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  1. Article: A Miniaturized Device Coupled with Digital Image Correlation for Mechanical Testing.

    Cruz, Daniel J / Xavier, Jose / Amaral, Rui L / Santos, Abel D

    Micromachines

    2022  Volume 13, Issue 11

    Abstract: Miniaturized mechanical testing based on small sample testing technology is a powerful technique to characterize the mechanical properties of different materials, and it is being used in different application fields. However, the small size of the ... ...

    Abstract Miniaturized mechanical testing based on small sample testing technology is a powerful technique to characterize the mechanical properties of different materials, and it is being used in different application fields. However, the small size of the specimens poses several challenges because the results are highly sensitive to measurement accuracy and the corresponding mechanical properties can change substantially due to the so-called specimen size effect. In this work, a novel testing device based on miniaturized specimens is presented. The equipment is designed to test materials in tensile and compressive loadings, but it is also capable of performing reverse-loading tests. Buckling of the specimen is an inherent phenomenon in compression loadings, especially for thin materials. Therefore, specimen geometry is properly studied and optimized to mitigate this effect. To evaluate the deformation of the specimen, the digital image correlation (DIC) technique is used to capture the full-field strain in the central gauge section of the sample. A sensitivity analysis of the DIC setting parameters was performed for this application. To evaluate the performance of the developed system, experimental results of monotonic tests and tests with reverse loadings (tension-compression) are presented, considering two high-strength steels (DP500 and DP780).
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi13112027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.

    Wick, Mark R / Santa Cruz, Daniel J / Gru, Alejandro A

    Seminars in diagnostic pathology

    2017  Volume 34, Issue 1, Page(s) 99–107

    Abstract: This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, ... ...

    Abstract This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered.
    MeSH term(s) Adenoma/diagnosis ; Carcinoma/diagnosis ; Diagnosis, Differential ; Hematologic Neoplasms/diagnosis ; Histiocytoma, Benign Fibrous/diagnosis ; Humans ; Melanoma/diagnosis ; Sarcoma/diagnosis ; Skin Neoplasms/diagnosis
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2016.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Atypical fibroxanthoma: a selective review.

    Gru, Alejandro A / Santa Cruz, Daniel J

    Seminars in diagnostic pathology

    2013  Volume 30, Issue 1, Page(s) 4–12

    Abstract: The head and neck area has disproportionate number of cutaneous tumors given the surface area, as compared with the rest of the body. Many of the tumors are related to chronic actinic damage and the most common by far are squamous and basal cell ... ...

    Abstract The head and neck area has disproportionate number of cutaneous tumors given the surface area, as compared with the rest of the body. Many of the tumors are related to chronic actinic damage and the most common by far are squamous and basal cell carcinomas. Atypical fibroxanthoma refers to a group of usually indolent cutaneous tumors that occur in older adults and are characterized histologically by a population of fusiform, epithelioid, and pleomorphic cells, numerous cells in mitosis, and intracytoplasmic lipidization in some cells. Numerous histologic variants have been described, including a clear-cell, desmoplastic or keloidal, granular, angiomatoid, hemosiderotic, and myxoid, among others. These tumors have a mesenchymal immunophenotype. Some authors believe that atypical fibroxanthoma is a dedifferentiated variant of squamous cell carcinoma. We present a review of this particular neoplasm with special emphasis on the histomorphology, subtypes, immunophenotypic profile, and discussion of differential diagnosis.
    MeSH term(s) Fibroma/metabolism ; Fibroma/pathology ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Mesoderm/metabolism ; Mesoderm/pathology ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Xanthomatosis/metabolism ; Xanthomatosis/pathology
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2012.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Osteochondrolipoma: a subcutaneous lipoma with chondroid and bone differentiation of the chest wall.

    Gru, Alejandro A / Santa Cruz, Daniel J

    Journal of cutaneous pathology

    2012  Volume 39, Issue 4, Page(s) 461–463

    Abstract: Lipomas are the most common subtype of benign soft tissue neoplasms and can occur anywhere in the body. Differentiation into a diversity of mesenchymal elements, such as blood vessels, fibrous tissue or muscle, is a frequent event. However, the presence ... ...

    Abstract Lipomas are the most common subtype of benign soft tissue neoplasms and can occur anywhere in the body. Differentiation into a diversity of mesenchymal elements, such as blood vessels, fibrous tissue or muscle, is a frequent event. However, the presence of bone or cartilage in these tumors is extraordinarily rare with very few cases reported in the head and neck area. We report a case of an 'osteochondrolipoma' of the chest wall, in a young individual, providing a rationale in support of this as a possible and distinctive histologic subtype of lipomas, as well as discussion in the differential diagnosis of this lesion.
    MeSH term(s) Adult ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Cartilage/metabolism ; Cartilage/pathology ; Cell Differentiation ; Humans ; Lipoma/metabolism ; Lipoma/pathology ; Male ; Osteochondroma/metabolism ; Osteochondroma/pathology ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Thoracic Wall/metabolism ; Thoracic Wall/pathology
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/j.1600-0560.2011.01855.x
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  5. Article: Introduction.

    Llombart-Bosch, Antonio / Monteagudo, Carlos / Santa Cruz, Daniel J

    Seminars in diagnostic pathology

    2013  Volume 30, Issue 1, Page(s) 1–3

    MeSH term(s) Cell Transformation, Neoplastic ; Dermis/cytology ; Humans ; Mesenchymal Stromal Cells/cytology ; Mesoderm/pathology ; Skin Neoplasms/diagnosis
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2012.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lipodermatosclerosis: a clinicopathological study of 25 cases.

    Walsh, Sarah N / Santa Cruz, Daniel J

    Journal of the American Academy of Dermatology

    2010  Volume 62, Issue 6, Page(s) 1005–1012

    Abstract: Background: Lipodermatosclerosis is a chronic fibrosing process that involves both lower legs and classically affects Caucasian women in their 60s.: Objective: The objective is to define the histologic spectrum seen this condition.: Methods: A ... ...

    Abstract Background: Lipodermatosclerosis is a chronic fibrosing process that involves both lower legs and classically affects Caucasian women in their 60s.
    Objective: The objective is to define the histologic spectrum seen this condition.
    Methods: A total of 25 cases were collected prospectively and all were stained with hematoxylin-eosin, von Kossa, and Verhoeff-van Gieson.
    Results: Patient age ranged from 33 to 84 years (mean age 62.6 years). The female to male ratio was approximately 12 to 1. All lesions were present on the lower extremities, between the knee and ankle. Lesion duration ranged from 2 months to 2 years (mean 9.5 months). Clinically, the lesions were erythematous, tender, indurated plaques or nodules. The characteristic histologic findings were seen almost exclusively in the subcutaneous tissue, involving primarily the lobules but also the septa. Adipose changes included micropseudocyst and macropseudocyst formation, necrotic adipocytes, lipomembranous change, and lipogranulomas with xanthomatous macrophages. The lesions were largely devoid of dermal, septal, or lobular neutrophilic or lymphocytic inflammation. Medium vessel calcification was seen in 13 cases. The accumulation of basophilic elastic fibers located deep in the septa was present in all the cases. These fibers had a moth-eaten appearance and resembled pseudoxanthoma elasticum. In 21 of 25 cases, these fibers were positive with both the von Kossa and Verhoeff-van Gieson stains.
    Limitations: The cases in the series were not compared with age-, sex-, and location-matched biopsy specimens or biopsy specimens of other fibrosing conditions.
    Conclusion: This constellation of histologic changes is diagnostic of lipodermatosclerosis. The presence of pseudoxanthoma elasticum-like changes is a helpful, but not unequivocal, clue in this condition.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Fat Necrosis/pathology ; Female ; Humans ; Leg Dermatoses/diagnosis ; Leg Dermatoses/pathology ; Male ; Middle Aged ; Panniculitis/pathology ; Scleroderma, Localized/diagnosis ; Scleroderma, Localized/pathology ; Subcutaneous Fat/pathology
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2009.08.006
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  7. Article ; Online: Hair cortex comedo: a series of 34 cases.

    Walsh, Sarah N / Cruz, Daniel J Santa / Hurt, Mark A

    The American Journal of dermatopathology

    2010  Volume 32, Issue 8, Page(s) 749–754

    Abstract: Hair cortex comedo was described originally in an article detailing 2 cases of a comedo-like clinical lesion that was histologically a keratinous plug with cornification similar to the cortex of the hair shaft. We have collected retro- and prospectively ... ...

    Abstract Hair cortex comedo was described originally in an article detailing 2 cases of a comedo-like clinical lesion that was histologically a keratinous plug with cornification similar to the cortex of the hair shaft. We have collected retro- and prospectively a series of 34 cases of hair cortex comedo. In our series, there was a slight female predominance (Male:Female of 1:1.4), and the mean patient age was 28.8 years. All lesions were solitary, distributed mainly on the head and neck or trunk, and were described clinically as a blue subcutaneous papule or nodule with "cyst" as the most common clinical differential diagnosis. Histologic examination showed a solitary, vertically oriented, uniformly sized oval nodule of compact laminated corneocytes sitting in a patulous invagination lined by epithelium similar to the infundibulum, isthmus, or combinations of them; rarely matrical epithelium was identified. Entrapped melanin (30/34 cases), shadow cells (16/34 cases), and calcification (12/34 cases) were identified commonly. Remnants of a surrounding follicle were noted in 15 cases, with infundibular epithelium in 9 of the cases, isthmic epithelium in 3, and matrical or supramatrical epithelium (or both) in 3. There was an associated dense granulomatous infiltrate in the majority of the cases (25/34). Although hair cortex comedo was thought originally to be a variant of dilated pore of Winer, we believe that these distinctive lesions, which are characterized histopathologically by a uniformly sized vertically oriented dermal plug of laminated corneocytes with entrapped melanin and surrounding granulomatous inflammation, are likely derived from matrical or supramatrical cells (or both).
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Calcinosis/pathology ; Child ; Child, Preschool ; Diagnosis, Differential ; Epithelial Cells/pathology ; Female ; Granuloma/pathology ; Hair Diseases/metabolism ; Hair Diseases/pathology ; Hair Follicle/chemistry ; Hair Follicle/pathology ; Humans ; Keratins/analysis ; Male ; Melanins/analysis ; Middle Aged ; Missouri ; Predictive Value of Tests ; Prospective Studies ; Retrospective Studies ; Young Adult
    Chemical Substances Melanins ; Keratins (68238-35-7)
    Language English
    Publishing date 2010-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0b013e3181e15b2e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Parathyroid hyperplasia of auto-transplanted tissue in forearm skin.

    Padgett, Sabrina N / Walsh, Sarah N / Santa Cruz, Daniel J

    Journal of cutaneous pathology

    2011  Volume 38, Issue 2, Page(s) 232–235

    Abstract: Currently, the treatment of choice for refractory tertiary hyperparathyroidism is a total parathyroidectomy with autotransplantation of the parathyroid tissue into the forearm. Recurrent hyperparathyroidism after autotransplantation requiring surgical ... ...

    Abstract Currently, the treatment of choice for refractory tertiary hyperparathyroidism is a total parathyroidectomy with autotransplantation of the parathyroid tissue into the forearm. Recurrent hyperparathyroidism after autotransplantation requiring surgical excision of the autograft is uncommon. We describe a female patient with recurrent hyperplasia who underwent an excision of her parathyroid autograft. The excisional specimen was submitted to pathology with the only provided history of a 'left arm mass'. The lack of clinical history led to a preliminary impression of an adnexal neoplasm by the primary pathologist.
    MeSH term(s) Adult ; Female ; Forearm/pathology ; Forearm/surgery ; Humans ; Hyperparathyroidism, Secondary/surgery ; Hyperplasia/pathology ; Kidney Failure, Chronic/complications ; Parathyroid Glands/pathology ; Parathyroid Glands/transplantation ; Transplantation, Autologous
    Language English
    Publishing date 2011-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/j.1600-0560.2009.01411.x
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  9. Article ; Online: Sclerotic glomus tumor.

    Vigovich, Felix A / Hurt, Mark A / Santa Cruz, Daniel J

    The American Journal of dermatopathology

    2010  Volume 32, Issue 1, Page(s) 76–78

    Abstract: We report an unusual histopathological variant of a glomus tumor that arose in a peculiar topographic site, a sclerotic glomus tumor. Unlike conventional glomus tumors or glomangiomas that have a loose fibrous stroma with variable hyaline and myxoid ... ...

    Abstract We report an unusual histopathological variant of a glomus tumor that arose in a peculiar topographic site, a sclerotic glomus tumor. Unlike conventional glomus tumors or glomangiomas that have a loose fibrous stroma with variable hyaline and myxoid changes, the case reported herein had a diffuse, hyalinized, sclerotic stroma. A further difference was that the majority of glomus tumors and glomangiomas occur in the subungual area, trunk, or extremities, whereas the present tumor occurred on the ear. Due to the peculiar histological features and location, other tumors were considered in the differential diagnosis to include Merkel cell carcinoma, primitive neuroectodermal tumor, and small cell melanoma. This article illustrates a unique variant of a glomus tumor, which to our knowledge has not been previously described.
    MeSH term(s) Adult ; Biomarkers, Tumor/metabolism ; Carcinoma, Merkel Cell/diagnosis ; Diagnosis, Differential ; Ear Auricle/pathology ; Ear Neoplasms/metabolism ; Ear Neoplasms/pathology ; Ear Neoplasms/surgery ; Female ; Glomus Tumor/metabolism ; Glomus Tumor/pathology ; Glomus Tumor/surgery ; Humans ; Immunoenzyme Techniques ; Melanoma/diagnosis ; Neuroectodermal Tumors, Primitive/diagnosis ; Sclerosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0b013e3181b119c6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Vascular tumors of the skin: a selective review.

    Hunt, Steven J / Santa Cruz, Daniel J

    Seminars in diagnostic pathology

    2005  Volume 21, Issue 3, Page(s) 166–218

    Abstract: Cutaneous vascular proliferations are a vast and complex spectrum. Many appear as hamartomas in infancy; others are acquired neoplasms. Some vascular proliferations are hyperplastic in nature, although they mimic hemangiomas, i.e., neoplasms. The vast ... ...

    Abstract Cutaneous vascular proliferations are a vast and complex spectrum. Many appear as hamartomas in infancy; others are acquired neoplasms. Some vascular proliferations are hyperplastic in nature, although they mimic hemangiomas, i.e., neoplasms. The vast majority of the vascular lesions are hemangiomas. Between the hemangiomas and frankly angiosarcomas, there is a group of neoplasms that are angiosarcomas, albeit ones of low grade histologically and, probably, biologically. The term "hemangioendothelioma" has been created to encompass these neoplasms. Vascular proliferations are, fundamentally, composed of endothelial cells. Some hemangiomas, however, contain also abundant pericytic, smooth muscle, or interstitial components, or a combination of them. These heterogeneous cellular components are present usually in hemangiomas. Some of the newly described vascular proliferations, however, are difficult to differentiate from some of the angiosarcomas. Others are markers, occasionally, of serious conditions such as Fabry's Disease (angiokeratoma) and POEM's syndrome (glomeruloid hemangioma). Kaposi's sarcoma continues to be an enigma. The demonstration of Herpes virus 8 in this condition raises doubt about its neoplastic nature. The demonstration of endothelial differentiation of its nodular lesions is tenuous and its true nature remains unresolved. While physicians have known about post-mastectomy angiosarcomas from the origin of the radical mastectomy, a new group of unusual vascular proliferations of the mammary skin are being defined. These lesions arise in the setting of breast-conserving surgical treatment with adjuvant radiation therapy. The incubation period is usually 3 to 5 years, in contrast with the 10, or more, in classical cases of post-mastectomy angiosarcoma. These lesions usually are subtle, both clinically and histologically, in contrast with the "classical," dramatic presentation of mammary angiosarcoma. The spectrum of findings ranges from "simple" lymphangiectasia-like vascular proliferations to unequivocal angiosarcomas. The pathogenesis of these lesions remains a mystery. There are very few clues that allow one to separate hemangiomas from angiosarcomas. The presence of heterologous cellular elements and, particularly, well-developed smooth muscle components tends to favor a hemangioma. Similarly, the presence of thrombosis usually supports hemangioma. Nevertheless, there are no unequivocal or reliable individual diagnostic criteria. A thorough knowledge of the different conditions and their differential diagnoses eventually leads to the proper diagnosis in most cases.
    MeSH term(s) Diagnosis, Differential ; Humans ; Skin Neoplasms/classification ; Skin Neoplasms/pathology ; Vascular Neoplasms/classification ; Vascular Neoplasms/pathology
    Language English
    Publishing date 2005-05-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2005.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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