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  1. Article ; Online: Defining Time in Acute Upper Gastrointestinal Bleeding

    Riccardo Marmo / Marco Soncini / Cristina Bucci / Clelia Marmo / Maria Elena Riccioni / on behalf of the GISED Study Group

    Journal of Clinical Medicine, Vol 12, Iss 2542, p

    When Should We Start the Clock?

    2023  Volume 2542

    Abstract: Introduction: The execution of upper endoscopy at the proper time is key to correctly managing patients with upper gastrointestinal bleeding (UGIB). Nonetheless, the definition of “time” for endoscopic examinations in UGIB patients is imprecise. The ... ...

    Abstract Introduction: The execution of upper endoscopy at the proper time is key to correctly managing patients with upper gastrointestinal bleeding (UGIB). Nonetheless, the definition of “time” for endoscopic examinations in UGIB patients is imprecise. The primary aim of this study was to verify whether the different definitions of “time” (i.e., the symptoms-to-endoscopy and presentation-to-endoscopy timeframes) impact mortality. The secondary purpose of this study was to evaluate the similarity between the two timeframes. Methods: A post-hoc analysis was performed on a prospective multicenter cohort study, which included UGIB patients admitted to 50 Italian hospitals. We collected the timings from symptoms and presentation to endoscopy, together with other demographic, organizational and clinical data and outcomes. Results: Out of the 3324 patients in the cohort, complete time data were available for 3166 patients. A significant difference of 9.2 h ( p < 0.001) was found between the symptoms-to-endoscopy vs. presentation-to-endoscopy timeframes. The symptoms-to-endoscopy timeframe demonstrated (1) a different death risk profile and (2) a statistically significant improvement in the prediction of mortality risk compared to the presentation-to-endoscopy timeframe ( p < 0.0002). The similarity between the two different timeframes was moderate (K = 0.42 ± 0.01; p < 0.001). Conclusions: The symptoms-to-endoscopy and presentation-to-endoscopy timeframes referred to different timings during the management of upper endoscopy in bleeding patients, with the former being more accurate in correctly identifying the mortality risk of these patients. We suggest that further studies be conducted to validate our observations, and, if confirmed, a different definition of time should be adopted in endoscopy.
    Keywords acute gastrointestinal bleeding ; scoring risk ; mortality ; prediction ; timing to endoscopy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Consumption of milk and dairy products: Facts and figures

    Zingone, Fabiana / Carolina Ciacci / Cristina Bucci / Paola Iovino

    Nutrition. 2017 Jan., v. 33

    2017  

    Abstract: Consumption of milk has been declining sharply in recent decades, particularly in developed countries. One of the reasons for this decline is the diagnosis or perception of lactose intolerance. The aim of this study was to investigate average consumption ...

    Abstract Consumption of milk has been declining sharply in recent decades, particularly in developed countries. One of the reasons for this decline is the diagnosis or perception of lactose intolerance. The aim of this study was to investigate average consumption of milk and dairy products in the Campania region of Italy, one of the main producers of dairy products in the country.Individuals aged 18 to 75 y and living in Campania were invited to answer an online questionnaire regarding their average consumption of milk and dairy products. The questionnaire was posted on the public access hospital site, as well as on several Facebook pages of friends and hospital personnel.The study found that 22.2% (260 of 1173) of responders from Campania do not drink milk, and 18.1% (213 of 1173) drink lactose-free milk, mainly because of gastrointestinal symptoms. The vast majority of the sample population chose to avoid consuming milk without undergoing the breath test for lactose intolerance or consulting a doctor. Women and underweight people drink more lactose-free milk than milk containing lactose. The population sample does not avoid dairy products; rather, they seem to be consumed quite frequently.The data support the need for mandatory implementation of a nutritional campaign to increase understanding regarding, for example, unnecessary avoidance of milk and excessive consumption of cheese.
    Keywords breath tests ; cheeses ; developed countries ; gastrointestinal system ; hospitals ; lactose ; lactose free diet ; lactose intolerance ; milk ; questionnaires ; underweight ; women ; Italy
    Language English
    Dates of publication 2017-01
    Size p. 322-325.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2016.07.019
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: A multicenter randomized phase 4 trial comparing sodium picosulphate plus magnesium citrate vs. polyethylene glycol plus ascorbic acid for bowel preparation before colonoscopy. The PRECOL trial

    Valentina D’Angelo / Maria Carmela Piccirillo / Massimo Di Maio / Ciro Gallo / Cristina Bucci / Corrado Civiletti / Elena Di Girolamo / Pietro Marone / Giovanni Battista Rossi / Alfonso Mario Tempesta / Maura C. Tracey / Marco Romano / Agnese Miranda / Domenico Taranto / Gabriella Sessa / Pasquale Esposito / Raffaele Salerno / Rossella Pumpo / Francesca Romana De Filippo /
    Elisabetta Della Valle / Mario de Bellis / Francesco Perrone

    Frontiers in Medicine, Vol

    2022  Volume 9

    Abstract: BackgroundAdequate bowel preparation before colonoscopy is crucial. Unfortunately, 25% of colonoscopies have inadequate bowel cleansing. From a patient perspective, bowel preparation is the main obstacle to colonoscopy. Several low-volume bowel ... ...

    Abstract BackgroundAdequate bowel preparation before colonoscopy is crucial. Unfortunately, 25% of colonoscopies have inadequate bowel cleansing. From a patient perspective, bowel preparation is the main obstacle to colonoscopy. Several low-volume bowel preparations have been formulated to provide more tolerable purgative solutions without loss of efficacy.ObjectivesInvestigate efficacy, safety, and tolerability of Sodium Picosulphate plus Magnesium Citrate (SPMC) vs. Polyethylene Glycol plus Ascorbic Acid (PEG-ASC) solutions in patients undergoing diagnostic colonoscopy.Materials and methodsIn this phase 4, randomized, multicenter, two-arm trial, adult outpatients received either SPMC or PEG-ASC for bowel preparation before colonoscopy. The primary aims were quality of bowel cleansing (primary endpoint scored according to Boston Bowel Preparation Scale) and patient acceptance (measured with six visual analogue scales). The study was open for treatment assignment and blinded for primary endpoint assessment. This was done independently with videotaped colonoscopies reviewed by two endoscopists unaware of study arms. A sample size of 525 patients was calculated to recognize a difference of 10% in the proportion of successes between the arms with a two-sided alpha error of 0.05 and 90% statistical power.ResultsOverall 550 subjects (279 assigned to PEG-ASC and 271 assigned to SPMC) represented the analysis population. There was no statistically significant difference in success rate according to BBPS: 94.4% with PEG-ASC and 95.7% with SPMC (P = 0.49). Acceptance and willing to repeat colonoscopy were significantly better for SPMC with all the scales. Compliance was less than full in 6.6 and 9.9% of cases with PEG-ASC and SPMC, respectively (P = 0.17). Nausea and meteorism were significantly more bothersome with PEG-ASC than SPMC. There were no serious adverse events in either group.ConclusionSPMC and PEG-ASC are not different in terms of efficacy, but SPMC is better tolerated than PEG-ASC. SPMC could be an alternative to ...
    Keywords bowel preparation ; sodium picosulphate plus magnesium citrate ; polyethylene glycol plus ascorbic acid ; patients compliance ; colonoscopy ; randomized controlled trial ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: The culture of gut explants: A model to study the mucosal response

    Russo, Ilaria / Alessandro Puzziello / Carolina Ciacci / Chiara Del Giorno / Cristina Bucci / Fabiana Zingone / Paola Iovino / Pio Zeppa

    Journal of Immunological Methods. 2016 Nov., v. 438

    2016  

    Abstract: Various experimental model designs have been used to analyze the inflammatory pathways in human gastrointestinal illnesses. Traditionally, analytical techniques and animal models are popular experimental tools to study the inflammation process of ... ...

    Abstract Various experimental model designs have been used to analyze the inflammatory pathways in human gastrointestinal illnesses. Traditionally, analytical techniques and animal models are popular experimental tools to study the inflammation process of intestinal diseases. However, the comparison of results between animal and human models is difficult for the inconsistency of outcomes. Although there are different animal models for studying the intestinal diseases, none of them fully represents the physiological and environmental conditions typical of the human species. Also, there is currently a concerted effort to decrease the experimental use of animals. On the converse, experimental protocols using the culture of gut mucosa had become popular with the advent of endoscopy which allows explanting multiple fragments from the intestine. The peculiar characteristic of this model is the ability to preserve in vitro the features that we found in vivo, thus also the response to various stimuli that differs from person to person.The aim of the present paper is to provide a review of some of the possible uses of the organ intestinal mucosa culture.
    Keywords analytical methods ; animal models ; digestive system diseases ; endoscopy ; environmental factors ; explants ; humans ; inflammation ; intestinal mucosa
    Language English
    Dates of publication 2016-11
    Size p. 1-10.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2016.07.004
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 795: Show issues Location:
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  5. Article ; Online: Life Events and the Onset of Celiac Disease from a Patient’s Perspective

    Paola Iovino / Ivonne Morra / Fabiana Zingone / Monica Siniscalchi / Cristina Bucci / Carolina Ciacci

    Nutrients, Vol 5, Iss 9, Pp 3388-

    2013  Volume 3398

    Abstract: Stressful events have been investigated in various immune-mediated diseases but not in celiac disease. Our aim was to examine the relationship of stressful events assessed by the standardized interview of Paykel with the diagnosis of celiac disease in ... ...

    Abstract Stressful events have been investigated in various immune-mediated diseases but not in celiac disease. Our aim was to examine the relationship of stressful events assessed by the standardized interview of Paykel with the diagnosis of celiac disease in comparison to patients, with a diagnosis of gastroesophageal reflux disease used as the control group. Adults with celiac disease (n = 186) reported more frequent and more severe life events in the years prior to the diagnosis than control patients (n = 96) (67.2% vs. 37.5%, p < 0.001, mean Paykel score 11.5 vs. 13.4, p = 0.001, respectively). Findings were not significantly different between celiac disease and control patients for the time lapse between the event and the diagnosis (mean 5.5 vs. 5.7 months). Pregnancy was defined as a negative event by 20.3% of celiac women, but never by control women. Findings were confirmed when analyses were repeated in the subgroup of patients of both groups with diagnosis made within one year of onset of symptoms. Data indicate that, before diagnosis, the number of stressful events in celiac disease was more frequent although less severe than in the control group suggesting that life events may favor the clinical appearance of celiac disease or accelerate its diagnosis.
    Keywords celiac disease ; life events ; symptoms ; onset of disease ; stress ; pregnancy ; Nutrition. Foods and food supply ; TX341-641 ; Home economics ; TX1-1110 ; Technology ; T ; DOAJ:Nutrition and Food Sciences ; DOAJ:Agriculture and Food Sciences
    Subject code 610
    Language English
    Publishing date 2013-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: LOX Gene Transcript Accumulation in Olive (Olea europaea L.) Fruits at Different Stages of Maturation

    Innocenzo Muzzalupo / Barbara Macchione / Cristina Bucci / Francesca Stefanizzi / Enzo Perri / Adriana Chiappetta / Antonio Tagarelli / Giovanni Sindona

    The Scientific World Journal, Vol

    Relationship between Volatile Compounds, Environmental Factors, and Technological Treatments for Oil Extraction

    2012  Volume 2012

    Abstract: The quality of olive oil is influenced by genetic and environmental factors and by the maturation state of drupes, but it is equally affected by technological treatments of the process. This work investigates the possible correlation between olive LOX ... ...

    Abstract The quality of olive oil is influenced by genetic and environmental factors and by the maturation state of drupes, but it is equally affected by technological treatments of the process. This work investigates the possible correlation between olive LOX gene transcript accumulation, evaluated in fruits collected at different stages of maturation, and chemical biomarkers of its activity. During olive fruit ripening, the same genotype harvested from two different farms shows a positive linear trend between LOX relative transcript accumulation and the content of volatile compounds present in the olive oil aroma. Interestingly, a negative linear trend was observed between LOX relative transcript accumulation and the content of volatile compounds present in the olive pastes obtained from olive fruits with and without malaxation. The changes in the olive LOX transcript accumulation reveal its environmental regulation and suggest differential physiological functions for the LOXs.
    Keywords Technology ; T ; Medicine ; R ; Science ; Q
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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