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  1. Article: Borreliose

    Craig-Müller, Nils / Venhoff, Nils

    Arthritis und Rheuma

    2022  Volume 42, Issue 02, Page(s) 106–113

    Abstract: Die Lyme-Borreliose mit sehr unterschiedlichen Krankheitsmanifestationen wird durch verschiedene Erreger des Genus Borrelia verursacht. Borrelien werden (in Deutschland) durch die Schildzecke Ixodes ricinus übertragen. Einblicke in die Pathophysiologie ... ...

    Abstract Die Lyme-Borreliose mit sehr unterschiedlichen Krankheitsmanifestationen wird durch verschiedene Erreger des Genus Borrelia verursacht. Borrelien werden (in Deutschland) durch die Schildzecke Ixodes ricinus übertragen. Einblicke in die Pathophysiologie erlauben ein besseres Verständnis von Krankheitsmanifestation, Diagnostik und Therapie der Borreliose. Abhängig vom jeweiligen Erreger (Spezies und Genotyp) können sich die Bakterien lokal vermehren oder auch in unterschiedliche Organe verteilen. Durch verschiedene Mechanismen entziehen sich Borrelien dem Zugriff durch unser Immunsystem, was zu einer starken jedoch ineffizienten Immunantwort führen kann. Die Symptome werden fast ausschließlich durch diese Immunantwort verursacht, was die Lyme-Borreliose zu einer wichtigen Differenzialdiagnose in der Rheumatologie macht. Neben der Klinik, Diagnostik und Therapie der Lyme-Borreliose befasst sich dieser Beitrag mit der Pathophysiologie, was über ein besseres Verstehen der Erkrankung zu Fehlervermeidung im klinischen Alltag führen dürfte.

    Lyme disease is caused by different bacterial species of the genus borrelia resulting in an infection with a plethora of different symptoms. The disease vector, in Germany, is the tick Ixodes ricinus. Knowledge of the pathophysiology of Lyme disease can help explain the clinical manifestations, diagnosis, and therapy of Lyme disease. Whether Lyme disease remains a local infection in the skin, or spreads to different organs, depends heavily on the species and genotype of the infecting bacteria. Borrelia can evade the immune system due to a multitude of strategies; this can result in a strong, however, inefficient response by the immune system. The symptoms of Lyme disease are almost exclusively caused by this errant immune response. As a result, Lyme disease is an important differential diagnosis for the field of rheumatology. This article describes not only the clinical manifestations, diagnosis, and treatment of Lyme disease, but also the pathophysiology. With this better understanding of the pathophysiology common errors in the diagnosis and treatment of Lyme disease can be prevented.
    Keywords Lyme-Borreliose ; Lyme-Arthritis ; Antibiotika-refraktäre Lyme-Arthritis ; Lyme disease ; Lyme arthritis ; antibiotic-refractary Lyme arthritis
    Language German
    Publishing date 2022-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223481-0
    ISSN 2567-5753 ; 0176-5167
    ISSN (online) 2567-5753
    ISSN 0176-5167
    DOI 10.1055/a-1754-9010
    Database Thieme publisher's database

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  2. Article: Borreliose - Über die Pathophysiologie zu Klinik und Therapie

    Craig-Müller, Nils / Venhoff, Nils

    Arthritis + Rheuma

    2022  Volume 42, Issue 2, Page(s) 106

    Language German
    Document type Article
    ZDB-ID 605764-0
    ISSN 0176-5167
    Database Current Contents Medicine

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  3. Conference proceedings: Inflammation: Infection or autoimmunity, or somewhere in-between?

    Craig-Müller, Nils / Venhoff, Nils

    2021  , Page(s) FA.30

    Event/congress Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); sine loco [digital]; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-09-14
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dgrh101
    Database German Medical Science

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  4. Conference proceedings: Severe and definite chronic rheumatic disease goes undiagnosed for years. Social aspects as decisive risk factors?

    Craig-Müller, Nils / Rump, Ina Caroline / Glaser, Cornelia / Venhoff, Nils

    2023  , Page(s) FA.07

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh074
    Database German Medical Science

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  5. Book ; Online ; Thesis: <dc:title>Modeling MyD88 deficiency</dc:title>

    Craig-Müller, Nils [Verfasser] / Cathomen, Anton [Akademischer Betreuer] / Cathomen, Anton [Sonstige] / Henneke, Philipp [Sonstige]

    2023  

    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universität
    Publishing place Freiburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Psoriasis and Psoriatic Arthritis Have a Major Impact on Quality of Life and Depressive Symptoms: A Cross-Sectional Study of 300 Patients.

    Frede, Natalie / Hiestand, Sonja / Schauer, Franziska / Endres, Dominique / Tebartz van Elst, Ludger / Zeisbrich, Markus / Craig-Mueller, Nils / Finzel, Stephanie / Thiel, Jens / Voll, Reinhard E / Schempp, Christoph / Venhoff, Nils

    Rheumatology and therapy

    2023  Volume 10, Issue 6, Page(s) 1655–1668

    Abstract: Introduction: Psoriasis (Pso) and psoriatic arthritis (PsA) can reduce the quality of life (QoL) and are known to be associated with depression. Within this study, we aimed to assess the burden of disease, functional capacity, quality of life, and ... ...

    Abstract Introduction: Psoriasis (Pso) and psoriatic arthritis (PsA) can reduce the quality of life (QoL) and are known to be associated with depression. Within this study, we aimed to assess the burden of disease, functional capacity, quality of life, and depressive symptoms and identify factors predicting functional impairment and depression in patients with psoriatic disease.
    Methods: A cross-sectional survey was conducted in a cohort of 300 patients with psoriatic disease including 150 patients from a university hospital dermatology outpatient clinic and 150 patients from a university hospital rheumatology outpatient clinic. Questionnaire-based assessment of signs of arthritis (Psoriasis Epidemiology Screening Tool; PEST), functional status (Functional Questionnaire Hannover; FFbH), quality of life (World Health Organization Quality of Life Brief Version; WHOQOL-BREF), and depressive symptoms (Patient health questionnaire 9; PHQ-9) and retrospective medical chart analysis were performed.
    Results: Despite treatment, burden of disease was high. Joint pain was reported in multiple regions in patients with Pso (n = 111) and patients with PsA (n = 189), but with differences in frequency and distribution patterns of symptoms. Functional impairment in everyday life was independently associated with diagnosis of PsA (odds ratio [OR] 9.56, p = 0.005), depressive symptoms (OR 5.44, p < 0.001) and age (OR 1.04, p = 0.033). At least mild depressive symptoms were demonstrated in 54% and 69% of patients with Pso and PsA, respectively. In a logistic regression model, depressive symptoms were independently associated with functional impairment (OR 4.50, p = 0.003), axial complaints (OR 2.80, p = 0.030), diagnosis of psoriatic arthritis (OR 2.69, p = 0.046), and number of joint regions with complaints (OR 1.10, p = 0.032).
    Conclusion: Functional impairment, QoL, and depressive symptoms are mutually interdependent. Early diagnosis of PsA and initiation of anti-inflammatory therapy are essential to avoid long-term damage, disability, and mental health complications. However, despite therapy many patients with PsA, and especially female patients, report a substantial residual disease burden due to their psoriatic disease which will need to be addressed by a more patient-centered approach.
    Language English
    Publishing date 2023-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2783278-8
    ISSN 2198-6584 ; 2198-6576
    ISSN (online) 2198-6584
    ISSN 2198-6576
    DOI 10.1007/s40744-023-00602-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Conference proceedings: Jung, sportlich, Angina pectoris – ein rheumatologischer Notfall?

    Schramm, Markus / Hesselbarth, David / Craig-Müller, Nils / Voll, Reinhard / Thiel, Jens / Venhoff, Nils

    2020  , Page(s) FA.09

    Event/congress Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); sine loco [digital]; ; Deutsche Gesellschaft für Orthopädische Rheumatologie; 2020
    Keywords Medizin, Gesundheit
    Publishing date 2020-09-09
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/20dgrh075
    Database German Medical Science

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  8. Article ; Online: COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis.

    Schramm, Markus A / Venhoff, Nils / Wagner, Dirk / Thiel, Jens / Huzly, Daniela / Craig-Mueller, Nils / Panning, Marcus / Hengel, Hartmut / Kern, Winfried V / Voll, Reinhard E

    Frontiers in immunology

    2020  Volume 11, Page(s) 2086

    Abstract: Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and ...

    Abstract Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at high risk for severe disease progression. With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA).
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Betacoronavirus/genetics ; COVID-19 ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/drug therapy ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cyclophosphamide/therapeutic use ; Drug Therapy, Combination ; Glucocorticoids/therapeutic use ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/drug therapy ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Prednisolone/therapeutic use ; RNA, Viral/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Rituximab/therapeutic use ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Glucocorticoids ; Immunosuppressive Agents ; RNA, Viral ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P) ; Prednisolone (9PHQ9Y1OLM)
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.02086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Modeling MyD88 Deficiency

    Craig-Mueller, Nils / Hammad, Ruba / Elling, Roland / Alzubi, Jamal / Timm, Barbara / Kolter, Julia / Knelangen, Nele / Bednarski, Christien / Gläser, Birgitta / Ammann, Sandra / Ivics, Zoltán / Fischer, Judith / Speckmann, Carsten / Schwarz, Klaus / Lachmann, Nico / Ehl, Stephan / Moritz, Thomas / Henneke, Philipp / Cathomen, Toni

    Frontiers in immunology

    2020  Volume 11, Page(s) 608802

    Abstract: Inherited defects in MyD88 and IRAK4, two regulators in Toll-like receptor (TLR) signaling, are clinically highly relevant, but still incompletely understood. MyD88- and IRAK4-deficient patients are exceedingly susceptible to a narrow spectrum of ... ...

    Abstract Inherited defects in MyD88 and IRAK4, two regulators in Toll-like receptor (TLR) signaling, are clinically highly relevant, but still incompletely understood. MyD88- and IRAK4-deficient patients are exceedingly susceptible to a narrow spectrum of pathogens, with ∼50% lethality in the first years of life. To better understand the underlying molecular and cellular characteristics that determine disease progression, we aimed at modeling the cellular response to pathogens
    MeSH term(s) Cell Differentiation/physiology ; Cell Line ; Cytokines/metabolism ; HEK293 Cells ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Macrophages/metabolism ; Monocytes/metabolism ; Myeloid Cells/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Primary Immunodeficiency Diseases/metabolism ; Signal Transduction/physiology
    Chemical Substances Cytokines ; MYD88 protein, human ; Myeloid Differentiation Factor 88 ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-12-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.608802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis

    Schramm, Markus A. / Venhoff, Nils / Wagner, Dirk / Thiel, Jens / Huzly, Daniela / Craig-Mueller, Nils / Panning, Marcus / Hengel, Hartmut / Kern, Winfried V. / Voll, Reinhard E.

    Frontiers in Immunology

    2020  Volume 11

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.02086
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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