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  1. Article ; Online: Real-world effectiveness of systemic anticancer therapy for advanced melanoma in the west of Scotland from 2010 to 2018.

    Clarke, Julie / Bennie, Marion / Kurdi, Amanj / Pan, Jiafeng / Mueller, Tanja / Crearie, Christine / Baillie, Kelly / Laskey, Jennifer / Waterston, Ashita

    Future oncology (London, England)

    2023  Volume 19, Issue 6, Page(s) 451–461

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Immunotherapy ; Ipilimumab ; Melanoma/drug therapy ; Neoplasms, Second Primary ; Retrospective Studies ; Scotland/epidemiology
    Chemical Substances Ipilimumab
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2022-0959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
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  2. Article ; Online: Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice.

    Mueller, Tanja / Laskey, Jennifer / Baillie, Kelly / Clarke, Julie / Crearie, Christine / Kavanagh, Kimberley / Graham, Janet / Graham, Kathryn / Waterson, Ashita / Jones, Robert / Kurdi, Amanj / Morrison, David / Bennie, Marion

    Health informatics journal

    2022  Volume 28, Issue 1, Page(s) 14604582221077055

    Abstract: The efficacy and safety of cancer medicines as reported from randomised clinical trials do not always translate into similar benefits in routine clinical practice; hence, post-marketing studies are a useful addition to the evidence base. With recent ... ...

    Abstract The efficacy and safety of cancer medicines as reported from randomised clinical trials do not always translate into similar benefits in routine clinical practice; hence, post-marketing studies are a useful addition to the evidence base. With recent advances in digital infrastructure and the advent of electronically available health records, linkage of routinely collected data has emerged as a promising evaluation method for these studies. This paper discusses the opportunities and challenges when applying an electronic record linkage methodology with respect to systemic anti-cancer therapy by showcasing exemplar studies conducted over a three-year period in Scotland, and highlights some of the potential pitfalls spanning the entire breadth and depth of the research process. Our experiences as an interdisciplinary team indicate that there is scope to conduct large cohort studies to generate results from routine clinical practice within a reasonable time frame; however, close collaboration between researchers, data controllers and clinicians is required in order to obtain valid and meaningful results.
    MeSH term(s) Delivery of Health Care ; Electronics ; Humans ; Neoplasms/drug therapy ; Scotland
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2213115-2
    ISSN 1741-2811 ; 1460-4582
    ISSN (online) 1741-2811
    ISSN 1460-4582
    DOI 10.1177/14604582221077055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction to: The impact of COVID-19 on systemic anticancer treatment delivery in Scotland.

    Baxter, Mark A / Murphy, John / Cameron, David / Jordan, Judith / Crearie, Christine / Lilley, Christina / Sadozye, Azmat / Maclean, Mary / Hall, Peter / Phillips, Angela / Greger, Alex / Madeleine, Jude / Petty, Russell D

    British journal of cancer

    2021  Volume 124, Issue 10, Page(s) 1745

    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01298-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The impact of COVID-19 on systemic anticancer treatment delivery in Scotland.

    Baxter, Mark A / Murphy, John / Cameron, David / Jordan, Judith / Crearie, Christine / Lilley, Christina / Sadozye, Azmat / Maclean, Mary / Hall, Peter / Phillips, Angela / Greger, Alex / Madeleine, Jude / Petty, Russell D

    British journal of cancer

    2021  Volume 124, Issue 8, Page(s) 1353–1356

    Abstract: Understanding the impact of the COVID-19 pandemic on systemic anticancer therapy delivery (SACT) is crucial to appreciate the short- and long-term consequences for cancer patients and plan future care. Here, we report real-time national SACT delivery ... ...

    Abstract Understanding the impact of the COVID-19 pandemic on systemic anticancer therapy delivery (SACT) is crucial to appreciate the short- and long-term consequences for cancer patients and plan future care. Here, we report real-time national SACT delivery data from NHS Scotland. We demonstrate an initial rapid reduction in patient attendance of 28.7% with subsequent rapid recovery following service redesign. The smallest decrease was seen in breast cancer (19.7%), which also had the most rapid recovery and the largest decrease seen in colorectal cancer (43.4%). Regional variation in the magnitude of impact on SACT delivery was observed, but nadirs occurred at the same time and the rate of recovery was similar across all regions. This recovery reflected a coordinated national approach and associated patient and clinician support structures, which facilitated the creation of COVID-19-protected areas for SACT delivery in Scottish cancer centres enabling rapid sharing of successful and innovative strategies. The data show that these actions have limited the disadvantage to cancer patients.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; COVID-19/virology ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/virology ; Female ; Humans ; Male ; Pandemics ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Scotland/epidemiology
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01262-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
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  5. Article ; Online: Use of record linkage to evaluate treatment outcomes and trial eligibility in a real-world metastatic prostate cancer population in Scotland.

    Baillie, Kelly / Mueller, Tanja / Pan, Jiafeng / Laskey, Jennifer / Bennie, Marion / Crearie, Christine / Kavanagh, Kimberley / Alvarez-Madrazo, Samantha / Morrison, David / Clarke, Julie / Keel, Aileen / Cameron, David / Wu, Olivia / Kurdi, Amanj / Jones, Robert J

    Pharmacoepidemiology and drug safety

    2020  Volume 29, Issue 6, Page(s) 653–663

    Abstract: Purpose: New treatments are introduced into standard care based on clinical trial results. However, it is not clear if these benefits are reflected in the broader population. This study analysed the clinical outcomes of patients with metastatic ... ...

    Abstract Purpose: New treatments are introduced into standard care based on clinical trial results. However, it is not clear if these benefits are reflected in the broader population. This study analysed the clinical outcomes of patients with metastatic castration-resistant prostate cancer, treated with abiraterone and enzalutamide, within the Scottish National Health Service.
    Methods: Retrospective cohort study using record linkage of routinely collected healthcare data (study period: February 2012 to February 2017). Overall survival (OS) was analysed using Kaplan-Meier methods and Cox Proportional Hazard models; a subgroup analysis comprised potentially trial-eligible patients.
    Results: Overall, 271 patients were included and 73.8% died during the study period. Median OS was poorer than in the pivotal trials, regardless of medication and indication: 10.8 months (95% confidence interval [CI] 8.6-15.1) and 20.9 months (95% CI 14.9-29.0) for abiraterone, and 12.6 months (95% CI 10.5-18.2) and 16.0 months (95% CI 9.8-not reached) for enzalutamide, post and pre chemotherapy, respectively. Only 46% of patients were potentially "trial eligible" and in this subgroup OS improved. Factors influencing survival included baseline performance status, and baseline prostate-specific antigen, alkaline phosphatase, and albumin levels.
    Conclusions: Poorer prognostic features of non-trial eligible patients impact real-world outcomes of cancer medicines. Electronic record linkage of routinely collected healthcare data offers an opportunity to report outcomes on cancer medicines at scale and describe population demographics. The availability of such observational data to supplement clinical trial results enables patients and clinicians to make more informed treatment decisions, and policymakers to contextualise trial findings.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Androgen Antagonists/adverse effects ; Androgen Antagonists/therapeutic use ; Androstenes/adverse effects ; Androstenes/therapeutic use ; Clinical Decision-Making ; Clinical Trials as Topic ; Electronic Health Records ; Eligibility Determination ; Humans ; Male ; Medical Record Linkage ; Middle Aged ; Neoplasm Metastasis ; Patient Selection ; Phenylthiohydantoin/adverse effects ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/mortality ; Prostatic Neoplasms, Castration-Resistant/pathology ; Retrospective Studies ; Scotland ; State Medicine ; Time Factors ; Treatment Outcome
    Chemical Substances Androgen Antagonists ; Androstenes ; Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU) ; abiraterone (G819A456D0)
    Language English
    Publishing date 2020-04-21
    Publishing country England
    Document type Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.4998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3395: Show issues Location:
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