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Book ; Online: Gene Polymorphism and Nutrition: Relationships with Chronic Disease

de Luis Roman, Daniel-Antonio / Crujeiras, Ana B

2023

Keywords	Medicine ; Chronic Disease ; Personalized Nutrition ; Single nucleotide polymorphism
Language	English
Size	1 electronic resource (152 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030649912
ISBN	9783036577715 ; 3036577718
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Resting metabolic rate of obese patients under very low calorie ketogenic diet

Crujeiras, Ana B

Nutrition & metabolism, 15:18

2018

Abstract: BACKGROUND: The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations ... ...

Abstract	BACKGROUND: The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet induced severe body weight (BW) loss. METHOD: From 20 obese patients who lost 20.2 kg of BW after a 4-months VLCK-diet, blood samples and body composition analysis, determined by DXA and MF-Bioimpedance, and RMR by indirect calorimetry, were obtained on four subsequent visits: visit C-1, basal, initial fat mass (FM) and free fat mass (FFM); visit C-2, − 7.2 kg in FM, − 4.3 kg in FFM, maximal ketosis; visit C-3, − 14.4 kg FM, − 4.5 kg FFM, low ketosis; visit C-4, − 16.5 kg FM, − 3.8 kg FFM, no ketosis. Each subject acted as his own control. RESULTS: Despite the large BW reduction, measured RMR varied from basal visit C-1 to visit C-2, − 1.0%; visit C-3, − 2.4% and visit C-4, − 8.0%, without statistical significance. No metabolic adaptation was observed. The absent reduction in RMR was not due to increased sympathetic tone, as thyroid hormones, catecholamines, and leptin were reduced at any visit from baseline. Under regression analysis FFM, adjusted by levels of ketonic bodies, was the only predictor of the RMR changes (R2 = 0.36; p < 0.001). CONCLUSION: The rapid and sustained weight and FM loss induced by VLCK-diet in obese subjects did not induce the expected reduction in RMR, probably due to the preservation of lean mass. TRIAL REGISTRATION: This is a follow up study on a published clinical trial.
Keywords	DXA ; Energy expenditure ; Ketogenic diet ; Indirect calorimetry ; Obesity ; Metabolic adaptation ; Multifrequency BIA ; Pronokal method ; Protein diet ; Very low-energy diet
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article ; Online: Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks.

Lorenzo, Paula M / Crujeiras, Ana B

Food & function

2021 Volume 12, Issue 4, Page(s) 1402–1414

Abstract: Obesity is a modifiable risk factor of breast cancer and epigenetic marks were proposed as a relevant mechanistic link. These mechanisms can be remodelled by modifying lifestyle factors and this fact could be useful in the treatment of obesity-related ... ...

Abstract	Obesity is a modifiable risk factor of breast cancer and epigenetic marks were proposed as a relevant mechanistic link. These mechanisms can be remodelled by modifying lifestyle factors and this fact could be useful in the treatment of obesity-related breast cancer. This review aimed to reveal the current evidence on the effects of differences in body composition and lifestyle factors on the risk, treatment, and survival of breast cancer with a focus on the effects of weight loss therapies based on different nutrients, bioactive compounds, and Mediterranean and ketogenic diets to counteract obesity-related breast cancer epigenetic marks. This review was framed on the most relevant and recently published articles and abstracts selected in PubMed using key words related to epigenetics, lifestyle, dietary habits, nutrients, bioactive compounds, ketone bodies, and weight loss treatments in obesity and breast cancer. Several studies have demonstrated that lifestyle interventions, including dietary modifications towards a healthy diet pattern, are effective therapies to prevent the onset of breast cancer and to improve the survival after treatment. These therapies reduce the main factors associated with obesity that are links between adiposity and cancer, including oxidative stress, inflammation and epigenetic mechanisms. However, although sufficient evidence exists regarding the effects of nutrients, dietary patterns, and weight loss therapies to prevent breast cancer or to improve survival, the effects of these strategies on the oncological treatment response were less studied. This review summarises the current scientific evidence regarding these nutritional strategies as adjuvant therapies in the management of obesity-related breast cancer by remodelling epigenetic marks related to carcinogenesis.
MeSH term(s)	Body Composition ; Breast Neoplasms/etiology ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Diet, Healthy ; Epigenesis, Genetic/genetics ; Female ; Genetic Markers ; Humans ; Life Style ; Nutrition Therapy ; Obesity/complications ; Prognosis ; Risk Factors ; Weight Loss
Chemical Substances	Genetic Markers
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d0fo01984d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Obesity-Related Epigenetic Changes After Bariatric Surgery.

Izquierdo, Andrea G / Crujeiras, Ana B

Frontiers in endocrinology

2019 Volume 10, Page(s) 232

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2019-04-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2019.00232
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of epigenomic mechanisms in the onset and management of insulin resistance.

Izquierdo, Andrea G / Crujeiras, Ana B

Reviews in endocrine & metabolic disorders

2019 Volume 20, Issue 1, Page(s) 89–102

Abstract: The prevalence of insulin resistance (IR) is increasing rapidly worldwide and it is a relevant health problem because it is associated with several diseases, such as type 2 diabetes, cardiovascular disorders and cancer. Understanding the mechanisms ... ...

Abstract	The prevalence of insulin resistance (IR) is increasing rapidly worldwide and it is a relevant health problem because it is associated with several diseases, such as type 2 diabetes, cardiovascular disorders and cancer. Understanding the mechanisms involved in IR onset and progression will open new avenues for identifying biomarkers for preventing and treating IR and its co-diseases. Epigenetic mechanisms such as DNA methylation are important factors that mediate the environmental effect in the genome by regulating gene expression and consequently its effect on the phenotype and the development of disease. Taking into account that IR results from a complex interplay between genes and the environment and that epigenetic marks are reversible, disentangling the relationship between IR and epigenetics will provide new tools to improve the management and prevention of IR. Here, we review the current scientific evidence regarding the association between IR and epigenetic markers as mechanisms involved in IR development and potential management.
MeSH term(s)	Biomarkers/chemistry ; DNA Methylation/genetics ; Diabetes Mellitus, Type 2/genetics ; Epigenomics/methods ; Humans ; Insulin Resistance/genetics ; Insulin Resistance/physiology ; RNA, Untranslated/genetics
Chemical Substances	Biomarkers ; RNA, Untranslated
Language	English
Publishing date	2019-03-18
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-019-09485-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reducing Metabolic Syndrome through a Group Educational Intervention Program in Adults with Obesity: IGOBE Program

Tejera, Cristina / Porca, Cristina / Rodriguez-Carnero, Gemma / Andújar, Paula / Casanueva, Felipe F. / Bellido, Diego / Crujeiras, Ana B.

Nutrients. 2022 Mar. 03, v. 14, no. 5

2022

Abstract: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, type 2 diabetes mellitus, and cancer. Despite the higher prevalence of MetS in obese adults, little is known about the effectiveness of intensive and group interventions in improving ...

Abstract	Metabolic syndrome (MetS) increases the risk of cardiovascular disease, type 2 diabetes mellitus, and cancer. Despite the higher prevalence of MetS in obese adults, little is known about the effectiveness of intensive and group interventions in improving MetS prevalence. This study aimed to investigate the effectiveness of an intensive lifestyle program in reducing the prevalence of MetS in adults with obesity. Patients with obesity (n = 456, 48.8 ± 12.8 years, 18.5% male) were randomized in two groups as indicated in a prospective interventional real-life study: a control group (CG), in which patients received usual care, and an interventional group (IG), in which the patients participate in a healthy lifestyle habits program in six weekly sessions, IGOBE program. Anthropometric, body composition, medications, and MetS features data were analyzed in both groups at the pre-intervention and post-intervention stages using a completer’s analysis. At 12 months of follow-up, the IG showed a relative reduction of 13.4% in the prevalence of MetS from baseline, while the CG showed a reduction of 2.1% (p < 0.001). A significant reduction was also observed in four of five MetS features. In this trial, implementation of the IGOBE program resulted in a significant reduction in MetS prevalence and better control of MetS features compared with the standard of care.
Keywords	body composition ; cardiovascular diseases ; lifestyle ; males ; metabolic syndrome ; noninsulin-dependent diabetes mellitus ; obesity ; risk
Language	English
Dates of publication	2022-0303
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051066
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gender Dimorphism in Hepatic Carcinogenesis-Related Gene Expression Associated with Obesity as a Low-Grade Chronic Inflammatory Disease.

Izquierdo, Andrea G / Carreira, Marcos C / Rodriguez-Carnero, Gemma / Perez-Lois, Raquel / Seoane, Luisa M / Casanueva, Felipe F / Crujeiras, Ana B

International journal of molecular sciences

2022 Volume 23, Issue 23

Abstract: Non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) show clear evidence of sexual dimorphism, with a significantly higher incidence in males. Among the determining factors that could explain this sex-based difference, the ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) show clear evidence of sexual dimorphism, with a significantly higher incidence in males. Among the determining factors that could explain this sex-based difference, the specific distribution of fat by sex has been suggested as a primary candidate, since obesity is a relevant risk factor. In this context, obesity, considered a low-grade chronic inflammatory pathology and responsible for the promotion of liver disease, could lead to sexual dimorphism in the expression profile of genes related to tumor development. When we compared the expression levels of genes associated with the early stages of carcinogenesis in the liver between male and female diet-induced obesity (DIO) rats, we observed that the expression pattern was similar in obese male and female animals. Interestingly, the
Language	English
Publishing date	2022-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232315002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Obesity and the reproductive system disorders: epigenetics as a potential bridge.

Crujeiras, Ana B / Casanueva, Felipe F

Human reproduction update

2015 Volume 21, Issue 2, Page(s) 249–261

Abstract: Background: Obesity and overweight are significantly involved in several reproductive pathologies contributing to infertility in men and women. In addition, several cancers of the reproductive system, such as endometrial, ovarian, breast, testicular and ...

Abstract	Background: Obesity and overweight are significantly involved in several reproductive pathologies contributing to infertility in men and women. In addition, several cancers of the reproductive system, such as endometrial, ovarian, breast, testicular and prostate cancers, are strongly influenced by obesity. However, the molecular mechanisms involved in the association between obesity and reproductive disorders remain unclear. Our proposal is to review the current scientific evidence regarding the effect of obesity-related factors as the core of the collective mechanisms directly and indirectly involved in the relationship between obesity and reproductive disorders, with a special and original focus on the effect of the obesity state microenvironment on the epigenetic profile as a reversible mechanistic link between obesity and the reproductive disorders. Methods: A PubMed search was performed using keywords related to obesity and adipose-related factors and epigenetics and associated with keywords related to reproduction. Full-text articles and abstracts in the English language published prior to 31 December 2013 were reviewed. Results: The obesity state notably contributes to a reproductive dysfunction in both men and women, ranging from infertility to oncological outcomes. Several epidemiological and experimental studies demonstrate that factors secreted by the adipose tissue and gut in an obesity state can directly induce reproductive disturbances. Relevantly, these same factors are able to alter the epigenetic regulation of genes, a dynamic and reversible mechanism by which the organism responds to environmental pressures critical to the reproductive function. Conclusion: This review outlines the evidence showing that the association between the reproductive pathologies and obesity is not inevitable but is potentially preventable and reversible. The epigenetic marks related to obesity could constitute a therapeutic target for the reproductive disorders associated with obesity.
MeSH term(s)	Adipose Tissue/metabolism ; Epigenesis, Genetic ; Female ; Gene Expression Regulation ; Humans ; Infertility/genetics ; Infertility/metabolism ; Male ; Models, Biological ; Obesity/complications ; Obesity/genetics ; Overweight ; Reproduction/physiology ; Stress, Physiological ; Urogenital Neoplasms/genetics
Language	English
Publishing date	2015-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1286738-x
ISSN	1460-2369 ; 1355-4786
ISSN (online)	1460-2369
ISSN	1355-4786
DOI	10.1093/humupd/dmu060
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Reducing Metabolic Syndrome through a Group Educational Intervention Program in Adults with Obesity: IGOBE Program.

Tejera, Cristina / Porca, Cristina / Rodriguez-Carnero, Gemma / Andújar, Paula / Casanueva, Felipe F / Bellido, Diego / Crujeiras, Ana B

Nutrients

2022 Volume 14, Issue 5

Abstract	Metabolic syndrome (MetS) increases the risk of cardiovascular disease, type 2 diabetes mellitus, and cancer. Despite the higher prevalence of MetS in obese adults, little is known about the effectiveness of intensive and group interventions in improving MetS prevalence. This study aimed to investigate the effectiveness of an intensive lifestyle program in reducing the prevalence of MetS in adults with obesity. Patients with obesity (n = 456, 48.8 ± 12.8 years, 18.5% male) were randomized in two groups as indicated in a prospective interventional real-life study: a control group (CG), in which patients received usual care, and an interventional group (IG), in which the patients participate in a healthy lifestyle habits program in six weekly sessions, IGOBE program. Anthropometric, body composition, medications, and MetS features data were analyzed in both groups at the pre-intervention and post-intervention stages using a completer’s analysis. At 12 months of follow-up, the IG showed a relative reduction of 13.4% in the prevalence of MetS from baseline, while the CG showed a reduction of 2.1% (p < 0.001). A significant reduction was also observed in four of five MetS features. In this trial, implementation of the IGOBE program resulted in a significant reduction in MetS prevalence and better control of MetS features compared with the standard of care.
MeSH term(s)	Adult ; Behavior Therapy ; Diabetes Mellitus, Type 2 ; Female ; Humans ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/prevention & control ; Obesity/complications ; Obesity/epidemiology ; Obesity/therapy ; Prospective Studies
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051066
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Food components affecting the epigenome: “Ergogenetic” aids for performance

Izquierdo, Andrea G / Portela, Manuel / Lorenzo, Paula M / Mallo, Federico / Crujeiras, Ana B

PharmaNutrition. 2020 Dec., v. 14

2020

Abstract: The interest in epigenetics has grown exponentially in recent years and this is because epigenetic marks are present in most life processes. It is known that the epigenome is determined by different environmental factors such as diet or exercise. For ... ...

Abstract	The interest in epigenetics has grown exponentially in recent years and this is because epigenetic marks are present in most life processes. It is known that the epigenome is determined by different environmental factors such as diet or exercise. For athletes, improving performance during physical activity or reducing recovery times after training are key priorities that are currently focusing on research in the world of sports. Nutritional strategies are important tools for this purpose, since more and more dietary supplements are used as ergogenic potentials. Therefore and given that nutrition modulates gene expression through epigenetic modifications, recent studies have aimed to elucidate possible epigenetic mechanisms responsible for the link between dietary supplements for athletes and improving performance during exercise. Thus, in this review we cite the latest most relevant studies carried out to date in relation to epigenetic marks associated with sports supplementation and performance.
Keywords	epigenetics ; epigenome ; exercise ; gene expression
Language	English
Dates of publication	2020-12
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ISSN	2213-4344
DOI	10.1016/j.phanu.2020.100231
Database	NAL-Catalogue (AGRICOLA)

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