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  1. Article: Alternative Treatments to Pharmacological Therapy in Pediatric Populations With Attention-Deficit/Hyperactivity Disorder (ADHD): A Scoping Review.

    Leon, Lexie / Tran, Tram / Navadia, Meera / Patel, Janavi / Vanderveen, Annelies / Cruz, Maria I / Le, Thuy-Mai / Assuah, Freda B / Prager, Victoria / Patel, Darshil / Costin, Joshua M

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55792

    Abstract: In recent years, there has been an increase in the prevalence of the diagnosis of attention-deficit/hyperactivity disorder (ADHD), a cognitive and behavioral disorder in which individuals present with inattention and impulsivity, in the pediatric ... ...

    Abstract In recent years, there has been an increase in the prevalence of the diagnosis of attention-deficit/hyperactivity disorder (ADHD), a cognitive and behavioral disorder in which individuals present with inattention and impulsivity, in the pediatric population. With an increase in diagnoses, there is also increasing concern regarding overdiagnosis and overtreatment with medications for ADHD. The objective of this study was to map out and compile the recent literature pertaining to alternative therapies (e.g., physical activity, diet, mindfulness, and computer-based interventions) for children and adolescents diagnosed with ADHD in an attempt to reduce or replace the use of pharmacological therapy. This scoping review searched articles from multiple databases (PubMed, ScienceDirect, Web of Science, Directory of Open Access Journals, Scopus, and CINAHL). Using search terms "children with ADHD," "alternative treatment," and "cognitive behavioral therapy," articles were identified that were specific to the research question. The inclusion criteria were patients under the age of 18 with a previous diagnosis of ADHD, no other comorbid illnesses, alternative treatments, and was limited to studies published between 2012 and 2022. After removing duplicates, screening for eligibility criteria, and conducting a critical appraisal of the articles, 16 articles were retained for the final review. The main alternative therapeutic domains that emerged were (1) physical activity, (2) diet, (3) mindfulness, (4) computer-based interventions, and (5) miscellaneous interventions. Seven articles assessed the effect of physical activity on executive and cognitive function in children and adolescents with ADHD. Most findings showed improvement with increased physical activity. Two articles explored the effect of diet on the improvement of ADHD symptoms and reported a positive impact. The two articles that evaluated the effects of mindfulness on ADHD symptoms reported a reduction in ADHD symptoms. Two studies evaluated the use of computer-based interventions as an adjunct treatment in children and adolescents with ADHD; improvements in symptoms were reported. One study each evaluated interventions based on music and nerve stimulation. These showed an improvement in attention, memory, and executive function. With the increasing prevalence of ADHD diagnosis in children and adolescents, alternative and/or adjunctive treatments may be a viable and valuable alternative to pharmaceutical interventions. The findings from this review suggest that multiple non-pharmacological interventions effectively reduce symptoms of ADHD in children and adolescents, including diet, exercise, mindfulness, computer-based interventions, music, and nerve stimulation. While there are implications for alternatives to be used in the future, more research is warranted using larger samples with controlled trials.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dual/multitargeted xanthone derivatives for Alzheimer's disease: where do we stand?

    Cruz, Maria I / Cidade, Honorina / Pinto, Madalena

    Future medicinal chemistry

    2017  Volume 9, Issue 14, Page(s) 1611–1630

    Abstract: To date, the current therapy for Alzheimer's disease (AD) based on acetylcholinesterase inhibitors is only symptomatic, being its efficacy limited. Hence, the recent research has been focused in the development of different pharmacological approaches. ... ...

    Abstract To date, the current therapy for Alzheimer's disease (AD) based on acetylcholinesterase inhibitors is only symptomatic, being its efficacy limited. Hence, the recent research has been focused in the development of different pharmacological approaches. Here we discuss the potential of xanthone derivatives as new anti-Alzheimer agents. The interference of xanthone derivatives with acetylcholinesterase and other molecular targets and cellular mechanisms associated with AD have been recently systematically reported. Therefore, we report xanthones with anticholinesterase, monoamine oxidase and amyloid β aggregation inhibitory activities as well as antioxidant properties, emphasizing xanthone derivatives with dual/multitarget activity as potential agents to treat AD. We also propose the structural features for these activities that may guide the design of new, more effective xanthone derivatives. [Formula: see text].
    MeSH term(s) Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Alzheimer Disease/drug therapy ; Amyloid beta-Peptides/metabolism ; Antioxidants/chemistry ; Antioxidants/metabolism ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/therapeutic use ; Humans ; Monoamine Oxidase/chemistry ; Monoamine Oxidase/metabolism ; Protein Binding ; Structure-Activity Relationship ; Xanthones/chemistry ; Xanthones/metabolism ; Xanthones/therapeutic use
    Chemical Substances Amyloid beta-Peptides ; Antioxidants ; Cholinesterase Inhibitors ; Xanthones ; Monoamine Oxidase (EC 1.4.3.4) ; Acetylcholinesterase (EC 3.1.1.7)
    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Journal Article
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2017-0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: M-tropic HIV envelope protein gp120 exhibits a different neuropathological profile than T-tropic gp120 in rat striatum.

    Bachis, Alessia / Cruz, Maria I / Mocchetti, Italo

    The European journal of neuroscience

    2010  Volume 32, Issue 4, Page(s) 570–578

    Abstract: Most early human immunodeficiency virus type 1 (HIV-1) strains are macrophage (M)-tropic HIV variants and use the chemokine receptor CCR5 for infection. Neuronal loss and dementia are less severe among individuals infected with M-tropic strains. However, ...

    Abstract Most early human immunodeficiency virus type 1 (HIV-1) strains are macrophage (M)-tropic HIV variants and use the chemokine receptor CCR5 for infection. Neuronal loss and dementia are less severe among individuals infected with M-tropic strains. However, after several years, the T-cell (T)-tropic HIV strain, which uses the CXCR4 variant, can emerge in conjunction with brain abnormalities, suggesting strain-specific differences in neuropathogenicity. The molecular and cellular mechanisms of such diversity remain under investigation. We have previously demonstrated that HIV envelope protein gp120IIIB, which binds to CXCR4, causes neuronal apoptosis in rodents. Thus, we have used a similar experimental model to examine the neurotoxic effects of M-tropic gp120BaL. gp120BaL was microinjected in the rat striatum and neuronal apoptosis was examined in the striatum, as well as in anatomically connected areas, such as the somatosensory cortex and the substantia nigra. gp120BaL promoted neuronal apoptosis and tissue loss that were confined to the striatum. Apoptosis was associated with microglial activation and increased levels of interleukin-1beta. Intriguingly, gp120BaL increased brain-derived neurotrophic factor in the striatum. Overall, our data show that gp120BaL demonstrates a different neuropathological profile than gp120IIIB. A better understanding of the pathogenic mechanisms mediating HIV neurotoxicity is vital for developing effective neuroprotective therapies against AIDS-associated dementia complex.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Brain/anatomy & histology ; Brain/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Cell Survival/drug effects ; HIV Envelope Protein gp120/metabolism ; HIV Envelope Protein gp120/pharmacology ; Humans ; Male ; Microglia/drug effects ; Microglia/metabolism ; Neurons/cytology ; Neurons/drug effects ; Neurons/physiology ; Protein Isoforms/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, CCR5/metabolism ; Receptors, CXCR4/metabolism
    Chemical Substances Brain-Derived Neurotrophic Factor ; HIV Envelope Protein gp120 ; Protein Isoforms ; Receptors, CCR5 ; Receptors, CXCR4
    Language English
    Publishing date 2010-07-28
    Publishing country France
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/j.1460-9568.2010.07325.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pathophysiological response to experimental diffuse brain trauma differs as a function of developmental age.

    Cernak, Ibolja / Chang, Taeun / Ahmed, Farid A / Cruz, Maria I / Vink, Robert / Stoica, Bogdan / Faden, Alan I

    Developmental neuroscience

    2010  Volume 32, Issue 5-6, Page(s) 442–453

    Abstract: The purpose of experimental models of traumatic brain injury (TBI) is to reproduce selected aspects of human head injury such as brain edema, contusion or concussion, and functional deficits, among others. As the immature brain may be particularly ... ...

    Abstract The purpose of experimental models of traumatic brain injury (TBI) is to reproduce selected aspects of human head injury such as brain edema, contusion or concussion, and functional deficits, among others. As the immature brain may be particularly vulnerable to injury during critical periods of development, and pediatric TBI may cause neurobehavioral deficits, our aim was to develop and characterize as a function of developmental age a model of diffuse TBI (DTBI) with quantifiable functional deficits. We modified a DTBI rat model initially developed by us in adult animals to study the graded response to injury as a function of developmental age - 7-, 14- and 21-day-old rats compared to young adult (3-month-old) animals. Our model caused motor deficits that persisted even after the pups reached adulthood, as well as reduced cognitive performance 2 weeks after injury. Moreover, our model induced prominent edema often seen in pediatric TBI, particularly evident in 7- and 14-day-old animals, as measured by both the wet weight/dry weight method and diffusion-weighted MRI. Blood-brain barrier permeability, as measured by the Evans blue dye technique, peaked at 20 min after trauma in all age groups, with a second peak found only in adult animals at 24 h after injury. Phosphorus MR spectroscopy showed no significant changes in the brain energy metabolism of immature rats with moderate DTBI, in contrast to significant decreases previously identified in adult animals.
    MeSH term(s) Age Factors ; Animals ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/physiopathology ; Brain/growth & development ; Brain/physiopathology ; Brain Edema/etiology ; Brain Edema/pathology ; Brain Edema/physiopathology ; Brain Injuries/complications ; Brain Injuries/pathology ; Brain Injuries/physiopathology ; Capillary Permeability ; Disease Models, Animal ; Magnetic Resonance Spectroscopy ; Male ; Rats ; Rats, Sprague-Dawley
    Language English
    Publishing date 2010
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 556887-0
    ISSN 1421-9859 ; 0378-5866
    ISSN (online) 1421-9859
    ISSN 0378-5866
    DOI 10.1159/000320085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pathophysiological Response to Experimental Diffuse Brain Trauma Differs as a Function of Developmental Age

    Cernak, Ibolja / Chang, Taeun / Ahmed, Farid A. / Cruz, Maria I. / Vink, Robert / Stoica, Bogdan / Faden, Alan I.

    Developmental Neuroscience

    2010  Volume 32, Issue 5-6, Page(s) 442–453

    Abstract: The purpose of experimental models of traumatic brain injury (TBI) is to reproduce selected aspects of human head injury such as brain edema, contusion or concussion, and functional deficits, among others. As the immature brain may be particularly ... ...

    Institution Department of Neuroscience, Georgetown University Medical Center, and Pediatrics and Neurology, Children’s National Medical Center, Washington, D.C Johns Hopkins University Applied Physics Laboratory Biomedicine Business Area, National Security Technology Department, Laurel, Md., and Shock Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, Md., USA Department of Pathology, University of Adelaide, Adelaide, S.A., Australia
    Abstract The purpose of experimental models of traumatic brain injury (TBI) is to reproduce selected aspects of human head injury such as brain edema, contusion or concussion, and functional deficits, among others. As the immature brain may be particularly vulnerable to injury during critical periods of development, and pediatric TBI may cause neurobehavioral deficits, our aim was to develop and characterize as a function of developmental age a model of diffuse TBI (DTBI) with quantifiable functional deficits. We modified a DTBI rat model initially developed by us in adult animals to study the graded response to injury as a function of developmental age – 7-, 14- and 21-day-old rats compared to young adult (3-month-old) animals. Our model caused motor deficits that persisted even after the pups reached adulthood, as well as reduced cognitive performance 2 weeks after injury. Moreover, our model induced prominent edema often seen in pediatric TBI, particularly evident in 7- and 14-day-old animals, as measured by both the wet weight/dry weight method and diffusion-weighted MRI. Blood-brain barrier permeability, as measured by the Evans blue dye technique, peaked at 20 min after trauma in all age groups, with a second peak found only in adult animals at 24 h after injury. Phosphorus MR spectroscopy showed no significant changes in the brain energy metabolism of immature rats with moderate DTBI, in contrast to significant decreases previously identified in adult animals.
    Keywords Diffuse traumatic brain injury ; Brain, immature ; Motor deficit ; Brain edema
    Language English
    Publishing date 2010-10-14
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Basic Science Research
    ZDB-ID 556887-0
    ISBN 978-3-8055-9543-8 ; 978-3-8055-9544-5 ; 3-8055-9543-3 ; 3-8055-9544-1
    ISSN 1421-9859 ; 0378-5866
    ISSN (online) 1421-9859
    ISSN 0378-5866
    DOI 10.1159/000320085
    Database Karger publisher's database

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  6. Article ; Online: Pathophysiological Response to Experimental Diffuse Brain Trauma Differs as a Function of Developmental Age

    Cernak, Ibolja / Chang, Taeun / Ahmed, Farid A. / Cruz, Maria I. / Vink, Robert / Stoica, Bogdan / Faden, Alan I.

    Developmental Neuroscience

    2010  Volume 32, Issue 5-6, Page(s) 442–453

    Abstract: The purpose of experimental models of traumatic brain injury (TBI) is to reproduce selected aspects of human head injury such as brain edema, contusion or concussion, and functional deficits, among others. As the immature brain may be particularly ... ...

    Abstract The purpose of experimental models of traumatic brain injury (TBI) is to reproduce selected aspects of human head injury such as brain edema, contusion or concussion, and functional deficits, among others. As the immature brain may be particularly vulnerable to injury during critical periods of development, and pediatric TBI may cause neurobehavioral deficits, our aim was to develop and characterize as a function of developmental age a model of diffuse TBI (DTBI) with quantifiable functional deficits. We modified a DTBI rat model initially developed by us in adult animals to study the graded response to injury as a function of developmental age - 7-, 14- and 21-day-old rats compared to young adult (3-month-old) animals. Our model caused motor deficits that persisted even after the pups reached adulthood, as well as reduced cognitive performance 2 weeks after injury. Moreover, our model induced prominent edema often seen in pediatric TBI, particularly evident in 7- and 14-day-old animals, as measured by both the wet weight/dry weight method and diffusion-weighted MRI. Blood-brain barrier permeability, as measured by the Evans blue dye technique, peaked at 20 min after trauma in all age groups, with a second peak found only in adult animals at 24 h after injury. Phosphorus MR spectroscopy showed no significant changes in the brain energy metabolism of immature rats with moderate DTBI, in contrast to significant decreases previously identified in adult animals.
    Keywords Diffuse traumatic brain injury ; Brain, immature ; Motor deficit ; Brain edema
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 556887-0
    ISSN 1421-9859 ; 0378-5866 ; 0378-5866
    ISSN (online) 1421-9859
    ISSN 0378-5866
    DOI 10.1159/000320085
    Database Karger publisher's database

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  7. Article: The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats.

    Cernak, Ibolja / Vink, Robert / Zapple, David N / Cruz, Maria I / Ahmed, Farid / Chang, Taeun / Fricke, Stanley T / Faden, Alan I

    Neurobiology of disease

    2004  Volume 17, Issue 1, Page(s) 29–43

    Abstract: Experimental models of traumatic brain injury have been developed to replicate selected aspects of human head injury, such as contusion, concussion, and/or diffuse axonal injury. Although diffuse axonal injury is a major feature of clinical head injury, ... ...

    Abstract Experimental models of traumatic brain injury have been developed to replicate selected aspects of human head injury, such as contusion, concussion, and/or diffuse axonal injury. Although diffuse axonal injury is a major feature of clinical head injury, relatively few experimental models of diffuse traumatic brain injury (TBI) have been developed, particularly in smaller animals such as rodents. Here, we describe the pathophysiological consequences of moderate diffuse TBI in rats generated by a newly developed, highly controlled, and reproducible model. This model of TBI caused brain edema beginning 20 min after injury and peaking at 24 h post-trauma, as shown by wet weight/dry weight ratios and diffusion-weighted magnetic resonance imaging. Increased permeability of the blood-brain barrier was present up to 4 h post-injury as evaluated using Evans blue dye. Phosphorus magnetic resonance spectroscopy showed significant declines in brain-free magnesium concentration and reduced cytosolic phosphorylation potential at 4 h post-injury. Diffuse axonal damage was demonstrated using manganese-enhanced magnetic resonance imaging, and intracerebral injection of a fluorescent vital dye (Fluoro-Ruby) at 24-h and 7-day post-injury. Morphological evidence of apoptosis and caspase-3 activation were also found in the cerebral hemisphere and brainstem at 24 h after trauma. These results show that this model is capable of reproducing major biochemical and neurological changes of diffuse clinical TBI.
    MeSH term(s) Animals ; Apoptosis/physiology ; Brain/metabolism ; Brain/pathology ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Caspase 3 ; Caspases/metabolism ; Disease Models, Animal ; Male ; Rats ; Rats, Sprague-Dawley ; Time Factors
    Chemical Substances CASP3 protein, human (EC 3.4.22.-) ; Casp3 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2004.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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