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  1. Article ; Online: HCC: We Prefer Fractionation Versus Dose Reduction.

    Hajj, Carla / Crane, Christopher H

    International journal of radiation oncology, biology, physics

    2023  Volume 115, Issue 2, Page(s) 277

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/radiotherapy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Drug Tapering ; Dose Fractionation, Radiation
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2022.08.061
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Balancing Fractionation and Advanced Technology in Consideration of Reirradiation.

    Crane, Christopher H

    Seminars in radiation oncology

    2020  Volume 30, Issue 3, Page(s) 201–203

    MeSH term(s) Dose Fractionation, Radiation ; Humans ; Neoplasms/radiotherapy ; Patient Safety ; Radiotherapy Dosage ; Re-Irradiation/adverse effects ; Re-Irradiation/methods
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2020.02.009
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    Zs.A 3654: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Chemo-Re-Irradiation and Salvage Surgery for Locally Recurrent Rectal Cancer.

    Romesser, Paul B / Crane, Christopher H

    Annals of surgical oncology

    2021  Volume 28, Issue 9, Page(s) 4769–4771

    MeSH term(s) Humans ; Neoplasm Recurrence, Local ; Re-Irradiation ; Rectal Neoplasms/surgery ; Rectum ; Salvage Therapy
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10198-5
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    Zs.A 4042: Show issues Location:
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  4. Article ; Online: Hypofractionated Radiation Therapy With BED >100 Gy May Rival Surgical Outcomes.

    Crane, Christopher H

    International journal of radiation oncology, biology, physics

    2017  Volume 99, Issue 2, Page(s) 301

    Language English
    Publishing date 2017-10-01
    Publishing country United States
    Document type Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.05.038
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Hypofractionated ablative radiotherapy for locally advanced pancreatic cancer.

    Crane, Christopher H

    Journal of radiation research

    2016  Volume 57 Suppl 1, Page(s) i53–i57

    Abstract: The role of radiation in locally advanced unresectable pancreatic cancer (LAPC) is controversial. Randomized trials evaluating standard doses of chemoradiation have not shown a significant benefit from the use of consolidative radiation. Results from non- ...

    Abstract The role of radiation in locally advanced unresectable pancreatic cancer (LAPC) is controversial. Randomized trials evaluating standard doses of chemoradiation have not shown a significant benefit from the use of consolidative radiation. Results from non-randomized studies of 3-5-fraction stereotactic body radiotherapy (SBRT) have been similar to standard chemoradiation, but with less toxicity and a shorter treatment time. Doses of SBRT have been reduced to subablative levels for the sake of tolerability. The benefit of both options is unclear. In contrast, ablative doses can be delivered using an SBRT technique in 15-28 fractions. The keys to the delivery of ablative doses are computed tomography (CT) image guidance and respiratory gating. Higher doses have resulted in encouraging long-term survival results. In this review, we present a comprehensive solution to achieving ablative doses for selected patients with pancreatic tumors by using a combination of classical, modern and novel concepts of radiotherapy: fractionation, CT image guidance, respiratory gating, intentional dose heterogeneity, and simultaneous integrated protection.
    MeSH term(s) Catheter Ablation ; Dose Hypofractionation ; Humans ; Neoplasm Staging ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/radiotherapy ; Radiosurgery
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1349-9157
    ISSN (online) 1349-9157
    DOI 10.1093/jrr/rrw016
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  6. Article: Improving Long-Term Survival in Patients With Locally Advanced Pancreatic Cancer via the Delivery of Definitive Radiotherapy Doses.

    Crane, Christopher H

    Oncology (Williston Park, N.Y.)

    2015  Volume 29, Issue 8, Page(s) 561–2, 566

    MeSH term(s) Dose Fractionation ; Humans ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/radiotherapy ; Radiosurgery ; Radiotherapy Dosage ; Tumor Burden
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3168: Show issues Location:
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    Zs.MO 372: Show issues

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  7. Article ; Online: Contemporary perspectives on the use of radiation therapy for locally advanced gallbladder cancer.

    Verma, Vivek / Crane, Christopher H

    Chinese clinical oncology

    2019  Volume 8, Issue 4, Page(s) 41

    Abstract: Locally advanced gallbladder cancer poor prognosis due to a high distant metastatic rate and poor overall disease control. The impact of standard therapeutic options is unfortunately modest. Due to the rarity of the disease, evidence-based management ... ...

    Abstract Locally advanced gallbladder cancer poor prognosis due to a high distant metastatic rate and poor overall disease control. The impact of standard therapeutic options is unfortunately modest. Due to the rarity of the disease, evidence-based management continues to evolve. The goal of this review is to highlight the contemporary landscape of radiation therapy for gallbladder cancer. First, the rationale for radiation therapy is described. This includes the risk of locoregional recurrence following resection based on patterns-of-failure data, along with the high locoregional disease burden being a frequent cause morbidity and mortality in unresected cases. Additionally, improvements in systemic therapy over the next decade could shift contemporary patterns of failure more towards proportionally higher locoregional recurrence rates. Second, clinical data of radiation therapy for gallbladder cancer are discussed. These include consideration of postoperative chemoradiotherapy for margin- and/or node-positive cases. Patients with localized unresectable disease could benefit from ablative radiation therapy, based on promising data in non-gallbladder cancer pancreaticobiliary neoplasms. The use of advanced radiation therapy technologies such as proton beam therapy, as a means to deliver ablative radiation therapy in a potentially safer manner, is also mentioned. Lastly, the emerging concept of neoadjuvant therapy for gallbladder cancer is also described, in efforts to allow more patients to receive curative resection.
    MeSH term(s) Gallbladder Neoplasms/pathology ; Gallbladder Neoplasms/radiotherapy ; Humans ; Radiotherapy, Adjuvant/methods
    Language English
    Publishing date 2019-09-03
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3865
    ISSN (online) 2304-3873
    ISSN 2304-3865
    DOI 10.21037/cco.2019.08.12
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  8. Article: Magnetic Resonance Imaging-Guided Adaptive Radiotherapy for Colorectal Liver Metastases.

    Romesser, Paul B / Tyagi, Neelam / Crane, Christopher H

    Cancers

    2021  Volume 13, Issue 7

    Abstract: Technological advances have enabled well tolerated and effective radiation treatment for small liver metastases. Stereotactic ablative radiation therapy (SABR) refers to ablative dose delivery (>100 Gy BED) in five fractions or fewer. For larger tumors, ... ...

    Abstract Technological advances have enabled well tolerated and effective radiation treatment for small liver metastases. Stereotactic ablative radiation therapy (SABR) refers to ablative dose delivery (>100 Gy BED) in five fractions or fewer. For larger tumors, the safe delivery of SABR can be challenging due to a more limited volume of healthy normal liver parenchyma and the proximity of the tumor to radiosensitive organs such as the stomach, duodenum, and large intestine. In addition to stereotactic treatment delivery, controlling respiratory motion, the use of image guidance, adaptive planning and increasing the number of radiation fractions are sometimes necessary for the safe delivery of SABR in these situations. Magnetic Resonance (MR) image-guided adaptive radiation therapy (MRgART) is a new and rapidly evolving treatment paradigm. MR imaging before, during and after treatment delivery facilitates direct visualization of both the tumor target and the adjacent normal healthy organs as well as potential intrafraction motion. Real time MR imaging facilitates non-invasive tumor tracking and treatment gating. While daily adaptive re-planning permits treatment plans to be adjusted based on the anatomy of the day. MRgART therapy is a promising radiation technology advance that can overcome many of the challenges of liver SABR and may facilitate the safe tumor dose escalation of colorectal liver metastases.
    Language English
    Publishing date 2021-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13071636
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  9. Article ; Online: Evolving Concepts Regarding Radiation Therapy for Pancreatic Cancer.

    Hall, William A / Erickson, Beth / Crane, Christopher H

    Surgical oncology clinics of North America

    2021  Volume 30, Issue 4, Page(s) 719–730

    Abstract: In todays practice most institutions individualize the use of adjuvant, neoadjuvant, and definitive RT based on their interpretation of the available data. This review highlights novel concepts and approaches to the use of RT that should be considered by ...

    Abstract In todays practice most institutions individualize the use of adjuvant, neoadjuvant, and definitive RT based on their interpretation of the available data. This review highlights novel concepts and approaches to the use of RT that should be considered by the surgical oncologist.
    MeSH term(s) Humans ; Neoadjuvant Therapy ; Pancreatic Neoplasms/radiotherapy
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2021.06.009
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  10. Article ; Online: External Beam Radiation Therapy for Liver Metastases.

    Romesser, Paul B / Neal, Brian P / Crane, Christopher H

    Surgical oncology clinics of North America

    2020  Volume 30, Issue 1, Page(s) 159–173

    Abstract: Stereotactic ablative radiotherapy (SABR) commonly is used for small liver metastases. Modern conformal radiotherapy techniques, including 3-dimensional conformal radiotherapy and intensity-modulated radiation therapy, enable the safe delivery of SABR to ...

    Abstract Stereotactic ablative radiotherapy (SABR) commonly is used for small liver metastases. Modern conformal radiotherapy techniques, including 3-dimensional conformal radiotherapy and intensity-modulated radiation therapy, enable the safe delivery of SABR to small liver volumes. For larger tumors, the safe delivery of SABR can be challenging due to a more limited volume of healthy normal liver parenchyma and the proximity of the tumor to radiosensitive organs, such as the stomach, duodenum, and large intestine. Controlling respiratory motion, the use of image guidance, and increasing the number of radiation fractions sometimes are necessary for the safe delivery of SABR in these situations.
    MeSH term(s) Humans ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/surgery ; Radiosurgery ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Conformal ; Radiotherapy, Intensity-Modulated
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2020.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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