LIVIVO - Search results -

Search results

Result 1 - 10 of total 50

Search options

Article ; Online: Molecular epidemiology of human herpesvirus 8 in patients with HHV-8-related diseases in Ireland.

O'Rourke, Sadhbh / Laoi, Bairbre Ni / Clarke, Susan / Crowley, Brendan

2024 Volume 96, Issue 5, Page(s) e29654

Abstract: Human Herpesvirus 8 (HHV-8) has been classified by sequence analysis of open reading frame (ORF) K1, ORF K15, and variable sequence loci within the central constant region. The purpose of this study was to examine the molecular epidemiology of HHV-8 in ... ...

Abstract	Human Herpesvirus 8 (HHV-8) has been classified by sequence analysis of open reading frame (ORF) K1, ORF K15, and variable sequence loci within the central constant region. The purpose of this study was to examine the molecular epidemiology of HHV-8 in an Irish population. This retrospective study included 30 patients who had HHV-8 DNA detected in plasma. Nested end-point PCR was used to characterise four regions of the HHV-8 genome, K1, T0.7 (K12), ORF 75, and K15. Sequencing data were obtained for 23 specimens from 19 patients. Phylogenetic analysis of ORF K1 demonstrated that subtypes A, B, C and F were present in 37%, 11%, 47% and 5%, respectively. For T0.7 and ORF 75, sequencing data were obtained for 12 patients. For T0.7, subtypes A/C, J, B, R and Q were present in 58%, 17%, 8%, 8%, and 8%, respectively. For ORF 75, subtypes A, B, C and D were present in 58%, 8%, 25%, and 8%, respectively. K15 sequences were determined for 13 patients. 69% had the P allele and 31% had the M allele. The data generated by this study demonstrate that a broad variety of HHV-8 subtypes are represented in patients exhibiting HHV-8-related disease in Ireland, a low prevalence country. The predominance of C and A K1 subtypes was as expected for a Western European population. The 31% prevalence for K15 subtype M was higher than expected for a Western European population. This may represent the changing and evolving epidemiology in Ireland due to altered migration patterns.
MeSH term(s)	Humans ; Ireland/epidemiology ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/virology ; Molecular Epidemiology ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/classification ; Herpesvirus 8, Human/isolation & purification ; Male ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Phylogeny ; DNA, Viral/genetics ; Aged ; Sequence Analysis, DNA ; Young Adult ; Polymerase Chain Reaction ; Genotype ; Adolescent ; Open Reading Frames ; Aged, 80 and over ; Child ; Molecular Sequence Data
Chemical Substances	DNA, Viral
Language	English
Publishing date	2024-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29654
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Disease-Modifying Treatments for Multiple Sclerosis Affect Measures of Cellular Immune Responses to EBNA-1 Peptides.

Dungan, Lara / Dunne, Jean / Savio, Michael / Kalaszi, Marianna / McElheron, Matt / Lynagh, Yvonne / O'Driscoll, Kate / Roche, Carmel / Qureshi, Ammara / Crowley, Brendan / Conlon, Niall / Kearney, Hugh

Neurology(R) neuroimmunology & neuroinflammation

2024 Volume 11, Issue 3, Page(s) e200217

Abstract: Background and objectives: Epstein-Barr virus (EBV) has been strongly implicated in the pathogenesis of multiple sclerosis (MS). Despite this, there are no routinely used tests to measure cellular response to EBV. In this study, we analyzed the cellular ...

Abstract	Background and objectives: Epstein-Barr virus (EBV) has been strongly implicated in the pathogenesis of multiple sclerosis (MS). Despite this, there are no routinely used tests to measure cellular response to EBV. In this study, we analyzed the cellular response to EBV nuclear antigen-1 (EBNA-1) in people with MS (pwMS) using a whole blood assay. Methods: This cross-sectional study took place in a dedicated MS clinic in a university hospital. We recruited healthy controls, people with epilepsy (PWE), and pwMS taking a range of disease-modifying treatments (DMTs) including natalizumab, anti-CD20 monoclonal antibodies (mAbs), dimethyl fumarate (DMF), and also treatment naïve. Whole blood samples were stimulated with commercially available PepTivator EBNA1 peptides and a control virus-cytomegalovirus (CMV) peptide. We recorded the cellular response to stimulation with both interferon gamma (IFN-γ) and interleukin-2 (IL-2). We also compared the cellular responses to EBNA1 with IgG responses to EBNA1, viral capsid antigen (VCA), and EBV viral load. Results: We recruited 86 pwMS, with relapsing remitting MS, in this group, and we observed a higher level of cellular response recorded with IFN-γ (0.79 IU/mL ± 1.36) vs healthy controls (0.29 IU/mL ± 0.90, Discussion: This study demonstrates how testing and recording the cellular response to EBNA-1 in pwMS may be beneficial. EBNA-1 stimulation of whole blood samples produced higher levels of IFN-γ and IL-2 in pwMS compared with controls and PWE. In addition, we show a differential effect of currently available DMTs on this response. The functional assay deployed uses whole blood samples with minimal preprocessing suggesting that employment as a treatment response measure in clinical trials targeting EBV may be possible.
MeSH term(s)	Humans ; Antibodies, Viral ; Antigens, Viral ; Capsid Proteins ; Cross-Sectional Studies ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Nuclear Antigens/immunology ; Herpesvirus 4, Human/immunology ; Immunity, Cellular ; Immunoglobulin G ; Interferon-gamma ; Interleukin-2 ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/virology
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; Capsid Proteins ; EBV-encoded nuclear antigen 1 (O5GA75RST7) ; Epstein-Barr Virus Nuclear Antigens ; Immunoglobulin G ; Interferon-gamma (82115-62-6) ; Interleukin-2
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000200217
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: How to use central venous catheter tip cultures.

O'Flaherty, Niamh / Crowley, Brendan

Archives of disease in childhood. Education and practice edition

2015 Volume 100, Issue 2, Page(s) 69–74

Abstract: Central venous catheter (CVC) tip cultures are useful in the assessment of a patient with a potential catheter-related bloodstream infection (CRBSI). However, these results can be misleading particularly in the absence of concomitant peripheral and ... ...

Abstract	Central venous catheter (CVC) tip cultures are useful in the assessment of a patient with a potential catheter-related bloodstream infection (CRBSI). However, these results can be misleading particularly in the absence of concomitant peripheral and central line blood cultures. Catheter tip cultures should not be submitted to the laboratory unless CRBSI is suspected as the predictive value of culture results depends on the pretest probability of CRBSI. A positive CVC tip culture does not usually warrant further investigation or therapy (except in the case of Staphylococcus aureus and possibly Candida sp) while a negative catheter tip culture in isolation does not definitively exclude CRBSI. Clinicians can use alternative criteria for the diagnosis of CRBSI that do not require catheter tip cultures if necessary. Further research into the significance of CVC tip cultures in the absence of concomitant bacteraemia is required.
MeSH term(s)	Bacteriological Techniques ; Candida/isolation & purification ; Candidiasis/diagnosis ; Candidiasis/drug therapy ; Catheter-Related Infections/diagnosis ; Catheter-Related Infections/drug therapy ; Central Venous Catheters/microbiology ; Child ; Humans ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/isolation & purification
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2148818-6
ISSN	1743-0593 ; 1743-0585
ISSN (online)	1743-0593
ISSN	1743-0585
DOI	10.1136/archdischild-2013-305096
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Um IV Zs.106 -E.P.Ed.-: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prevalence, Macrolide Resistance, and Fluoroquinolone Resistance in Mycoplasma genitalium in Men Who Have Sex With Men Attending an Sexually Transmitted Disease Clinic in Dublin, Ireland in 2017-2018.

Mulligan, Vanessa / Lynagh, Yvonne / Clarke, Susan / Unemo, Magnus / Crowley, Brendan

Sexually transmitted diseases

2019 Volume 46, Issue 4, Page(s) e35–e37

Abstract: This is the first prevalence study of Mycoplasma genitalium and antimicrobial resistance study in Ireland. In urine samples from men who have sex with men (n = 400) attending a sexually transmitted disease clinic in Dublin, the prevalence of M. ... ...

Abstract	This is the first prevalence study of Mycoplasma genitalium and antimicrobial resistance study in Ireland. In urine samples from men who have sex with men (n = 400) attending a sexually transmitted disease clinic in Dublin, the prevalence of M. genitalium was 3% (12 of 400 specimens; 95% confidence interval, 1.3-4.7%), and the prevalences of macrolide resistance (75%), fluoroquinolone resistance (33.3%), and multidrug resistance (33.3%) were very high.
MeSH term(s)	Adult ; Anti-Bacterial Agents/pharmacology ; Cross-Sectional Studies ; DNA, Bacterial ; Drug Resistance, Multiple, Bacterial/genetics ; Fluoroquinolones/pharmacology ; Homosexuality, Male ; Humans ; Ireland/epidemiology ; Macrolides/pharmacology ; Male ; Middle Aged ; Mutation ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/microbiology ; Mycoplasma Infections/urine ; Mycoplasma genitalium/drug effects ; Mycoplasma genitalium/genetics ; Prevalence ; RNA, Ribosomal, 23S/genetics ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; DNA, Bacterial ; Fluoroquinolones ; Macrolides ; RNA, Ribosomal, 23S
Language	English
Publishing date	2019-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000000940
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1217: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Molecular characterization of clinical isolates of herpes simplex virus type 1 collected in a tertiary-care hospital in Dublin, Ireland.

Rose, Lisa / Crowley, Brendan

Journal of medical virology

2013 Volume 85, Issue 5, Page(s) 839–844

Abstract: Herpes simplex virus type 1 (HSV-1) is a ubiquitous human pathogen. While there has been extensive research into the evolutionary relationships among herpesviruses, there is little data on the evolutionary relationship of HSV-1 based on sequence analysis ...

Abstract	Herpes simplex virus type 1 (HSV-1) is a ubiquitous human pathogen. While there has been extensive research into the evolutionary relationships among herpesviruses, there is little data on the evolutionary relationship of HSV-1 based on sequence analysis of clinical isolates. The present study aims to be the first to document the molecular epidemiology and genetic diversity and frequency of recombination of HSV-1 (n = 42) clinical isolates in Ireland. The entire 1,171 bp of the gI-1 gene and 717 bp of the gG-1 gene of 42 clinical Irish isolates were amplified, sequenced and the phylogenies reconstructed. Putative recombinants were examined using bootscan analysis. Phylogenetic reconstruction of the nucleotide sequence alignments of the entire genes of amplified glycoproteins gI and gG suggested that three distinct HSV-1 genogroups were circulating in the Irish population. At least 15 HSV-1 intergenic recombinants with a recombination point between gI and gG, and 11 HSV-1 intragenic recombinants were detected. There was no evident association between genetic group and gender, disease recurrence or anatomical site of infection. Genital isolates (n = 30) belonged to all genogroups. However, two HSV-1 isolates, Irl 31 and Irl32, from a patient with severe mucocutaneous infection nonresponsive to acyclovir and isolated over a prolonged period were both intragenic and intergenic recombinants. The detection of variability and recombination in gG and gI genes of both HSV-1 may provide a mechanism to evade the host immune response thereby maintaining the viral genome. The variability and recombination detected may also have implications for the detection, diagnosis and treatment of HSV.
MeSH term(s)	Cluster Analysis ; DNA, Viral/chemistry ; DNA, Viral/genetics ; Genetic Variation ; Genotype ; Herpes Simplex/epidemiology ; Herpes Simplex/virology ; Herpesvirus 1, Human/classification ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/isolation & purification ; Humans ; Ireland/epidemiology ; Molecular Epidemiology ; Phylogeny ; Recombination, Genetic ; Sequence Analysis, DNA ; Tertiary Care Centers ; Viral Envelope Proteins/genetics
Chemical Substances	DNA, Viral ; Viral Envelope Proteins ; glycoprotein I, herpes simplex virus type 1 ; glycoprotein gG-1, herpes simplex virus type 1
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.23541
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Multiple introductions of monkeypox virus to Ireland during the international mpox outbreak, May 2022 to October 2023.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2024 Volume 29, Issue 16

Abstract: BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when a global epidemic of cases in non-endemic countries led to the declaration of a Public Health Emergency of International Concern. Cases of mpox ...

Abstract	BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when a global epidemic of cases in non-endemic countries led to the declaration of a Public Health Emergency of International Concern. Cases of mpox in Ireland, a country without previous mpox reports, could reflect extended local transmission or multiple epidemiological introductions.AimTo elucidate the origins and molecular characteristics of MPXV circulating in Ireland between May 2022 and October 2023.MethodsWhole genome sequencing of MPXV from 75% of all Irish mpox cases (182/242) was performed and compared to sequences retrieved from public databases (n = 3,362). Bayesian approaches were used to infer divergence time between sequences from different subclades and evaluate putative importation events from other countries.ResultsOf 242 detected mpox cases, 99% were males (median age: 35 years; range: 15-60). All 182 analysed genomes were assigned to Clade IIb and, presence of 12 distinguishable subclades suggests multiple introductions into Ireland. Estimation of time to divergence of subclades further supports the hypothesis for multiple importation events from numerous countries, indicative of extended and sustained international spread of mpox. Further analysis of sequences revealed that 92% of nucleotide mutations were from cytosine to thymine (or from guanine to adenine), leading to a high number of non-synonymous mutations across subclades; mutations associated with tecovirimat resistance were not observed.ConclusionWe provide insights into the international transmission dynamics supporting multiple introductions of MPXV into Ireland. Such information supported the implementation of evidence-informed public health control measures.
MeSH term(s)	Male ; Humans ; Adult ; Female ; Ireland/epidemiology ; Monkeypox virus/genetics ; Bayes Theorem ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/epidemiology ; Disease Outbreaks
Language	English
Publishing date	2024-04-19
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2024.29.16.2300505
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5066: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Ganciclovir treatment of symptomatic congenital cytomegalovirus infection.

Crowley, Brendan

The Journal of antimicrobial chemotherapy

2002 Volume 50, Issue 3, Page(s) 435–6; author reply 436

MeSH term(s)	Adult ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Cytomegalovirus/drug effects ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/drug therapy ; Female ; Ganciclovir/adverse effects ; Ganciclovir/therapeutic use ; Humans ; Infant, Newborn ; Male ; Pregnancy
Chemical Substances	Antiviral Agents ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	2002-09
Publishing country	England
Document type	Case Reports ; Comment ; Letter
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkf144
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development of chronic hepatitis B infection in a hepatitis B vaccine responder.

Sadlier, Corinna / Madden, Keeva / O'Gorman, Sean / Crowley, Brendan / Bergin, Colm

International journal of STD & AIDS

2017 Volume 28, Issue 5, Page(s) 526–528

Abstract: The Hepatitis B vaccine is highly effective for the prevention of hepatitis B (HBV) infection. We report the development of chronic HBV infection (Genotype F) in a vaccinated immunocompetent individual with an anti-HBsAb of 35 mIU/mL post completion of ... ...

Abstract	The Hepatitis B vaccine is highly effective for the prevention of hepatitis B (HBV) infection. We report the development of chronic HBV infection (Genotype F) in a vaccinated immunocompetent individual with an anti-HBsAb of 35 mIU/mL post completion of vaccine series. HBV vaccine is based on recombinant proteins of genotype-A and D (predominant genotypes in Europe). It may not be as effective for the prevention of more genetically diverse viruses such as genotype F (predominant genotype in Central and South America). Healthcare providers and patients should be aware that the HB vaccine does not confer 100% protection against HBV infection, even in the setting of protective antibody levels. Partners of individuals infected with non-A or -D genotypes should be advised to consider additional precautions to prevent transmission even in the setting protective antibody levels. Surveillance of circulating HBV genotypes should be undertaken to inform public health policy in relation to prevention of HB in high-risk groups such as men who have sex with men.
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/0956462416674835
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2829: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in

Chengalroyen, Melissa D / Mason, Mandy K / Borsellini, Alessandro / Tassoni, Raffaella / Abrahams, Garth L / Lynch, Sasha / Ahn, Yong-Mo / Ambler, Jon / Young, Katherine / Crowley, Brendan M / Olsen, David B / Warner, Digby F / Barry Iii, Clifton E / Boshoff, Helena I M / Lamers, Meindert H / Mizrahi, Valerie

ACS infectious diseases

2022 Volume 8, Issue 3, Page(s) 612–625

Abstract: Natural products provide a rich source of potential antimicrobials for treating infectious diseases for which drug resistance has emerged. Foremost among these diseases is tuberculosis. Assessment of the antimycobacterial activity of nargenicin, a ... ...

Abstract	Natural products provide a rich source of potential antimicrobials for treating infectious diseases for which drug resistance has emerged. Foremost among these diseases is tuberculosis. Assessment of the antimycobacterial activity of nargenicin, a natural product that targets the replicative DNA polymerase of
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Cryoelectron Microscopy ; DNA-Directed DNA Polymerase ; Humans ; Mycobacterium tuberculosis/genetics ; Tuberculosis/drug therapy ; Tuberculosis/microbiology
Chemical Substances	Anti-Bacterial Agents ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ISSN	2373-8227
ISSN (online)	2373-8227
DOI	10.1021/acsinfecdis.1c00643
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Seroprevalence of human herpesvirus 8 in Ireland among blood donors, men who have sex with men, and heterosexual genitourinary medicine and infectious diseases clinic attendees.

O'Rourke, Sadhbh / O'Flaherty, Niamh / Coyne, Dermot / Lynam, Almida / Clarke, Susan / O'Dea, Siobhán / Fitzpatrick, Sarah / Connell, Jeff / Crowley, Brendan

Journal of medical virology

2021 Volume 93, Issue 8, Page(s) 5058–5064

Abstract: Human herpesvirus 8 (HHV-8) seroprevalence varies geographically and between subpopulations. High seroprevalence rates have been ascribed to men who have sex with men (MSM), African migrants, and HIV-infected individuals. The objective of this study was ... ...

Abstract	Human herpesvirus 8 (HHV-8) seroprevalence varies geographically and between subpopulations. High seroprevalence rates have been ascribed to men who have sex with men (MSM), African migrants, and HIV-infected individuals. The objective of this study was to determine the seroprevalence of HHV-8 in an Irish population, including specific risk groups. A cross-sectional study of 200 blood donors and 200 genitourinary medicine (GUM) and infectious diseases (ID) clinic patients was performed, with testing for Immunoglobulin G (IgG) antibodies to HHV-8 lytic antigens using a commercial indirect fluorescence assay (Scimedx Corp.). Verification was performed at the Centers for Disease Control and Prevention (CDC). All 200 blood donor samples were negative for HHV-8 IgG antibodies. 21% of GUM and ID patients were positive for HHV-8 IgG antibodies. One hundred of these patients were MSM, 35% of whom were HHV-8 seropositive (46% of HIV-positive MSM and 24% of HIV-negative MSM). Of 100 heterosexual patients, only 7% were HHV-8 seropositive. The absence of seropositivity in 200 Irish blood donors may suggest that Ireland has a low overall population HHV-8 seroprevalence. The proportion of HHV-8 seropositivity in the MSM population was significantly higher than in the heterosexual population and most marked in HIV-positive MSM.
MeSH term(s)	Adult ; Aged ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Basic-Leucine Zipper Transcription Factors/immunology ; Blood Donors/statistics & numerical data ; Communicable Diseases/blood ; Communicable Diseases/epidemiology ; Cross-Sectional Studies ; Female ; HIV Seropositivity/blood ; HIV Seropositivity/epidemiology ; Herpesviridae Infections/blood ; Herpesviridae Infections/epidemiology ; Herpesvirus 8, Human/immunology ; Herpesvirus 8, Human/isolation & purification ; Heterosexuality/statistics & numerical data ; Homosexuality, Male/statistics & numerical data ; Humans ; Ireland/epidemiology ; Male ; Middle Aged ; Repressor Proteins/immunology ; Seroepidemiologic Studies ; Viral Proteins/immunology ; Young Adult
Chemical Substances	Antibodies, Viral ; Basic-Leucine Zipper Transcription Factors ; K8 protein, Human herpesvirus 8 ; Repressor Proteins ; Viral Proteins
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26813
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito