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  1. Book: Schwermetalle im Grundwasser Nordrhein-Westfalens unter besonderer Berücksichtigung des Nickels in tieferen Grundwasserleitern der Niederrheinischen Bucht

    Cremer, Nils

    (Besondere Mitteilungen zum Deutschen gewässerkundlichen Jahrbuch ; 60)

    2002  

    Author's details von Nils Cremer
    Series title Besondere Mitteilungen zum Deutschen gewässerkundlichen Jahrbuch ; 60
    Collection
    Keywords Nordrhein-Westfalen ; Grundwasser ; Schwermetallbelastung ; Niederrheinische Bucht ; Schwermetall ; Remobilisierung
    Subject Remobilisation ; Schwermetalle ; Schwermetall
    Language German
    Size XVI, 178 S. : graph. Darst., Kt.
    Publisher Landesumweltamt Nordrhein-Westfalen
    Publishing place Essen
    Publishing country Germany
    Document type Book
    Note Zsfassung in dt. u. engl. Sprache
    HBZ-ID HT013497400
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    054/1088 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.

    Roske, Yvette / Cappel, Cedric / Cremer, Nils / Hoffmann, Patrick / Koudelka, Tomas / Tholey, Andreas / Heinemann, Udo / Daumke, Oliver / Damme, Markus

    Nucleic acids research

    2023  Volume 52, Issue 1, Page(s) 370–384

    Abstract: The phospholipase D (PLD) family is comprised of enzymes bearing phospholipase activity towards lipids or endo- and exonuclease activity towards nucleic acids. PLD3 is synthesized as a type II transmembrane protein and proteolytically cleaved in ... ...

    Abstract The phospholipase D (PLD) family is comprised of enzymes bearing phospholipase activity towards lipids or endo- and exonuclease activity towards nucleic acids. PLD3 is synthesized as a type II transmembrane protein and proteolytically cleaved in lysosomes, yielding a soluble active form. The deficiency of PLD3 leads to the slowed degradation of nucleic acids in lysosomes and chronic activation of nucleic acid-specific intracellular toll-like receptors. While the mechanism of PLD phospholipase activity has been extensively characterized, not much is known about how PLDs bind and hydrolyze nucleic acids. Here, we determined the high-resolution crystal structure of the luminal N-glycosylated domain of human PLD3 in its apo- and single-stranded DNA-bound forms. PLD3 has a typical phospholipase fold and forms homodimers with two independent catalytic centers via a newly identified dimerization interface. The structure of PLD3 in complex with an ssDNA-derived thymidine product in the catalytic center provides insights into the substrate binding mode of nucleic acids in the PLD family. Our structural data suggest a mechanism for substrate binding and nuclease activity in the PLD family and provide the structural basis to design immunomodulatory drugs targeting PLD3.
    MeSH term(s) Humans ; Lysosomes/metabolism ; Phospholipase D/chemistry ; Phospholipases ; Exodeoxyribonucleases/chemistry
    Chemical Substances Phospholipase D (EC 3.1.4.4) ; Phospholipases (EC 3.1.-) ; PLD3 protein, human (EC 3.1.4.4) ; Exodeoxyribonucleases (EC 3.1.-)
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad1114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: TapA acts as specific chaperone in TasA filament formation by strand complementation.

    Roske, Yvette / Lindemann, Florian / Diehl, Anne / Cremer, Nils / Higman, Victoria A / Schlegel, Brigitte / Leidert, Martina / Driller, Kristina / Turgay, Kürşad / Schmieder, Peter / Heinemann, Udo / Oschkinat, Hartmut

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 17, Page(s) e2217070120

    Abstract: Studying mechanisms of bacterial biofilm generation is of vital importance to understanding bacterial cell-cell communication, multicellular cohabitation principles, and the higher resilience of microorganisms in a biofilm against antibiotics. Biofilms ... ...

    Abstract Studying mechanisms of bacterial biofilm generation is of vital importance to understanding bacterial cell-cell communication, multicellular cohabitation principles, and the higher resilience of microorganisms in a biofilm against antibiotics. Biofilms of the nonpathogenic, gram-positive soil bacterium
    MeSH term(s) Bacterial Proteins/metabolism ; Bacillus subtilis/metabolism ; Magnetic Resonance Spectroscopy ; Protein Structure, Secondary ; Molecular Chaperones/metabolism ; Biofilms
    Chemical Substances Bacterial Proteins ; Molecular Chaperones
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2217070120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online: Kooperationsprojekt GROWA+ NRW 2021 Teil VII

    Wendland, Frank / Bergmann, Sabine / Cremer, Nils ( 19XX ) / Gömann, Horst / Eisele, Michael / Kreins, Peter / Kunkel, Ralf

    Minderungsbedarf der Stickstoffeinträge zur Erreichung der Ziele für das Grundwasser und für den Meeresschutz

    2021  

    Keywords Text ; ddc:630
    Language German
    Publisher Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen (LANUV)
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Checking the plausibility of modelled nitrate concentrations in the leachate on federal state scale in Germany

    Wolters, Tim / Cremer, Nils ( 19XX ) / Eisele, Michael / Herrmann, Frank / Kreins, Peter / Kunkel, Ralf / Wendland, Frank

    2021  

    Abstract: In Germany, modelled nitrate concentrations in the leachate are of great importance for the development of scenarios for the long‐term achievement of the groundwater quality target according to the specific requirements of the EU Water Framework ... ...

    Abstract In Germany, modelled nitrate concentrations in the leachate are of great importance for the development of scenarios for the long‐term achievement of the groundwater quality target according to the specific requirements of the EU Water Framework Directive as well as within the context of the recently adopted general administrative regulation for the designation of nitrate‐polluted areas in Germany. For the German federal states o fNorth Rhine‐Westphalia (NRW) and Rhineland‐Palatinate( RLP), an area‐covering modelling of mean long‐term nitrate concentrations in leachate with high spatial resolution was carried out using the model system RAUMIS‐m GROWA‐DENUZ. Hotspot regions with nitrate concentrations in the leachate of 50mg NO3 /L and more were identified for intensively farmed areas in the Münsterland, LowerRhine, and Vorderpfalz. The validity of modelled values was checked using measured values from 1119 preselected monitoring stations from shallow springs and aquifers filtered near to the surface with oxidizing properties. For the landuse categories of urban areas, arable land, grassland, and forest, an at least good agreement of modelled nitrate concentrations in the leachate and measured nitrate concentrations in groundwater was obtained at numerous sites. An equally good agreement was obtained for 1461 measuring stations from the area of responsibility of the Erftverband, which is a major water supplier in the Lower Rhine region. Here, discrepancies have been analyzed in detail due to profound regional knowledge on observation sites. It turned out that in most cases, accuracy limitations of input data (e.g., N balance surpluses of agriculture at the municipal leve,l 1:50,000 soil map) have been the reaason for larger deviations between observed and modelled values. In a broader sense ,the case study has shown on the one hand that the model system RAUMIS‐m GROWA‐DENUZ is able to reliably represent interrelationships and influencing factors that determine simulated nitrate concentrations in the leachate. On ...
    Keywords Text ; ddc:630 ; nitrate -- groundwater -- leachate -- modelling -- validation -- state scale
    Subject code 550
    Language English
    Publishing date 2021-01-18
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Hydrogeochemie von Eisenausfällungen an Grundwasseraustritten der Abraumkippe Berrenrath (Rheinisches Braunkohlenrevier)

    Lenk, Stephan / Wisotzky, Frank / Cremer, Nils

    Grundwasser. 2013 Mar., v. 18, no. 1

    2013  

    Abstract: Groundwater at the abandoned lignite mine in Berrenrath (Germany) is acidic and highly mineralised. Average iron concentrations of 588 mg/l indicate a high potential for acidification. Furthermore, investigations revealed a complete depletion of the ... ...

    Title translation Chemistry of iron oxides at groundwater seepage sites of the lignite mine Berrenrath (Germany)
    Abstract Groundwater at the abandoned lignite mine in Berrenrath (Germany) is acidic and highly mineralised. Average iron concentrations of 588 mg/l indicate a high potential for acidification. Furthermore, investigations revealed a complete depletion of the carbonate buffer capacity (CaCO₃ and [Formula: see text]) during chemical groundwater evolution. Over the next few decades, no decrease of dissolved pyrite oxidation products is expected. On the contrary, within the drainage ditches at the edges of the dump, an intense precipitation of iron oxides is occurring. However, despite oxygen saturation, precipitation of iron oxides is incomplete due to strong acidification of the surface water (pH<3.0). The main contamination of the iron sludge is caused by high nickel concentrations. This element is only loosely bound to the iron oxides and is easily mobilised. Because of high nickel- and sulphate-concentrations, the excavated material has to be deposited in a controlled landfill (German dump category of 2 to 3).
    Keywords acidification ; calcium carbonate ; drainage channels ; groundwater ; iron oxides ; landfills ; lignite ; nickel ; oxidation ; oxygen ; seepage ; sludge ; surface water ; Germany
    Language German
    Dates of publication 2013-03
    Size p. 35-45.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 1330005-2
    ISSN 1432-1165 ; 1430-483X
    ISSN (online) 1432-1165
    ISSN 1430-483X
    DOI 10.1007/s00767-012-0203-3
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7586: Show issues

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  7. Book ; Thesis: Schwermetalle im Grundwasser Nordrhein-Westfalens unter besonderer Berücksichtigung des Nickels in tieferen Grundwasserleitern der Niederrheinischen Bucht

    Cremer, Nils

    (Besondere Mitteilungen zum Deutschen Gewässerkundlichen Jahrbuch ; 60)

    2002  

    Institution Nordrhein-Westfalen / Landesumweltamt
    Author's details von Nils Cremer
    Series title Besondere Mitteilungen zum Deutschen Gewässerkundlichen Jahrbuch ; 60
    Language German
    Size XVI, 178 S., Ill., graph. Darst., Kt.
    Publisher Landesumweltamt Nordrhein-Westfalen
    Publishing place Essen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bochum, 2002
    Note Zsfassung in engl. Sprache
    Database Former special subject collection: coastal and deep sea fishing

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Book ; Thesis: Schwermetalle im Grundwasser Nordrhein-Westfalens unter besonderer Berücksichtigung des Nickels in tieferen Grundwasserleitern der Niederrheinischen Bucht

    Cremer, Nils

    (Besondere Mitteilungen zum Deutschen Gewässerkundlichen Jahrbuch ; 60)

    2002  

    Institution Nordrhein-Westfalen / Landesumweltamt
    Author's details von Nils Cremer
    Series title Besondere Mitteilungen zum Deutschen Gewässerkundlichen Jahrbuch ; 60
    Language German
    Size XVI, 178 S., Ill., graph. Darst., Kt.
    Publisher Landesumweltamt Nordrhein-Westfalen
    Publishing place Essen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bochum, 2002
    Note Zsfassung in engl. Sprache
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Thesis: Schwermetalle im Grundwasser Nordrhein-Westfalens unter besonderer Berücksichtigung des Nickels in tieferen Grundwasserleitern der Niederrheinischen Bucht

    Cremer, Nils

    (Besondere Mitteilungen zum Deutschen Gewässerkundlichen Jahrbuch ; 60)

    2002  

    Institution Nordrhein-Westfalen / Landesumweltamt
    Author's details von Nils Cremer
    Series title Besondere Mitteilungen zum Deutschen Gewässerkundlichen Jahrbuch ; 60
    Language German
    Size XVI, 178 S., Ill., graph. Darst., Kt.
    Publisher Landesumweltamt Nordrhein-Westfalen
    Publishing place Essen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bochum, 2002
    Note Zsfassung in engl. Sprache
    Database Johann Heinrich von Thünen-Institut, Federal Research Institute for Rural Areas, Forestry and Fisheries

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Book: Schwermetalle im Grundwasser Nordrhein-Westfalens unter besonderer Beruecksichtigung des Nickels in tieferen Grundwasserleitern der Niederrheinischen Bucht

    Cremer, Nils

    2002  Volume 60, Page(s) XVI, 178 S., Anh.

    Abstract: In einem ersten Arbeitsteil werden die landesweite Verteilung und die Konzentrationen verschiedener Schwermetalle (Pb, Cd, Cr, Co, Cu, Ni, Hg, Zn) sowie des Halbmetalls Arsen im Grundwasser Nordrhein-Westfalens dargestellt, deren Mobilisation aus ... ...

    Abstract In einem ersten Arbeitsteil werden die landesweite Verteilung und die Konzentrationen verschiedener Schwermetalle (Pb, Cd, Cr, Co, Cu, Ni, Hg, Zn) sowie des Halbmetalls Arsen im Grundwasser Nordrhein-Westfalens dargestellt, deren Mobilisation aus geogenen Quellen erfolgt. Zu diesem Zweck wurden Grundwasseranalysen der Jahre 1990 bis 2000 von Proben aus 4819 ueber Nordrhein-Westfalen verteilten Grundwassermessstellen und Foerderbrunnen zusammengetragen und ausgewertet. Insbesondere hohe und z. T. weiter steigende Nickelkonzentrationen stellen ein Problem fuer die Wasserqualitaet in Nordrhein-Westfalen dar. In dem wasserwirtschaftlich intensiv genutzten Gebiet des linken Niederrheins tritt eine Haeufung hoher Konzentrationen des Nickels und anderer Schwermetalle auf und begruendet die Auswahl des Hauptuntersuchungsstandortes im Raum Moenchengladbach/Viersen (Niederrheinische Bucht). Es wird gezeigt, dass hohe Nickelkonzentrationen im oberflaechennahen Grundwasser mit niedrigen pH-Werten zusammenhaengen, weil die Versauerung eine Desorption der Schwermetallkationen von Tonmineral- und Eisenhydroxidoberflaechen bewirkt. Hohe Konzentrationswerte treten ausserdem im Nahbereich von Erzkoerpern auf. Im zweiten Arbeitsteil werden die Bindungsformen der Schwermetalle untersucht und gemeinsam mit den hydrochemischen Daten bezueglich der Schwermetallmobilisationsprozesse interpretiert. In einem unter fluviatilen Bedingungen gebildeten tieferen Porengrundwasserleiter - drittes lokales Grundwasserstockwerk in 50 bis 70 m Tiefe - loest der Zustrom sauerstoff- und nitratreichen Grundwassers in den tiefen Aquifer einen Wechsel der Redoxbedingungen und damit verbundene Schwermetallmobilisationsprozesse aus. Anhand hydrochemischer Daten wird die Oxidation schwermetallhaltiger Pyrite durch Nitrat als eine Ursache fuer die Freisetzung von Nickel, Kobalt, Zink und Arsen identifiziert. Das freigesetzte zweiwertige Eisen wird oxidiert und in Form von Eisenhydroxiden ausgefaellt, wodurch es im Grundwasserleiter zu einer Mobilisation von Protonen kommt. Die gebildete Saeure wird teilweise durch die Loesung von schwermetallhaltigen (Ni, Co, Zn) Karbonatmineralen gepuffert. Mittels eines in Plexiglassaeulen durchgefuehrten sequentiellen Extraktionsverfahrens wurden die Schwermetallbindungsformen und Schwermetallgehalte der reaktiven Mineralphasen bestimmt. Dies gestattete - vertieft durch hydrogeochemische Modellrechnungen mit dem Programm PHREEQC-2 - die Quantifizierung der Mobilisation oder Immobilisation von Schwermetallen im Zusammenhang mit jedem der betrachteten hydrogeochemischen Prozesse. Demnach tragen die Pyritoxidation und die Karbonatloesung zu gleichen Teilen zur Nickelfreisetzung in das Grundwasser bei. Die niedrigen pH-Werte um 5,5 verhindern weitgehend eine sorptive Bindung der Schwermetallkationen an die frisch gefaellten Eisenhydroxide. Hydrogeochemische Modellrechnungen ermoeglichen eine Prognose der Schwermetallkonzentrationsentwicklung im tieferen Grundwasser der Untersuchungsgebiete.
    Keywords Grundwasserverunreinigung ; Schwermetallbelastung ; Grundwasserleiter ; Hydrogeologie ; Wasserguete ; Schadstoffverhalten ; Schadstoffausbreitung ; Schadstoffdeposition ; Schwermetallbindung ; Adsorption ; Komplexbildung ; Ionenaustausch ; Chemische Reaktion ; Hydrochemie ; Schwermetallmobilisierung ; Gewaesserueberwachung ; Belastungsanalyse ; Schwefelverbindung ; Arsengehalt ; Hintergrundwert ; Schwermetallgehalt ; Kupfer ; Nickel ; Zinkgehalt ; Grundwasserstockwerk ; Wasserwerk ; Regionale Verteilung ; Schwefelgehalt ; Pyrit ; Kohlenstoffgehalt ; Sediment ; Speziation (Chemie) ; Modellierung ; Szenario ; Kationen ; Eisen ; Sulfatgehalt ; Bleigehalt ; Cadmiumgehalt ; Chrom ; Quecksilbergehalt ; Redoxpotential ; Grundwasserbeschaffenheit
    Language German
    Document type Book
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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