Article: Diversity of Solid Forms Promoted by Ball Milling: Characterization and Intrinsic Dissolution Studies of Pioglitazone Hydrochloride and Fluvastatin Sodium Drug-Drug Systems.
Pharmaceuticals (Basel, Switzerland)
2023 Volume 16, Issue 6
Abstract: Coamorphous salt in a 1:1 ratio prepared by ball milling from Fluvastatin sodium (FLV) and Pioglitazone hydrochloride (PGZ·HCl) can be selectively formed by neat grinding (NG). Furthermore, the salt-cocrystal continuum was preferably formed by employing ... ...
| Abstract | Coamorphous salt in a 1:1 ratio prepared by ball milling from Fluvastatin sodium (FLV) and Pioglitazone hydrochloride (PGZ·HCl) can be selectively formed by neat grinding (NG). Furthermore, the salt-cocrystal continuum was preferably formed by employing liquid-assisted grinding (LAG) using ethanol (EtOH). Attempts to prepare the coamorphous salt starting from the salt-cocrystal continuum by NG were unsuccessful. Interestingly, through ball milling by NG or LAG, a great diversity of solid forms (PGZ·HCl-FLV 1:1) could be accessed: NG and hexane (coamorphous); ethyl acetate (physical mixture); EtOH (salt-cocrystal continuum); and water (which presents two T |
|---|---|
| Language | English |
| Publishing date | 2023-05-24 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2193542-7 |
| ISSN | 1424-8247 |
| ISSN | 1424-8247 |
| DOI | 10.3390/ph16060781 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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