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Article ; Online: Current practice in the perioperative management of patients with diabetes mellitus: a narrative review.

Crowley, Kieran / Scanaill, Pádraig Ó / Hermanides, Jeroen / Buggy, Donal J

2023 Volume 131, Issue 2, Page(s) 242–252

Abstract: The prevalence of diabetes is increasing, and patients with diabetes mellitus have both an increased likelihood of requiring surgery and of developing postoperative complications when they do. We summarise available evidence underpinning current ... ...

Abstract	The prevalence of diabetes is increasing, and patients with diabetes mellitus have both an increased likelihood of requiring surgery and of developing postoperative complications when they do. We summarise available evidence underpinning current guidelines on preoperative assessment and optimisation, perioperative management of prescribed insulin and oral hypoglycaemic medication, intraoperative glycaemic control, and postoperative patient care.
MeSH term(s)	Humans ; Diabetes Mellitus/drug therapy ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Postoperative Care ; Postoperative Complications/etiology ; Diabetes Mellitus, Type 2/complications ; Blood Glucose
Chemical Substances	Hypoglycemic Agents ; Insulin ; Blood Glucose
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2023.02.039
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Help out of the habit.

Crowley, Karolyn

Nursing standard (Royal College of Nursing (Great Britain) : 1987)

2014 Volume 29, Issue 4, Page(s) 63

MeSH term(s)	Behavior, Addictive/therapy ; Humans ; Nurses/psychology ; Prescription Drug Misuse ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/therapy ; United Kingdom
Language	English
Publishing date	2014-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	645016-7
ISSN	2047-9018 ; 0029-6570
ISSN (online)	2047-9018
ISSN	0029-6570
DOI	10.7748/ns.29.4.63.s49
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Article: Diclofenac and dexamethasone modulate the effect of cannabidiol on the rat colon motility

Chłopecka, Magdalena / Kiraga, Łukasz / Crowley, Kijan / Jank, Michał / Latek, Urszula / Mendel, Marta / Karlik, Wojciech

Journal of veterinary research

2023 Volume 67, Issue 2, Page(s) 289–295

Abstract: Introduction: Due to the growing interest in the use of cannabinoids in supportive therapies, they are increasingly used together with anti-inflammatory drugs. Cannabinoids inhibit gastrointestinal motility, while steroidal and nonsteroidal anti- ... ...

Abstract	Introduction: Due to the growing interest in the use of cannabinoids in supportive therapies, they are increasingly used together with anti-inflammatory drugs. Cannabinoids inhibit gastrointestinal motility, while steroidal and nonsteroidal anti-inflammatory drugs influence motility in other ways. The aim of the research was to study the interactions between cannabidiol (CBD) and these two classes of anti-inflammatory drugs in the context of gastrointestinal motility. Dexamethasone (DEX) was selected as a steroidal drug and diclofenac (DCF) as a nonsteroidal counterpart. Material and methods: The experiments were performed on isolated rat colon strips in isometric conditions. The contractile response to acetylcholine (ACh) (1 μM) was measured with no substance applied as a control value and was measured after application of CBD (80 μM), DEX (100 μM), DCF (100 μM), or a combination of these substances. Results: Cannabidiol strongly inhibited intestinal motility mediated by ACh application, DCF inhibited it non-significantly, while DEX intensified it. When CBD was co-administered with DEX, the combination inhibited intestinal motility non-significantly relative to the ACh-only control. Co-administration of CBD with DCF inhibited motility more than when these substances were administered separately. Conclusion: Inhibition of the intestinal response to ACh is likely due to the synergistic effect of CBD and endogenous cannabinoids. Dexamethasone lessened the inhibitory effect of CBD, likely because of diminished availability of the arachidonic acid necessary for endogenous cannabinoid synthesis. However, diclofenac may increase endogenous cannabinoid synthesis, because of the greater availability of arachidonic acid caused by DCF blocking the cyclooxygenation pathway.
Language	English
Publishing date	2023-06-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2855010-9
ISSN	2450-8608 ; 2450-7393
ISSN (online)	2450-8608
ISSN	2450-7393
DOI	10.2478/jvetres-2023-0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: PROMs in the Community Practice Setting: An Institutional Experience.

Turcotte, Justin / Crowley, Kevin / Adams, Stephanie / Gelfand, Jeffrey / Patton, Chad

HSS journal : the musculoskeletal journal of Hospital for Special Surgery

2022 Volume 19, Issue 1, Page(s) 7–12

Language	English
Publishing date	2022-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2250601-9
ISSN	1556-3324 ; 1556-3316
ISSN (online)	1556-3324
ISSN	1556-3316
DOI	10.1177/15563316221109827
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Book ; Online: The Design of Tangible Digital Musical Instruments

Young, Gareth W. / Crowley, Katie

2020

Abstract: Here we present guidelines that highlight the impact of haptic feedback upon the experiences of computer musicians using Digital Musical Instruments (DMIs). In this context, haptic feedback offers a tangible, bi-directional exchange between a musician ... ...

Abstract	Here we present guidelines that highlight the impact of haptic feedback upon the experiences of computer musicians using Digital Musical Instruments (DMIs). In this context, haptic feedback offers a tangible, bi-directional exchange between a musician and a DMI. We propose that by adhering to and exploring these guidelines the application of haptic feedback can enhance and augment the physical and affective experiences of a musician in interactions with these devices. It has been previously indicated that in the design of haptic DMIs, the experiences and expectations of a musician must be considered for the creation of tangible DMIs and that haptic feedback can be used to address the physical-digital divide that currently exists between users of such instruments. Comment: MusTWork 2016
Keywords	Computer Science - Human-Computer Interaction ; Computer Science - Multimedia
Publishing date	2020-10-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sleep and sleep disorders in older adults.

Crowley, Kate

Neuropsychology review

2011 Volume 21, Issue 1, Page(s) 41–53

Abstract: A common but significant change associated with aging is a profound disruption to the daily sleep-wake cycle. It has been estimated that as many as 50% of older adults complain about difficulty initiating or maintaining sleep. Poor sleep results in ... ...

Abstract	A common but significant change associated with aging is a profound disruption to the daily sleep-wake cycle. It has been estimated that as many as 50% of older adults complain about difficulty initiating or maintaining sleep. Poor sleep results in increased risk of significant morbidity and mortality. Moreover, in younger adults, compromised sleep has been shown to have a consistent effect on cognitive function, which may suggest that sleep problems contribute to the cognitive changes that accompany older age. The multifactorial nature of variables affecting sleep in old age cannot be overstated. Changes in sleep have been thought to reflect normal developmental processes, which can be further compromised by sleep disturbances secondary to medical or psychiatric diseases (e.g., chronic pain, dementia, depression), a primary sleep disorder that can itself be age-related (e.g., Sleep Disordered Breathing and Periodic Limb Movements During Sleep), or some combination of any of these factors. Given that changes in sleep quality and quantity in later life have implications for quality of life and level of functioning, it is imperative to distinguish the normal age-related sleep changes from those originating from pathological processes.
MeSH term(s)	Aged/physiology ; Aging/physiology ; Circadian Rhythm/physiology ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Nervous System Diseases/complications ; REM Sleep Behavior Disorder/physiopathology ; REM Sleep Behavior Disorder/psychology ; Sleep/physiology ; Sleep Apnea Syndromes/physiopathology ; Sleep Apnea Syndromes/psychology ; Sleep Initiation and Maintenance Disorders/physiopathology ; Sleep Initiation and Maintenance Disorders/psychology ; Sleep Wake Disorders/physiopathology ; Sleep, REM/physiology
Language	English
Publishing date	2011-01-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1062572-0
ISSN	1573-6660 ; 1040-7308
ISSN (online)	1573-6660
ISSN	1040-7308
DOI	10.1007/s11065-010-9154-6
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Article ; Online: A Quantitative Framework to Identify and Prioritize Opportunities in Biomedical Product Innovation: A Proof-of-Concept Study.

Gressler, Laura Elisabeth / Crowley, Kenyon / Berliner, Elise / Leroy, Hartley / Krofah, Esther / Eloff, Benjamin / Marinac-Dabic, Danica / Vythilingam, Meena

JAMA health forum

2023 Volume 4, Issue 5, Page(s) e230894

Abstract: Importance: Prioritization and funding for health initiatives, including biomedical innovation, may not consistently target unmet public health needs.: Objective: To (1) develop a quantitative, databased framework to identify and prioritize ... ...

Abstract	Importance: Prioritization and funding for health initiatives, including biomedical innovation, may not consistently target unmet public health needs. Objective: To (1) develop a quantitative, databased framework to identify and prioritize opportunities for biomedical product innovation investments based on a multicriteria decision-making model (MCDM) that includes comprehensive measures of public health burden and health care costs, and (2) pilot test the model. Design, setting, and participants: The Department of Health and Human Services (HHS) convened public and private experts to develop a model, select measures, and complete a longitudinal pilot study to identify and prioritize opportunities for investment in biomedical product innovations that have the greatest public health benefit. Cross-sectional and longitudinal data (2012-2019) for 13 pilot medical disorders were obtained from the Institute for Health Metrics Global Burden of Disease database (IHME GBD) and the National Center for Health Statistics (NCHS). Main outcome measures: The main outcome measure was an overall gap score reflecting high public health burden (composite measure of mortality, prevalence, years lived with disability, and health disparities), or high health care costs (composite measure of total, public, and out-of-pocket health spending) relative to low biomedical innovation. Sixteen innovation metrics were selected to reflect the pipeline of biomedical products from research and development to market approval. A higher score indicates a greater gap. Normalized composite scores were calculated for public health burden, cost, and innovation investment using the MCDM Technique for Order of Preference by Similarity to Ideal Solution method. Results: Among the 13 conditions tested in the pilot study, diabetes (0.61), osteoarthritis (0.46), and drug-use disorders (0.39) had the highest overall gap score reflecting high public health burden, or high health care costs relative to low biomedical innovation in these medical disorders. Chronic kidney disease (0.05), chronic obstructive pulmonary disease (0.09), and cirrhosis and other liver diseases (0.10) had the least amount of biomedical product innovation despite similar public health burden and health care cost scores. Conclusions: In this cross-sectional pilot study, we developed and implemented a data-driven, proof-of-concept model that can help identify, quantify, and prioritize opportunities for biomedical product innovation. Quantifying the relative alignment between biomedical product innovation, public health burden, and health care cost may help identify and prioritize investments that can have the greatest public health benefit.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Pilot Projects ; Health Care Costs ; Health Expenditures ; Prevalence
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article
ISSN	2689-0186
ISSN (online)	2689-0186
DOI	10.1001/jamahealthforum.2023.0894
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reduction in Antibiotic Delivery Time Following Improving Pediatric Sepsis Outcomes Quality Improvement Initiative at a Major Children's Hospital.

Gill, Meghan / Raghu, Vikram / Ferguson, Elizabeth / Marcinick, Adrienne / Rosen, Johanna / Butler, Gabriella / Horvat, Christopher / Crowley, Kelli

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

2023 Volume 28, Issue 1, Page(s) 55–62

Abstract: Objective: Sepsis causes morbidity and mortality in pediatric patients, but timely antibiotic administration can improve sepsis outcomes. The pharmacy department can affect the time from order to delivery of antibiotics. By evaluating the pharmacy ... ...

Abstract	Objective: Sepsis causes morbidity and mortality in pediatric patients, but timely antibiotic administration can improve sepsis outcomes. The pharmacy department can affect the time from order to delivery of antibiotics. By evaluating the pharmacy process, this study aimed to decrease the time from antibiotic order to delivery to within 45 minutes. Methods: All antibiotic orders placed following a positive sepsis screen for acute care patients at a freestanding children's hospital from April 1, 2019, to December 31, 2019, were reviewed. Lean Six Sigma methodology including process mapping was used to identify and implement improvements, including educational interventions for providers. Outcome measures included time from antibiotic order placement to delivery and to administration. Additional assessment of process measures included evaluation of order priority, PowerPlan (an internally created order set) use, and delivery method. Results: Ninety-eight antibiotic orders for 85 patients were evaluated. In an individual chart of antibiotic delivery time, a trend towards faster delivery time was observed after interventions. Stat orders (40.5 minutes [IQR, 19.5-48]) were delivered more quickly than routine orders (51 minutes [IQR, 45-65]; p < 0.001). Orders using the PowerPlan (20.5 minutes [IQR, 18.5-38]) were delivered more quickly than those that did not (47 minutes [IQR, 34-64]; p < 0.01). Shorter time to administration was observed with pneumatic tube delivery (41 minutes [IQR, 20-50]) than with direct delivery to a health care provider (51 minutes [IQR, 31-83]; p < 0.05) or to the automated dispensing cabinet's refrigerator (47 minutes [IQR, 41-62]; p < 0.0001). Conclusions: Multifactorial coordinated interventions within the pharmacy department improve medication delivery time for pediatric sepsis antibiotic orders.
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028543-4
ISSN	1551-6776
ISSN	1551-6776
DOI	10.5863/1551-6776-28.1.55
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: The Bible Exposed - Why God has Left the Building

Crowley, Keith

2012

Abstract: In 'The Bible Exposed - Why God has left the building' the author deconstructs many of Christianity's most cherished illusions. He lifts the lid off the Christian Bible's collection of scientific errors, ancient myths, legends and constant contradictions, ...

Abstract	In 'The Bible Exposed - Why God has left the building' the author deconstructs many of Christianity's most cherished illusions. He lifts the lid off the Christian Bible's collection of scientific errors, ancient myths, legends and constant contradictions, and demonstrates that the Bible can only be a man-made artefact untouched by divine involvement or inspiration. The difference between what the Bible actually says and what Christianity teaches will astonish you. For instance, who killed Goliath? Everyone thinks that they know the answer. Everyone is amazed when they read what the Bible actu
Language	English
Size	Online-Ressource (430 p)
Publisher	Grosvenor House Publishing
Publishing place	Claygate
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781781485385 ; 1781485380
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Enhancing Partner Nation Security: A Mixed-Methods Evaluation of A Peacekeeping Public Health Capacity Building Initiative.

Snowden, Bobbi S / Licina, Derek / Crowley, Kathleen / Migliaccio, Gene / Ramsey, Sueann

Military medicine

2021 Volume 188, Issue 1-2, Page(s) e359–e367

Abstract: Introduction: One way the U.S. Department of Defense (DoD) works to achieve national security is through security cooperation, by way of building and enhancing partner nation capacity. This study evaluated a health-related security cooperation training ... ...

Abstract	Introduction: One way the U.S. Department of Defense (DoD) works to achieve national security is through security cooperation, by way of building and enhancing partner nation capacity. This study evaluated a health-related security cooperation training initiative delivered by the DoD to military peacekeepers. The study specifically examined outcomes of change, including the beginning phase of sustainability. Materials and methods: The U.S. DoD employed a train-the-trainer model in Ghana, Rwanda, Senegal, and Uganda to support the African Peacekeeping Rapid Response Partnership program. U.S. instructors trained 192 peacekeepers through 11 training iterations between December 2016 and March 2020. A mixed-method explanatory sequential design was used to explore training outcomes. Quantitatively, three hypotheses were tested using nonparametric statistical analysis. Qualitative analysis of documents was used to inform and contextually understand the quantitative results. This study was submitted to the George Washington University Institutional Review Board and was fully approved (NCR202918). Results: Quantitative and qualitative results indicated improved short-term public health knowledge and upskill among partner nation participants. There was the beginning of a cascade effect of the partner nations' ability to autonomously teach tasks and skills to their military to sustain the initiative. Differences in achieving and maintaining change outcomes were related to student characteristics, the training course, and the partner nation. Conclusions: This research serves as the first published study to empirically examine health-related security cooperation train-the-trainer initiative change outcomes. This research is an essential building block to empirically evaluate and capture change outcomes from security cooperation capacity building training initiatives. The findings and recommendations inform security cooperation policy and associated investments.
MeSH term(s)	Humans ; Capacity Building ; Public Health ; Washington ; Military Personnel ; Universities
Language	English
Publishing date	2021-07-25
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usab306
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