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  1. Article ; Online: Diagnosing medullary thyroid carcinoma is facilitated by measuring calcitonin in FNA washout fluids: Alea iacta est.

    Trimboli, Pierpaolo / Crescenzi, Anna

    Cancer cytopathology

    2024  Volume 132, Issue 3, Page(s) 139

    MeSH term(s) Humans ; Calcitonin ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology ; Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/pathology
    Chemical Substances Calcitonin (9007-12-9)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22797
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6893: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Immunohistochemistry in the pathologic diagnosis and management of thyroid neoplasms.

    Crescenzi, Anna / Baloch, Zubair

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1198099

    Abstract: The use of immunohistochemistry cannot be underestimated in the everyday practice of thyroid pathology. It has evolved over the years beyond the traditional confirmation of thyroid origin to molecular profiling and the prediction of clinical behavior. In ...

    Abstract The use of immunohistochemistry cannot be underestimated in the everyday practice of thyroid pathology. It has evolved over the years beyond the traditional confirmation of thyroid origin to molecular profiling and the prediction of clinical behavior. In addition, immunohistochemistry has served to implement changes in the current thyroid tumor classification scheme. It is prudent to perform a panel of immunostains, and the immunoprofile should be interpreted in light of the cytologic and architectural features. Immunohistochemistry can also be easily performed in the limited cellularity specimen preparation generated from thyroid fine-needle aspiration and core biopsy; however, it will require laboratory validation of immunostains specific to these preparations to avoid diagnostic pitfalls. This review discusses the application of immunohistochemistry in thyroid pathology with a focus on limited cellularity preparations.
    MeSH term(s) Humans ; Immunohistochemistry ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/therapy ; Thyroid Neoplasms/pathology ; Biopsy, Fine-Needle ; Biopsy, Large-Core Needle
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1198099
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  3. Article ; Online: Fluorescence confocal microscopy for rapid evaluation of EUS fine-needle biopsy in pancreatic solid lesions.

    Stigliano, Serena / Crescenzi, Anna / Taffon, Chiara / Marocchi, Gianmarco / Di Matteo, Francesco Maria

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2023  Volume 8, Issue 3, Page(s) 113–114

    Abstract: Video 1EUS fine-needle biopsy of a pancreatic solid lesion evaluated with fluorescence confocal microscopy. ...

    Abstract Video 1EUS fine-needle biopsy of a pancreatic solid lesion evaluated with fluorescence confocal microscopy.
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2022.11.010
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  4. Article ; Online: A new tool for rapid evaluation of endoscopic ultrasound through the needle biopsy in pancreatic cystic neoplasm.

    Stigliano, Serena / Crescenzi, Anna / Marocchi, Gianmarco / Taffon, Chiara / Verri, Martina / Di Matteo, Francesco Maria

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 8, Page(s) 1161–1163

    MeSH term(s) Humans ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Endosonography ; Biopsy, Needle ; Neoplasms, Cystic, Mucinous, and Serous/pathology ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Pancreatic Cyst/diagnostic imaging ; Pancreatic Cyst/pathology
    Language English
    Publishing date 2023-06-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.05.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Real-Time Evaluation of Thyroid Cytology Using New Digital Microscopy Allows for Sample Adequacy Assessment, Morphological Classification, and Supports Molecular Analysis.

    Verri, Martina / Scarpino, Stefania / Naciu, Anda Mihaela / Lopez, Gianluca / Tabacco, Gaia / Taffon, Chiara / Pilozzi, Emanuela / Palermo, Andrea / Crescenzi, Anna

    Cancers

    2023  Volume 15, Issue 17

    Abstract: Thyroid cytological examination, a key tool in preoperative thyroid nodule evaluation, is specific and accurate; some drawbacks are due to inadequate or indeterminate cytological reports and there is a need for an innovative approach overcoming the ... ...

    Abstract Thyroid cytological examination, a key tool in preoperative thyroid nodule evaluation, is specific and accurate; some drawbacks are due to inadequate or indeterminate cytological reports and there is a need for an innovative approach overcoming the limits of traditional cytological diagnostics. Fluorescence laser confocal microscopes (FCM) is a new optical technique for allowing immediate digital imaging of fresh unfixed tissues and real-time assessment of sample adequacy and diagnostic evaluation for small biopsies and cytological samples. Currently, there are no data about the use of FCMs in the field of thyroid nodular pathology. The aims of this study were to test FCM technology for evaluating the adequacy of FNA samples at the time of the procedure and to assess the level of concordance between FCM cytological evaluations, paired conventional cytology, and final surgical histology. The secondary aim was to define the integrity of nucleic acids after FCM evaluation through NGS molecular analysis. Sample adequacy was correctly stated. Comparing FCM evaluation with the final histology, all cases resulting in malignant or suspicious for malignancy at FCM, were confirmed to be carcinomas (PPV 100%). In conclusion, we describe a successful application of FCM in thyroid preoperative cytological evaluation, with advantages in immediate adequacy assessment and diagnostic information, while preserving cellular specimens for permanent morphology and molecular analysis, thus improving timely and accurate patient management.
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15174215
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  6. Article: Potential Use of Vivascope for Real-Time Histological Evaluation in Endoscopic Laryngeal Surgery.

    De Benedetto, Luigi / Moffa, Antonio / Baptista, Peter / Di Giovanni, Simone / Giorgi, Lucrezia / Verri, Martina / Taffon, Chiara / Crescenzi, Anna / Casale, Manuele

    Journal of personalized medicine

    2023  Volume 13, Issue 8

    Abstract: We aimed to assess the feasibility of using confocal laser scanning microscopy (CLSM) for the real-time ex vivo examination of histological samples of laryngeal lesions and to evaluate the correlation between CLSM and definitive histological results. ... ...

    Abstract We aimed to assess the feasibility of using confocal laser scanning microscopy (CLSM) for the real-time ex vivo examination of histological samples of laryngeal lesions and to evaluate the correlation between CLSM and definitive histological results. This preliminary study included eight consecutive patients with "suspected" laryngeal lesions who were candidates for endoscopic laryngeal surgery. The obtained samples were evaluated using CLSM and classified as "inadequate" or "adequate" (high- and low-grade dysplasia, in situ and invasive carcinoma, positive surgical margin, and inflammatory outbreaks). CLSM showed the macro image in all cases and generated a digital version. All the samples were defined as adequate during CLSM and confirmed at histopathology: low-grade dysplasia (
    Language English
    Publishing date 2023-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13081252
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  7. Article ; Online: RE: Thyroid Core Needle Biopsy: The Strengths of Guidelines of the Korean Society of Thyroid Radiology.

    Crescenzi, Anna / Trimboli, Pierpaolo

    Korean journal of radiology

    2017  Volume 18, Issue 5, Page(s) 867–869

    Language English
    Publishing date 2017-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2017.18.5.867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5591: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Considerations on chemical composition of psammoma bodies: Automated detection strategy by infrared microspectroscopy in ovarian and thyroid cancer tissues.

    Porcelli, Francesco / Verri, Martina / De Santis, Serena / Crescenzi, Anna / Bianchi, Antonella / Felici, Anna Candida / Sotgiu, Giovanni / Romano, Susanna / Orsini, Monica

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2023  Volume 298, Page(s) 122792

    Abstract: Ectopic calcifications are observed in many soft tissues and are associated with several diseases, including cancer. The mechanism of their formation and the correlation with disease progression are often unclear. Detailed knowledge of the chemical ... ...

    Abstract Ectopic calcifications are observed in many soft tissues and are associated with several diseases, including cancer. The mechanism of their formation and the correlation with disease progression are often unclear. Detailed knowledge of the chemical composition of these inorganic formations can be very helpful in better understanding their relationship with unhealthy tissue. In addition, information on microcalcifications can be very useful for early diagnosis and provide insight into prognosis. In this work the chemical composition of psammoma bodies (PBs) found in tissues of human ovarian serous tumors was examined. The analysis using Micro Fourier Transform Infrared Spectroscopy (micro-FTIR) revealed that these microcalcifications contain amorphous calcium carbonate phosphate. Moreover, some PB grains showed the presence of phospholipids. This interesting result corroborates the proposed formation mechanism reported in many studies according to which ovarian cancer cells switch to a calcifying phenotype by inducing the deposition of calcifications. In addition, other techniques as X-ray Fluorescence Spectroscopy (XRF), Inductively Coupled Plasma Optical Emission Spectroscopy(ICP-OES) and Scanning electron microscopy (SEM) with Energy Dispersive X-ray Spectroscopy (EDX) were performed on the PBs from ovary tissues to determine the elements present. The PBs found in ovarian serous cancer showed a composition comparable to PBs isolated from papillary thyroid. Based on the chemical similarity of IR spectra, using micro-FTIR spectroscopy combined with multivariate analysis, an automatic recognition method was constructed. With this prediction model it was possible to identify PBs microcalcifications in tissues of both ovarian cancers, regardless of tumor grade, and thyroid cancer with high sensitivity. Such approach could become a valuable tool for routine macrocalcification detection because it eliminates sample staining, and the subjectivity of conventional histopathological analysis.
    MeSH term(s) Female ; Humans ; Thyroid Neoplasms ; Ovarian Neoplasms/diagnosis ; Calcinosis/pathology ; Multivariate Analysis ; Spectroscopy, Fourier Transform Infrared/methods
    Language English
    Publishing date 2023-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2023.122792
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    In stock of ZB MED Bonn / Germany

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    924/340: Show issues

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  9. Article: Liver involvement in the course of thymoma-associated multiorgan autoimmunity: The first histological description.

    Citarella, Fabrizio / Vespasiani-Gentilucci, Umberto / Crescenzi, Anna / Bianchi, Antonella / Virzì, Vladimir / Tonini, Giuseppe

    Hepatobiliary & pancreatic diseases international : HBPD INT

    2021  Volume 21, Issue 1, Page(s) 86–89

    MeSH term(s) Autoimmune Diseases/etiology ; Humans ; Liver/immunology ; Liver/pathology ; Thymoma/complications
    Language English
    Publishing date 2021-02-13
    Publishing country Singapore
    Document type Letter
    ZDB-ID 2241386-8
    ISSN 1499-3872
    ISSN 1499-3872
    DOI 10.1016/j.hbpd.2021.02.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6313: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Head-to-head comparison of FNA cytology vs. calcitonin measurement in FNA washout fluids (FNA-CT) to diagnose medullary thyroid carcinoma. A systematic review and meta-analysis.

    Trimboli, Pierpaolo / Giannelli, Jacopo / Marques, Bernardo / Piccardo, Arnoldo / Crescenzi, Anna / Deandrea, Maurilio

    Endocrine

    2021  Volume 75, Issue 1, Page(s) 33–39

    Abstract: Purpose: The sensitivity of cytology after fine needle aspiration (FNA-cytology) in detecting medullary thyroid carcinoma (MTC) is low. To overcome this problem, measuring calcitonin (CT) in washout fluid of FNA (FNA-CT) has been largely diffused and ... ...

    Abstract Purpose: The sensitivity of cytology after fine needle aspiration (FNA-cytology) in detecting medullary thyroid carcinoma (MTC) is low. To overcome this problem, measuring calcitonin (CT) in washout fluid of FNA (FNA-CT) has been largely diffused and showed good performance. However, no evidence-based study exists comparing systematically the sensitivity of FNA-cytology and FNA-CT. This study aimed to systematically review the literature and collect data allowing a head-to-head comparison meta-analysis between FNA-cytology and FNA-CT in detecting MTC lesions.
    Methods: The online databases of PubMed/MEDLINE and Scopus were searched until June 2021. Original articles reporting the use of both FNA-cytology and FNA-CT in the same series of histologically proven MTC lesions were included They were extracted general features of each study, number of MTC lesions (nodule and neck lymph nodes), and true positive and false negatives of both FNA-cytology and FNA-CT.
    Results: Six studies were included. The sensitivity of FNA-cytology varied from 20% to 86% with a pooled value of 54% (95% CI 35-73%) and significant heterogeneity. The sensitivity of FNA-CT was higher than 95% in almost all studies with a pooled value of 98% (95% CI 96-100%) without heterogeneity. The sensitivity of FNA-CT was significantly higher than that of FNA-cytology.
    Conclusions: FNA-CT is significantly more sensitive than FNA-cytology in detecting MTC. Accordingly, FNA-CT represents the standard method to use in patients with suspicious MTC lesions, combined with cytology.
    MeSH term(s) Biopsy, Fine-Needle ; Calcitonin ; Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/pathology ; Humans ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology ; Thyroid Nodule/pathology ; Tomography, X-Ray Computed
    Chemical Substances Calcitonin (9007-12-9)
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-021-02892-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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