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  1. AU="Croda, Júlio Henrique Rosa"
  2. AU="Arkun, Ani"
  3. AU="Fan-tao KONG"
  4. AU="Field, R C"
  5. AU="Coombes, Brandon J"
  6. AU="Garay, Raúl O."
  7. AU="Jingfeng Xue"
  8. AU="Kelliher, Christina M"
  9. AU="Busby, Marjorie G"

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  1. Buch ; Online: Resposta imediata da Vigilância em Saúde à epidemia da COVID-19

    Croda, Julio Henrique Rosa / Garcia, Leila Posenato

    Epidemiologia e Serviços de Saúde v.29 n.1 2020

    2020  

    Schlagwörter covid19
    Sprache Portugiesisch
    Erscheinungsdatum 2020-01-01
    Verlag Secretaria de Vigilância em Saúde - Ministério da Saúde do Brasil
    Erscheinungsland br
    Dokumenttyp Buch ; Online
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  2. Artikel ; Online: Immediate Health Surveillance Response to COVID-19 Epidemic.

    Croda, Julio Henrique Rosa / Garcia, Leila Posenato

    Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

    2020  Band 29, Heft 1, Seite(n) e2020002

    Titelübersetzung Resposta imediata da Vigilância em Saúde à epidemia da COVID-19.
    Mesh-Begriff(e) Betacoronavirus ; Brazil/epidemiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Outbreaks/prevention & control ; Epidemics ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Public Health Surveillance ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Portugiesisch
    Erscheinungsdatum 2020-03-23
    Erscheinungsland Brazil
    Dokumenttyp Editorial
    ZDB-ID 2880588-4
    ISSN 2237-9622 ; 1679-4974
    ISSN (online) 2237-9622
    ISSN 1679-4974
    DOI 10.5123/S1679-49742020000100021
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  3. Artikel: Resposta imediata da Vigilância em Saúde à epidemia da COVID-19/ Respuesta inmediata de la Vigilancia en Salud a la epidemia de COVID-19/ Immediate Health Surveillance Response to COVID-19 Epidemic

    Croda, Julio Henrique Rosa / Garcia, Leila Posenato

    Epidemiol. serv. saúde

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #819091
    Datenquelle COVID19

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  4. Artikel: Resposta imediata da Vigilância em Saúde à epidemia da COVID-19./ Resposta imediata da Vigilância em Saúde à epidemia da COVID-19./ Immediate Health Surveillance Response to COVID-19 Epidemic

    Croda, Julio Henrique Rosa / Garcia, Leila Posenato

    Epidemiol Serv Saude

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #32215535
    Datenquelle COVID19

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  6. Artikel ; Online: Gestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study.

    Sousa, Iara Beatriz Andrade de / Souza, Cristina / Barbosa, Marcelo Dos Santos / Croda, Julio Henrique Rosa / Gonçalves, Crhistinne Cavalheiro Maymone / Bernardes, Sara Santos / Marchioro, Silvana Beutinger

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Band 98, Seite(n) 359–365

    Abstract: Objectives: This study aimed to describe the demographic and clinical parameters of women infected by Zika virus who had infants with stigmata of Congenital Zika Syndrome (CZS) versus those who had normal-appearing infants at birth, thereby providing ... ...

    Abstract Objectives: This study aimed to describe the demographic and clinical parameters of women infected by Zika virus who had infants with stigmata of Congenital Zika Syndrome (CZS) versus those who had normal-appearing infants at birth, thereby providing further details on the clinical caveats of neonatal ZIKV infection.
    Methodology: This cross-sectional study was performed in the state of Mato Grosso do Sul, Central-West region of Brazil, and included 117 mother-infant pairs who were interviewed and 120 gestational outcomes. All mothers had laboratory confirmation by qRT-PCR of ZIKV infection during pregnancy.
    Results: The prevalence of congenital abnormalities related to ZIKV was 2.69 cases per 10,000 live births during this period. Exanthem was the main clinical finding, observed in 92.5% of the mothers in this study. Regarding the timing of ZIKV infection, the first trimester was the most frequent time of infection among mothers of infants with CZS (54.55%) (p=0.0007). The case fatality rate was 5% (n=6). Among the 23 children who were classified as having CZS, 13 (56.52%) of them presented with microcephaly. Only 13 (56.52%) children with CZS were tested by qRT-PCR for ZIKV infection at birth, five (38%) were positive.
    Conclusions: This study highlights the congenital alterations of ZIKV infection during pregnancy in an epidemic burst, demonstrating that the alterations found in other studies are similar to the present research.
    Mesh-Begriff(e) Adult ; Brazil/epidemiology ; Cross-Sectional Studies ; Exanthema/diagnosis ; Exanthema/epidemiology ; Exanthema/physiopathology ; Exanthema/virology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Microcephaly/diagnosis ; Microcephaly/epidemiology ; Microcephaly/physiopathology ; Microcephaly/virology ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/physiopathology ; Pregnancy Complications, Infectious/virology ; Pregnancy Outcome ; Retrospective Studies ; Young Adult ; Zika Virus/genetics ; Zika Virus/isolation & purification ; Zika Virus/physiology
    Sprache Englisch
    Erscheinungsdatum 2020-06-30
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.06.084
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  7. Artikel ; Online: Effect of Supplementation with Hydroethanolic Extract of

    Cardozo, Carla Maiara Lopes / Inada, Aline Carla / Cardoso, Claudia Andrea Lima / Filiú, Wander Fernando de Oliveira / Farias, Bernardo Barcelar de / Alves, Flávio Macedo / Tatara, Mariana Bento / Croda, Júlio Henrique Rosa / Guimarães, Rita de Cássia Avellaneda / Hiane, Priscila Aiko / Freitas, Karine de Cássia

    Molecules (Basel, Switzerland)

    2020  Band 25, Heft 11

    Abstract: There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications. ...

    Abstract There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications.
    Mesh-Begriff(e) Animals ; Anti-Inflammatory Agents/pharmacology ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Ethanol/chemistry ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/prevention & control ; Male ; Metabolic Diseases/etiology ; Metabolic Diseases/metabolism ; Metabolic Diseases/pathology ; Metabolic Diseases/prevention & control ; Mice ; Myrtaceae/chemistry ; Obesity/etiology ; Obesity/metabolism ; Obesity/pathology ; Obesity/prevention & control ; Oxidative Stress ; Plant Extracts/pharmacology
    Chemische Substanzen Anti-Inflammatory Agents ; Plant Extracts ; Ethanol (3K9958V90M)
    Sprache Englisch
    Erscheinungsdatum 2020-06-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25112693
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations - a study protocol from the clinical and applied research in Chikungunya (REPLICK network).

    da Silva Duarte, Giselle / Jones, Alexandra D / de Goes Cavalcanti, Luciano Pamplona / de Melo Rêgo, Moacyr Jesus Barreto / Ribeiro, Guilherme S / Boyton, Rosemary J / Pereira, Dhelio Batista / Croda, Julio Henrique Rosa / Costa, Fabio Trindade Maranhão / Duarte, Angela Pinto / Consolaro, Marcia Edilaine Lopes / Stabeli, Rodrigo Guerino / Negrão, Fábio Juliano / Proenca-Modena, Jose Luiz / Villalobos-Salcedo, Juan Miguel / da Rocha Castelar Pinheiro, Geraldo / de Barros Albuquerque, Amanda Pinheiro / de Almeida Barreto, Francisca Kalline / Moreira, Jose /
    Ferrari, Idalina Cristina / Évora, Patricia Martinez / da Silva, Vânia Ramos Sela / Lacerda, Marcus Vinicius Guimarães / Altmann, Daniel M / Siqueira, André M

    BMC infectious diseases

    2023  Band 23, Heft 1, Seite(n) 499

    Abstract: Background: Chikungunya is associated with high morbidity and the natural history of symptomatic infection has been divided into three phases (acute, post-acute, and chronic) according to the duration of musculoskeletal symptoms. Although this ... ...

    Abstract Background: Chikungunya is associated with high morbidity and the natural history of symptomatic infection has been divided into three phases (acute, post-acute, and chronic) according to the duration of musculoskeletal symptoms. Although this classification has been designed to help guide therapeutic decisions, it does not encompass the complexity of the clinical expression of the disease and does not assist in the evaluation of the prognosis of severity nor chronic disease. Thus, the current challenge is to identify and diagnose musculoskeletal disorders and to provide the optimal treatment in order to prevent perpetuation or progression to a potentially destructive disease course.
    Methods: The study is the first product of the Clinical and Applied Research Network in Chikungunya (REPLICK). This is a prospective, outpatient department-based, multicenter cohort study in Brazil. Four work packages were defined: i. Clinical research; ii) Translational Science - comprising immunology and virology streams; iii) Epidemiology and Economics; iv) Therapeutic Response and clinical trials design. Scheduled appointments on days 21 (D21) ± 7 after enrollment, D90 ± 15, D120 ± 30, D180 ± 30; D360 ± 30; D720 ± 60, and D1080 ± 60 days. On these visits a panel of blood tests are collected in addition to the clinical report forms to obtain data on socio-demographic, medical history, physical examination and questionnaires devoted to the evaluation of musculoskeletal manifestations and overall health are performed. Participants are asked to consent for their specimens to be maintained in a biobank. Aliquots of blood, serum, saliva, PAXgene, and when clinically indicated to be examined, synovial fluid, are stored at -80° C. The study protocol was submitted and approved to the National IRB and local IRB at each study site.
    Discussion: Standardized and harmonized patient cohorts are needed to provide better estimates of chronic arthralgia development, the clinical spectra of acute and chronic disease and investigation of associated risk factors. This study is the largest evaluation of the long-term sequelae of individuals infected with CHIKV in the Brazilian population focusing on musculoskeletal manifestations, mental health, quality of life, and chronic pain. This information will both define disease burden and costs associated with CHIKV infection, and better inform therapeutic guidelines.
    Mesh-Begriff(e) Humans ; Chikungunya Fever/diagnosis ; Chikungunya Fever/epidemiology ; Chikungunya Fever/therapy ; Cohort Studies ; Prospective Studies ; Quality of Life ; Chronic Disease ; Multicenter Studies as Topic
    Sprache Englisch
    Erscheinungsdatum 2023-07-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08292-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Importation and early local transmission of COVID-19 in Brazil, 2020

    Jesus, Jaqueline Goes de / Sacchi, Claudio / Candido, Darlan da Silva / Claro, Ingra Morales / Sales, Flávia Cristina Silva / Manuli, Erika Regina / Silva, Daniela Bernardes Borges da / Paiva, Terezinha Maria de / Pinho, Margarete Aparecida Benega / Santos, Katia Correa de Oliveira / Hill, Sarah Catherine / Aguiar, Renato Santana / Romero, Filipe / Santos, Fabiana Cristina Pereira dos / Gonçalves, Claudia Regina / Timenetsky, Maria do Carmo / Quick, Joshua / Croda, Julio Henrique Rosa / Oliveira, Wanderson de /
    Rambaut, Andrew / Pybus, Oliver G. / Loman, Nicholas J. / Sabino, Ester Cerdeira / Faria, Nuno Rodrigues

    Revista do Instituto de Medicina Tropical de São Paulo v.62 2020

    2020  

    Abstract: ABSTRACT We conducted the genome sequencing and analysis of the first confirmed COVID-19 infections in Brazil. Rapid sequencing coupled with phylogenetic analyses in the context of travel history corroborate multiple independent importations from Italy ... ...

    Abstract ABSTRACT We conducted the genome sequencing and analysis of the first confirmed COVID-19 infections in Brazil. Rapid sequencing coupled with phylogenetic analyses in the context of travel history corroborate multiple independent importations from Italy and local spread during the initial stage of COVID-19 transmission in Brazil.
    Schlagwörter Public health surveillance ; COVID-19 ; SARS-CoV-2 ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-01-01
    Verlag Instituto de Medicina Tropical
    Erscheinungsland br
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol.

    do Nascimento, Kamilla Felipe / Moreira, Flora Martinez Figueira / Alencar Santos, Joyce / Kassuya, Candida Aparecida Leite / Croda, Julio Henrique Rosa / Cardoso, Claudia Andrea Lima / Vieira, Maria do Carmo / Góis Ruiz, Ana Lúcia Tasca / Ann Foglio, Mary / de Carvalho, João Ernesto / Formagio, Anelise Samara Nazari

    Journal of ethnopharmacology

    2018  Band 210, Seite(n) 351–358

    Abstract: Ethnopharmacological relevance: Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence demonstrating this activity.: Aim of the study: To evaluate the ... ...

    Abstract Ethnopharmacological relevance: Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence demonstrating this activity.
    Aim of the study: To evaluate the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of P. guineense and spathulenol (a major constituent). The study was conducted in part to provide evidence supporting the ethnobotanical use of the leaves of this species.
    Material and methods: The essential oil (EOPG) was extracted from the leaves of P. guineense by hydrodistillation and analysed by gas chromatography-mass spectrometry (GC-MS). The major compound, spathulenol (PG-1), was isolated in a chromatographic column and characterized by nuclear magnetic resonance (NMR). EOPG and PG-1 were evaluated in vitro for antioxidant activity by DPPH, ABTS and MDA methods; anti-inflammatory potential was assessed using two models, including pleurisy and oedema, in mice. The impact of EOPG and PG-1 on cell proliferation was determined via spectrophotometric quantification of the cellular protein content using a sulforhodamine B assay, and anti-Mycobacterium tuberculosis activity was determined using the REMA method.
    Results: A total of 38 components were identified from the EOPG, with the sesquiterpenic alcohol spathulenol (PG-1) (80.7%) being the major constituent. EOPG and PG-1 exhibited the highest antioxidant activities in the DPPH and MDA system compared with reference standard, with IC
    Conclusion: For the first time, this study demonstrated the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial properties of the essential oil of P. guineense (leaves were collected in Dourados-MS) and spathulenol, collaborating the etnhopharmacologycal use of this plant due to its an anti-inflammatory effect.
    Mesh-Begriff(e) Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Antioxidants/administration & dosage ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Antitubercular Agents/administration & dosage ; Antitubercular Agents/isolation & purification ; Antitubercular Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Edema/drug therapy ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Inhibitory Concentration 50 ; Male ; Mice ; Oils, Volatile/administration & dosage ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Plant Leaves ; Pleurisy/drug therapy ; Psidium/chemistry ; Rats ; Rats, Wistar ; Sesquiterpenes/administration & dosage ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/pharmacology
    Chemische Substanzen Anti-Inflammatory Agents ; Antineoplastic Agents, Phytogenic ; Antioxidants ; Antitubercular Agents ; Oils, Volatile ; Plant Extracts ; Sesquiterpenes ; spathulenol (7XV9L96SJJ)
    Sprache Englisch
    Erscheinungsdatum 2018-01-10
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2017.08.030
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