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  1. Article ; Online: Short- and long-term outcomes of sphincteroplasty for anal incontinence related to obstetric injury: a systematic review.

    Mongardini, Federico Maria / Cozzolino, Giovanni / Karpathiotakis, Menelaos / Cacciatore, Chiara / Docimo, Ludovico

    Updates in surgery

    2023  Volume 75, Issue 6, Page(s) 1423–1430

    Abstract: Anal incontinence is a frequent pathological condition with devastating impact on quality of life. The prevalence is approximately 15% of the population, with higher incidence reported in the elderly and multiparous women, and several factors have a ... ...

    Abstract Anal incontinence is a frequent pathological condition with devastating impact on quality of life. The prevalence is approximately 15% of the population, with higher incidence reported in the elderly and multiparous women, and several factors have a major role in its pathogenesis, such as anatomical sphincter defects (Glasgow and Lowry in Dis Colon Rectum 55(4): 482-490, 2012), delivery injuries, and colorectal, uro-gynecological, and perineal surgery. The direct surgical approach is the gold standard treatment for fecal incontinence, especially through anterior sphincteroplasty, although a permanent defect of continence persists over time. The aim of our study is to evaluate, throughout a systematic review of the literature, the short- and long-term outcomes of sphincteroplasty performed for obstetric injuries anal incontinence. A systematic review of the studies published in the literature from January 2000 to December 2021 was performed in accordance with the PRISMA guidelines. Of the 2543 studies extrapolated, only eight fulfilled the inclusion criteria and were admitted represented by retrospective and prospective studies. The data analyzed from the included studies were number and mean age of the female population, and incontinence improvement with preoperative and postoperative short- and long-term outcomes, as reported by QoL questionaries and incontinence scores. Overall 355 patients with obstetric sphincter damage underwent sphincteroplasty with an anterior external sphincter overlapping procedure. A consistent improvement in fecal incontinence at short-term follow-up with relative improvement in QoL was reported. In 7 of 8 studies, the authors found a progressive worsening of the incontinence symptoms on the long-term follow-up. However, it is not clear whether the decrease in long-term continence results is parallel to a simultaneous decrease in QoL scores. Nevertheless, compared to the preoperative findings, the improvement was maintained in the long-term follow-up. Despite the limited data in the literature, a properly performed sphincteroplasty can guarantee a consistent improvement of the continence in short term with encouraging outcomes, especially for solid stool continence, in long time. We believe that anterior sphincteroplasty, as a low cost, feasible, and safe procedure, still has a role in the treatment of fecal incontinence for obstetric injury. Further large cohort randomized clinical trials are necessary to validate these results.
    MeSH term(s) Pregnancy ; Humans ; Female ; Aged ; Fecal Incontinence/etiology ; Fecal Incontinence/surgery ; Treatment Outcome ; Quality of Life ; Retrospective Studies ; Prospective Studies ; Anal Canal/surgery
    Language English
    Publishing date 2023-07-29
    Publishing country Italy
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01609-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review.

    Parisi, Simona / Gambardella, Claudio / Ruggiero, Roberto / Tolone, Salvatore / Iovino, Francesco / Lucido, Francesco Saverio / Fisone, Francesca / Lanza Volpe, Mariachiara / Cozzolino, Giovanni / Mongardini, Federico Maria / Brusciano, Luigi / Andrea, Ronchi / Docimo, Ludovico

    Oncology letters

    2024  Volume 27, Issue 2, Page(s) 86

    Abstract: Cancers of unknown primary (CUPs) are a heterogeneous group of tumors characterized by a difficult diagnosis. The primitive tumor remains unknown, whereas metastases are the most common manifestation. Occult male breast cancers are very rare types of ... ...

    Abstract Cancers of unknown primary (CUPs) are a heterogeneous group of tumors characterized by a difficult diagnosis. The primitive tumor remains unknown, whereas metastases are the most common manifestation. Occult male breast cancers are very rare types of CUPs. The present study describes the case of a 64-year-old man affected by a CUP of presumed mammary origin. The aim of the article and the present review was to focus on their management. To the best of our knowledge, only thirteen cases have been reported in the literature. Because no specific guidelines are available, various approaches have been applied, influencing the treatment and the prognosis of patients with CUP.
    Language English
    Publishing date 2024-01-05
    Publishing country Greece
    Document type Case Reports
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2024.14220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review.

    Parisi, Simona / Gambardella, Claudio / Iovino, Francesco / Ruggiero, Roberto / Lucido, Francesco Saverio / Nesta, Giusiana / Tolone, Salvatore / Brusciano, Luigi / Fisone, Francesca / Mongardini, Federico Maria / Cozzolino, Giovanni / Della Corte, Carminia Maria / Napolitano, Stefania / Orditura, Michele / Esposito, Rosetta / Docimo, Ludovico

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite multimodal treatment, angiosarcomas represent an ... ...

    Abstract Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite multimodal treatment, angiosarcomas represent an incurable disease for many patients and a significant cause of deterioration in their quality of life. Surgery is a cornerstone in management, but high recurrence rates are reported. Electrochemotherapy (ECT) is a practicable locoregional treatment for patients with advanced angiosarcoma as part of a multimodal therapeutic strategy. The palliative benefits of ECT include optimal patient compliance, good local hemostasis control, and positive local responses. Since only 22 cases are described in the literature, we reported a rare case of RAS treated with ECT after a multidisciplinary approach, including Next Generation Sequencing (NGS). A literature review on the feasibility of ECT in RAS management was also performed.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of Inflammatory Biomarkers (NLR, LMR, PLR) in the Prognostication of Malignancy in Indeterminate Thyroid Nodules.

    Gambardella, Claudio / Mongardini, Federico Maria / Paolicelli, Maddalena / Bentivoglio, Davide / Cozzolino, Giovanni / Ruggiero, Roberto / Pizza, Alessandra / Tolone, Salvatore / Del Genio, Gianmattia / Parisi, Simona / Brusciano, Luigi / Cerbara, Loredana / Docimo, Ludovico / Lucido, Francesco Saverio

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Indeterminate follicular thyroid lesions (Thyr 3A and 3B) account for 10% to 30% of all cytopathologic diagnoses, and their unpredictable behavior represents a hard clinical challenge. The possibility to preoperatively predict malignancy is largely ... ...

    Abstract Indeterminate follicular thyroid lesions (Thyr 3A and 3B) account for 10% to 30% of all cytopathologic diagnoses, and their unpredictable behavior represents a hard clinical challenge. The possibility to preoperatively predict malignancy is largely advocated to establish a tailored surgery, preventing diagnostic thyroidectomy. We analyzed the role of the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR) and the lymphocyte-to-monocyte ratio (LMR) as prognostic factors of malignancy for indeterminate thyroid nodules. In patients affected by cytological Thyr 3A/3B nodules, NLR, PLR and LMR were retrospectively compared and correlated with definitive pathology malignancy, utilizing student's
    MeSH term(s) Humans ; Thyroid Nodule/diagnosis ; Thyroid Nodule/pathology ; Neutrophils/pathology ; Monocytes/pathology ; Retrospective Studies ; Biomarkers ; Lymphocytes/pathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Impact of Current Technology in Laparoscopic Adrenalectomy: 20 Years of Experience in the Treatment of 254 Consecutive Clinical Cases.

    Conzo, Giovanni / Patrone, Renato / Flagiello, Luigi / Catauro, Antonio / Conzo, Alessandra / Cacciatore, Chiara / Mongardini, Federico Maria / Cozzolino, Giovanni / Esposito, Rosetta / Pasquali, Daniela / Bellastella, Giuseppe / Esposito, Katherine / Docimo, Ludovico

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Background: Laparoscopic adrenalectomy (LA), which avoids large abdomen incisions, is considered the gold standard technique for the treatment of benign small- and medium-size adrenal masses (<6 cm) and weighing < 100 g. A trascurable mortality and ... ...

    Abstract Background: Laparoscopic adrenalectomy (LA), which avoids large abdomen incisions, is considered the gold standard technique for the treatment of benign small- and medium-size adrenal masses (<6 cm) and weighing < 100 g. A trascurable mortality and morbidity rate, short hospitalization and patient rapid recovery are the main advantages compared to traditional surgery. During the past decade, a new surgical technology has been developed that expedites a "clipless" adrenalectomy. Here, the authors analyze a clinical series of 254 consecutive patients who were affected by adrenal gland neoplasms and underwent LA by the transabdominal lateral approach over the two last decades. A literature review is also presented.
    Methods: Preoperative, intraoperative and postoperative data from 254 patients who underwent LA between January 2003 and December 2022 were retrospectively collected and reviewed. Diagnosis was obtained on the basis of clinical examination, laboratory values and imaging techniques. Doxazosin was preoperatively administered in the case of pheochromocytoma (PCC) while spironolactone and potassium were employed to treat Conn's disease. The same surgeon (CG) performed all the LA and utilized the same laparoscopic transabdominal lateral approach. Different dissection tools-ultrasonic, bipolar or mixed scissors-and hemostatic agents were used during this period. The following results were obtained: 254 patients were included in the study; functioning tumors were diagnosed in 155 patients, 52 patients were affected by PCCs, 55 by Conn's disease, 48 by Cushing's disease. Surgery mean operative time was 137.33 min (range 100-180 min) during the learning curve adrenalectomies and 98.5 min (range 70-180) in subsequent procedures. Mean blood loss was respectively 160.2 mL (range 60-280) and 96.98 mL (range 50-280) in the first 30 procedures and the subsequent ones. Only three conversions (1.18%) to open surgery occurred. No mortality or postoperative major complications were observed, while minor complications occurred in 19 patients (3.54%). In 153 out of 155 functioning neoplasms, LA was effective in the normalization of the endocrine profile. According to our experience, a learning curve consisting of 30 cases was identified. In fact, a lower operative time and a lower complication rate was reported following 30 LA.
    Conclusions: LA is a safe procedure, even for masses larger than 6 cm and PCCs. Undoubtedly, the development of surgical technology has made it possible reducing operative times, performing a "clipless" adrenalectomy and extending the indications in the treatment of more complex patients. A multidisciplinary team, in referral high-volume centers, is recommended in the management of adrenal pathology. A 30-procedure learning curve is necessary to improve surgical outcomes.
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Thyroid-Bed Schwannoma Mimicking a Thyroid Neoplasm: A Challenging Diagnosis: Report of a Case and Literature Review.

    Gambardella, Claudio / Docimo, Ludovico / Candela, Giancarlo / Cozzolino, Giovanni / Mongardini, Federico / Serilli, Francesca / Nesta, Giusiana / Filograna Pignatelli, Marcello / Ferrandes, Sonia / Gambardella, Antonio / Docimo, Giovanni

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 10

    Abstract: Background: Schwannomas, also called neurinomas, are rare benign tumors of the neural cells that can develop from the sheaths of nervous structures of several districts, although the most frequent sites are the cranial nerves (25%-45%). Rarely, cases ... ...

    Abstract Background: Schwannomas, also called neurinomas, are rare benign tumors of the neural cells that can develop from the sheaths of nervous structures of several districts, although the most frequent sites are the cranial nerves (25%-45%). Rarely, cases show neck schwannomas in the thyroid parenchyma, while the cases of thyroid-bed schwannomas mimicking a thyroid-gland lesions are anecdotal.
    Methods: We report the case of a 70-year-old man with a preoperative-imaging diagnosis of a thyroid neoplasm, confirmed as Thyr 4 by fine-needle cytology.
    Results: During surgery, an extra-thyroidal lesion was discovered, determined to be a neck schwannoma through definitive pathology. A literature review of cases of thyroid-bed-lesion schwannomas misinterpreted as thyroid neoplasms was carried out.
    Conclusions: In the case of suspicious extra-thyroidal lesions, we advocate for a close routine cooperation between the cytologist, the radiologist, and the surgeon in the attempt to reach an accurate preoperative diagnosis.
    MeSH term(s) Male ; Humans ; Aged ; Thyroidectomy/methods ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Neurilemmoma/diagnosis ; Neurilemmoma/pathology ; Neurilemmoma/surgery ; Neck
    Language English
    Publishing date 2022-09-24
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58101345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A study on textual features for medical records classification.

    Alicante, Anita / Amato, Flora / Cozzolino, Giovanni / Gargiulo, Francesco / Improda, Nicla / Mazzeo, Antonino

    Studies in health technology and informatics

    2014  Volume 207, Page(s) 370–379

    Abstract: Healthcare domain is characterized by a huge amount of data, contained in medical records, reports, test results and so on. In order to give support to healthcare workers and manage relevant data in effective and efficient way, it is important to ... ...

    Abstract Healthcare domain is characterized by a huge amount of data, contained in medical records, reports, test results and so on. In order to give support to healthcare workers and manage relevant data in effective and efficient way, it is important to correctly classify the unstructured parts of text, embedded in the medical documents. In this paper, we propose a classification system for medical records categorization, focused on the combination of different methodologies, based on lexical, syntactical and semantic analysis of the documents. We will show that a Classification System based on a combination of different text analysis methodologies overcomes the performances of each methodology taken alone. The obtained results will be presented in terms of Accuracy-Rejection Curves. Eventually, pro and cons of the architecture proposed and some future work will be pointed out.
    Language English
    Publishing date 2014
    Publishing country Netherlands
    Document type Journal Article
    ISSN 0926-9630
    ISSN 0926-9630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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