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  1. Article ; Online: Impact of Depression in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy With Cytoreductive Surgery.

    de Boissieu, Paul / Crespel, Céline / Duminil, Laura / de Mestier, Louis

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2016  Volume 34, Issue 28, Page(s) 3482

    MeSH term(s) Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Depression ; Humans ; Hyperthermia, Induced ; Peritoneal Neoplasms
    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2016.68.1593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  2. Article ; Online: Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier: a case report.

    Montero-Macias, Rosa / Koual, Meriem / Crespel, Céline / Le Frére-Belda, Marie Aude / Hélène, Hélène Blons / Nguyen-Xuan, Huyen-Thu / Garinet, Simon / Perkins, Géraldine / Balay, Vincent / Durdux, Catherine / Florin, Marie / Péré, Hélène / Bats, Anne-Sophie

    Journal of medical case reports

    2021  Volume 15, Issue 1, Page(s) 210

    Abstract: Background: Homologous recombination deficiency is a marker of response to poly(ADP-ribose) polymerase inhibitors in different cancer types including ovary, prostate, and pancreatic cancer. To date, no report about poly(ADP-ribose) polymerase inhibitors ...

    Abstract Background: Homologous recombination deficiency is a marker of response to poly(ADP-ribose) polymerase inhibitors in different cancer types including ovary, prostate, and pancreatic cancer. To date, no report about poly(ADP-ribose) polymerase inhibitors has been published on cervical cancer.
    Case presentation: Here we present the case of a patient with cervical cancer treated in this setting. A 49-year-old woman diagnosed with International Federation of Obstetricians and Gynecologists stage 2018 IIIC2 locally advanced undifferentiated cervical cancer received first-line chemoradiotherapy followed by carboplatin, paclitaxel, and bevacizumab with partial response. Because of a family history of cancers, the patient was tested and found positive for a pathogenic BRCA1 germline and somatic mutation, which motivated bevacizumab plus olaparib maintenance treatment. A simple hysterectomy was performed after 2 years stable disease; pathological report showed complete pathological response, and 12 months follow-up showed no recurrence.
    Conclusion: Poly(ADP-ribose) polymerase inhibitors could be an alternative maintenance treatment for patients with persistent advanced cervical cancer previously treated with platinum, especially when familial history of cancers is reported. Clinical trials using poly(ADP-ribose) polymerase inhibitors for advanced cervical cancer are warranted.
    MeSH term(s) BRCA1 Protein/genetics ; Bevacizumab/therapeutic use ; Chemoradiotherapy ; Female ; Humans ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Phthalazines ; Piperazines ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics
    Chemical Substances BRCA1 Protein ; BRCA1 protein, human ; Phthalazines ; Piperazines ; Bevacizumab (2S9ZZM9Q9V) ; olaparib (WOH1JD9AR8)
    Language English
    Publishing date 2021-04-23
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-021-02767-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nephrotoxicity Associated With Niraparib.

    Lazareth, Hélène / Delanoy, Nicolas / Cohen, Raphaël / Boissier, Emilie / Ayari, Hamza / Combe, Pierre / Crespel, Céline / Mercadier-Riaz, Elise / Karras, Alexandre / Courbebaisse, Marie / Thervet, Eric / Pallet, Nicolas

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2020  Volume 76, Issue 6, Page(s) 898–900

    MeSH term(s) Aged ; Aged, 80 and over ; Dose-Response Relationship, Drug ; Female ; Humans ; Indazoles/administration & dosage ; Indazoles/adverse effects ; Kidney Diseases/chemically induced ; Middle Aged ; Ovarian Neoplasms/drug therapy ; Piperidines/administration & dosage ; Piperidines/adverse effects ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Risk Factors
    Chemical Substances Indazoles ; Piperidines ; Poly(ADP-ribose) Polymerase Inhibitors ; niraparib (HMC2H89N35)
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Letter
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2020.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 468: Show issues

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  4. Article: Syndrome héréditaire de prédisposition au cancer du sein et de l’ovaire : diagnostic et implications thérapeutiques.

    Koual, Meriem / Perkins, Géraldine / Delanoy, Nicolas / Crespel, Céline / Medioni, Jacques / Nguyen-Xuan, Huyên-Thu / Douay-Hauser, Nathalie / Blons, Hélène / Le Frère-Belda, Marie-Aude / Molière, Diane / Achen, Guillaume / Nos, Claude / Balaya, Vincent / Montero, Rosa / Laurent-Puig, Pierre / Bats, Anne-Sophie

    Annales de pathologie

    2020  Volume 40, Issue 2, Page(s) 70–77

    Abstract: Patients who carry the BReast Cancer 1 or 2 (BRCA) gene mutations have an underlying hereditary predisposition for breast and ovarian cancers. These deleterious genetic mutations are the most common ones implicated in hereditary breast and ovarian ... ...

    Title translation Hereditary breast and ovarian cancer syndrome: Diagnosis and therapeutic implications.
    Abstract Patients who carry the BReast Cancer 1 or 2 (BRCA) gene mutations have an underlying hereditary predisposition for breast and ovarian cancers. These deleterious genetic mutations are the most common ones implicated in hereditary breast and ovarian cancers. Oncogenetic counselling plays a key role in identifying patient for BRCA testing and for mutation identification. BRCA1/2 carriers have to be followed up regularly and may justify breast and/or adnexal prophylactic surgery, according to the French National Cancer Institute guidelines (INCa). Poly- (DNA-riboses) polymerases inhibitors, notably olaparib, have a major role in the management of epithelial ovarian cancer in patients with BRCA mutation and many studies are ongoing to expand their indications in a near future.
    MeSH term(s) BRCA1 Protein/analysis ; BRCA1 Protein/genetics ; BRCA2 Protein/analysis ; BRCA2 Protein/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Genetic Testing ; Hereditary Breast and Ovarian Cancer Syndrome/diagnosis ; Hereditary Breast and Ovarian Cancer Syndrome/drug therapy ; Hereditary Breast and Ovarian Cancer Syndrome/genetics ; Humans ; Mutation ; Ovarian Neoplasms/drug therapy ; Phthalazines/therapeutic use ; Piperazines/therapeutic use ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use
    Chemical Substances BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; Phthalazines ; Piperazines ; Poly(ADP-ribose) Polymerase Inhibitors ; olaparib (WOH1JD9AR8)
    Language French
    Publishing date 2020-02-08
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2020.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1652: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Évaluation de la faisabilité d’un programme d’activité physique adaptée en hôpital de jour de cancérologie digestive : à partir du point de vue des patients.

    Crespel, Céline / Brami, Cloé / de Boissieu, Paul / Mazza, Camille / Chauvet, Kevin / Lemoine, Amélie / Gavlak, Benoit / Léandri, Chloé / Brasseur, Mathilde / Bertin, Eric / Bouché, Olivier

    Bulletin du cancer

    2018  Volume 105, Issue 3, Page(s) 228–233

    Abstract: Introduction: Adapted physical activity (APA) is recognized as an effective supportive care for asthenia and quality of life in oncology. Before an APA program was organized, the feasibility of such a program was evaluated among the patients.: Methods! ...

    Title translation Evaluation of the feasibility of a program of adapted physical activity in day hospital of digestive oncology: From the point of view of patients.
    Abstract Introduction: Adapted physical activity (APA) is recognized as an effective supportive care for asthenia and quality of life in oncology. Before an APA program was organized, the feasibility of such a program was evaluated among the patients.
    Methods: Descriptive, prospective, semi-qualitative, single-center study over a 3-month period in patients treated with ambulatory chemotherapy for digestive cancer. A self-questionnaire was offered to all patients to evaluate their practice and knowledge about APA. In ten patients, fatigue, anxiety and depression were assessed, before and after 9 weeks of hospital-based APA. The scores were compared by matched Student test.
    Results: Of the 123 patients treated, 80 questionnaires (65%) were exploitable. Before the diagnosis of cancer, 40 patients (50%) were physically active, 20% after (n=16). The reasons for not practicing were: lack of interest/not the idea (42%), lack of time (34%), do not believe in profit (9%), too expensive (8%). Fifty-three patients (66%) were interested in the program. In 10 patients, the APA program significantly reduced the depression score (P=0.024) and a non-significant improvement in anxiety and fatigue.
    Discussion: This study shows that patients treated with chemotherapy are unaware of the usefulness of APA and that medical information can improve adherence to such a program. The establishment of an intra-hospital APA program proved to be possible and relevant.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Ambulatory Care/methods ; Anxiety/diagnosis ; Depression/diagnosis ; Digestive System Neoplasms/drug therapy ; Digestive System Neoplasms/psychology ; Exercise ; Fatigue/diagnosis ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Program Development ; Prospective Studies ; Surveys and Questionnaires
    Language French
    Publishing date 2018-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2017.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.15: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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