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  1. Article: Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis.

    Potter, Aimee D / Criss, Alison K

    Emerging topics in life sciences

    2023  Volume 8, Issue 1, Page(s) 15–28

    Abstract: Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, is a human-adapted pathogen that does not productively infect other organisms. The ongoing relationship between N. gonorrhoeae and the human host is facilitated ... ...

    Abstract Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, is a human-adapted pathogen that does not productively infect other organisms. The ongoing relationship between N. gonorrhoeae and the human host is facilitated by the exchange of nutrient resources that allow for N. gonorrhoeae growth in the human genital tract. What N. gonorrhoeae 'eats' and the pathways used to consume these nutrients have been a topic of investigation over the last 50 years. More recent investigations are uncovering the impact of N. gonorrhoeae metabolism on infection and inflammatory responses, the environmental influences driving N. gonorrhoeae metabolism, and the metabolic adaptations enabling antimicrobial resistance. This mini-review is an introduction to the field of N. gonorrhoeae central carbon metabolism in the context of pathogenesis. It summarizes the foundational work used to characterize N. gonorrhoeae central metabolic pathways and the effects of these pathways on disease outcomes, and highlights some of the most recent advances and themes under current investigation. This review ends with a brief description of the current outlook and technologies under development to increase understanding of how the pathogenic potential of N. gonorrhoeae is enabled by metabolic adaptation.
    MeSH term(s) Humans ; Neisseria gonorrhoeae/physiology ; Gonorrhea
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20220111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diverse Functions of C4b-Binding Protein in Health and Disease.

    Werner, Lacie M / Criss, Alison K

    Journal of immunology (Baltimore, Md. : 1950)

    2023  Volume 211, Issue 10, Page(s) 1443–1449

    Abstract: C4b-binding protein (C4BP) is a fluid-phase complement inhibitor that prevents uncontrolled activation of the classical and lectin complement pathways. As a complement inhibitor, C4BP also promotes apoptotic cell death and is hijacked by microbes and ... ...

    Abstract C4b-binding protein (C4BP) is a fluid-phase complement inhibitor that prevents uncontrolled activation of the classical and lectin complement pathways. As a complement inhibitor, C4BP also promotes apoptotic cell death and is hijacked by microbes and tumors for complement evasion. Although initially characterized for its role in complement inhibition, there is an emerging recognition that C4BP functions in a complement-independent manner to promote cell survival, protect against autoimmune damage, and modulate the virulence of microbial pathogens. In this Brief Review, we summarize the structure and functions of human C4BP, with a special focus on activities that extend beyond the canonical role of C4BP in complement inhibition.
    MeSH term(s) Humans ; Complement C4b-Binding Protein/metabolism ; Complement System Proteins/metabolism ; Complement Inactivating Agents ; Complement Pathway, Mannose-Binding Lectin ; Virulence ; Protein Binding ; Complement C4b/metabolism
    Chemical Substances Complement C4b-Binding Protein ; Complement System Proteins (9007-36-7) ; Complement Inactivating Agents ; Complement C4b (80295-50-7)
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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  3. Article ; Online: Transcriptome-guided metabolic network analysis reveals rearrangements of carbon flux distribution in

    Potter, Aimee D / Baiocco, Christopher M / Papin, Jason A / Criss, Alison K

    mSystems

    2023  Volume 8, Issue 4, Page(s) e0126522

    Abstract: The ability of bacterial pathogens to metabolically adapt to the environmental conditions of their hosts is critical to both colonization and invasive disease. Infection ... ...

    Abstract The ability of bacterial pathogens to metabolically adapt to the environmental conditions of their hosts is critical to both colonization and invasive disease. Infection with
    MeSH term(s) Humans ; Neisseria gonorrhoeae/genetics ; Neutrophils ; Gonorrhea/genetics ; Transcriptome ; Coculture Techniques ; Metabolic Networks and Pathways/genetics
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-5077
    ISSN (online) 2379-5077
    DOI 10.1128/msystems.01265-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity.

    Liyayi, Ian K / Forehand, Amy L / Ray, Jocelyn C / Criss, Alison K

    PLoS pathogens

    2023  Volume 19, Issue 2, Page(s) e1011091

    MeSH term(s) Humans ; Neisseria gonorrhoeae ; Metals ; Gonorrhea
    Chemical Substances Metals
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Comparison of lipooligosaccharides from human challenge strains of

    John, Constance M / Phillips, Nancy J / Cardenas, Amaris J / Criss, Alison K / Jarvis, Gary A

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1215946

    Abstract: The alarming rise of antibiotic resistance and the emergence of new vaccine technologies have increased the focus on vaccination to control gonorrhea. ...

    Abstract The alarming rise of antibiotic resistance and the emergence of new vaccine technologies have increased the focus on vaccination to control gonorrhea.
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1215946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development and implementation of a Type I-C CRISPR-based programmable repression system for

    Geslewitz, Wendy E / Cardenas, Amaris / Zhou, Xufei / Zhang, Yan / Criss, Alison K / Seifert, H Steven

    mBio

    2023  Volume 15, Issue 2, Page(s) e0302523

    Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR) are prokaryotic adaptive immune systems regularly utilized as DNA-editing tools. ... ...

    Abstract Clustered regularly interspaced short palindromic repeats (CRISPR) are prokaryotic adaptive immune systems regularly utilized as DNA-editing tools. While
    MeSH term(s) Humans ; CRISPR-Cas Systems ; Neisseria gonorrhoeae/genetics ; Gonorrhea ; Isopropyl Thiogalactoside ; DNA
    Chemical Substances Isopropyl Thiogalactoside (367-93-1) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03025-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neisseria gonorrhoeae

    Cardenas, Amaris J / Thomas, Keena S / Broden, Mary W / Ferraro, Noel J / Pires, Marcos M / John, Constance M / Jarvis, Gary A / Criss, Alison K

    mBio

    2024  Volume 15, Issue 5, Page(s) e0011924

    Abstract: Gonorrhea, caused by the bacterium : Importance: Neisseria ... ...

    Abstract Gonorrhea, caused by the bacterium
    Importance: Neisseria gonorrhoeae
    MeSH term(s) Neisseria gonorrhoeae/immunology ; Neisseria gonorrhoeae/genetics ; Neisseria gonorrhoeae/metabolism ; Humans ; N-Acetylneuraminic Acid/metabolism ; Neutrophils/immunology ; Neutrophils/metabolism ; Neutrophils/microbiology ; Neutrophil Activation ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism ; Sialic Acid Binding Immunoglobulin-like Lectins/genetics ; Gonorrhea/immunology ; Gonorrhea/microbiology ; Complement System Proteins/immunology ; Complement System Proteins/metabolism ; Lipopolysaccharides/metabolism ; Bacterial Outer Membrane Proteins/metabolism ; Bacterial Outer Membrane Proteins/immunology ; Bacterial Outer Membrane Proteins/genetics ; Respiratory Burst ; Host-Pathogen Interactions/immunology ; Immune Evasion
    Chemical Substances N-Acetylneuraminic Acid (GZP2782OP0) ; Sialic Acid Binding Immunoglobulin-like Lectins ; Complement System Proteins (9007-36-7) ; lipid-linked oligosaccharides ; Lipopolysaccharides ; Bacterial Outer Membrane Proteins ; Opa protein, Neisseria (156319-92-5)
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00119-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neisseria gonorrhoeae

    Cardenas, Amaris J / Thomas, Keena S / Broden, Mary W / Ferraro, Noel J / John, Constance M / Pires, Marcos M / Jarvis, Gary A / Criss, Alison K

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Gonorrhea, caused by the ... ...

    Abstract Gonorrhea, caused by the bacterium
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.17.576097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Protocols to Interrogate the Interactions Between Neisseria gonorrhoeae and Primary Human Neutrophils.

    Ragland, Stephanie A / Criss, Alison K

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1997, Page(s) 319–345

    Abstract: Neisseria gonorrhoeae (Gc) infection of its obligate human host results in a robust neutrophil-driven immune response. Despite neutrophils' intrinsic ability to neutralize microbes, Gc can survive in the presence of neutrophils. To interrogate how this ... ...

    Abstract Neisseria gonorrhoeae (Gc) infection of its obligate human host results in a robust neutrophil-driven immune response. Despite neutrophils' intrinsic ability to neutralize microbes, Gc can survive in the presence of neutrophils. To interrogate how this pathogen evades killing by neutrophils, we employ an ex vivo model of Gc infection with Interleukin-8-primed and adhered primary human neutrophils. This chapter will describe how primary human neutrophils are purified from venous blood, how Gc is prepared for infection, how to assess Gc survival in the presence of human neutrophils by enumeration of colony forming units, and how to determine Gc internalization by human neutrophils using an immunofluorescence-based approach.
    MeSH term(s) Cells, Cultured ; Colony Count, Microbial/methods ; Humans ; Immune Evasion ; Microbial Viability/immunology ; Neisseria gonorrhoeae/growth & development ; Neisseria gonorrhoeae/immunology ; Neutrophils/immunology ; Phagocytosis ; Primary Cell Culture/methods
    Language English
    Publishing date 2019-06-17
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9496-0_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Gonococcal Defenses against Antimicrobial Activities of Neutrophils.

    Palmer, Allison / Criss, Alison K

    Trends in microbiology

    2018  Volume 26, Issue 12, Page(s) 1022–1034

    Abstract: Neisseria gonorrhoeae initiates a strong local immune response that is characterized by copious recruitment of neutrophils to the site of infection. Neutrophils neutralize microbes by mechanisms that include phagocytosis, extracellular trap formation, ... ...

    Abstract Neisseria gonorrhoeae initiates a strong local immune response that is characterized by copious recruitment of neutrophils to the site of infection. Neutrophils neutralize microbes by mechanisms that include phagocytosis, extracellular trap formation, production of reactive oxygen species, and the delivery of antimicrobial granular contents. However, neutrophils do not clear infection with N. gonorrhoeae. N. gonorrhoeae not only expresses factors that defend against neutrophil bactericidal components, but it also manipulates neutrophil production and release of these components. In this review, we highlight the numerous approaches used by N. gonorrhoeae to survive exposure to neutrophils both intracellularly and extracellularly. These approaches reflect the exquisite adaptation of N. gonorrhoeae to its obligate human host.
    MeSH term(s) Adaptation, Biological/immunology ; Anti-Infective Agents/pharmacology ; Antioxidants ; Bacterial Proteins/immunology ; Disease Susceptibility ; Extracellular Traps/metabolism ; Extracellular Traps/microbiology ; Gonorrhea/drug therapy ; Gonorrhea/immunology ; Humans ; Immune Evasion ; Neisseria gonorrhoeae/drug effects ; Neisseria gonorrhoeae/immunology ; Neisseria gonorrhoeae/pathogenicity ; Neutrophils/immunology ; Neutrophils/metabolism ; Neutrophils/microbiology ; Peptidoglycan/immunology ; Phagocytosis ; Phagosomes/immunology ; Phagosomes/microbiology ; Respiratory Burst
    Chemical Substances Anti-Infective Agents ; Antioxidants ; Bacterial Proteins ; Peptidoglycan
    Language English
    Publishing date 2018-08-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2018.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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