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  1. Artikel ; Online: Omadacycline Is Highly Active

    Waites, Ken B / Crabb, Donna M / Atkinson, T Prescott / Geisler, William M / Xiao, Li

    Microbiology spectrum

    2022  Band 10, Heft 6, Seite(n) e0365422

    Abstract: ... Here, we ... ...

    Abstract Here, we performed
    Mesh-Begriff(e) Humans ; Tetracycline/pharmacology ; Mycoplasma genitalium ; Mycoplasma Infections/drug therapy ; Drug Resistance, Bacterial ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Macrolides/pharmacology ; Quinolones/pharmacology ; Quinolones/therapeutic use ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Mitomycin/pharmacology ; Mitomycin/therapeutic use ; Protein Synthesis Inhibitors/pharmacology
    Chemische Substanzen omadacycline (090IP5RV8F) ; Tetracycline (F8VB5M810T) ; Anti-Bacterial Agents ; Macrolides ; Quinolones ; Minocycline (FYY3R43WGO) ; Mitomycin (50SG953SK6) ; Protein Synthesis Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-10-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03654-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Antimicrobial susceptibilities and mechanisms of resistance of commensal and invasive

    Xiao, Li / Totten, Arthur H / Crabb, Donna M / Atkinson, Thomas Prescott / Waites, Ken B

    Frontiers in microbiology

    2022  Band 13, Seite(n) 914464

    Abstract: Mycoplasma ... ...

    Abstract Mycoplasma salivarium
    Sprache Englisch
    Erscheinungsdatum 2022-08-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.914464
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Latest Advances in Laboratory Detection of Mycoplasma genitalium.

    Waites, Ken B / Crabb, Donna M / Ratliff, Amy E / Geisler, William M / Atkinson, T Prescott / Xiao, Li

    Journal of clinical microbiology

    2023  Band 61, Heft 3, Seite(n) e0079021

    Abstract: Mycoplasma genitalium is an important sexually transmitted pathogen affecting both men and women. Its extremely slow ... ...

    Abstract Mycoplasma genitalium is an important sexually transmitted pathogen affecting both men and women. Its extremely slow growth
    Mesh-Begriff(e) Male ; Humans ; Female ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Mycoplasma genitalium/genetics ; Laboratories ; Drug Resistance, Bacterial ; Mycoplasma Infections/microbiology ; Macrolides ; Urethritis/microbiology
    Chemische Substanzen Anti-Bacterial Agents ; Macrolides
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00790-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: In Vitro

    Waites, Ken B / Crabb, Donna M / Xiao, Li / Duffy, Lynn B / Leal, Sixto M

    Antimicrobial agents and chemotherapy

    2020  Band 64, Heft 8

    Abstract: ... We ... ...

    Abstract We performed
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Humans ; Microbial Sensitivity Tests ; Mycoplasma Infections/drug therapy ; Mycoplasma hominis ; Tetracyclines/pharmacology ; Ureaplasma ; Ureaplasma Infections/drug therapy ; Ureaplasma urealyticum
    Chemische Substanzen Anti-Bacterial Agents ; Anti-Infective Agents ; Tetracyclines ; eravacycline (07896928ZC)
    Sprache Englisch
    Erscheinungsdatum 2020-07-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00698-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Septic polyarthritis with

    Totten, Arthur H / Xiao, Li / Crabb, Donna M / Ratliff, Amy E / Waites, Ken B / Hwangpo, Tracy / Atkinson, T Prescott

    Access microbiology

    2021  Band 3, Heft 4, Seite(n) 221

    Abstract: Mycoplasma ... ...

    Abstract Mycoplasma salivarium
    Sprache Englisch
    Erscheinungsdatum 2021-04-09
    Erscheinungsland England
    Dokumenttyp Case Reports
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000221
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: In Vitro

    Waites, Ken B / Crabb, Donna M / Xiao, Li / Duffy, Lynn B

    Antimicrobial agents and chemotherapy

    2017  Band 61, Heft 10

    Abstract: Gepotidacin, a novel first-in-class triazaacenaphthylene topoisomerase II inhibitor, was tested against 85 type strains and clinical isolates ... ...

    Abstract Gepotidacin, a novel first-in-class triazaacenaphthylene topoisomerase II inhibitor, was tested against 85 type strains and clinical isolates of
    Mesh-Begriff(e) Acenaphthenes/pharmacology ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/physiology ; Fluoroquinolones/pharmacology ; Heterocyclic Compounds, 3-Ring/pharmacology ; Humans ; Macrolides/pharmacology ; Microbial Sensitivity Tests ; Mycoplasma Infections/drug therapy ; Mycoplasma genitalium/drug effects ; Mycoplasma genitalium/isolation & purification ; Mycoplasma hominis/drug effects ; Mycoplasma hominis/isolation & purification ; Mycoplasma pneumoniae/drug effects ; Mycoplasma pneumoniae/isolation & purification ; Tetracyclines/pharmacology ; Topoisomerase II Inhibitors/pharmacology ; Ureaplasma/drug effects ; Ureaplasma/isolation & purification ; Ureaplasma Infections/drug therapy ; Ureaplasma urealyticum/drug effects ; Ureaplasma urealyticum/isolation & purification
    Chemische Substanzen Acenaphthenes ; Anti-Bacterial Agents ; Fluoroquinolones ; Heterocyclic Compounds, 3-Ring ; Macrolides ; Tetracyclines ; Topoisomerase II Inhibitors ; gepotidacin (DVF0PR037D)
    Sprache Englisch
    Erscheinungsdatum 2017-09-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01064-17
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Macrolide-resistant Mycoplasma pneumoniae pneumonia in transplantation: Increasingly typical?

    Eschenauer, Gregory A / Xiao, Li / Waites, Ken B / Crabb, Donna M / Ratliff, Amy E / Gandhi, Tejal N / Riddell, James / Kaul, Daniel R

    Transplant infectious disease : an official journal of the Transplantation Society

    2020  Band 22, Heft 5, Seite(n) e13318

    Abstract: Mycoplasma pneumoniae is one of the most common bacterial causes of pneumonia. Macrolide-resistant M pneumoniae (MRMP) was documented in 7.5% of isolates in the United States. Resistance portends poor outcomes to macrolide therapy, yet patients respond ... ...

    Abstract Mycoplasma pneumoniae is one of the most common bacterial causes of pneumonia. Macrolide-resistant M pneumoniae (MRMP) was documented in 7.5% of isolates in the United States. Resistance portends poor outcomes to macrolide therapy, yet patients respond well to fluoroquinolones or tetracyclines such as minocycline. However, MRMP may be under-appreciated because M pneumoniae generally causes relatively mild infections in non-immunosuppressed adults that may resolve without effective therapy and because microbiological confirmation and susceptibility are not routinely performed. We report two cases of pneumonia due to MRMP in kidney transplant recipients. Both patients required hospital admission, worsened on macrolide therapy, and rapidly defervesced on doxycycline or levofloxacin. In one case, M pneumoniae was only identified by multiplex respiratory pathogen panel analysis of BAL fluid. Macrolide resistance was confirmed in both cases by real-time PCR and point mutations associated with macrolide resistance were identified. M pneumoniae was isolated from both cases, and molecular genotyping revealed the same genotype. In conclusion, clinicians should be aware of the potential for macrolide resistance in M pneumoniae, and may consider non-macrolide-based therapy for confirmed or non-responding infections in patients who are immunocompromised or hospitalized.
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial/drug effects ; Humans ; Macrolides/pharmacology ; Microbial Sensitivity Tests ; Mycoplasma pneumoniae/drug effects
    Chemische Substanzen Anti-Bacterial Agents ; Macrolides
    Sprache Englisch
    Erscheinungsdatum 2020-05-19
    Erscheinungsland Denmark
    Dokumenttyp Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13318
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas.

    Waites, Ken B / Crabb, Donna M / Liu, Yang / Duffy, Lynn B

    Antimicrobial agents and chemotherapy

    2016  Band 60, Heft 12, Seite(n) 7502–7504

    Abstract: In vitro activities of omadacycline, a new aminomethylcycline, were determined for Mycoplasma and Ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 μg/ml. ... ...

    Abstract In vitro activities of omadacycline, a new aminomethylcycline, were determined for Mycoplasma and Ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 μg/ml. MIC
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; China ; Clindamycin/pharmacology ; Doxycycline/pharmacology ; Drug Resistance, Multiple, Bacterial ; Fluoroquinolones/pharmacology ; Humans ; Microbial Sensitivity Tests ; Mycoplasma Infections/microbiology ; Mycoplasma hominis/drug effects ; Mycoplasma hominis/growth & development ; Mycoplasma hominis/isolation & purification ; Mycoplasma pneumoniae/drug effects ; Mycoplasma pneumoniae/growth & development ; Mycoplasma pneumoniae/isolation & purification ; Tetracycline/pharmacology ; Tetracyclines/pharmacology ; United States
    Chemische Substanzen Anti-Bacterial Agents ; Fluoroquinolones ; Tetracyclines ; omadacycline (090IP5RV8F) ; Clindamycin (3U02EL437C) ; Azithromycin (83905-01-5) ; Tetracycline (F8VB5M810T) ; Doxycycline (N12000U13O) ; moxifloxacin (U188XYD42P)
    Sprache Englisch
    Erscheinungsdatum 2016-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01734-16
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: In vitro antibacterial activity of AZD0914 against human Mycoplasmas and Ureaplasmas.

    Waites, Ken B / Crabb, Donna M / Duffy, Lynn B / Huband, Michael D

    Antimicrobial agents and chemotherapy

    2015  Band 59, Heft 6, Seite(n) 3627–3629

    Abstract: In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of ... ...

    Abstract In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma pneumoniae. The AZD0914 MIC90 against Mycoplasma hominis was 8-fold greater than that for levofloxacin. The AZD0914 MIC90 against Ureaplasma species was 4-fold less than that for azithromycin and 8-fold less than that for levofloxacin and doxycycline.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Barbiturates/pharmacology ; Doxycycline/pharmacology ; Humans ; Levofloxacin/pharmacology ; Microbial Sensitivity Tests ; Mycoplasma/drug effects ; Mycoplasma genitalium/drug effects ; Mycoplasma pneumoniae/drug effects ; Spiro Compounds/pharmacology ; Ureaplasma/drug effects
    Chemische Substanzen Anti-Bacterial Agents ; Barbiturates ; Spiro Compounds ; Levofloxacin (6GNT3Y5LMF) ; Azithromycin (83905-01-5) ; zoliflodacin (FWL2263R77) ; Doxycycline (N12000U13O)
    Sprache Englisch
    Erscheinungsdatum 2015-03-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.04945-14
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Evaluation of the ELITe InGenius PCR Platform for Detection of Mycoplasma pneumoniae.

    Totten, Arthur H / Leal, Sixto M / Ratliff, Amy E / Xiao, Li / Crabb, Donna M / Waites, Ken B

    Journal of clinical microbiology

    2019  Band 57, Heft 6

    Abstract: Mycoplasma ... ...

    Abstract Mycoplasma pneumoniae
    Mesh-Begriff(e) Humans ; Molecular Diagnostic Techniques ; Mycoplasma pneumoniae/classification ; Mycoplasma pneumoniae/genetics ; Pneumonia, Mycoplasma/diagnosis ; Pneumonia, Mycoplasma/microbiology ; Real-Time Polymerase Chain Reaction/methods ; Real-Time Polymerase Chain Reaction/standards ; Reproducibility of Results ; Sensitivity and Specificity
    Sprache Englisch
    Erscheinungsdatum 2019-05-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00287-19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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