal-fetal interface that function in anti-microbial defense have been understudied to-date and how 'TORCH' pathogens evade maternal innate immunity to infect the fetus remains poorly understood. Herein, we discuss how newly described decidual innate lymphoid cells and maternal placenta-associated macrophage subsets may be involved in anti-pathogen defense. Moreover, we outline recent advances in our understanding of how placental trophoblasts and fetal-derived macrophages (Hofbauer cells) function in anti-microbial defense. In summary, we highlight current gaps in knowledge and describe novel experimental models of the human decidua and placenta that are poised to advance our knowledge of innate immune defenses at the maternal-fetal interface.
    MeSH term(s) Decidua ; Female ; Humans ; Immunity, Innate ; Lymphocytes ; Placenta ; Pregnancy ; Trophoblasts
    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2021.10.007
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  10. Article: Trophoblast organoids with physiological polarity model placental structure and function.

    Yang, Liheng / Liang, Pengfei / Yang, Huanghe / Coyne, Carolyn B

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Human trophoblast organoids (TOs) are a three- ... ...

    Abstract Human trophoblast organoids (TOs) are a three-dimensional
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.12.523752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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