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  1. Article ; Online: Introduction to a review series on hematopoietic stem cells.

    Crispino, John D

    Blood

    2023  Volume 142, Issue 6, Page(s) 497

    MeSH term(s) Hematopoietic Stem Cells ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023020909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Introduction to a review series on megakaryopoiesis and platelet production.

    Crispino, John D

    Blood

    2022  Volume 139, Issue 22, Page(s) 3227

    MeSH term(s) Blood Platelets ; Megakaryocytes ; Thrombopoiesis
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022016023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Introduction to a review series on molecular mechanisms of hematologic malignancies.

    Crispino, John D

    Blood

    2021  Volume 138, Issue 8, Page(s) 587

    MeSH term(s) Hematologic Neoplasms ; Humans
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021012680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bone Marrow Avatars: Mimicking Hematopoiesis in a Dish.

    Derecka, Marta / Crispino, John D

    Cancer discovery

    2023  Volume 13, Issue 2, Page(s) 263–265

    Abstract: Summary: Faithful recapitulation of human bone marrow complexity has been a major challenge for the sci-entific community for many years. In this issue of Cancer Discovery, Khan and colleagues present an improved induced pluripotent stem cell ... ...

    Abstract Summary: Faithful recapitulation of human bone marrow complexity has been a major challenge for the sci-entific community for many years. In this issue of Cancer Discovery, Khan and colleagues present an improved induced pluripotent stem cell differentiation protocol that generates bone marrow organoids re-creating key characteristics of human marrow. See related article by Khan et al., p. 364 (8).
    MeSH term(s) Humans ; Bone Marrow ; Hematopoiesis ; Cell Differentiation ; Organoids ; Hematologic Neoplasms
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-22-1303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Malignant progression of pre-leukemic disorders.

    Hall, Trent / Gurbuxani, Sandeep / Crispino, John D

    Blood

    2024  

    Abstract: The spectrum of myeloid disorders ranges from aplastic bone marrow failure characterized by an empty bone marrow completely lacking in hematopoiesis to acute myeloid leukemia where the marrow space is replaced by undifferentiated leukemic blasts. Recent ... ...

    Abstract The spectrum of myeloid disorders ranges from aplastic bone marrow failure characterized by an empty bone marrow completely lacking in hematopoiesis to acute myeloid leukemia where the marrow space is replaced by undifferentiated leukemic blasts. Recent advances in the capacity to sequence bulk tumor population as well as at a single cell level has provided significant insight into the stepwise process of transformation to acute myeloid leukemia. Using models of progression in the context of germline predisposition (trisomy 21, GATA2 deficiency, SAMD9/9L syndrome), premalignant states (clonal hematopoiesis and clonal cytopenia of unknown significance) and myelodysplastic syndrome, we review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations and the bone marrow environment in progression to acute myeloid leukemia. Despite major advances in our understanding, preventing progression of these disorders or treating them at the acute leukemia phase remains a major area of unmet medical need.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023020817
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  6. Article ; Online: JAK2 and JMJD1C activate NFE2 in MPNs.

    Crispino, John D

    Blood

    2018  Volume 131, Issue 18, Page(s) 1998–1999

    MeSH term(s) Bone Marrow Neoplasms/genetics ; Epigenesis, Genetic ; Humans ; Janus Kinase 2/genetics ; Jumonji Domain-Containing Histone Demethylases ; Myeloproliferative Disorders/genetics ; Oxidoreductases, N-Demethylating
    Chemical Substances JMJD1C protein, human (EC 1.14.11.-) ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; Oxidoreductases, N-Demethylating (EC 1.5.-) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2018-04-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-03-839779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CALR goes rogue.

    Melo-Cardenas, Johanna / Crispino, John D

    Blood

    2022  Volume 141, Issue 8, Page(s) 818–820

    MeSH term(s) Humans ; Calreticulin ; Neoplasms ; Computer Simulation ; Biological Transport ; Myeloproliferative Disorders
    Chemical Substances Calreticulin
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Role of Megakaryocytes in Myelofibrosis.

    Melo-Cardenas, Johanna / Migliaccio, Anna Rita / Crispino, John D

    Hematology/oncology clinics of North America

    2021  Volume 35, Issue 2, Page(s) 191–203

    Abstract: Megakaryocytes give rise to platelets, which have a wide variety of functions in coagulation, immune response, inflammation, and tissue repair. Dysregulation of megakaryocytes is a key feature of in the myeloproliferative neoplasms, especially ... ...

    Abstract Megakaryocytes give rise to platelets, which have a wide variety of functions in coagulation, immune response, inflammation, and tissue repair. Dysregulation of megakaryocytes is a key feature of in the myeloproliferative neoplasms, especially myelofibrosis. Megakaryocytes are among the main drivers of myelofibrosis by promoting myeloproliferation and bone marrow fibrosis. In vivo targeting of megakaryocytes by genetic and pharmacologic approaches ameliorates the disease, underscoring the important role of megakaryocytes in myeloproliferative neoplasms. Here we review the current knowledge of the function of megakaryocytes in the JAK2, CALR, and MPL-mutant myeloproliferative neoplasms.
    MeSH term(s) Calreticulin/genetics ; Humans ; Janus Kinase 2/genetics ; Megakaryocytes ; Mutation ; Myeloproliferative Disorders/genetics ; Neoplasms/genetics ; Primary Myelofibrosis/genetics ; Receptors, Thrombopoietin/genetics
    Chemical Substances CALR protein, human ; Calreticulin ; Receptors, Thrombopoietin ; MPL protein, human (143641-95-6) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2020.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: GATA1 mutations in red cell disorders.

    Ling, Te / Crispino, John D

    IUBMB life

    2019  Volume 72, Issue 1, Page(s) 106–118

    Abstract: GATA1 is an essential regulator of erythroid cell gene expression and maturation. In its absence, erythroid progenitors are arrested in differentiation and undergo apoptosis. Much has been learned about GATA1 function through animal models, which include ...

    Abstract GATA1 is an essential regulator of erythroid cell gene expression and maturation. In its absence, erythroid progenitors are arrested in differentiation and undergo apoptosis. Much has been learned about GATA1 function through animal models, which include genetic knockouts as well as ones with decreased levels of expression. However, even greater insights have come from the finding that a number of rare red cell disorders, including Diamond-Blackfan anemia, are associated with GATA1 mutations. These mutations affect the amino-terminal zinc finger (N-ZF) and the amino-terminus of the protein, and in both cases can alter the DNA-binding activity, which is primarily conferred by the third functional domain, the carboxyl-terminal zinc finger (C-ZF). Here we discuss the role of GATA1 in erythropoiesis with an emphasis on the mutations found in human patients with red cell disorders.
    MeSH term(s) GATA1 Transcription Factor/genetics ; Hematologic Diseases/genetics ; Hematologic Diseases/pathology ; Humans ; Mutation ; Red-Cell Aplasia, Pure/genetics ; Red-Cell Aplasia, Pure/pathology
    Chemical Substances GATA1 Transcription Factor
    Language English
    Publishing date 2019-10-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.2177
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  10. Article ; Online: Preface to IUBMB life special issue on GATA transcription factors in development, differentiation, and disease.

    Strouboulis, John / Crispino, John D

    IUBMB life

    2019  Volume 72, Issue 1, Page(s) 8–9

    MeSH term(s) Animals ; Cell Differentiation ; GATA Transcription Factors/genetics ; GATA Transcription Factors/metabolism ; Humans ; Leukemia/genetics ; Leukemia/metabolism ; Leukemia/pathology ; Molecular Biology ; Periodicals as Topic
    Chemical Substances GATA Transcription Factors
    Language English
    Publishing date 2019-11-28
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.2205
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