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  1. Article: Gene regulation of infection-associated L-tartrate metabolism in

    Rojas, Vivian K / Winter, Maria G / Jimenez, Angel G / Tanner, Natasha W / Crockett, Stacey L / Spiga, Luisella / Hendrixson, David R / Winter, Sebastian E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Enteric pathogens such ... ...

    Abstract Enteric pathogens such as
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.05.578992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Infection-associated gene regulation of L-tartrate metabolism in

    Rojas, Vivian K / Winter, Maria G / Jimenez, Angel G / Tanner, Natasha W / Crockett, Stacey L / Spiga, Luisella / Hendrixson, David R / Winter, Sebastian E

    mBio

    2024  , Page(s) e0035024

    Abstract: Enteric pathogens such as : Importance: Bacterial pathogens must adapt their gene expression profiles to cope with diverse environments encountered during infection. This coordinated process is carried out by the integration of cues that the pathogen ... ...

    Abstract Enteric pathogens such as
    Importance: Bacterial pathogens must adapt their gene expression profiles to cope with diverse environments encountered during infection. This coordinated process is carried out by the integration of cues that the pathogen senses to fine-tune gene expression in a spatiotemporal manner. Many studies have elucidated the regulatory mechanisms of how
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00350-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy.

    Siricilla, Shajila / Hansen, Christopher J / Rogers, Jackson H / De, Debasmita / Simpson, Carolyn L / Waterson, Alex G / Sulikowski, Gary A / Crockett, Stacey L / Boatwright, Naoko / Reese, Jeff / Paria, Bibhash C / Newton, J / Herington, Jennifer L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Currently, there is a lack of FDA-approved tocolytics for the management of preterm labor (PL). In prior drug discovery efforts, we identified mundulone and its analog mundulone acetate (MA) as inhibitors ... ...

    Abstract Currently, there is a lack of FDA-approved tocolytics for the management of preterm labor (PL). In prior drug discovery efforts, we identified mundulone and its analog mundulone acetate (MA) as inhibitors of
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.06.543921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy.

    Siricilla, Shajila / Hansen, Christopher J / Rogers, Jackson H / De, Debasmita / Simpson, Carolyn L / Waterson, Alex G / Sulikowski, Gary A / Crockett, Stacey L / Boatwright, Naoko / Reese, Jeff / Paria, Bibhash C / Newton, J / Herington, Jennifer L

    Pharmacological research

    2023  Volume 195, Page(s) 106876

    Abstract: There is a lack of FDA-approved tocolytics for the management of preterm labor (PL). In prior drug discovery efforts, we identified mundulone and mundulone acetate (MA) as inhibitors of in vitro intracellular ... ...

    Abstract There is a lack of FDA-approved tocolytics for the management of preterm labor (PL). In prior drug discovery efforts, we identified mundulone and mundulone acetate (MA) as inhibitors of in vitro intracellular Ca
    MeSH term(s) Female ; Infant, Newborn ; Mice ; Animals ; Humans ; Tocolytic Agents/pharmacology ; Tocolytic Agents/therapeutic use ; Premature Birth/drug therapy ; Nifedipine/pharmacology ; Nifedipine/therapeutic use ; Mifepristone/therapeutic use ; Biological Products/therapeutic use ; Obstetric Labor, Premature/drug therapy
    Chemical Substances Tocolytic Agents ; Nifedipine (I9ZF7L6G2L) ; atosiban (081D12SI0Z) ; Mifepristone (320T6RNW1F) ; Biological Products
    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Molecular and mechanical factors contributing to ductus arteriosus patency and closure.

    Crockett, Stacey L / Berger, Courtney D / Shelton, Elaine L / Reese, Jeff

    Congenital heart disease

    2018  Volume 14, Issue 1, Page(s) 15–20

    Abstract: Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a ... ...

    Abstract Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic influences. Despite significant advances, questions remain regarding signaling dynamics and the natural time course of ductus closure, particularly in preterm neonates. This review highlights the contributions of early investigators and more recent clinician scientists to our understanding of the molecular and mechanical factors that mediate ductus patency and closure.
    MeSH term(s) Cardiac Surgical Procedures/methods ; Ductus Arteriosus/diagnostic imaging ; Ductus Arteriosus, Patent/metabolism ; Ductus Arteriosus, Patent/psychology ; Ductus Arteriosus, Patent/surgery ; Hemodynamics/physiology ; Humans ; Infant, Newborn ; Oxidative Stress/physiology
    Language English
    Publishing date 2018-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2274321-2
    ISSN 1747-0803 ; 1747-079X
    ISSN (online) 1747-0803
    ISSN 1747-079X
    DOI 10.1111/chd.12714
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6693: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Selective Polyprotein Processing Determines Norovirus Sensitivity to Trim7.

    Sullender, Meagan E / Pierce, Linley R / Annaswamy Srinivas, Mridula / Crockett, Stacey L / Dunlap, Bria F / Rodgers, Rachel / Schriefer, Lawrence A / Kennedy, Elizabeth A / Stewart, Brittany M / Doench, John G / Baldridge, Megan T / Orchard, Robert C

    Journal of virology

    2022  Volume 96, Issue 17, Page(s) e0070722

    Abstract: Noroviruses are a leading cause of gastroenteritis worldwide, yet the molecular mechanisms of how host antiviral factors restrict norovirus infection are poorly understood. Here, we present a CRISPR activation screen that identifies mouse genes which ... ...

    Abstract Noroviruses are a leading cause of gastroenteritis worldwide, yet the molecular mechanisms of how host antiviral factors restrict norovirus infection are poorly understood. Here, we present a CRISPR activation screen that identifies mouse genes which inhibit murine norovirus (MNV) replication. Detailed analysis of the major hit Trim7 demonstrates a potent inhibition of the early stages of MNV replication. Leveraging
    MeSH term(s) Animals ; Caliciviridae Infections ; Immune Evasion ; Mice ; Norovirus/genetics ; Norovirus/physiology ; Polyproteins/genetics ; Polyproteins/metabolism ; Protein Processing, Post-Translational ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virus Replication
    Chemical Substances Polyproteins ; Tripartite Motif Proteins ; Viral Nonstructural Proteins ; Trim7 protein, mouse (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00707-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness.

    Crockett, Stacey L / Harris, Micah / Boatwright, Naoko / Su, Rachel L / Yarboro, Michael T / Berger, Courtney D / Shelton, Elaine L / Reese, Jeff / Segar, Jeffrey L

    Pediatric research

    2019  Volume 87, Issue 6, Page(s) 991–997

    Abstract: Background: Indomethacin treatment for patent ductus arteriosus (PDA) is associated with acute kidney injury (AKI). Fenoldopam, a dopamine (DA) DA: Methods: DA receptor expression in CD-1 mouse vessels was analyzed by qPCR and immunohistochemistry. ... ...

    Abstract Background: Indomethacin treatment for patent ductus arteriosus (PDA) is associated with acute kidney injury (AKI). Fenoldopam, a dopamine (DA) DA
    Methods: DA receptor expression in CD-1 mouse vessels was analyzed by qPCR and immunohistochemistry. Concentration-response curves were established using pressure myography. Pretreatment with SCH23390 (DA
    Results: DA
    Conclusion(s): DA receptors are present in the ductus but have limited physiologic effects. DA-induced ductus vasoconstriction is mediated via α-adrenergic pathways. The absence of DA
    MeSH term(s) Animals ; Dopamine/metabolism ; Dopamine Agonists/pharmacology ; Ductus Arteriosus/drug effects ; Ductus Arteriosus/metabolism ; Ductus Arteriosus/physiopathology ; Ductus Arteriosus, Patent/drug therapy ; Ductus Arteriosus, Patent/metabolism ; Ductus Arteriosus, Patent/physiopathology ; Female ; Fenoldopam/pharmacology ; Indomethacin/toxicity ; Mice ; Oxygen/toxicity ; Pregnancy ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D1/metabolism ; Signal Transduction ; Vasoconstriction/drug effects ; Vasodilation/drug effects ; Vasodilator Agents/pharmacology
    Chemical Substances Dopamine Agonists ; Drd1 protein, mouse ; Receptors, Dopamine D1 ; Vasodilator Agents ; Fenoldopam (INU8H2KAWG) ; Oxygen (S88TT14065) ; Dopamine (VTD58H1Z2X) ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-019-0716-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 373: Show issues

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