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Article: Conversion hip arthroplasty for failed internal fixation of ipsilateral femoral neck and shaft fractures: a case report.

Mencia, Marlon M / Cruz, Pablo Pedro Hernandez

2023 Volume 17, Issue 1, Page(s) 1

Abstract: Background: Ipsilateral femoral neck and hip fractures are uncommon high energy injuries. In the literature no single method of treatment has emerged as superior to the others. A recent publication has documented the successful application of the ... ...

Abstract	Background: Ipsilateral femoral neck and hip fractures are uncommon high energy injuries. In the literature no single method of treatment has emerged as superior to the others. A recent publication has documented the successful application of the rendezvous technique using dual-implants for treating these injuries. However in some cases, this technique may fail and revision surgery is required. Case presentation: A 67-year old man sustained ipsilateral fractures of his femur and femoral neck in a road traffic accident. His injuries were treated by a dual construct consisting of a retrograde femoral nail and dynamic hip screw. Three months after surgery the hip screw cut out of the femoral head necessitating revision to a total hip arthroplasty. Surgery was carried out using a single stage two part procedure on a standard operating table without having to reposition or redrape the patient. There were no postoperative complications and at 1 year from surgery the patient is satisfied with the result and has returned to work. Conclusion: Conversion hip arthroplasty in the presence of dual implants is a technically challenging and unpredictable procedure, with an increased risk of complications. Our surgical approach provides a framework for orthopedic surgeons to safely perform this complex procedure.
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2409244-7
ISSN	1754-9493
ISSN	1754-9493
DOI	10.1186/s13037-023-00352-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Cytoplasmic Region of SARAF Reduces Triple-Negative Breast Cancer Metastasis through the Regulation of Store-Operated Calcium Entry.

Saldías, María Paz / Cruz, Pablo / Silva, Ian / Orellana-Serradell, Octavio / Lavanderos, Boris / Maureira, Diego / Pinto, Raquel / Cerda, Oscar

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: Triple-negative breast cancer has a poor prognosis and is non-responsive to first-line therapies; hence, new therapeutic strategies are needed. Enhanced store-operated ... ...

Abstract	Triple-negative breast cancer has a poor prognosis and is non-responsive to first-line therapies; hence, new therapeutic strategies are needed. Enhanced store-operated Ca
MeSH term(s)	Mice ; Humans ; Animals ; Membrane Proteins/metabolism ; Calcium/metabolism ; Triple Negative Breast Neoplasms/metabolism ; Ion Transport ; Cytoplasm/metabolism ; Calcium Signaling ; Stromal Interaction Molecule 1/metabolism
Chemical Substances	Membrane Proteins ; Calcium (SY7Q814VUP) ; Stromal Interaction Molecule 1
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065306
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Article ; Online: Influence of Teachers' Vocal Quality on Students' Learning and/or Cognition: A Scoping Review.

da Silva, Kelly / Ribeiro, Vanessa Veis / Santos, Allicia Diely Nunes / Almeida, Sabryna Beatriz Santos / Cruz, Pablo Jordão Alcântara / Behlau, Mara

Journal of voice : official journal of the Voice Foundation

2023

Abstract: Objective: To verify if the teacher's vocal quality can influence the student's cognition.: Methods: The present study is a scoping review performed to answer the research question: Can the teacher's vocal quality influence the student's learning and ...

Abstract	Objective: To verify if the teacher's vocal quality can influence the student's cognition. Methods: The present study is a scoping review performed to answer the research question: Can the teacher's vocal quality influence the student's learning and cognition?. To verify if the teacher's vocal quality can influence the student's cognition. The electronic search was performed in PubMed, Lilacs, SciELO, Scopus, Web of Science, Embase, and databases, in addition to a manual search in citation and gray literature. Two independent authors performed selection and extraction. Data were extracted about the study design: the sample, the cognitive tests used, the assessed cognitive skills, the type of altered voice (real or simulated), the assessment of the vocal quality, alone or associated with environmental noise, and the main outcomes evaluated. Results: The initial research identified 476 articles, and 13 were selected for analysis. Seven (54%) studies evaluated the impact of altered voices in an isolated way on cognitive abilities. From these, they verified that the altered voices could negatively influence children's cognitive performance. Other 6 studies (46%) associated altered voices with competitive noise in their analysis, and 4 concluded that competitive noise rather than altered voices influenced students' cognitive performance. Conclusion: The altered voice seems to affect the cognitive tasks involved in the learning process. The competitive noise associated with the presentation of deviant voices had a stronger influence on cognitive performance than altered voice alone, demonstrating that cognitive performance is sensitive to the stages of information acquisition (input of acoustic signals).
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	17459-2
ISSN	1873-4588 ; 1557-8658 ; 0892-1997
ISSN (online)	1873-4588 ; 1557-8658
ISSN	0892-1997
DOI	10.1016/j.jvoice.2023.02.022
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Article: When the Past Lives in the Present. Agrarian Landscapes and Historical Social Dynamics in the Southern Andes (Quebrada de Humahuaca, Jujuy, Argentina)

Cruz, Pablo / Egan, Nancy / Joffre, Richard / Cladera, Jorge L. / Winkel, Thierry

Land. 2021 June 30, v. 10, no. 7

2021

Abstract: This article examines the agrarian landscape in one part of the southern Andes (Quebrada of Humahuaca, Jujuy, Argentina). The region possesses extensive and well-preserved archaeological remains of agricultural systems, which stretch back to pre-Hispanic ...

Abstract	This article examines the agrarian landscape in one part of the southern Andes (Quebrada of Humahuaca, Jujuy, Argentina). The region possesses extensive and well-preserved archaeological remains of agricultural systems, which stretch back to pre-Hispanic times. In this study, we employ an interdisciplinary approach in our analysis of the components that structure the agrarian landscape, especially those historical processes that intervened in its formation. The creation of a cartographic base, built from remote sensing and fieldwork data, allowed for the identification of four principal components of the landscape, each of which correspond to distinct phases or periods that mark the region’s history. Our study shows that, in contrast to what is observed in many other rural areas, the successive productive dynamics that developed in the area did not result in the destruction of previous productive structures. Rather, the agrarian landscape in the study area presents a multi-temporal agglutinating combination or composition, which transcends historical discontinuities in the productive matrix. This is owing to the partial reutilisation of previous structures in each period; however, religious and cultural factors play an important role. The agrarian landscape we studied is not only a passive result of human activity, but also a force influencing the productive and lifestyle decisions of the peasant populations that live there today. Our research amplifies the understanding of agrarian landscapes in the Andes and shows how past temporalities are articulated with the present through a dialectical process.
Keywords	agricultural landscapes ; archaeology ; humans ; land ; lifestyle ; peasantry ; Andes region ; Argentina
Language	English
Dates of publication	2021-0630
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2682955-1
ISSN	2073-445X
ISSN	2073-445X
DOI	10.3390/land10070687
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Adsorción extracorpórea de citoquinas en el tratamiento del shock séptico refractario. Casos clínicos.

Rathkamp, Mario / Tomicic, Vinko / Cornejo, Juan / Cruz, Pablo

Revista medica de Chile

2018 Volume 146, Issue 6, Page(s) 796–801

Abstract: If Septic shock (SS) evolves to refractory SS, mortality could reach 90%, despite giving an optimal treatment. Nowadays, extracorporeal devices which adsorb inflammatory cytokines are available, reducing the systemic inflammatory response syndrome. These ...

Title translation	Extracorporeal cytokine hemadsorption for the treatment of refractory septic shock. Report of two cases.
Abstract	If Septic shock (SS) evolves to refractory SS, mortality could reach 90%, despite giving an optimal treatment. Nowadays, extracorporeal devices which adsorb inflammatory cytokines are available, reducing the systemic inflammatory response syndrome. These devices can be used with continuous renal replacement therapy or conventional hemodialysis. We report two diabetic females aged 50 and 58 years, who underwent a total colectomy and amputation of diabetic foot and who developed a SS with high requirements of vasoactive drugs (norepinephrine and adrenaline) to maintain a mean arterial pressure about 60 mmHg. Both were subjected to hemodialysis, connected to a cytokine hemadsorption device. The most important finding was the progressive reduction of vasopressor doses, effect that was observed nine hours after the beginning of the hemadsorption and lasted until its removal at 26 hours. Both patients survived.
MeSH term(s)	Cytokines/blood ; Female ; Hemoperfusion/instrumentation ; Hemoperfusion/methods ; Humans ; Middle Aged ; Renal Dialysis/instrumentation ; Renal Dialysis/methods ; Reproducibility of Results ; Shock, Septic/therapy ; Time Factors ; Treatment Outcome
Chemical Substances	Cytokines
Language	Spanish
Publishing date	2018-08-27
Publishing country	Chile
Document type	Case Reports ; Journal Article
ZDB-ID	732136-3
ISSN	0717-6163 ; 0034-9887
ISSN (online)	0717-6163
ISSN	0034-9887
DOI	10.4067/s0034-98872018000600796
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Article ; Online: K

Canales, Jimena / Cruz, Pablo / Díaz, Nicolás / Riquelme, Denise / Leiva-Salcedo, Elías / Cerda, Oscar

Cells

2020 Volume 9, Issue 10

Abstract: Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and ... ...

Abstract	Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Cell Adhesion/genetics ; Cell Line ; Cell Movement/genetics ; Focal Adhesions/genetics ; Humans ; Mice ; Potassium Channels/metabolism ; Potassium Channels/physiology ; Signal Transduction ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligases/metabolism ; rac1 GTP-Binding Protein/metabolism
Chemical Substances	KCTD5 protein, human ; Potassium Channels ; Transcription Factors ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; rac1 GTP-Binding Protein (EC 3.6.5.2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-10-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9102273
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Article: TRP Channels Regulation of Rho GTPases in Brain Context and Diseases.

Lavanderos, Boris / Silva, Ian / Cruz, Pablo / Orellana-Serradell, Octavio / Saldías, María Paz / Cerda, Oscar

Frontiers in cell and developmental biology

2020 Volume 8, Page(s) 582975

Abstract: Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood- ... ...

Abstract	Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood-vessel barrier function. In this context, critical pathways involved in the pathogenesis of these diseases are related to structural, scaffolding, and enzymatic activity-bearing proteins, which participate in Ca
Language	English
Publishing date	2020-11-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2020.582975
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Article: Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target.

Bustos, Galdo / Cruz, Pablo / Lovy, Alenka / Cárdenas, César

Frontiers in oncology

2017 Volume 7, Page(s) 199

Abstract: Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to establish the relationship between ... ...

Abstract	Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to establish the relationship between cancer and mitochondria; however, he interpreted enhanced aerobic glycolysis as mitochondrial dysfunction. Today it is accepted that many cancer cell types need fully functional mitochondria to maintain their homeostasis. Calcium (Ca
Language	English
Publishing date	2017-09-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2017.00199
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Article ; Online: Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells.

Cruz, Pablo / Ahumada-Castro, Ulises / Bustos, Galdo / Molgó, Jordi / Sauma, Daniela / Lovy, Alenka / Cárdenas, César

International journal of molecular sciences

2021 Volume 22, Issue 2

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an ... ...

Abstract	T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an interesting therapeutic target given its essential role in maintaining bioenergetic and metabolic homeostasis. T-ALL cells are characterized by high levels of mitochondrial respiration, making them suitable for this type of intervention. Mitochondrial function is sustained by a constitutive transfer of calcium from the endoplasmic reticulum to mitochondria through the inositol 1,4,5-trisphosphate receptor (InsP3R), making T-ALL cells vulnerable to its inhibition. Here, we determine the bioenergetic profile of the T-ALL cell lines CCRF-CEM and Jurkat and evaluate their sensitivity to InsP3R inhibition with the specific inhibitor, Xestospongin B (XeB). Our results show that T-ALL cell lines exhibit higher mitochondrial respiration than non-malignant cells, which is blunted by the inhibition of the InsP3R. Prolonged treatment with XeB causes T-ALL cell death without affecting the normal counterpart. Moreover, the combination of XeB and glucocorticoids significantly enhanced cell death in the CCRF-CEM cells. The inhibition of InsP3R with XeB rises as a potential therapeutic alternative for the treatment of T-ALL.
MeSH term(s)	Biomarkers ; Cell Death ; Cell Line, Tumor ; Cell Respiration/drug effects ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/antagonists & inhibitors ; Leukocytes, Mononuclear/metabolism ; Macrocyclic Compounds/pharmacology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxazoles/pharmacology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/etiology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
Chemical Substances	Biomarkers ; Inositol 1,4,5-Trisphosphate Receptors ; Macrocyclic Compounds ; Oxazoles ; xestospongin B (88840-01-1)
Language	English
Publishing date	2021-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22020651
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Article: TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer.

Saldías, María Paz / Maureira, Diego / Orellana-Serradell, Octavio / Silva, Ian / Lavanderos, Boris / Cruz, Pablo / Torres, Camila / Cáceres, Mónica / Cerda, Oscar

Frontiers in oncology

2021 Volume 11, Page(s) 621614

Abstract: Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, breast cancer still caused ... ...

Abstract	Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, breast cancer still caused 627,000 deaths in 2018. Since cancer is a multifactorial disease, it has become necessary to develop new molecular therapies that can target several relevant cellular processes at once. Ion channels are versatile regulators of several physiological- and pathophysiological-related mechanisms, including cancer-relevant processes such as tumor progression, apoptosis inhibition, proliferation, migration, invasion, and chemoresistance. Ion channels are the main regulators of cellular functions, conducting ions selectively through a pore-forming structure located in the plasma membrane, protein-protein interactions one of their main regulatory mechanisms. Among the different ion channel families, the Transient Receptor Potential (TRP) family stands out in the context of breast cancer since several members have been proposed as prognostic markers in this pathology. However, only a few approaches exist to block their specific activity during tumoral progress. In this article, we describe several TRP channels that have been involved in breast cancer progress with a particular focus on their binding partners that have also been described as drivers of breast cancer progression. Here, we propose disrupting these interactions as attractive and potential new therapeutic targets for treating this neoplastic disease.
Language	English
Publishing date	2021-06-10
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.621614
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