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  1. Book ; Online: Roles of Fc Receptors in Disease and Therapy

    Ganesan, Latha P. / Cragg, Mark S. / Vidarsson, Gestur

    2020  

    Keywords Medicine ; Immunology ; antibody ; Fc gamma receptor (FcγR) ; immune response ; disease ; therapy
    Size 1 electronic resource (372 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230194
    ISBN 9782889638758 ; 2889638758
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: (SUMO)-wrestling with rituximab.

    Cragg, Mark S

    Blood

    2022  Volume 139, Issue 18, Page(s) 2728–2730

    MeSH term(s) Immunologic Factors/therapeutic use ; Killer Cells, Natural ; Macrophages ; Rituximab/therapeutic use ; Sumoylation
    Chemical Substances Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022015912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy.

    Nimmerjahn, Falk / Vidarsson, Gestur / Cragg, Mark S

    Nature immunology

    2023  Volume 24, Issue 8, Page(s) 1391

    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01577-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy.

    Nimmerjahn, Falk / Vidarsson, Gestur / Cragg, Mark S

    Nature immunology

    2023  Volume 24, Issue 11, Page(s) 1961

    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01632-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy.

    Nimmerjahn, Falk / Vidarsson, Gestur / Cragg, Mark S

    Nature immunology

    2023  Volume 24, Issue 8, Page(s) 1244–1255

    Abstract: Humoral immune responses are characterized by complex mixtures of polyclonal antibody species varying in their isotype, target epitope specificity and affinity. Posttranslational modifications occurring during antibody production in both the antibody ... ...

    Abstract Humoral immune responses are characterized by complex mixtures of polyclonal antibody species varying in their isotype, target epitope specificity and affinity. Posttranslational modifications occurring during antibody production in both the antibody variable and constant domain create further complexity and can modulate antigen specificity and antibody Fc-dependent effector functions, respectively. Finally, modifications of the antibody backbone after secretion may further impact antibody activity. An in-depth understanding of how these posttranslational modifications impact antibody function, especially in the context of individual antibody isotypes and subclasses, is only starting to emerge. Indeed, only a minute proportion of this natural variability in the humoral immune response is currently reflected in therapeutic antibody preparations. In this Review, we summarize recent insights into how IgG subclass and posttranslational modifications impact IgG activity and discuss how these insights may be used to optimize therapeutic antibody development.
    MeSH term(s) Immunoglobulin G ; Epitopes ; Immunotherapy
    Chemical Substances Immunoglobulin G ; Epitopes
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01544-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Delivering co-stimulatory tumor necrosis factor receptor agonism for cancer immunotherapy: past, current and future perspectives.

    Dadas, Osman / Ertay, Ayse / Cragg, Mark S

    Frontiers in immunology

    2023  Volume 14, Page(s) 1147467

    Abstract: The tumor necrosis factor superfamily (TNFSF) and their receptors (TNFRSF) are important regulators of the immune system, mediating proliferation, survival, differentiation, and function of immune cells. As a result, their targeting for immunotherapy is ... ...

    Abstract The tumor necrosis factor superfamily (TNFSF) and their receptors (TNFRSF) are important regulators of the immune system, mediating proliferation, survival, differentiation, and function of immune cells. As a result, their targeting for immunotherapy is attractive, although to date, under-exploited. In this review we discuss the importance of co-stimulatory members of the TNFRSF in optimal immune response generation, the rationale behind targeting these receptors for immunotherapy, the success of targeting them in pre-clinical studies and the challenges in translating this success into the clinic. The efficacy and limitations of the currently available agents are discussed alongside the development of next generation immunostimulatory agents designed to overcome current issues, and capitalize on this receptor class to deliver potent, durable and safe drugs for patients.
    MeSH term(s) Humans ; Neoplasms ; Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha ; Immune System/pathology ; Immunotherapy
    Chemical Substances Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1147467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Engineered antibodies to combat viral threats.

    Yu, Xiaojie / Cragg, Mark S

    Nature

    2020  Volume 588, Issue 7838, Page(s) 398–399

    MeSH term(s) CD8-Positive T-Lymphocytes ; Coronavirus Infections ; Humans ; Spike Glycoprotein, Coronavirus
    Chemical Substances Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2020-11-18
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-03196-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Remodeling the Tumor Myeloid Landscape to Enhance Antitumor Antibody Immunotherapies.

    Hussain, Khiyam / Cragg, Mark S / Beers, Stephen A

    Cancers

    2021  Volume 13, Issue 19

    Abstract: Among the diverse tumor resident immune cell types, tumor-associated macrophages (TAMs) are often the most abundant, possess an anti-inflammatory phenotype, orchestrate tumor immune evasion and are frequently associated with poor prognosis. However, TAMs ...

    Abstract Among the diverse tumor resident immune cell types, tumor-associated macrophages (TAMs) are often the most abundant, possess an anti-inflammatory phenotype, orchestrate tumor immune evasion and are frequently associated with poor prognosis. However, TAMs can also be harnessed to destroy antibody-opsonized tumor cells through the process of antibody-dependent cellular phagocytosis (ADCP). Clinically important tumor-targeting monoclonal antibodies (mAb) such as Rituximab, Herceptin and Cetuximab, function, at least in part, by inducing macrophages to eliminate tumor cells via ADCP. For IgG mAb, this is mediated by antibody-binding activating Fc gamma receptors (FcγR), with resultant phagocytic activity impacted by the level of co-engagement with the single inhibitory FcγRIIb. Approaches to enhance ADCP in the tumor microenvironment include the repolarization of TAMs to proinflammatory phenotypes or the direct augmentation of ADCP by targeting so-called 'phagocytosis checkpoints'. Here we review the most promising new strategies targeting the cell surface molecules present on TAMs, which include the inhibition of 'don't eat me signals' or targeting immunostimulatory pathways with agonistic mAb and small molecules to augment tumor-targeting mAb immunotherapies and overcome therapeutic resistance.
    Language English
    Publishing date 2021-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13194904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Agonist Antibodies for Cancer Immunotherapy: History, Hopes, and Challenges.

    Lim, Sean H / Beers, Stephen A / Al-Shamkhani, Aymen / Cragg, Mark S

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 30, Issue 9, Page(s) 1712–1723

    Abstract: Immunotherapy is among the most promising new treatment modalities to arise over the last two decades; antibody drugs are delivering immunotherapy to millions of patients with many different types of cancer. Initial success with antibody therapeutics ... ...

    Abstract Immunotherapy is among the most promising new treatment modalities to arise over the last two decades; antibody drugs are delivering immunotherapy to millions of patients with many different types of cancer. Initial success with antibody therapeutics came in the form of direct targeting or cytotoxic antibodies, such as rituximab and trastuzumab, which bind directly to tumor cells to elicit their destruction. These were followed by immunomodulatory antibodies that elicit antitumor responses by either stimulating immune cells or relieving tumor-mediated suppression. By far the most successful approach in the clinic to date has been relieving immune suppression, with immune checkpoint blockade now a standard approach in the treatment of many cancer types. Despite equivalent and sometimes even more impressive effects in preclinical models, agonist antibodies designed to stimulate the immune system have lagged behind in their clinical translation. In this review, we document the main receptors that have been targeted by agonist antibodies, consider the various approaches that have been evaluated to date, detail what we have learned, and consider how their anticancer potential can be unlocked.
    MeSH term(s) Humans ; Neoplasms/immunology ; Neoplasms/drug therapy ; Neoplasms/therapy ; Immunotherapy/methods ; Animals ; Antineoplastic Agents, Immunological/therapeutic use ; Antineoplastic Agents, Immunological/pharmacology
    Chemical Substances Antineoplastic Agents, Immunological
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-1014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Deleting Malignant B Cells With Second-Generation Anti-CD20 Antibodies.

    Sopp, Josh / Cragg, Mark S

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2018  Volume 36, Issue 22, Page(s) 2323–2325

    MeSH term(s) Antibodies, Monoclonal, Humanized ; B-Lymphocytes ; Bendamustine Hydrochloride ; Humans ; Lymphoma, Non-Hodgkin ; Rituximab
    Chemical Substances Antibodies, Monoclonal, Humanized ; Rituximab (4F4X42SYQ6) ; Bendamustine Hydrochloride (981Y8SX18M) ; obinutuzumab (O43472U9X8)
    Language English
    Publishing date 2018-06-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2018.78.7390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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