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  1. Article ; Online: Optimising endometrial cancer survivorship through lifestyle change.

    Kitson, S J / Crosbie, E J

    Gynecologic oncology

    2023  Volume 179, Page(s) A1–A2

    MeSH term(s) Female ; Humans ; Cancer Survivors ; Life Style ; Endometrial Neoplasms/therapy
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2023.11.032
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  2. Article ; Online: Does the vaginal microbiome drive cervical carcinogenesis?

    Njoku, K / Crosbie, E J

    BJOG : an international journal of obstetrics and gynaecology

    2019  Volume 127, Issue 2, Page(s) 181

    MeSH term(s) Carcinogenesis ; Female ; Humans ; Microbiota ; Network Meta-Analysis ; Papillomaviridae ; Papillomavirus Infections ; Uterine Cervical Neoplasms ; Vagina
    Language English
    Publishing date 2019-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.15867
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  3. Article ; Online: The vaginal microbiome and gynaecological cancer: exercise caution when considering causation.

    Ramchander, N C / Crosbie, E J

    BJOG : an international journal of obstetrics and gynaecology

    2017  Volume 125, Issue 3, Page(s) 316

    MeSH term(s) Exercise ; Female ; Genital Neoplasms, Female ; Humans ; Microbiota ; Vagina
    Language English
    Publishing date 2017-06-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.14704
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  4. Article ; Online: Global human papillomavirus vaccination: can it be cost-effective?

    Crosbie, E J

    BJOG : an international journal of obstetrics and gynaecology

    2012  Volume 119, Issue 2, Page(s) 125–128

    MeSH term(s) Cost-Benefit Analysis ; Drug Costs ; Female ; Forecasting ; Global Health ; Humans ; Immunity, Active/immunology ; Mass Screening/economics ; Mass Vaccination/economics ; Papillomavirus Infections/economics ; Papillomavirus Infections/immunology ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines/economics ; Papillomavirus Vaccines/immunology ; Uterine Cervical Neoplasms/economics ; Uterine Cervical Neoplasms/prevention & control ; Uterine Cervical Neoplasms/virology
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/j.1471-0528.2011.03090.x
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  5. Article ; Online: Impact of socio-economic deprivation on endometrial cancer survival in the North West of England: a prospective database analysis.

    Njoku, K / Barr, C E / Hotchkies, L / Quille, N / Wan, Y L / Crosbie, E J

    BJOG : an international journal of obstetrics and gynaecology

    2021  Volume 128, Issue 7, Page(s) 1215–1224

    Abstract: Objective: To assess the impact of socio-economic deprivation on endometrial cancer survival.: Design: Single-centre prospective database study.: Setting: North West England.: Population: Women with endometrial cancer treated between 2010 and ... ...

    Abstract Objective: To assess the impact of socio-economic deprivation on endometrial cancer survival.
    Design: Single-centre prospective database study.
    Setting: North West England.
    Population: Women with endometrial cancer treated between 2010 and 2015.
    Methods: Areal-level socio-economic status, using the English indices of multiple deprivation from residential postcodes, was analysed in relation to survival using Kaplan-Meier estimation and multivariable Cox regression.
    Main outcome measures: Overall survival, cancer-specific survival and patterns and rates of recurrence.
    Results: A total of 539 women, with a median age of 66 years (interquartile range, IQR 56-73 years) and a body mass index (BMI) of 32 kg/m
    Conclusions: We found that socio-economically deprived women with endometrial cancer were more likely to develop fatal recurrence. Larger studies are needed to confirm these findings and to identify modifiable contributing factors.
    Tweetable abstract: Socio-economic deprivation is linked to an increased risk of death from endometrial cancer in the North West of England.
    MeSH term(s) Aged ; Databases, Factual ; Diabetes Mellitus/epidemiology ; Endometrial Neoplasms/mortality ; Endometrial Neoplasms/pathology ; England/epidemiology ; Female ; Health Status Disparities ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/mortality ; Obesity/epidemiology ; Prospective Studies ; Social Class ; Socioeconomic Factors
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.16618
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  6. Article ; Online: Eliminating Cervical Cancer: Progress and Challenges for High-income Countries.

    Davies-Oliveira, J C / Smith, M A / Grover, S / Canfell, K / Crosbie, E J

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2021  Volume 33, Issue 9, Page(s) 550–559

    Abstract: In 2020, the World Health Organization launched a major initiative to eliminate cervical cancer globally. The initiative is built around the three key pillars of human papillomavirus (HPV) vaccination, cervical screening and treatment, with associated ... ...

    Abstract In 2020, the World Health Organization launched a major initiative to eliminate cervical cancer globally. The initiative is built around the three key pillars of human papillomavirus (HPV) vaccination, cervical screening and treatment, with associated intervention targets for the year 2030. The '90-70-90' targets specify that 90% of adolescent girls receive prophylactic HPV vaccination, 70% of adult women receive a minimum twice-in-a-lifetime cervical HPV test and 90% receive appropriate treatment for preinvasive or invasive disease. Modelling has shown that if these targets are met, the elimination of cervical cancer, defined as fewer than four cases per 100 000 women per annum, will be achieved within a century. Many high-income countries are well positioned to eliminate cervical cancer within the coming decades, but few have achieved '90-70-90' and many challenges must still be addressed to deliver these critical interventions effectively. This review considers the current status of cervical cancer control in relation to each of the three elimination pillars in high-income countries and discusses some of the developments that will assist countries in reaching these ambitious targets by 2030.
    MeSH term(s) Adolescent ; Adult ; Developed Countries ; Early Detection of Cancer ; Female ; Humans ; Mass Screening ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control
    Language English
    Publishing date 2021-07-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2021.06.013
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  7. Article ; Online: Population-based testing of non-mucinous epithelial ovarian cancer in Scotland.

    Evans, D G / Edmondson, R / Crosbie, E J

    BJOG : an international journal of obstetrics and gynaecology

    2018  Volume 125, Issue 11, Page(s) 1459

    MeSH term(s) BRCA2 Protein ; Carcinoma, Ovarian Epithelial ; Female ; Germ Cells ; Humans ; Neoplasms, Glandular and Epithelial ; Ovarian Neoplasms ; Scotland
    Chemical Substances BRCA2 Protein ; BRCA2 protein, human
    Language English
    Publishing date 2018-05-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.15174
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  8. Article ; Online: Detection of MCM5 as a novel non-invasive aid for the diagnosis of endometrial and ovarian tumours.

    Stockley, J / Akhand, R / Kennedy, A / Nyberg, C / Crosbie, E J / Edmondson, R J

    BMC cancer

    2020  Volume 20, Issue 1, Page(s) 1000

    Abstract: Background: MCM5 is a protein involved in DNA replication, facilitating cell proliferation. In normal epithelium MCM5 expression is restricted to the cells in the basal proliferative compartments, however in the presence of a tumour MCM5 positive cells ... ...

    Abstract Background: MCM5 is a protein involved in DNA replication, facilitating cell proliferation. In normal epithelium MCM5 expression is restricted to the cells in the basal proliferative compartments, however in the presence of a tumour MCM5 positive cells are present at the surface epithelium and are shed into bodily fluids. The aim of this study was to determine the sensitivity of MCM5 as a biomarker for the detection of endometrial and ovarian cancer.
    Methods: Patients with known ovarian or endometrial cancers, or known benign gynaecological conditions, were enrolled. Informed consent was obtained prior to the collection of full void urine, and either a vaginal tampon (worn for 6-8 h), or a vaginal swab. Vaginal secretions were extracted from the tampon or swab, centrifuged and lysed. Urine samples were centrifuged and lysed. MCM5 levels were determined by MCM5-ELISA (Arquer Diagnostics Ltd).
    Results: 125 patients completed the study protocol, 41 patients had endometrial cancer, 26 ovarian cancer, and 58 benign controls. All patients provided a urine sample and either a tampon or vaginal swab sample. Urine MCM5 levels were higher in cancer patients than controls (p < 0.0001), there was no significant difference in levels between tampon samples or vaginal swab samples in cancer patients when compared to controls. Performance of MCM5 to discriminate cancer from benign disease was high with an area under the ROC curve of 0.83 for endometrial cancer and 0.68 for ovarian cancer. Using a cut off of 12 pg/mL, overall sensitivity for endometrial cancer was 87.8, and 61.5% for ovarian cancer with a specificity of 75.9%.
    Conclusions: MCM5 is a novel sensitive and specific biomarker for the detection of ovarian and endometrial tumours in urine samples, which is likely to have clinical utility as a diagnostic aid.
    MeSH term(s) Aged ; Biomarkers, Tumor/metabolism ; Cell Cycle Proteins/metabolism ; Early Detection of Cancer ; Endometrial Neoplasms/diagnosis ; Female ; Humans ; Middle Aged ; Ovarian Neoplasms/diagnosis
    Chemical Substances Biomarkers, Tumor ; Cell Cycle Proteins ; MCM5 protein, human
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-020-07468-y
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  9. Article ; Online: A mismatch in care: results of a United Kingdom-wide patient and clinician survey of gynaecological services for women with Lynch syndrome.

    Ryan, Naj / Nobes, M / Sedgewick, D / Teoh, S-N / Evans, D G / Crosbie, E J

    BJOG : an international journal of obstetrics and gynaecology

    2020  Volume 128, Issue 4, Page(s) 728–736

    Abstract: Objective: To describe the current testing practice, referral pathways and gynaecological services available to women with Lynch syndrome (LS) in the UK.: Design: Cross-sectional nationwide survey of gynaecological oncologists and women with LS.: ... ...

    Abstract Objective: To describe the current testing practice, referral pathways and gynaecological services available to women with Lynch syndrome (LS) in the UK.
    Design: Cross-sectional nationwide survey of gynaecological oncologists and women with LS.
    Setting: United Kingdom.
    Methods: Gynaecological oncologists were contacted directly. Women with LS were identified from national and regional clinical databases and the patient support group, Lynch syndrome UK.
    Main outcome measures: Gynaecological oncologists were asked to report rates of LS testing and current practice regarding risk-reducing strategies and gynaecological surveillance for women with LS. Women with LS were asked to describe their experiences of gynaecological care.
    Results: In total, 41 gynaecological oncologists and 298 women with LS responded to the survey. Of the gynaecological oncologists surveyed, 37% were unfamiliar with any clinical guidelines for the management of LS. Only 29% of gynaecological oncologists supported universal testing of endometrial cancer for LS; one centre routinely performed such testing. In all, 83% said they perform risk-reducing gynaecological surgery and 43% were aware of a local gynaecological surveillance service for women with LS. Of women with LS, most had undergone a hysterectomy (n = 191/64.1%), most frequently to reduce their gynaecological cancer risk (n = 86/45%). A total of 10% were initially referred for LS testing by their gynaecologist and 55% of those eligible regularly attended gynaecological surveillance; however, 62% wanted more regular surveillance. Regional variation was evident across all standards of care.
    Conclusions: There is widespread variation in the services offered to women with LS in the UK. As a community, gynaecological oncologists should move towards a nationally agreed provision of services.
    Tweetable abstract: A mismatch in care for mismatch repair. Survey finds significant variation in gynaecological care for #Lynchsyndrome in the UK.
    MeSH term(s) Adult ; Aged ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/therapy ; Cross-Sectional Studies ; Female ; Gynecology/organization & administration ; Gynecology/statistics & numerical data ; Health Care Surveys ; Health Services Accessibility/organization & administration ; Health Services Accessibility/statistics & numerical data ; Healthcare Disparities/statistics & numerical data ; Humans ; Middle Aged ; Practice Patterns, Physicians'/statistics & numerical data ; Referral and Consultation/organization & administration ; Referral and Consultation/statistics & numerical data ; State Medicine/organization & administration ; State Medicine/statistics & numerical data ; United Kingdom ; Women's Health Services/organization & administration ; Women's Health Services/statistics & numerical data
    Language English
    Publishing date 2020-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.16432
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  10. Article ; Online: Biomarkers needed to predict progestin response in endometrial cancer.

    Derbyshire, A E / Ryan, Naj / Crosbie, E J

    BJOG : an international journal of obstetrics and gynaecology

    2017  Volume 124, Issue 10, Page(s) 1584

    MeSH term(s) Adenocarcinoma ; Biomarkers ; DNA Mismatch Repair ; Endometrial Hyperplasia ; Endometrial Neoplasms ; Female ; Humans ; Hyperplasia ; Progestins
    Chemical Substances Biomarkers ; Progestins
    Language English
    Publishing date 2017-01-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.14490
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