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  1. Article ; Online: African ancestry is a predictor factor to secondary progression in clinical course of multiple sclerosis.

    Ferreira Vasconcelos, Claudia Cristina / Cruz Dos Santos, Gutemberg Augusto / Thuler, Luiz Claudio / Camargo, Solange Maria / Papais Alvarenga, Regina Maria

    ISRN neurology

    2012  Volume 2012, Page(s) 410629

    Abstract: Background. Studies on the clinical course of multiple sclerosis have indicated that certain initial clinical factors are predictive of disease progression. Regions with a low prevalence for disease, which have environmental and genetic factors that ... ...

    Abstract Background. Studies on the clinical course of multiple sclerosis have indicated that certain initial clinical factors are predictive of disease progression. Regions with a low prevalence for disease, which have environmental and genetic factors that differ from areas of high prevalence, lack studies on the progressive course and disabling characteristics of the disease. Objective. To analyse the long-term evolution to the progressive phase of the relapsing-remitting multiple sclerosis and its prognosis factors in mixed population. Methods. We performed a survival study and logistic regression to examine the influence of demographic and initial clinical factors on disease progression. Among 553 relapsing-remitting patients assisted at a Brazilian reference centre for multiple sclerosis, we reviewed the medical records of 150 patients who had a disease for ten or more years. Results. African ancestry was a factor that conferred more risk for secondary progression followed by age at the onset of the disease and the number of relapses in the year after diagnosis. A greater understanding of the influence of ancestry on prognosis serves to stimulate genetics and pharmacogenomics research and may clarify the poorly understood neurodegenerative progression of MS.
    Language English
    Publishing date 2012-11-25
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2612992-9
    ISSN 2090-5513 ; 2090-5513
    ISSN (online) 2090-5513
    ISSN 2090-5513
    DOI 10.5402/2012/410629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Differences in the progression of primary progressive multiple sclerosis in Brazilians of African descent versus white Brazilian patients.

    Ferreira Vasconcelos, Claudia Cristina / Santos Thuler, Luiz Claudio / Cruz dos Santos, Gutemberg Augusto / Papais Alvarenga, Marcos / Papais Alvarenga, Marina / Gomes Camargo, Solange Maria das Graças / Papais Alvarenga, Regina Maria

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2010  Volume 16, Issue 5, Page(s) 597–603

    Abstract: Recent studies have suggested faster clinical progression and greater disability in multiple sclerosis patients of African descent. This study analysed the effect of ethnicity on progression and disability. Sixty-five patients with primary progressive ... ...

    Abstract Recent studies have suggested faster clinical progression and greater disability in multiple sclerosis patients of African descent. This study analysed the effect of ethnicity on progression and disability. Sixty-five patients with primary progressive multiple sclerosis were selected and classified as being of African descent or white. Time from onset of the disease until reaching Expanded Disability Status Scale grades 3, 6, and 8 was assessed, as well as irreversible disability (Expanded Disability Status Scale grade maintained for >or=6 months). In the African descent group, the median time to reach Expanded Disability Status Scale 3 was 1 year shorter (1 year vs 2 years, p= 0.02), and to reach Expanded Disability Status Scale 6 was 2 years shorter (3 years vs 5 years, p= 0.01) than in the group of white patients. According to the Kaplan-Meier survival curves, patients of African descent reached every disability stage faster than white patients (p= 0.03, p = 0.04, and p = 0.03, respectively, for Expanded Disability Status Scale grades 3, 6, and 8). As in United States and European patients of African descent, the more severe and faster progression of multiple sclerosis seen in Brazilian primary progressive multiple sclerosis patients of African descent suggests a possibly greater effect of ethnicity rather than environment on the progression of multiple sclerosis.
    MeSH term(s) Adult ; African Continental Ancestry Group ; Age of Onset ; Brazil ; Disability Evaluation ; Disease Progression ; European Continental Ancestry Group ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Chronic Progressive/ethnology ; Multiple Sclerosis, Chronic Progressive/physiopathology ; Severity of Illness Index ; Young Adult
    Language English
    Publishing date 2010-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458509360987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Clinical Features of COVID-19 on Patients With Neuromyelitis Optica Spectrum Disorders.

    Apostolos-Pereira, Samira Luisa / Campos Ferreira, Lis / Boaventura, Mateus / de Carvalho Sousa, Nise Alessandra / Joca Martins, Gabriela / d'Almeida, José Arthur / Pitombeira, Milena / Silvestre Mendes, Lucas / Fukuda, Thiago / Souza Cabeça, Hideraldo Luíz / Chaves Rocha, Luciano / Santos de Oliveira, Bianca / Vieira Stella, Carla Renata / Lobato de Oliveira, Enedina Maria / de Souza Amorim, Leizian / Ferrari de Castro, Andréa / Pereira Gomes Neto, Antonio / Diogo Silva, Guilherme / Bueno, Lucas /
    de Morais Machado, Maria / Castello Dias-Carneiro, Rafael / Maciel Dias, Ronaldo / Porto Moreira, Alvaro / Piccolo, Ana / Kuntz Grzesiuk, Anderson / Muniz, Andre / Diniz Disserol, Caio / Ferreira Vasconcelos, Claudia / Kaimen-Maciel, Damacio / Sisterolli Diniz, Denise / Comini-Frota, Elizabeth / Coronetti Rocha, Fernando / Cruz Dos Santos, Gutemberg Augusto / Dadalti Fragoso, Yara / Sciascia do Olival, Guilherme / Ruocco, Heloisa Helena / Siqueira, Heloise Helena / Sato, Henry Koity / Figueiredo, José Alexandre / Cortoni Calia, Leandro / Teixeira Dourado, Mario Emilio / Scolari, Letícia / Ribeiro Soares Neto, Herval / Melges, Luiz / Magno Gonçalves, Marcus Vinicius / Vellutini Pimentel, Maria Lucia / de Castro Ribeiro, Marlise / Gurrola Arambula, Omar / Diniz da Gama, Paulo / Leite Menon, Renata / Barbosa Thomaz, Rodrigo / de Rizo Morales, Rogério / Sobreira, Silvana / Machado, Suzana Nunes / Gonsalves Jubé Ribeiro, Taysa / Coelho Santa Rita Pereira, Valéria / Maia Costa, Vanessa / da Nóbrega Junior, Adaucto Wanderley / Vieira Alves-Leon, Soniza / Mamprim de Morais Perin, Marilia / Donadi, Eduardo / Adoni, Tarso / Gomes, Sidney / Brito Ferreira, Maria / Callegaro, Dagoberto / Mendes, Maria Fernanda / Brum, Doralina / von Glehn, Felipe

    Neurology(R) neuroimmunology & neuroinflammation

    2021  Volume 8, Issue 6

    Abstract: Background and objectives: To describe the clinical features and disease outcomes of coronavirus disease 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorder (NMOSD).: Methods: The Neuroimmunology Brazilian Study Group has set up ... ...

    Abstract Background and objectives: To describe the clinical features and disease outcomes of coronavirus disease 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorder (NMOSD).
    Methods: The Neuroimmunology Brazilian Study Group has set up the report of severe acute respiratory syndrome (SARS-CoV2) cases in patients with NMOSD (pwNMOSD) using a designed web-based case report form. All neuroimmunology outpatient centers and individual neurologists were invited to register their patients across the country. Data collected between March 19 and July 25, 2020, were uploaded at the REDONE.br platform. Inclusion criteria were as follows: (1) NMOSD diagnosis according to the 2015 International Panel Criteria and (2) confirmed SARS-CoV2 infection (reverse transcription-polymerase chain reaction or serology) or clinical suspicion of COVID-19, diagnosed according to Center for Disease Control / Council of State and Territorial Epidemiologists (CDC/CSTE) case definition. Demographic and NMOSD-related clinical data, comorbidities, disease-modifying therapy (DMT), COVID-19 clinical features, and severity were described.
    Results: Among the 2,061 pwNMOSD followed up by Brazilian neurologists involved on the registry of COVID-19 in pwNMOSD at the REDONE.br platform, 34 patients (29 women) aged 37 years (range 8-77), with disease onset at 31 years (range 4-69) and disease duration of 6 years (range 0.2-20.5), developed COVID-19 (18 confirmed and 16 probable cases). Most patients exhibited mild disease, being treated at home (77%); 4 patients required admission at intensive care units (severe cases); and 1 patient died. Five of 34 (15%) presented neurologic manifestations (relapse or pseudoexacerbation) during or after SARS-CoV2 infection.
    Discussion: Most NMOSD patients with COVID-19 presented mild disease forms. However, pwNMOSD had much higher odds of hospitalization and intensive care unit admission comparing with the general Brazilian population. The frequency of death was not clearly different. NMOSD disability, DMT type, and comorbidities were not associated with COVID-19 outcome. SARS-CoV2 infection was demonstrated as a risk factor for NMOSD relapses. Collaborative studies using shared NMOSD data are needed to suitably define factors related to COVID-19 severity and neurologic manifestations.
    MeSH term(s) Adolescent ; Adult ; Aged ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; Child ; Disease Progression ; Female ; Hospitalization/statistics & numerical data ; Humans ; Immunosuppressive Agents/therapeutic use ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Neuromyelitis Optica/drug therapy ; Neuromyelitis Optica/epidemiology ; Neuromyelitis Optica/physiopathology ; Recurrence ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000001060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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