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Article ; Online: Prurigo: review of its pathogenesis, diagnosis, and treatment.

Criado, Paulo Ricardo / Ianhez, Mayra / Criado, Roberta Fachini Jardim / Nakano, Juliana / Lorenzini, Daniel / Miot, Hélio Amante

Anais brasileiros de dermatologia

2024

Abstract: Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and ... ...

Abstract	Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and underlying etiological factors. The immunology of chronic prurigo shows similarities with atopic dermatitis due to the involvement of IL-4 and IL-13, IL-22, and IL-31. Treatment includes antihistamines, topical steroids, dupilumab, and JAK inhibitors. Several conditions manifest clinically as prurigo-like lesions, and the correct clinical diagnosis must precede correct treatment. Furthermore, chronic prurigos represent a recalcitrant and distressing dermatosis, and at least 50% of these patients have atopic diathesis, the treatment of which may induce adverse effects, especially in the elderly. The quality of life is significantly compromised, and topical treatments are often unable to control symptoms and skin lesions. Systemic immunosuppressants, immunobiologicals, and JAK inhibitors, despite the cost and potential adverse effects, may be necessary to achieve clinical improvement and quality of life. This manuscript reviews the main types of prurigo, associated diseases, their immunological bases, diagnosis, and treatment.
Language	English
Publishing date	2024-03-16
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2023.11.003
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Article ; Online: What the physicians should know about mast cells, dendritic cells, urticaria, and omalizumab during COVID-19 or asymptomatic infections due to SARS-CoV-2?

Criado, Paulo Ricardo / Pagliari, Carla / Criado, Roberta Fachini Jardim / Marques, Gabriela Franco / Belda, Walter

Dermatologic therapy

2020 Volume 33, Issue 6, Page(s) e14068

Abstract: Coronavirus disease (COVID-19) pandemic presents several dermatological manifestations described in the present indexed literature, with around 700 cases reported until May 2020, some described as urticaria or urticarial rashes. Urticaria is constituted ... ...

Abstract	Coronavirus disease (COVID-19) pandemic presents several dermatological manifestations described in the present indexed literature, with around 700 cases reported until May 2020, some described as urticaria or urticarial rashes. Urticaria is constituted by evanescent erythematous-edematous lesions (wheals and flare), which does not persist in the same site for more than 24 to 48 hours and appears in other topographic localization, resolving without residual hyper pigmentation. During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, some cytokines are synthesized, including Interferon (IFN) type I, TNF-α, and chemokines which may induce mast cells (MCs) and basophils degranulation by mechanisms similar to the autoinflammatory monogenic or polygenic diseases. In this article, we discuss the spectrum of the urticaria and urticarial-like lesions in the COVID-19's era, besides other aspects related to innate and adaptative immune response to viral infections, interactions between dermal dendritic cells and MCs, and degranulation of MCs by different stimuli. Plasmacytoid dendritic cells share, in allergic patients, expression of the high-affinity IgE receptors on cell membranes and demonstrated a low pattern of type I IFN secretion in viral infections. We discuss the previous descriptions of the effects of omalizumab, a monoclonal antibody directed to IgE and high-affinity IgE receptors, to improve the IFN responses and enhance their antiviral effects.
MeSH term(s)	Antiviral Agents/pharmacology ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/immunology ; Cytokines/immunology ; Dendritic Cells/immunology ; Humans ; Immunoglobulin E/immunology ; Mast Cells/immunology ; Omalizumab/pharmacology ; SARS-CoV-2/isolation & purification ; Urticaria/drug therapy ; Urticaria/immunology ; Urticaria/virology
Chemical Substances	Antiviral Agents ; Cytokines ; Omalizumab (2P471X1Z11) ; Immunoglobulin E (37341-29-0)
Keywords	covid19
Language	English
Publishing date	2020-08-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.14068
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Article ; Online: What lessons can we learn? Clinical and epidemiological retrospective analysis of 267 patients with urticaria in a Brazilian tertiary center.

Criado, Roberta Fachini Jardim / Criado, Paulo Ricardo / Baldavira, Nathalia / Cardial, Debora / Gimenez-Arnau, Ana Maria / Machado Filho, Carlos D'Apparecida

Anais brasileiros de dermatologia

2021 Volume 96, Issue 4, Page(s) 436–441

Abstract: Background: There are few epidemiological studies of urticaria, published in the indexed literature (PubMed/Medline).: Objective: The study aimed to evaluate the epidemiological and clinical data among patients with urticaria/angioedema attending a ... ...

Abstract	Background: There are few epidemiological studies of urticaria, published in the indexed literature (PubMed/Medline). Objective: The study aimed to evaluate the epidemiological and clinical data among patients with urticaria/angioedema attending a reference clinic in Brazil. Methods: Two hundred sixty-seven patients were evaluated retrospectively considering demographic data, time course of the disease, triggering symptoms, the presence of angioedema, complementary laboratory tests including total blood count, reactive-C protein, erythrocyte sedimentation rate, IgE serum levels, and other, as necessary. Results: The most commonly diagnosed type of urticaria was chronic spontaneous urticaria (56.93%). Angioedema was associated with chronic urticaria in 108 patients (40.08%). Study limitations: Unicentered and retrospective. Conclusion: Some relevant findings in this study are the observation of a female prevalence of cases (4-females: 1-man), a result more elevated than demonstrated in previous studies in Europe and Asia, the median age was 43-years old and the delay of time between the diagnosis of urticaria and the admission for treatment in a specialized center was approximately 2-years. Other multicenter studies can better establish these differences in Brazilian patients.
MeSH term(s)	Adult ; Angioedema/diagnosis ; Angioedema/epidemiology ; Brazil/epidemiology ; Chronic Disease ; Female ; Humans ; Retrospective Studies ; Urticaria/epidemiology
Language	English
Publishing date	2021-05-24
Publishing country	Spain
Document type	Journal Article
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2020.12.003
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Article ; Online: Update on vasculitis: overview and relevant dermatological aspects for the clinical and histopathological diagnosis - Part II.

Morita, Thâmara Cristiane Alves Batista / Criado, Paulo Ricardo / Criado, Roberta Fachini Jardim / Trés, Gabriela Franco S / Sotto, Mirian Nacagami

Anais brasileiros de dermatologia

2020 Volume 95, Issue 4, Page(s) 493–507

Abstract: Vasculitis is a group of several clinical conditions in which the main histopathological finding is fibrinoid necrosis in the walls of blood vessels. This article assesses the main dermatological aspects relevant to the clinical and laboratory diagnosis ... ...

Abstract	Vasculitis is a group of several clinical conditions in which the main histopathological finding is fibrinoid necrosis in the walls of blood vessels. This article assesses the main dermatological aspects relevant to the clinical and laboratory diagnosis of small- and medium-vessel cutaneous and systemic vasculitis syndromes. The most important aspects of treatment are also discussed.
MeSH term(s)	Humans ; Skin ; Vasculitis
Language	English
Publishing date	2020-05-24
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2020.04.004
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Article ; Online: Update on vasculitis: an overview and dermatological clues for clinical and histopathological diagnosis - part I.

Morita, Thâmara Cristiane Alves Batista / Trés, Gabriela Franco S / Criado, Roberta Fachini Jardim / Sotto, Mirian Nacagami / Criado, Paulo Ricardo

Anais brasileiros de dermatologia

2020 Volume 95, Issue 3, Page(s) 355–371

Abstract: The term vasculitis refers to the inflammation of vessel walls. It may range in severity from a self-limited disorder in one single organ to a life-threatening disease due to multiple organ failure. It has many causes, although they result in only a few ... ...

Abstract	The term vasculitis refers to the inflammation of vessel walls. It may range in severity from a self-limited disorder in one single organ to a life-threatening disease due to multiple organ failure. It has many causes, although they result in only a few histological patterns of vascular inflammation. Vessels of any type and in any organ can be affected, a fact that results in a broad variety of signs and symptoms. Different vasculitides with indistinguishable clinical presentations have quite different prognosis and treatments. This condition presents many challenges to physicians in terms of classification, diagnosis, appropriate laboratory workup, and treatment. Moreover, it compels a careful follow-up. This article reviews the Chapel-Hill 2012 classification, etiology, recent insights in pathophysiology, some important dermatological clues for the diagnosis and summarizes treatment of some of these complex vasculitis syndromes.
MeSH term(s)	Female ; Humans ; Male ; Necrosis ; Skin Diseases, Vascular/classification ; Skin Diseases, Vascular/diagnosis ; Skin Diseases, Vascular/pathology ; Syndrome ; Vasculitis/classification ; Vasculitis/diagnosis ; Vasculitis/pathology
Language	English
Publishing date	2020-03-26
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2020.01.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 359: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Potential interactions of SARS-CoV-2 with human cell receptors in the skin: Understanding the enigma for a lower frequency of skin lesions compared to other tissues.

Ricardo Criado, Paulo / Pincelli, Thais Prota Hussein / Criado, Roberta Fachini Jardim / Abdalla, Beatrice Martinez Zugaib / Belda Junior, Walter

Experimental dermatology

2020 Volume 29, Issue 10, Page(s) 936–944

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a new public health problem, with a total of 10.577.263 documented COVID-19 cases worldwide and 513.441 deaths up to the present date. Few cases of disease-related cutaneous ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a new public health problem, with a total of 10.577.263 documented COVID-19 cases worldwide and 513.441 deaths up to the present date. Few cases of disease-related cutaneous manifestations have been reported in the literature, and such manifestations are scarce. Integumentary manifestations from COVID-19 include exanthemas and papular dermatoses, urticarial eruptions, atopic dermatitis, vesiculobullous lesions and skin signs of hypercoagulable states, such as acral ischaemia, livedo and retiform purpura. Most common extracutaneous manifestations from the disease include headache, cough, anosmia, ageusia, fever, dyspnoea, nausea, diarrhoea and cardiovascular events. The objectives of this review were to discuss the role of human cell receptors described as interaction targets of SARS-CoV-2, as well to understand the current state of knowledge on skin expression of these receptors, in order to substantiate future research. The authors present a thorough literature review on SARS-CoV-2 and its possible interaction with cell receptors and human tissues including the skin. They discuss a molecular hypothesis to explain the lower prevalence of dermatological manifestations from direct SARS-CoV-2 infection. Distinct human cell receptors binding the virus appear to be less expressed in the skin compared to other organs. Additionally, the presence of resolvins and the disintegrin metalloprotease ADAM17 provide a putative protection to the skin, explaining the majority of COVID-19 manifestations to be extracutaneous. This review represents an excellent opportunity for future studies using skin biopsies from COVID-19 patients to investigate molecular expression in the pathophysiology of cutaneous manifestations of the disease.
MeSH term(s)	Angiotensin-Converting Enzyme 2/physiology ; COVID-19/pathology ; COVID-19/physiopathology ; COVID-19/virology ; Female ; Host Microbial Interactions/physiology ; Humans ; Male ; Models, Biological ; Organ Specificity ; Receptors, Virus/physiology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Serine Endopeptidases/physiology ; Skin/pathology ; Skin/physiopathology ; Skin/virology ; Virus Activation/physiology ; Virus Internalization
Chemical Substances	Receptors, Virus ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
Keywords	covid19
Language	English
Publishing date	2020-10-05
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.14186
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ab Jg. 2022: Lesesaal (EG)

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Article: What the physicians should know about mast cells, dendritic cells, urticaria, and omalizumab during COVID-19 or asymptomatic infections due to SARS-CoV-2?

Criado, Paulo Ricardo / Pagliari, Carla / Criado, Roberta Fachini Jardim / Marques, Gabriela Franco / Belda, Walter

Dermatol Ther

Abstract	Coronavirus disease (COVID-19) pandemic presents several dermatological manifestations described in the present indexed literature, with around 700 cases reported until May 2020, some described as urticaria or urticarial rashes. Urticaria is constituted by evanescent erythematous-edematous lesions (wheals and flare), which does not persist in the same site for more than 24 to 48 hours and appears in other topographic localization, resolving without residual hyper pigmentation. During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, some cytokines are synthesized, including Interferon (IFN) type I, TNF-α, and chemokines which may induce mast cells (MCs) and basophils degranulation by mechanisms similar to the autoinflammatory monogenic or polygenic diseases. In this article, we discuss the spectrum of the urticaria and urticarial-like lesions in the COVID-19's era, besides other aspects related to innate and adaptative immune response to viral infections, interactions between dermal dendritic cells and MCs, and degranulation of MCs by different stimuli. Plasmacytoid dendritic cells share, in allergic patients, expression of the high-affinity IgE receptors on cell membranes and demonstrated a low pattern of type I IFN secretion in viral infections. We discuss the previous descriptions of the effects of omalizumab, a monoclonal antibody directed to IgE and high-affinity IgE receptors, to improve the IFN responses and enhance their antiviral effects.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #670121
Database	COVID19

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Article ; Online: What the physicians should know about mast cells, dendritic cells, urticaria, and omalizumab during COVID ‐19 or asymptomatic infections due to SARS‐CoV ‐2?

Criado, Paulo Ricardo / Pagliari, Carla / Criado, Roberta Fachini Jardim / Marques, Gabriela Franco / Belda, Walter

Dermatologic Therapy ; ISSN 1396-0296 1529-8019

2020

Keywords	Dermatology ; General Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/dth.14068
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Potential interactions of SARS-CoV-2 with human cell receptors in the skin: understanding the enigma for a lower frequency of skin lesions compared to other tissues

Criado, Paulo Ricardo / Pincelli, Thais Prota Hussein / Criado, Roberta Fachini Jardim / Abdalla, Beatrice Martinez Zugaib / Belda Junior, Walter

Exp. dermatol

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a new public health problem, with a total of 10.577.263 documented COVID-19 cases worldwide and 513.441 deaths up to the present date. Few cases of disease-related cutaneous manifestations have been reported in the literature and such manifestations are scarce. Integumentary manifestations from COVID-19 include exanthemas and papular dermatoses, urticarial eruptions, atopic dermatitis, vesiculobullous lesions and skin signs of hypercoagulable states, such as acral ischemia, livedo and retiforme purpura. Most common extra cutaneous manifestations from the disease include headache, cough, anosmia, ageusia, fever, dyspnea, nausea, diarrhea and cardiovascular events. The objectives of this review are to discuss the role of human cell receptors described as interaction targets of SARS-CoV-2, as well to understand the current state of knowledge on skin expression of these receptors, in order to substantiate future research. The authors present a thorough literature review on SARS-CoV-2 and its possible interaction with cell receptors and human tissues including the skin. They discuss a molecular hypothesis to explain the lower prevalence of dermatological manifestations from direct SARS-CoV-2 infection. Distinct human cell receptors binding the virus appear to be less expressed in the skin compared to other organs. Additionally, the presence of resolvins and the desintegrin metalloprotease ADAM17 provide a putative protection to the skin, explaining the majority of COVID-19 manifestations to be extra cutaneous. This review represents an excellent opportunity for future studies using skin biopsies from COVID-19 patients to investigate molecular expression in the pathophysiology of cutaneous manifestations of the disease.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #735918
Database	COVID19

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Article ; Online: Potential interactions of SARS‐CoV‐2 with human cell receptors in the skin

Criado, Paulo Ricardo / Pincelli, Thais Prota Hussein / Criado, Roberta Fachini Jardim / Abdalla, Beatrice Martinez Zugaib / Belda Junior, Walter

Experimental Dermatology ; ISSN 0906-6705 1600-0625

understanding the enigma for a lower frequency of skin lesions compared to other tissues

2020

Keywords	Biochemistry ; Molecular Biology ; Dermatology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/exd.14186
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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