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  1. Book ; Online ; E-Book: Animal welfare in a pandemic

    Hancock, John T. / Rouse, Ros C. / Craig, Tim J.

    What does COVID-19 tell us for the future?

    (CRC one health one welfare)

    2024  

    Abstract: This book explores the impact of COVID-19 on a wide array of animals, from those in the wild to companion and captive animals. It contributea to a genuinely One Health approach where the health and welfare of both humans and animals are considered ... ...

    Author's details John T. Hancock, Ros C. Rouse, Tim J. Craig
    Series title CRC one health one welfare
    Abstract This book explores the impact of COVID-19 on a wide array of animals, from those in the wild to companion and captive animals. It contributea to a genuinely One Health approach where the health and welfare of both humans and animals are considered holistically.

    Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Authors -- Preface -- Acknowledgements -- Chapter 1 The coronavirus disease 2019 (COVID-19) pandemic -- 1.1 Introduction -- 1.2 COVID-19 pandemic and the virus that caused it -- 1.3 The origin of the SARS-CoV-2 -- 1.4 Effects of SARS-CoV-2 on the human population -- 1.5 Why it is important to incorporate animals into the discussion: One Health/One Welfare/One Medicine -- 1.6 Conclusions -- Notes -- Chapter 2 Can the susceptibility of animals to SARS-CoV-2 be predicted? -- 2.1 Introduction -- 2.2 A quick crash course in molecular biology -- 2.3 Can molecular biology help? -- 2.4 Which animals are predicted to be infected with SARS-CoV-2? -- 2.5 What data are missing? -- 2.6 How can analysis using in silico techniques be improved to aid in future predictions? -- 2.7 Conclusions -- Notes -- Chapter 3 Animals that were infected in the real world -- 3.1 Introduction -- 3.2 Animals that were infected -- 3.3 What was not known -- 3.4 How risk, uncertainty, and ambiguity were handled -- 3.5 How can transmission of the virus in animals be better tracked and real-time evidence made publicly and globally available? -- 3.6 Non-mammals and COVID-19 -- 3.7 Conclusions -- Notes -- Chapter 4 Animal vaccines -- 4.1 Introduction -- 4.2 Vaccines developed in animals -- 4.3 Should animals be vaccinated when human populations are not? -- 4.4 Use of laboratory animal models -- 4.5 Vaccines of the future, will this transform their use in animals? -- 4.6 Conclusions -- Notes -- Chapter 5 Animal conservation and the pandemic -- 5.1 Introduction -- 5.2 The impact of the pandemic on animal conservation and zoos, wildlife parks, and aquaria -- 5.3 The impact on animals in the wild -- 5.4 Conclusions -- Notes -- Chapter 6 The indirecteffects of COVID-19on animals.
    Subject code 179.3
    Language English
    Size 1 Online-Ressource (250 Seiten)
    Publisher Taylor & Francis Group
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030741145
    ISBN 978-1-04-001700-5 ; 9781003427254 ; 9781032521091 ; 9781032547343 ; 1-04-001700-2 ; 1003427251 ; 1032521090 ; 1032547340
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Re‐Examining Temporal Variations in Intermediate‐Depth Seismicity

    Wimpenny, Sam / Craig, Tim / Marcou, Savvas

    Journal of Geophysical Research: Solid Earth. 2023 June, v. 128, no. 6 p.e2022JB026269-

    2023  

    Abstract: Changes in the frequency of intermediate‐depth (60–300 km) earthquakes in response to static stress transfer can provide insights into the mechanisms of earthquake generation within subducting slabs. In this study, we use the most up‐to‐date global and ... ...

    Abstract Changes in the frequency of intermediate‐depth (60–300 km) earthquakes in response to static stress transfer can provide insights into the mechanisms of earthquake generation within subducting slabs. In this study, we use the most up‐to‐date global and regional earthquake catalogs to show that both the aftershock productivity of large earthquakes, and the changes in the frequency of intermediate‐depth earthquakes around the timing of major megathrust slip, support the view that faults within the slab are relatively insensitive to static stress transfer on the order of earthquake stress drops. We interpret these results to suggest the population of faults within the slab are much further from their failure stress than is typical for shallow fault systems. We also find that aftershock productivity varies within slabs over small spatial scales, indicating that the mechanism that enables faults to rupture at intermediate depths is likely to be spatially heterogeneous over length‐scales of a few tens of kilometres. We suggest dehydration‐related weakening mechanisms can best account for this heterogeneity.
    Keywords earthquakes ; geophysics ; research
    Language English
    Dates of publication 2023-06
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2022JB026269
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Impact of technological advances in treatment planning, image guidance, and treatment delivery on target margin design for prostate cancer radiotherapy: an updated review.

    Winter, Jeff D / Reddy, Varun / Li, Winnie / Craig, Tim / Raman, Srinivas

    The British journal of radiology

    2024  Volume 97, Issue 1153, Page(s) 31–40

    Abstract: Recent innovations in image guidance, treatment delivery, and adaptive radiotherapy (RT) have created a new paradigm for planning target volume (PTV) margin design for patients with prostate cancer. We performed a review of the recent literature on PTV ... ...

    Abstract Recent innovations in image guidance, treatment delivery, and adaptive radiotherapy (RT) have created a new paradigm for planning target volume (PTV) margin design for patients with prostate cancer. We performed a review of the recent literature on PTV margin selection and design for intact prostate RT, excluding post-operative RT, brachytherapy, and proton therapy. Our review describes the increased focus on prostate and seminal vesicles as heterogenous deforming structures with further emergence of intra-prostatic GTV boost and concurrent pelvic lymph node treatment. To capture recent innovations, we highlight the evolution in cone beam CT guidance, and increasing use of MRI for improved target delineation and image registration and supporting online adaptive RT. Moreover, we summarize new and evolving image-guidance treatment platforms as well as recent reports of novel immobilization strategies and motion tracking. Our report also captures recent implementations of artificial intelligence to support image guidance and adaptive RT. To characterize the clinical impact of PTV margin changes via model-based risk estimates and clinical trials, we highlight recent high impact reports. Our report focusses on topics in the context of PTV margins but also showcase studies attempting to move beyond the PTV margin recipes with robust optimization and probabilistic planning approaches. Although guidelines exist for target margins conventional using CT-based image guidance, further validation is required to understand the optimal margins for online adaptation either alone or combined with real-time motion compensation to minimize systematic and random uncertainties in the treatment of patients with prostate cancer.
    MeSH term(s) Male ; Humans ; Artificial Intelligence ; Brachytherapy ; Cone-Beam Computed Tomography ; Lymph Nodes ; Prostatic Neoplasms
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1093/bjr/tqad041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: AuNP/MIL-88B-NH

    Lelouche, Sorraya N K / Lemir, Ignacio / Biglione, Catalina / Craig, Tim / Bals, Sara / Horcajada, Patricia

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e202400442

    Abstract: The efficiency of a catalytic process is assessed based on conversion, yield, and time effectiveness. However, these parameters are insufficient for evaluating environmentally sustainable research. As the world is urged to shift towards green catalysis, ... ...

    Abstract The efficiency of a catalytic process is assessed based on conversion, yield, and time effectiveness. However, these parameters are insufficient for evaluating environmentally sustainable research. As the world is urged to shift towards green catalysis, additional factors such as reaction media, raw material availability, sustainability, waste minimization and catalyst biosafety, need to be considered to accurately determine the efficacy and sustainability of the process. By combining the high porosity and versatility of metal organic frameworks (MOFs) and the activity of gold nanoparticles (AuNPs), efficient, cyclable and biosafe composite catalysts can be achieved. Thus, a composite based on AuNPs and the nanometric flexible porous iron(III) aminoterephthalate MIL-88B-NH
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Conference proceedings: Allergic rhinitis after hours: the relevance and consequence of nighttime symptoms

    Craig, Timothy J. / Meltzer, Eli O.

    [Symposium "Allergic Rhinitis After Hours: the Relevance and Consequence of Nighttime Symptoms" ... 2004]

    (The journal of allergy and clinical immunology ; 114,5, Suppl.)

    2004  

    Event/congress Symposium Allergic Rhinitis After Hours: the Relevance and Consequence of Nighttime Symptoms (2004)
    Author's details [contributing authors Timothy J. Craig]. Guest ed. Eli O. Meltzer
    Series title The journal of allergy and clinical immunology ; 114,5, Suppl.
    Collection
    Language English
    Size 3A S., S. S133 - S153 : graph. Darst.
    Publisher Mosby
    Publishing place St. Louis, Mo.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014212587
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Insights From Image Guided Radiation Therapy Credentialing for the NRG Oncology RTOG 1112 Liver Stereotactic Body Radiation Therapy Trial.

    Craig, Tim / Xiao, Ying / McNulty, Susan / Dawson, Laura A

    Practical radiation oncology

    2022  Volume 13, Issue 3, Page(s) 239–245

    Abstract: Purpose: NRG Oncology trial RTOG 1112 is a randomized phase 3 study of sorafenib with or without stereotactic body radiation therapy for locally advanced hepatocellular carcinoma. Image guided radiation therapy (IGRT) credentialing is essential for this ...

    Abstract Purpose: NRG Oncology trial RTOG 1112 is a randomized phase 3 study of sorafenib with or without stereotactic body radiation therapy for locally advanced hepatocellular carcinoma. Image guided radiation therapy (IGRT) credentialing is essential for this study because of the high doses, respiratory motion, and variety of delivery technologies. This analysis presents the IGRT credentialing experience.
    Methods and materials: Credentialing of volumetric IGRT requires submission of planning and localization images, planning structures, and resulting IGRT shifts for a patient treated according to the study requirements. A study reviewer uses these data to repeat the registrations and compare to the actual clinical registrations. Agreement within 5 mm was considered acceptable for credentialing.
    Results: Volumetric images of 130 fractions from 42 institutions between June 2013 and January 2018 were reviewed. The median agreement between clinical registrations and study reviewer was 3 mm, with 95% of all fractions within 5 mm. A subanalysis identified a statistically significant difference between the use of low-contrast soft tissue and high-contrast surrogates (eg, implanted fiducial markers, surgical clips, metallic stents) for registration. Soft tissue and high-contrast surrogate registrations both agreed within 3 mm in 50% of fractions. However, soft tissue registrations exceeded 10 mm in 3% of fractions, while no high-contrast surrogate registrations exceeded 5 mm.
    Conclusions: The RTOG 1112 credentialing experience suggests that most institutions perform liver IGRT with sufficient accuracy to deliver stereotactic body radiation therapy safely, as assessed by expert reviewers. Both soft tissue and high-contrast surrogates appear adequate for consistent registration in most instances; however, some disagreements were observed when using soft-tissue registration targets. The use of high-contrast surrogates appears to reduce the small risk of substantial geographic miss owing to mis-registration in liver IGRT.
    MeSH term(s) Humans ; Radiotherapy, Image-Guided/methods ; Credentialing ; Fiducial Markers ; Radiosurgery ; Liver ; Radiotherapy Planning, Computer-Assisted/methods
    Language English
    Publishing date 2022-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2022.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Liver SBRT dose accumulation to assess the impact of anatomic variations on normal tissue doses and toxicity in patients treated with concurrent sorafenib.

    Chen, Jasmine / Bissonnette, Jean-Pierre / Craig, Tim / Munoz-Schuffenegger, Pablo / Tadic, Tony / Dawson, Laura A / Velec, Michael

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2023  Volume 182, Page(s) 109588

    Abstract: Background and purpose: Unexpected liver volume reductions occurred during trials of liver SBRT and concurrent sorafenib. The aims were to accumulate liver SBRT doses to assess the impact of these anatomic variations on normal tissue dose parameters and ...

    Abstract Background and purpose: Unexpected liver volume reductions occurred during trials of liver SBRT and concurrent sorafenib. The aims were to accumulate liver SBRT doses to assess the impact of these anatomic variations on normal tissue dose parameters and toxicity.
    Materials and methods: Thirty-two patients with hepatocellular carcinoma (HCC) or metastases treated on trials of liver SBRT (30-57 Gy, 6 fractions) and concurrent sorafenib were analyzed. SBRT doses were accumulated using biomechanical deformable registration of daily cone-beam CT. Dose deviations (accumulated-planned) for normal tissues were compared for patients with liver volume reductions > 100 cc versus stable volumes, and accumulated doses were reported for three patients with grade 3-5 luminal gastrointestinal toxicities.
    Results: Patients with reduced (N = 12) liver volumes had larger mean deviations of 0.4-1.3 Gy in normal tissues, versus -0.2-0.4 Gy for stable cases (N = 20), P > 0.05. Deviations > 5% of the prescribed dose occurred in both groups. Two HCC patients with toxicities to small and large bowel had liver volume reductions and deviations to the maximum dose of 4% (accumulated 36.9 Gy) and 3% (accumulated 33.4 Gy) to these organs respectively. Another HCC patient with a toxicity of unknown location plus tumor rupture, had stable liver volumes and deviations to luminal organs of -6% to 4.5% (accumulated < 30.5 Gy).
    Conclusion: Liver volume reductions during SBRT and concurrent sorafenib were associated with larger increases in accumulated dose to normal tissues versus stable liver volumes. These dosimetric changes may have further contributed to toxicities in HCC patients who have higher baseline risks.
    MeSH term(s) Humans ; Sorafenib/adverse effects ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Radiosurgery/adverse effects ; Radiotherapy Dosage
    Chemical Substances Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2023-02-28
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2023.109588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Protein SUMOylation regulates insulin secretion at multiple stages.

    Davey, Jeffrey S / Carmichael, Ruth E / Craig, Tim J

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 2895

    Abstract: Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the ... ...

    Abstract Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the failure of normal glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells. Several lines of evidence suggest that vesicle trafficking events such as insulin secretion are regulated by the post-translational modification, SUMOylation, and indeed SUMOylation has been proposed to act as a 'brake' on insulin exocytosis. Here, we show that diabetic stimuli which inhibit GSIS are correlated with an increase in cellular protein SUMOylation, and that inhibition of deSUMOylation reduces GSIS. We demonstrate that manipulation of cellular protein SUMOylation levels, by overexpression of several different components of the SUMOylation pathway, have varied and complex effects on GSIS, indicating that SUMOylation regulates this process at multiple stages. We further demonstrate that inhibition of syntaxin1A SUMOylation, via a knockdown-rescue strategy, greatly enhances GSIS. Our data are therefore consistent with the model that SUMOylation acts as a brake on GSIS, and we have identified SUMOylation of syntaxin 1 A as a potential component of this brake. However, our data also demonstrate that the role of SUMOylation in GSIS is complex and may involve many substrates.
    MeSH term(s) Animals ; Exocytosis/drug effects ; Glucose/pharmacology ; Insulin Secretion/drug effects ; Insulin Secretion/physiology ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/physiology ; Protein Processing, Post-Translational ; Qa-SNARE Proteins/chemistry ; Qa-SNARE Proteins/metabolism ; Rats ; Sumoylation ; Sweetening Agents/pharmacology
    Chemical Substances Qa-SNARE Proteins ; Sweetening Agents ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-39681-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes.

    Carmichael, Ruth E / Wilkinson, Kevin A / Craig, Tim J

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 6477

    Abstract: Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues today, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. One of the key pathological traits of this disease is insulin resistance ... ...

    Abstract Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues today, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. One of the key pathological traits of this disease is insulin resistance at 'glucose sink' tissues (mostly skeletal muscle), and this remains one of the features of this disease most intractable to therapeutic intervention. Several lines of evidence have implicated the post-translational modification, SUMOylation, in insulin signalling and insulin resistance in skeletal muscle. In this study, we examined this possibility by manipulation of cellular SUMOylation levels using multiple different tools, and assaying the effect on insulin-stimulated GLUT4 surface expression in differentiated L6 rat myocytes. Although insulin stimulation of L6 myocytes produced a robust decrease in total cellular SUMO1-ylation levels, manipulating cellular SUMOylation had no effect on insulin-responsive GLUT4 surface trafficking using any of the tools we employed. Whilst we cannot totally exclude the possibility that SUMOylation plays a role in the insulin signalling pathway in human health and disease, our data strongly argue that GLUT4 trafficking in response to insulin is not regulated by protein SUMOylation, and that SUMOylation does not therefore represent a viable therapeutic target for the treatment of insulin resistance.
    MeSH term(s) Animals ; Cell Line ; Glucose Transporter Type 4/metabolism ; Humans ; Hypoglycemic Agents/pharmacology ; Insulin/pharmacology ; Insulin Resistance ; Models, Biological ; Muscle Cells/cytology ; Muscle Cells/drug effects ; Muscle Cells/metabolism ; Muscle, Skeletal/cytology ; Muscle, Skeletal/metabolism ; Protein Transport/drug effects ; Rats ; SUMO-1 Protein/metabolism ; Signal Transduction/drug effects ; Sumoylation/drug effects
    Chemical Substances Glucose Transporter Type 4 ; Hypoglycemic Agents ; Insulin ; SUMO-1 Protein
    Language English
    Publishing date 2019-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-42574-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fighting polyglutamine disease by wrestling with SUMO.

    Craig, Tim J / Henley, Jeremy M

    The Journal of clinical investigation

    2015  Volume 125, Issue 2, Page(s) 498–500

    Abstract: Spinobulbar muscular atrophy (SBMA) is an X-linked disease characterized by degeneration of motor neurons, muscle atrophy, and progressive weakness. It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription factor ... ...

    Abstract Spinobulbar muscular atrophy (SBMA) is an X-linked disease characterized by degeneration of motor neurons, muscle atrophy, and progressive weakness. It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription factor that is activated upon hormone binding. The polyQ expansion in AR causes it to form intracellular aggregates and impairs transcriptional activity. Intriguingly, SUMOylation (where SUMO indicates small ubiquitin-like modifier) of AR inhibits its transcriptional activity and reduces aggregation of the polyQ form of this protein, but it is unclear whether SUMOylation plays a pathogenic or protective role in SBMA. In this issue of the JCI, Chua et al. address this question by generating knockin mice in which the native AR is replaced by either a polyQ AR or a polyQ AR lacking the two lysine residues that are SUMOylated. The results from this study demonstrate that inhibiting SUMOylation of polyQ AR restores much of its transcriptional activity and prevents many (but not all) SBMA-associated symptoms in this mouse model.
    MeSH term(s) Animals ; Muscle Fibers, Slow-Twitch/metabolism ; Muscular Disorders, Atrophic/metabolism ; Peptides/metabolism ; Receptors, Androgen/metabolism ; Sumoylation ; Transcription, Genetic
    Chemical Substances Peptides ; Receptors, Androgen ; polyglutamine (26700-71-0)
    Language English
    Publishing date 2015-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI80278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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