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Article ; Online: Eosinophilia and elevated IgE serum levels: a red flag: when your diagnosis is not a common atopic eczema or common allergy.

Criado, Paulo Ricardo / Miot, Hélio Amante / Ianhez, Mayra

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2023 Volume 72, Issue 3, Page(s) 541–551

Abstract: Objective and design: The hallmark of type 2 inflammation is eosinophilia and/or high IgE serum levels, mostly in atopic dermatitis. Nevertheless, many dermatoses may present similar findings. Our aim is to explore the biological and clinical spectrum ... ...

Abstract	Objective and design: The hallmark of type 2 inflammation is eosinophilia and/or high IgE serum levels, mostly in atopic dermatitis. Nevertheless, many dermatoses may present similar findings. Our aim is to explore the biological and clinical spectrum of cutaneous manifestations involving tissue and/or systemic eosinophilia, and distinct serum levels of IgE, where atopic dermatitis or other primary allergic eczema, not always is the definitive diagnosis. Materials/methods: A total of 37 scientific papers were enrolled in this narrative review. Results: A diagnostic approach for patients with elevated serum IgE level and a list of conditions not related to atopic dermatitis that runs through inborn errors of immunity, inflammatory disorders, lung disorders, malignancy, infections/infestations are displayed. Regarding to peripheral eosinophilia, differential diagnosis is also explored and clinical patterns of skin diseases associated with tissue eosinophilia are listed, to facilitate our diagnosis. Conclusions: We should maintain a high level of suspicion about other differential diagnosis involving eosinophilia and IgE dysregulation, especially in patients very young (when innate errors of the immunity may present) and in middle to elderly patients classified as having atopic dermatitis, due to the possibility of cutaneous hematological malignancies, paraneoplasia or autoimmune blistering diseases.
MeSH term(s)	Humans ; Aged ; Dermatitis, Atopic ; Immunoglobulin E ; Eosinophilia/diagnosis ; Eosinophilia/complications ; Eosinophilia/pathology ; Eosinophils ; Skin/pathology
Chemical Substances	Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-023-01690-7
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Zs.A 675: Show issues

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Article ; Online: Prurigo: review of its pathogenesis, diagnosis, and treatment.

Criado, Paulo Ricardo / Ianhez, Mayra / Criado, Roberta Fachini Jardim / Nakano, Juliana / Lorenzini, Daniel / Miot, Hélio Amante

Anais brasileiros de dermatologia

2024

Abstract: Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and ... ...

Abstract	Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and underlying etiological factors. The immunology of chronic prurigo shows similarities with atopic dermatitis due to the involvement of IL-4 and IL-13, IL-22, and IL-31. Treatment includes antihistamines, topical steroids, dupilumab, and JAK inhibitors. Several conditions manifest clinically as prurigo-like lesions, and the correct clinical diagnosis must precede correct treatment. Furthermore, chronic prurigos represent a recalcitrant and distressing dermatosis, and at least 50% of these patients have atopic diathesis, the treatment of which may induce adverse effects, especially in the elderly. The quality of life is significantly compromised, and topical treatments are often unable to control symptoms and skin lesions. Systemic immunosuppressants, immunobiologicals, and JAK inhibitors, despite the cost and potential adverse effects, may be necessary to achieve clinical improvement and quality of life. This manuscript reviews the main types of prurigo, associated diseases, their immunological bases, diagnosis, and treatment.
Language	English
Publishing date	2024-03-16
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2023.11.003
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Zs.A 359: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Axillary papules: an uncommon location of lichen nitidus.

Belda, Walter / Criado, Paulo Ricardo / Di Chiacchio, Nilton Gioia

Anais brasileiros de dermatologia

2021 Volume 96, Issue 3, Page(s) 381–383

MeSH term(s)	Axilla ; Humans ; Keratosis ; Lichen Nitidus/diagnosis ; Skin Abnormalities ; Tongue Diseases
Language	English
Publishing date	2021-03-16
Publishing country	Spain
Document type	Journal Article
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2020.04.015
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Zs.MO 344: Show issues

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Article ; Online: Chronic Urticaria and Angioedema: Masqueraders and Misdiagnoses.

Bernstein, Jonathan A / Ziaie, Navid / Criado, Roberta / Criado, Paulo Ricardo / Rea, Stephanie / Davis, Mark

The journal of allergy and clinical immunology. In practice

2023 Volume 11, Issue 8, Page(s) 2251–2263

Abstract: Chronic urticaria is a common condition presenting with intensely pruritic wheals. Although individual lesions resolve within 24 hours, by definition, chronic urticaria lasts for a duration of at least 6 weeks. Both spontaneous and inducible forms exist. ...

Abstract	Chronic urticaria is a common condition presenting with intensely pruritic wheals. Although individual lesions resolve within 24 hours, by definition, chronic urticaria lasts for a duration of at least 6 weeks. Both spontaneous and inducible forms exist. In the spontaneous variant, chronic urticaria occurs in the absence of clearly identifiable triggers. In chronic inducible urticaria, specific triggers may include dermatographism, cholinergic (heat), cold, exercise, delayed pressure, and solar. Extensive laboratory evaluation for chronic spontaneous urticaria is not required unless indicated by clinical history or physical examination. Angioedema describes sudden onset of localized edema involving the deep layers of the skin and submucosal tissues. It can be seen in isolation or in conjunction with chronic urticaria. Angioedema typically resolves slower than wheals, taking up to 72 hours or longer. Histamine- and bradykinin-mediated forms exist. Both chronic urticaria and angioedema have many mimics, and a broad range of differential diagnoses should be considered. Importantly, an incorrect diagnosis may have significant implications for the additional investigation, treatment, and prognosis of the affected patient. The aim of this article is to discuss the characteristics of chronic urticaria and angioedema, and an approach to the investigation and diagnosis of their mimics.
MeSH term(s)	Humans ; Angioedema/drug therapy ; Urticaria/diagnosis ; Urticaria/drug therapy ; Chronic Urticaria ; Histamine ; Diagnostic Errors ; Chronic Disease
Chemical Substances	Histamine (820484N8I3)
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2023.06.033
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Article ; Online: Panniculitis as main clinical manifestation of alpha-1 antitrypsin deficiency revealing a SerpinA1 gene mutation.

Abdalla, Beatrice Martinez Zugaib / Criado, Paulo Ricardo

The Australasian journal of dermatology

2020 Volume 61, Issue 4, Page(s) e470–e471

MeSH term(s)	Adult ; Female ; Humans ; Mutation ; Panniculitis/etiology ; Panniculitis/pathology ; alpha 1-Antitrypsin/genetics ; alpha 1-Antitrypsin/therapeutic use ; alpha 1-Antitrypsin Deficiency/complications ; alpha 1-Antitrypsin Deficiency/diagnosis ; alpha 1-Antitrypsin Deficiency/drug therapy ; alpha 1-Antitrypsin Deficiency/genetics
Chemical Substances	SERPINA1 protein, human ; alpha 1-Antitrypsin
Language	English
Publishing date	2020-05-19
Publishing country	Australia
Document type	Case Reports ; Letter
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.13332
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Zs.A 236: Show issues

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Article ; Online: Case Report: Treatment of Chromoblastomycosis with Combinations including Acitretin: A Report of Two Cases.

Belda, Walter / Criado, Paulo Ricardo / Domingues Passero, Luiz Felipe

The American journal of tropical medicine and hygiene

2020 Volume 103, Issue 5, Page(s) 1852–1854

Abstract: Chromoblastomycosis is a cutaneous fungal infection caused by dematiaceous fungi that belong to the ... ...

Abstract	Chromoblastomycosis is a cutaneous fungal infection caused by dematiaceous fungi that belong to the order
MeSH term(s)	Acitretin/administration & dosage ; Acitretin/therapeutic use ; Adjuvants, Immunologic/administration & dosage ; Adjuvants, Immunologic/therapeutic use ; Antifungal Agents/administration & dosage ; Antifungal Agents/therapeutic use ; Chromoblastomycosis/drug therapy ; Chromoblastomycosis/pathology ; Drug Therapy, Combination ; Humans ; Imiquimod/administration & dosage ; Imiquimod/therapeutic use ; Itraconazole/administration & dosage ; Itraconazole/therapeutic use ; Keratolytic Agents/administration & dosage ; Keratolytic Agents/therapeutic use ; Male ; Middle Aged
Chemical Substances	Adjuvants, Immunologic ; Antifungal Agents ; Keratolytic Agents ; Itraconazole (304NUG5GF4) ; Acitretin (LCH760E9T7) ; Imiquimod (P1QW714R7M)
Language	English
Publishing date	2020-08-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-0471
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Article ; Online: Atypical clinical presentation of an Arthroderma gypseum infection in a renal transplant recipient.

Belda Junior, Walter / Criado, Paulo Ricardo

Revista do Instituto de Medicina Tropical de Sao Paulo

2020 Volume 62, Page(s) e42

Abstract: Dermatophytes are known as a common cause of superficial mycosis, but atypical presentations in immunosuppressed patients make the diagnosis more challenging. Here, we report a case of a 39-year-old patient, a renal transplant recipient from a living ... ...

Abstract	Dermatophytes are known as a common cause of superficial mycosis, but atypical presentations in immunosuppressed patients make the diagnosis more challenging. Here, we report a case of a 39-year-old patient, a renal transplant recipient from a living donor, who presented with atypical cutaneous lesions of lower extremities caused by Arthroderma gypseum (Nannizzia gypsea), four months after receiving a renal transplant. It is important to highlight the importance of the early detection of fungal infections in immunosuppressed patients. Clinicians should have a high degree of suspicion for the early detection and treatment of the cases.
MeSH term(s)	Adult ; Arthrodermataceae/isolation & purification ; Dermatomycoses/diagnosis ; Dermatomycoses/pathology ; Diagnosis, Differential ; Female ; Humans ; Hyalohyphomycosis/diagnosis ; Immunocompromised Host ; Kidney Transplantation/adverse effects
Language	English
Publishing date	2020-06-22
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946202062042
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Article ; Online: Successful treatment of chromoblastomycosis caused by Fonsecaea pedrosoi using imiquimod.

Belda, Walter / Criado, Paulo Ricardo / Passero, Luiz Felipe Domingues

The Journal of dermatology

2020 Volume 47, Issue 4, Page(s) 409–412

Abstract: Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as physical approaches, is considered ...

Abstract	Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as physical approaches, is considered complex and ineffective due to the high rate of relapses. Thus, new strategies are needed to manage CBM; in this regard, the present work reports the evolution of lesions in patients successfully treated with imiquimod. Of note, classic treatment was not effective in healing the lesions of two of them, but single topical treatment with imiquimod healed the lesions.
MeSH term(s)	Adult ; Brazil ; Chromoblastomycosis/diagnosis ; Chromoblastomycosis/drug therapy ; Chromoblastomycosis/microbiology ; Chromoblastomycosis/pathology ; Fonsecaea/isolation & purification ; Hand ; Humans ; Imiquimod/administration & dosage ; Male ; Middle Aged ; Skin/microbiology ; Skin/pathology ; Skin Cream/administration & dosage ; Treatment Outcome
Chemical Substances	Imiquimod (P1QW714R7M)
Language	English
Publishing date	2020-01-21
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.15225
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Article ; Online: First report of cutaneous mycetoma by Paecilomyces variotii and the successful treatment with combined itraconazole and terbinafine along with resection surgeries.

Criado, Paulo Ricardo / Belda Junior, Walter / da Matta, Vania Lucia Ribeiro

The Australasian journal of dermatology

2021 Volume 62, Issue 3, Page(s) e397–e399

Abstract: Mycetoma is a progressively mutilating infectious disease of the subcutaneous tissue that affects the skin and deep structures, which is poorly responsive to chemotherapy. Here, we report a skin mycetoma caused by Paecilomyces variotii, an uncommon ... ...

Abstract	Mycetoma is a progressively mutilating infectious disease of the subcutaneous tissue that affects the skin and deep structures, which is poorly responsive to chemotherapy. Here, we report a skin mycetoma caused by Paecilomyces variotii, an uncommon fungus of human infections, and the therapeutic approach that resulted in a complete cure of the patient.
MeSH term(s)	Administration, Cutaneous ; Antifungal Agents/therapeutic use ; Byssochlamys ; Humans ; Itraconazole/therapeutic use ; Mycetoma/drug therapy ; Terbinafine/therapeutic use ; Treatment Outcome
Chemical Substances	Antifungal Agents ; Itraconazole (304NUG5GF4) ; Terbinafine (G7RIW8S0XP)
Language	English
Publishing date	2021-03-24
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.13592
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Zs.A 236: Show issues

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Article ; Online: A case of tuberculosis verrucosa cutis in Brazil undiagnosed for 15 years.

Wedy, Glaucia Ferreira / Passero, Luiz Felipe Domingues / Criado, Paulo Ricardo / Belda, Walter

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

2021 Volume 25, Issue 3, Page(s) 101593

Abstract: Tuberculosis verrucosa cutis is a rare medical condition that is caused by the inoculation of Mycobacterium tuberculosis into the skin of a previously sensitized individual. This clinical form of tuberculosis corresponds to 1-2% of all cases of ... ...

Abstract	Tuberculosis verrucosa cutis is a rare medical condition that is caused by the inoculation of Mycobacterium tuberculosis into the skin of a previously sensitized individual. This clinical form of tuberculosis corresponds to 1-2% of all cases of tuberculosis and due to the paucibacillary characteristic of the lesions, patients can be misdiagnosed, accounting for the chronification of the skin infection. Herein, we report the case of a 26-year-old male farmer, presenting plaques with verrucosa and hyperkeratosis features in the left thigh and buttocks during 15 years. M. tuberculosis was identified by PCR and the patient was treated with standard anti-tuberculosis drugs, with subsequent improvement of the skin lesions.
MeSH term(s)	Adult ; Antitubercular Agents/therapeutic use ; Brazil ; Humans ; Male ; Mycobacterium tuberculosis/genetics ; Skin ; Tuberculosis, Cutaneous/diagnosis ; Tuberculosis, Cutaneous/drug therapy
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2021-07-06
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2041400-6
ISSN	1678-4391 ; 1413-8670
ISSN (online)	1678-4391
ISSN	1413-8670
DOI	10.1016/j.bjid.2021.101593
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