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  1. AU="Crețu, Oana Iulia"
  2. AU="Kim, Y G"
  3. AU=Lejuste Florian
  4. AU="Xavier-Carvalho, Caroline"
  5. AU="Lamb, Keith"
  6. AU="Şenbabaoğlu, Yasin"
  7. AU="Papaparaskeva, Kleo" AU="Papaparaskeva, Kleo"
  8. AU="Hanmer, Stuart B"
  9. AU="de Graaf, Gimon"
  10. AU=Bryan Nathan S
  11. AU="Bhatia, Chitra"
  12. AU="Neufeld, Niko"
  13. AU="Martínez-Cruz, Nayeli"
  14. AU="Joffe, Marshall M"
  15. AU="Wilunda, Calistus"
  16. AU="Das, Partha Pratim"
  17. AU="Staiano, Leopoldo"
  18. AU="Tibbatts, Clare"
  19. AU="Bandeira, Igor D"
  20. AU="Papathanassiou, Dimitri"
  21. AU="Mazurek, Camille"
  22. AU="Jenkinson, Crispin"
  23. AU="Hernández-Huérfano, Emilio Ernesto"
  24. AU="Conowall, Peter"
  25. AU="Nesan, Daniel"
  26. AU="Ueda, Takashi"
  27. AU="Yuan, Jiacheng"
  28. AU="Kahama, C B"
  29. AU="D’Alessio, Roberto"
  30. AU="Reuhl, Kenneth"
  31. AU="Seeleman, Conny"
  32. AU="Delaquis, Pascal"
  33. AU="Bommineni, Gopal R"
  34. AU="Kuhn, Cynthia M."
  35. AU="Olson, Jason C"
  36. AU="Buchholz, V."
  37. AU="Urquhart, Bradley L"
  38. AU="Ezaki, Kazune"
  39. AU="Choi, Jong Hyun"
  40. AU="Xie, Qiaowei"
  41. AU=Rojas-Marte G AU=Rojas-Marte G
  42. AU="Belli, A"
  43. AU="Moolman, M Charl"
  44. AU="Mazzoni, Stefania"
  45. AU=Stryjewski Martin E
  46. AU=Vallon Volker AU=Vallon Volker
  47. AU="Knowland, K E"
  48. AU="Beker, M. G."

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  1. Artikel: Immunoexpression of Claudin 4 in Gastric Adenocarcinomas.

    Crețu, Oana Iulia / Stepan, Mioara Desdemona / Florescu, Mirela Marinela / Stepan, Alex Emilian

    Current health sciences journal

    2022  Band 48, Heft 4, Seite(n) 373–378

    Abstract: Disturbance of the intercellular adhesion system represents a basic biomolecular mechanism in gastric carcinogenesis. Claudin 4 is member of a protein family involved in maintaining homeostasis and epithelial integrity. In this study, we analyzed the ... ...

    Abstract Disturbance of the intercellular adhesion system represents a basic biomolecular mechanism in gastric carcinogenesis. Claudin 4 is member of a protein family involved in maintaining homeostasis and epithelial integrity. In this study, we analyzed the immunoexpression of Claudin 4 in 58 cases of gastric adenocarcinomas, in relation to the main histopathological parameters of aggressiveness, the reactions obtained being evaluated through the intensity of the reactions and the number of positive cells. Positive membranous reactions of Claudin 4 were observed in all cases, in tumor cells and some stromal elements, but in some high grade gastric adenocarcinomas also cytoplasmic immunostaining was present. Claudin 4 high scores were associated with tubular, tubulopapillary and hepatoid adenocarcinomas, of low grade and in early stages, aspects that suggest the usefulness of the marker in evaluating the aggressiveness of gastric epithelial tumors.
    Sprache Englisch
    Erscheinungsdatum 2022-12-31
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.04.02
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Snail Immunoexpression in Endometrioid Endometrial Carcinomas.

    Florescu, Mirela Marinela / Crețu, Oana Iulia / Muraru, Andrei / Florescu, Dan Nicolae / Simionescu, Cristiana Eugenia

    Current health sciences journal

    2022  Band 48, Heft 4, Seite(n) 393–397

    Abstract: Endometrial carcinoma is one of the most prevalent cancers affecting women with epidemiological placing it as the sixth most common cancer in women. One of the factors implicated in EMT (epithelial-mesenchymal transition), Snail is regarded as having a ... ...

    Abstract Endometrial carcinoma is one of the most prevalent cancers affecting women with epidemiological placing it as the sixth most common cancer in women. One of the factors implicated in EMT (epithelial-mesenchymal transition), Snail is regarded as having a pivotal role. We selected a number of 30 endometrial carcinomas, in a 2-year period (2020-2022). Snail immunoexpression was identified in the tumor cells for 70% of the endometroid carcinoma cases studied. Tumor cells showed both nuclear and cytoplasmic expression but only nuclear signals were quantified. The average percent of marked tumor cells was 38.6±24.9, corresponding to well differentiated carcinomas. Our analysis also showed a significant association between higher tumor grade and snail expression (p=0.000). Alteration of the epithelial-mesenchymal phenotype in endometrial carcinomas by Snail overexpression in high-grade and advanced-stage lesions constitutes mechanisms involved in the process of tumor progression.
    Sprache Englisch
    Erscheinungsdatum 2022-12-31
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.04.05
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Classification and Grading Systems in Gastric Adenocarcinomas.

    Crețu, Oana Iulia / Stepan, Alex Emilian / Simionescu, Cristiana Eugenia / Marinescu, Daniela / Stepan, Mioara Desdemona

    Current health sciences journal

    2022  Band 48, Heft 3, Seite(n) 284–291

    Abstract: Gastric adenocarcinomas are lesions that raise important issues in clinical practice, due to their incidence and biological behavior. Over time, various systems have been used for classifying and grading of gastric adenocarcinomas, in the hope of ... ...

    Abstract Gastric adenocarcinomas are lesions that raise important issues in clinical practice, due to their incidence and biological behavior. Over time, various systems have been used for classifying and grading of gastric adenocarcinomas, in the hope of increasing the diagnostic accuracy. In this study we statistically analyzed 112 cases of gastric adenocarcinomas in relation to different classification and grading systems, in order to identify their efficacy and concordance in the histopathological diagnosis. The results indicated a significant association of the Lauren and World Health Organization 2019 classifications and also between these and the three-tier and two-tier grading systems, which supports their practical utility in establishing the diagnosis and assessment of the tumor aggressiveness, for the differentiated therapy.
    Sprache Englisch
    Erscheinungsdatum 2022-09-30
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.03.06
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Immunoexpression of E-cadherin, CD44 and Claudin 7 in gastric adenocarcinomas.

    Creţu, Oana Iulia / Simionescu, Cristiana Eugenia / Florescu, Mirela Marinela / Stepan, Mioara Desdemona / Sapalidis, Konstantinos / Stepan, Alex Emilian

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2023  Band 63, Heft 3, Seite(n) 529–537

    Abstract: Gastric adenocarcinomas represent frequent malignant tumors in the digestive tract, with a high and constant mortality rate in last decades. The disturbance of the adhesion molecules expression, which normally is essential in maintaining epithelial ... ...

    Abstract Gastric adenocarcinomas represent frequent malignant tumors in the digestive tract, with a high and constant mortality rate in last decades. The disturbance of the adhesion molecules expression, which normally is essential in maintaining epithelial homeostasis, has a critical role in the initiation and progression of tumors. In this study, we analyzed the immunoexpression of E-cadherin, cluster of differentiation 44 (CD44), and Claudin 7 in 58 cases of gastric adenocarcinomas, in relation to the histopathological parameters of the lesions' aggressiveness. Increased E-cadherin immunoexpression was observed in tubular adenocarcinomas, those of low grade and in stages I-III. CD44 presented high scores in discohesive, hepatoid, tubular, and tubulopapillary adenocarcinomas, those of high grade and in advanced stages. Claudin 7 associated increased scores for tubular, tubulopapillary and micropapillary tumors, those of low grade and mainly in stage I. The markers used in the study can be useful for assessing the aggressiveness of gastric adenocarcinomas, in the context of specific adapted therapy.
    Mesh-Begriff(e) Humans ; Cadherins ; Adenocarcinoma/pathology ; Stomach Neoplasms/pathology ; Claudins ; Biomarkers, Tumor ; Hyaluronan Receptors
    Chemische Substanzen Cadherins ; Claudins ; Biomarkers, Tumor ; CD44 protein, human ; Hyaluronan Receptors
    Sprache Englisch
    Erscheinungsdatum 2023-01-19
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.63.3.07
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Statical Association between Clinical and Histopathological Parameters for Keratinocyte Carcinomas.

    Badiu, Alin Cristian / Simionescu, Cristiana Eugenia / Stepan, Alex Emilian / Mărgăritescu, Claudiu / Florescu, Mirela Marinela / Andreiana, Bianca Cătălina / Badiu, Anne-Marie / Crețu, Oana Iulia / Muraru, Andrei / Geormăneanu, Cristina / Ciurea, Raluca Niculina

    Current health sciences journal

    2023  Band 49, Heft 2, Seite(n) 237–243

    Abstract: The most common tumor of the western world is comprised of forms of non-melanoma skin cancers, previously known as keratinocyte carcinomas (KCs) The purpose of this study was to determine de incidence of non-melanoma skin tumors and the relationship ... ...

    Abstract The most common tumor of the western world is comprised of forms of non-melanoma skin cancers, previously known as keratinocyte carcinomas (KCs) The purpose of this study was to determine de incidence of non-melanoma skin tumors and the relationship between histopathological risk factors in patients with skin cancers. The study was composed from 332 cases of skin malignancies for which clinical and histopathological aggressivity factors were statistically analyzed through comparison tests and also stored digitally. For basal cell carcinoma (BCC) statistical analysis indicated significant relationships between pT category and gender, tumor size, ulceration, depth of invasion and positive resection limits. For squamous cell carcinoma (SCC) statistical analysis indicated significant relationships between pT category and tumor size, depth of invasion and positive resection limits. Clinical and histological analysis of certain characteristics of the above-mentioned skin cancers is an essential step in documenting and improving both prognosis and therapy standards.
    Sprache Englisch
    Erscheinungsdatum 2023-06-30
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.49.02.237
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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