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  1. Article: Excitation wavelength dependence of water-window line emissions from boron-nitride laser-produced plasmas.

    Crank, M / Harilal, S S / Hassan, S M / Hassanein, A

    Journal of applied physics

    2012  Volume 111, Issue 3, Page(s) 33301–333016

    Abstract: We investigated the effects of laser excitation wavelength on water-window emission lines of laser-produced boron-nitride plasmas. Plasmas are produced by focusing 1064 nm and harmonically generated 532 and 266 nm radiation from a Nd:YAG laser on BN ... ...

    Abstract We investigated the effects of laser excitation wavelength on water-window emission lines of laser-produced boron-nitride plasmas. Plasmas are produced by focusing 1064 nm and harmonically generated 532 and 266 nm radiation from a Nd:YAG laser on BN target in vacuum. Soft x-ray emission lines in the water-window region are recorded using a grazing-incidence spectrograph. Filtered photodiodes are used to obtain complementary data for water-window emission intensity and angular dependence. Spectral emission intensity changes in nitrogen Ly-α and He-α are used to show how laser wavelength affects emission. Our results show that the relative intensity of spectral lines is laser wavelength dependent, with the ratio of Ly-α to He-α emission intensity decreasing as laser wavelength is shortened. Filtered photodiode measurements of angular dependence showed that 266 and 532 nm laser wavelengths produce uniform emission.
    Language English
    Publishing date 2012-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1476463-5
    ISSN 1089-7550 ; 0021-8979
    ISSN (online) 1089-7550
    ISSN 0021-8979
    DOI 10.1063/1.3682087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pituitary tumour apoplexy within prolactinomas in children: a more aggressive condition?

    Culpin, Elizabeth / Crank, Matthew / Igra, Mark / Connolly, Daniel J A / Dimitri, Paul / Mirza, Showkat / Sinha, Saurabh

    Pituitary

    2018  Volume 21, Issue 5, Page(s) 474–479

    Abstract: Objectives: To evaluate clinical presentations, diagnosis and management of paediatric patients presenting with pituitary apoplexy.: Methods: A retrospective case series describing a cohort of paediatric patients presenting with this condition from ... ...

    Abstract Objectives: To evaluate clinical presentations, diagnosis and management of paediatric patients presenting with pituitary apoplexy.
    Methods: A retrospective case series describing a cohort of paediatric patients presenting with this condition from 2010-2016 to a tertiary referral children's hospital in the United Kingdom.
    Results: Pituitary apoplexy is a rare condition that seems to have a higher relative incidence in children than adults. Our series suggests that pituitary apoplexy in paediatric patients with adenomas appears more common than previously described. All our patients required surgery, either as an acute or delayed procedure, for visual compromise. Two patients had commenced growth hormone (GH) for GH deficiency two weeks prior to the onset of pituitary apoplexy.
    Conclusions: With only a limited number of published case reports surrounding this topic our case series contributes to help further understand and manage this condition.
    MeSH term(s) Adolescent ; Female ; Growth Hormone/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Male ; Pituitary Apoplexy/diagnosis ; Pituitary Apoplexy/diagnostic imaging ; Pituitary Apoplexy/drug therapy ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/drug therapy ; Prolactinoma/diagnosis ; Prolactinoma/diagnostic imaging ; Prolactinoma/drug therapy ; Retrospective Studies
    Chemical Substances Growth Hormone (9002-72-6)
    Language English
    Publishing date 2018-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-018-0900-8
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  3. Article ; Online: IL-1β enhances inflammatory TH2 differentiation.

    Caucheteux, Stephan M / Hu-Li, Jane / Guo, Liying / Bhattacharyya, Nisan / Crank, Michelle / Collins, Michael T / Paul, William E

    The Journal of allergy and clinical immunology

    2016  Volume 138, Issue 3, Page(s) 898–901.e4

    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Immunoglobulin E/immunology ; Inflammation/immunology ; Interleukin-1beta/immunology ; Interleukin-4/immunology ; Interleukin-5/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Receptors, Interleukin-1 Type I/immunology ; Th2 Cells/immunology
    Chemical Substances Interleukin-1beta ; Interleukin-5 ; Receptors, Interleukin-1 Type I ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2016-04-19
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2016.02.033
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  4. Article ; Online: Inzet biomassa optie voor de toekomst? Biotechnologie vor bulkproductie van organische chemicaliën

    Patel, M.K. / Crank, M. / Dornburg, V. / van Overbeek, L.S.

    Milieu dossier

    2007  Volume 3

    Abstract: Tegenwoordig worden bijna alle organische chemische stoffen en plastics geproduceerd uit ruwe olie en aardags. Moet dit zo blijven of zijn er andere, meer duurzame manieren om chemische stoffen te produceren? Het gebruik van biomassa als grondstof en het ...

    Abstract Tegenwoordig worden bijna alle organische chemische stoffen en plastics geproduceerd uit ruwe olie en aardags. Moet dit zo blijven of zijn er andere, meer duurzame manieren om chemische stoffen te produceren? Het gebruik van biomassa als grondstof en het inzetten van biotechnologie zijn twee mogelijkheden. Maar wanneer we deze methoden gebruiken, lopen we dan tegen nieuwe, onvoorziene risico's aan? Dit artikel geeft een samenvatting van de uitkomst van een gedetailleerde studie, gefinancierd door de Europese Unie, over deze en andere belangrijke vragen.
    Keywords biobased chemistry ; biobased economy ; biotechnology ; chemical industry ; economic viability ; environmental impact ; genetically engineered organisms ; scenario analysis ; biotechnologie ; chemie op basis van biologische grondstoffen ; chemische industrie ; economische haalbaarheid ; genetisch gemanipuleerde organismen ; milieueffect ; scenario-analyse
    Language Dutch
    Publishing country nl
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: IL-1 acts on T cells to enhance the magnitude of in vivo immune responses.

    Ben-Sasson, S Z / Caucheteux, Stephane / Crank, Michelle / Hu-Li, Jane / Paul, William E

    Cytokine

    2011  Volume 56, Issue 1, Page(s) 122–125

    Abstract: IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action ... ...

    Abstract IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cells are transferred to B6 IL-1R1-/- recipients and only cells that express IL-1 receptors can respond. The major mechanism through which IL-1 enhances responses is by increasing survival of responding cells. IL-1 enhances the proportion of responding CD4 T cells that differentiate into Th17 cells and increases the proportion of responding CD8 cells that express granzyme B. Of a wide range of cytokines tested, only IL-1α and IL-1β mediate this function. The potency of IL-1 as an enhancer of T cell responses suggests that it could act to enhance responses to weak vaccines and that the pathway utilized by IL-1 might be considered in the design of new generations of adjuvants.
    MeSH term(s) Animals ; Cross-Priming/drug effects ; Cross-Priming/immunology ; Humans ; Immunity/drug effects ; Immunity/immunology ; Interleukin-1/pharmacology ; Receptors, Interleukin-1/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Vaccines/immunology
    Chemical Substances Interleukin-1 ; Receptors, Interleukin-1 ; Vaccines
    Language English
    Publishing date 2011-08-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2011.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2840: Show issues Location:
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  6. Article ; Online: Biotechnologie voor bulkproducten van organische chemicalien

    Patel, M.K. / Crank, M. / Dornburg, V. / Hermann, B.G. / van Overbeek, L.S.

    Milieu : opinieblad van de Vereniging van Milieuprofessionals

    2007  Volume 13, Issue 3

    Keywords Life Science
    Language Dutch
    Publishing country nl
    Document type Article ; Online
    ISSN 1873-5436
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Mutations in PIK3CD can cause hyper IgM syndrome (HIGM) associated with increased cancer susceptibility.

    Crank, M C / Grossman, J K / Moir, S / Pittaluga, S / Buckner, C M / Kardava, L / Agharahimi, A / Meuwissen, H / Stoddard, J / Niemela, J / Kuehn, H / Rosenzweig, S D

    Journal of clinical immunology

    2014  Volume 34, Issue 3, Page(s) 272–276

    Abstract: Autosomal dominant gain of function mutations in the gene encoding PI3K p110δ were recently associated with a novel combined immune deficiency characterized by recurrent sinopulmonary infections, CD4 lymphopenia, reduced class-switched memory B cells, ... ...

    Abstract Autosomal dominant gain of function mutations in the gene encoding PI3K p110δ were recently associated with a novel combined immune deficiency characterized by recurrent sinopulmonary infections, CD4 lymphopenia, reduced class-switched memory B cells, lymphadenopathy, CMV and/or EBV viremia and EBV-related lymphoma. A subset of affected patients also had elevated serum IgM. Here we describe three patients in two families who were diagnosed with HIGM at a young age and were recently found to carry heterozygous mutations in PIK3CD. These patients had an abnormal circulating B cell distribution featuring a preponderance of early transitional (T1) B cells and plasmablasts. When stimulated in vitro, PIK3CD mutated B cells were able to secrete class-switched immunoglobulins. This finding implies that the patients' elevated serum IgM levels were unlikely a product of an intrinsic B cell functional inability to class switch. All three patients developed malignant lymphoproliferative syndromes that were not associated with EBV. Thus, we identified a novel subset of patients with PIK3CD mutations associated with HIGM, despite indications of preserved in vitro B cell class switch recombination, as well as susceptibility to non-EBV-associated malignancies.
    MeSH term(s) Adult ; Biopsy ; Child ; Class I Phosphatidylinositol 3-Kinases/genetics ; Female ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Hyper-IgM Immunodeficiency Syndrome/complications ; Hyper-IgM Immunodeficiency Syndrome/diagnosis ; Hyper-IgM Immunodeficiency Syndrome/genetics ; Lymph Nodes/pathology ; Male ; Mutation ; Neoplasms/diagnosis ; Neoplasms/etiology ; Pedigree ; Young Adult
    Chemical Substances Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CD protein, human (EC 2.7.1.137)
    Language English
    Publishing date 2014-03-08
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-014-0012-9
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    Zs.A 1640: Show issues Location:
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  8. Article: Rituximab but not other anti-CD20 antibodies reverses multidrug resistance in 2 B lymphoma cell lines, blocks the activity of P-glycoprotein (P-gp), and induces P-gp to translocate out of lipid rafts.

    Ghetie, Maria-Ana / Crank, Michelle / Kufert, Stephanie / Pop, Iliodora / Vitetta, Ellen

    Journal of immunotherapy (Hagerstown, Md. : 1997)

    2006  Volume 29, Issue 5, Page(s) 536–544

    Abstract: The objective of this study was to investigate the ability of the anti-CD20 antibody, Rituximab (RTX), to inhibit the activity of P-glycoprotein (P-gp), and reverse multidrug resistance (MDR) in 2 P-gp/CD20 lymphoma cell lines. We determined whether RTX ... ...

    Abstract The objective of this study was to investigate the ability of the anti-CD20 antibody, Rituximab (RTX), to inhibit the activity of P-glycoprotein (P-gp), and reverse multidrug resistance (MDR) in 2 P-gp/CD20 lymphoma cell lines. We determined whether RTX would chemosensitize the 2 P-gp cell lines in vitro, and inhibit the ability of the cells to efflux Rhodamine 123. One cell line was infected with an MDR1 vector and the other was generated by drug selection. We also determined whether RTX induced P-gp to translocate out of lipid rafts. RTX chemosensitized 2 different MDR cell lines, inhibited the activity of P-gp in both, and induced P-gp to translocate out of lipid rafts in the 1 cell line that was studied in greater detail. In contrast, 3 other anti-CD20 antibodies did not chemosensitize, inhibit the activity of P-gp, or induce it to translocate out of rafts, despite the fact that 1 antibody recognized the same epitope on CD20. Our results suggest that RTX can chemosensitize 2 CD20/P-gp cell lines in vitro by inhibiting the activity of the P-gp pump. The inhibition of P-gp activity correlated with the ability of RTX to induce P-gp to translocate out of lipid rafts. Although the mechanisms by which RTX effects P-gp translocation and activity are not yet known, they are not associated with acid-sphingomyelinase activation in raft microdomains, as described for the antiproliferative activity of RTX.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20/immunology ; Antineoplastic Agents/immunology ; Antineoplastic Agents/pharmacology ; Burkitt Lymphoma ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Resistance, Multiple/drug effects ; Humans ; Immunoglobulin Fc Fragments/immunology ; Membrane Microdomains/metabolism ; Membrane Proteins/metabolism ; Mice ; Mitochondrial Proteins/metabolism ; Protein Transport ; Rhodamine 123 ; Rituximab ; Vincristine/pharmacology
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20 ; Antineoplastic Agents ; Immunoglobulin Fc Fragments ; Membrane Proteins ; Mitochondrial Proteins ; TMEM243 protein, human ; Rhodamine 123 (1N3CZ14C5O) ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F)
    Language English
    Publishing date 2006-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1064067-8
    ISSN 1537-4513 ; 1524-9557 ; 1053-8550
    ISSN (online) 1537-4513
    ISSN 1524-9557 ; 1053-8550
    DOI 10.1097/01.cji.0000211307.05869.6c
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    Zs.A 1778: Show issues Location:
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  9. Book: Techno-economic Feasibility of Large-scale Produktion of Bio-based Polymers in Europe (PRO-BIP)

    Crank, Manuela / Patel, Martin / Marscheider-Weidemann, Frank

    Final Report

    2004  , Page(s) 231 S.

    Language German
    Document type Book
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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  10. Article ; Online: IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells.

    Ben-Sasson, Shlomo Z / Hogg, Alison / Hu-Li, Jane / Wingfield, Paul / Chen, Xi / Crank, Michelle / Caucheteux, Stephane / Ratner-Hurevich, Maya / Berzofsky, Jay A / Nir-Paz, Ran / Paul, William E

    The Journal of experimental medicine

    2013  Volume 210, Issue 3, Page(s) 491–502

    Abstract: Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of ... ...

    Abstract Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of wild-type but not IL1R1(-/-) OT-I cells, particularly in spleen, liver, and lung, upon immunization with OVA and lipopolysaccharide. IL-1 administration also results in an enhancement in the frequency of antigen-specific cells that are granzyme B(+), have cytotoxic activity, and/ or produce interferon γ (IFN-γ). Cells primed in the presence of IL-1 display enhanced expression of granzyme B and increased capacity to produce IFN-γ when rechallenged 2 mo after priming. In three in vivo models, IL-1 enhances the protective value of weak immunogens. Thus, IL-1 has a marked enhancing effect on antigen-specific CD8 T cell expansion, differentiation, migration to the periphery, and memory.
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Female ; Immunization ; Immunologic Memory/drug effects ; Interferon-gamma/biosynthesis ; Interleukin-1/pharmacology ; Listeria monocytogenes/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL
    Chemical Substances Interleukin-1 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2013-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20122006
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