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  1. Article ; Online: A thermoregulatory role of the medullary raphe in birds.

    Cristina-Silva, Caroline / Gargaglioni, Luciane H / Bícego, Kênia Cardoso

    The Journal of experimental biology

    2021  

    Abstract: The brainstem region medullary raphe modulates non-shivering and shivering thermogenesis and cutaneous vasomotion in rodents. Whether the same scenario occurs in the other endothermic group, i.e. birds, is still unknown. Therefore, we hypothesised that ... ...

    Abstract The brainstem region medullary raphe modulates non-shivering and shivering thermogenesis and cutaneous vasomotion in rodents. Whether the same scenario occurs in the other endothermic group, i.e. birds, is still unknown. Therefore, we hypothesised that the medullary raphe modulates heat gain and loss thermoeffectors in birds. We investigated the effect of glutamatergic and GABAergic inhibitions in this specific region on body temperature (Tb), oxygen consumption (thermogenesis), ventilation (O
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.234344
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  2. Article: Metabolic and respiratory chemosensitivity and brain monoaminergic responses to cold exposure in chicks subjected to thermal manipulation during incubation.

    Rocha, Aline C G / Patrone, Luis Gustavo A / Cristina-Silva, Caroline / Silva, Kaoma Stephani da Costa / Bícego, Kênia C / Szawka, Raphael E / Gargaglioni, Luciane H

    Journal of thermal biology

    2022  Volume 109, Page(s) 103317

    Abstract: We evaluated ventilation (V˙ ...

    Abstract We evaluated ventilation (V˙
    MeSH term(s) Animals ; Brain/metabolism ; Carbon Dioxide ; Chickens/physiology ; Female ; Hydroxyindoleacetic Acid ; Hypercapnia/metabolism ; Hyperventilation ; Hypothermia ; Hypoxia ; Male ; Oxygen Consumption/physiology ; Serotonin/metabolism
    Chemical Substances Carbon Dioxide (142M471B3J) ; Serotonin (333DO1RDJY) ; Hydroxyindoleacetic Acid (54-16-0)
    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2022.103317
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  3. Article: Metabolic and respiratory chemosensitivity and brain monoaminergic responses to cold exposure in chicks subjected to thermal manipulation during incubation

    Rocha, Aline C.G. / Patrone, Luis Gustavo A. / Cristina-Silva, Caroline / Silva, Kaoma Stephani da Costa / Bícego, Kênia C. / Szawka, Raphael E. / Gargaglioni, Luciane H.

    Journal of thermal biology. 2022 Oct., v. 109

    2022  

    Abstract: We evaluated ventilation (V˙E), body temperature (TB), oxygen consumption (V˙ O₂), respiratory equivalent (V˙E/ V˙ O₂), and monoamine concentrations of 14-day-old (14d) male and female chicks from eggs incubated at low (LT, 36 °C), control (CT, 37.5 °C) ... ...

    Abstract We evaluated ventilation (V˙E), body temperature (TB), oxygen consumption (V˙ O₂), respiratory equivalent (V˙E/ V˙ O₂), and monoamine concentrations of 14-day-old (14d) male and female chicks from eggs incubated at low (LT, 36 °C), control (CT, 37.5 °C) and high (HT, 39 °C) temperature during the early embryonic phase, to normoxia, hypercapnia and hypoxia under exposure to cold environment (20 °C). At normoxia, acute cold exposure did not affect the ventilatory variables, with the exception of HT males, in which cold prevented the reduced V˙E observed under thermoneutral conditions. Exposure to 20 °C caused a decrease in TB in both sexes, and LT and HT females presented a greater hypothermic response. Hypercapnia combined with cold did not alter the ventilatory variables, but LT females and CT males and females showed a blunted CO₂-induced hyperventilation due to a higher V˙ O₂, compared to the same groups in thermoneutral conditions. Unlike with thermoneutral conditions, the blunted hypercapnic hyperventilation observed in the HT groups was not observed during cold challenge. CO₂ exposure promoted a similar decrease in TB in the thermoneutral and acutely cold exposed groups, while LT females under cold condition presented a blunted hypothermic response. During hypoxia, cold challenge attenuated the increase in V˙E in LT females and HT males, due to changes in VT. Hypoxic metabolic depression was greater in LT females and males and HT males during cold exposure, while no change in V˙E/ V˙ O₂ was observed. The only alteration in monoaminergic concentration under cold challenge was an increase in brainstem 5-HIAA and 5-HIAA/5-HT ratio in HT females, and an enhanced 5-HT concentration in HT males. In summary, thermal manipulation during embryogenesis induces 14d old chicks to respond differently to cold stress with LT females and HT males being more sensitive.
    Keywords body temperature ; brain stem ; carbon dioxide ; cold ; cold stress ; cold zones ; embryogenesis ; females ; hypercapnia ; hypoxia ; males ; normoxia ; oxygen consumption ; serotonin
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2022.103317
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  4. Article ; Online: Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats.

    Cristina-Silva, Caroline / Martins, Victor / Gargaglioni, Luciane H / Bícego, Kênia C

    Pflugers Archiv : European journal of physiology

    2017  Volume 469, Issue 9, Page(s) 1151–1161

    Abstract: The periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in body temperature (Tb) regulation ...

    Abstract The periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in body temperature (Tb) regulation during psychological stress such as restraint. Because activation of mu and kappa receptors increases and reduces Tb, respectively, we tested the hypothesis that they exert excitatory and inhibitory modulation, respectively, of the restraint-induced fever in rats. To this end, Tb, heat loss index (HLI, inference for peripheral vasoconstriction/vasodilation), and oxygen consumption (inference for thermogenesis) were monitored in unanesthetized rats, restrained or unrestrained, before and after intra-PAG microinjection of the selective mu opioid receptor antagonist (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH
    MeSH term(s) Animals ; Body Temperature/drug effects ; Male ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Narcotic Antagonists/pharmacology ; Oxygen Consumption/drug effects ; Pain/drug therapy ; Pain/metabolism ; Periaqueductal Gray/drug effects ; Periaqueductal Gray/metabolism ; Rats ; Rats, Wistar ; Receptors, Opioid, kappa/metabolism ; Stress, Psychological/metabolism ; Thermogenesis/drug effects ; Thermogenesis/physiology
    Chemical Substances Narcotic Antagonists ; Receptors, Opioid, kappa ; norbinaltorphimine (36OOQ86QM1) ; Naltrexone (5S6W795CQM)
    Language English
    Publishing date 2017-04-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-017-1966-2
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  5. Article: Cutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds.

    Cristina-Silva, Caroline / Amaral-Silva, Lara / Santos, Kassia Moreira / Correa, Gabriela Monteiro / da Silva, Welex Candido / Fernandes, Marcia H M R / da Silva, Glauber S F / Gargaglioni, Luciane H / Almeida, Maria C / Bicego, Kenia C

    Frontiers in physiology

    2022  Volume 13, Page(s) 892828

    Abstract: Transient receptor potential vanilloid 4 (TRPV4) channels are sensitive to warm ambient temperatures ( ... ...

    Abstract Transient receptor potential vanilloid 4 (TRPV4) channels are sensitive to warm ambient temperatures (T
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.892828
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  6. Article ; Online: Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats.

    da Silva Junior, Carlos Aparecido / Patrone, Luís Gustavo A / Biancardi, Vivian / Vilela-Costa, Heloísa H / Marques, Danuzia A / Cristina-Silva, Caroline / da Costa Silva, Kaoma Stephani / Bícego, Kênia C / Szawka, Raphael E / Gargaglioni, Luciane H

    Pflugers Archiv : European journal of physiology

    2022  Volume 474, Issue 11, Page(s) 1185–1200

    Abstract: Pregnancy is highly affected by anxiety disorders, which may be treated with benzodiazepines, especially diazepam (DZP), that can cross the placental barrier and interact with the fetal GABAergic system. We tested whether prenatal exposure to DZP ... ...

    Abstract Pregnancy is highly affected by anxiety disorders, which may be treated with benzodiazepines, especially diazepam (DZP), that can cross the placental barrier and interact with the fetal GABAergic system. We tested whether prenatal exposure to DZP promotes sex-specific postnatal changes in the respiratory control of rats. We evaluated ventilation ([Formula: see text]) and oxygen consumption ([Formula: see text] O<sub>2</sub>) in resting conditions and under hypercapnia (7% CO<sub>2</sub>) and hypoxia (10% O<sub>2</sub>) in newborn [postnatal day (P) 0-1 and P12-13)] and young (P21-22) rats from mothers treated with DZP during pregnancy. We also analyzed brainstem monoamines at the same ages. DZP exposure had minimal effects on room air-breathing variables in females, but caused hypoventilation (drop in [Formula: see text]/[Formula: see text] O<sub>2</sub>) in P12-13 males, lasting until P21-22. The hypercapnic ventilatory response was attenuated in P0-1 and P12-13 DZP-treated females mainly by a decrease in tidal volume (V<sub>T</sub>), whereas males had a reduction in respiratory frequency (f<sub>R</sub>) at P12-13. Minor changes were observed in hypoxia, but an attenuation in [Formula: see text] was seen in P12-13 males. In the female brainstem, DZP increased dopamine concentration and decreased 5-hydroxyindole-3-acetic acid (5-HIAA) and the 3,4-dihydroxyphenylacetic acid (DOPAC)/dopamine ratio at P0-1, and reduced DOPAC concentration at P12-13. In males, DZP decreased brainstem noradrenaline at P0-1. Our results demonstrate that prenatal DZP exposure reduces CO<sub>2</sub> chemoreflex only in postnatal females and does not affect hypoxia-induced hyperventilation in both sexes. In addition, prenatal DZP alters brainstem monoamine concentrations throughout development differently in male and female rats.
    MeSH term(s) 3,4-Dihydroxyphenylacetic Acid ; Acetates ; Animals ; Carbon Dioxide ; Diazepam/pharmacology ; Dopamine ; Female ; Hydroxyindoleacetic Acid ; Hypercapnia ; Hypoxia ; Male ; Norepinephrine ; Placenta ; Pregnancy ; Rats
    Chemical Substances Acetates ; 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Carbon Dioxide (142M471B3J) ; Hydroxyindoleacetic Acid (54-16-0) ; Diazepam (Q3JTX2Q7TU) ; Dopamine (VTD58H1Z2X) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2022-07-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-022-02730-7
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  7. Article: Embryonic Thermal Manipulation Affects Ventilation, Metabolism, Thermal Control and Central Dopamine in Newly Hatched and Juvenile Chicks.

    Rocha, Aline C G / Cristina-Silva, Caroline / Taxini, Camila L / da Costa Silva, Kaoma Stephani / Lima, Virgínia T M / Macari, Marcos / Bícego, Kênia C / Szawka, Raphael E / Gargaglioni, Luciane H

    Frontiers in physiology

    2021  Volume 12, Page(s) 699142

    Abstract: The first third of incubation is critical for embryonic development, and environmental changes during this phase can affect the physiology and survival of the embryos. We evaluated the effects of low (LT), control (CT), and high (HT) temperatures during ... ...

    Abstract The first third of incubation is critical for embryonic development, and environmental changes during this phase can affect the physiology and survival of the embryos. We evaluated the effects of low (LT), control (CT), and high (HT) temperatures during the first 5 days of incubation on ventilation (
    Language English
    Publishing date 2021-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.699142
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  8. Article ; Online: Hypothalamic TRPV4 channels participate in the medial preoptic activation of warmth-defence responses in Wistar male rats.

    Scarpellini, Carolina da Silveira / Cristina-Silva, Caroline / Biancardi, Vivian / Gargaglioni, Luciane H / Almeida, Maria Camila / Bícego, Kênia Cardoso

    Pflugers Archiv : European journal of physiology

    2019  Volume 471, Issue 9, Page(s) 1191–1203

    Abstract: Recently, we have described, in non-genetically modified rats, that peripheral transient receptor potential vanilloid-4 (TRPV4) channels are activated and trigger warmth-defence responses at ambient temperatures of 26-30 °C. Evidence points to the ... ...

    Abstract Recently, we have described, in non-genetically modified rats, that peripheral transient receptor potential vanilloid-4 (TRPV4) channels are activated and trigger warmth-defence responses at ambient temperatures of 26-30 °C. Evidence points to the presence of TRPV4 in the medial preoptic area, a region described to be involved in the activation of thermoeffector pathways, including those involved in heat loss. Thus, we tested the hypothesis that TRPV4 in the medial preoptic area modulates thermoregulation under warm conditions. To this end, under two ambient temperatures (21 and 28 °C), body temperature was measured in rats following blockade of preoptic TRPV4 with two antagonists, HC-067047 and GSK 2193874. Oxygen consumption, heat loss index and preferred ambient temperature were also determined in order to assess thermoeffector activity. Antagonism of central TRPV4 caused an increase in body temperature in rats exposed to 28 °C, but not in those exposed to 21 °C. The body temperature increase at 28 °C was accompanied by an increase in oxygen consumption and an earlier reduction of the heat loss index. In behavioural experiments, control animals previously exposed to warm ambient temperatures (28-30 °C) for 2 h selected colder temperatures in a thermogradient compared to those injected with HC-067047. Our results support the idea that preoptic TRPV4 modulates thermoregulation in a warm environment by activating both autonomic and behavioural heat loss responses. Thus, according to the present study and to that published recently by our group, the activation of warmth-defence responses by TRPV4 seems to be dependent on the activity of both peripheral and central channels.
    MeSH term(s) Animals ; Autonomic Nervous System/metabolism ; Body Temperature/physiology ; Body Temperature Regulation/physiology ; Cold Temperature ; Hot Temperature ; Hypothalamus/metabolism ; Male ; Oxygen Consumption/physiology ; Preoptic Area/metabolism ; Rats ; Rats, Wistar ; TRPV Cation Channels/metabolism
    Chemical Substances TRPV Cation Channels ; Trpv4 protein, rat
    Language English
    Publishing date 2019-08-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-019-02303-1
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