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  1. Article ; Online: Are Airway Epithelial p73 Levels a Therapeutic Target to Treat Chronic Obstructive Pulmonary Disease?

    Crystal, Ronald G

    American journal of respiratory and critical care medicine

    2023  Volume 209, Issue 2, Page(s) 123–124

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Lung/physiopathology
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202311-2073ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Gene Therapy for Immunoglobulin E, Complement-Mediated, and Eosinophilic Disorders.

    Pagovich, Odelya E / Crystal, Ronald G

    Human gene therapy

    2023  Volume 34, Issue 19-20, Page(s) 986–1002

    Abstract: Immunoglobulin E, complement, and eosinophils play an important role in host defense, but dysfunction of each of these components can lead to a variety of human disorders. In this review, we summarize how investigators have adapted gene therapy and ... ...

    Abstract Immunoglobulin E, complement, and eosinophils play an important role in host defense, but dysfunction of each of these components can lead to a variety of human disorders. In this review, we summarize how investigators have adapted gene therapy and antisense technology to modulate immunoglobulin E, complement, and/or eosinophil levels to treat these disorders.
    MeSH term(s) Humans ; Immunoglobulin E ; Eosinophils ; Complement System Proteins/genetics
    Chemical Substances Immunoglobulin E (37341-29-0) ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2023.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2988: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: My Pathway to Gene Therapy.

    Crystal, Ronald G

    Human gene therapy

    2020  Volume 31, Issue 5-6, Page(s) 273–282

    MeSH term(s) Career Choice ; Cystic Fibrosis/genetics ; Cystic Fibrosis/therapy ; Genetic Therapy ; Humans ; Neuronal Ceroid-Lipofuscinoses/genetics ; Neuronal Ceroid-Lipofuscinoses/therapy ; alpha 1-Antitrypsin Deficiency/genetics ; alpha 1-Antitrypsin Deficiency/therapy
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article ; Personal Narrative ; Portrait
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2020.29112.rgc
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils.

    Strulovici-Barel, Yael / Kaner, Robert J / Crystal, Ronald G

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 180

    Abstract: While asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling and angiogenesis in some individuals with this ...

    Abstract While asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling and angiogenesis in some individuals with this condition. The inflammation is typically characterized as type-2 high (eosinophilic) vs type 2-low (neutrophilic and pauci-granulocytic); we hypothesized that the type-2 high group would be more likely to evidence endothelial dysfunction. As a biomarker of these processes, we hypothesized that nonsmokers with allergic asthma may have elevated plasma levels of endothelial microparticles (EMPs), membrane vesicles that are shed when endothelial cells undergo activation or apoptosis. Total and apoptotic circulating EMPs were measured by fluorescence-activated cell analysis in patients with allergic asthma (n = 29) and control subjects (n = 26), all nonsmokers. When the entire group of patients with asthma were compared to the control subjects, there were no differences in total circulating EMPs nor apoptotic EMPs. However, patients with asthma with elevated levels of IgE and eosinophils had higher levels of apoptotic EMPs, compared to patients with asthma with mildly increased IgE and eosinophil levels. This observation is relevant to precision therapies for asthma and highlights the importance of sub-phenotyping in the condition.
    MeSH term(s) Humans ; Eosinophils ; Endothelial Cells ; Asthma/diagnosis ; Biomarkers ; Immunoglobulin E
    Chemical Substances Biomarkers ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Letter
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02470-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: The lung / 2

    Crystal, Ronald G.

    scientific foundations

    1997  

    Author's details ed.-in-chief: Ronald G. Crystal
    Collection The lung
    Language English
    Size XLVIII, S. 1447 - 2811, I-68 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Raven Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007366464
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    WF 600 H 8 not available for loan Lesesaal EG Handbücher
    2004 A 8674 order for loan Magazin
    1997 A 1371 -2- order for loan Magazin

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  6. Book: The lung / 1

    Crystal, Ronald G.

    scientific foundations

    1997  

    Author's details ed.-in-chief: Ronald G. Crystal
    Collection The lung
    Keywords Lunge
    Subject Pulmo
    Language English
    Size XLVIII, 1446, I-68 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Raven Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007366376
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 8673 order for loan Magazin
    1997 A 1371 -1- order for loan Magazin

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  7. Article ; Online: Compelling evidence for the efficacy of α1-antitrypsin augmentation treatment for α1-antitrypsin deficiency.

    Crystal, Ronald G

    The Lancet. Respiratory medicine

    2017  Volume 5, Issue 1, Page(s) 7–8

    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(16)30434-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  8. Book: Alpha 1-antitrypsin deficiency

    Crystal, Ronald G.

    biology, pathogenesis, clinical manifestations, therapy

    (Lung biology in health and disease ; 88)

    1996  

    Author's details ed. by Ronald G. Crystal
    Series title Lung biology in health and disease ; 88
    Collection
    Keywords Lung Diseases, Obstructive / therapy ; alpha 1-Antitrypsin / deficiency ; alpha 1-Antitrypsin / genetics ; Antitrypsin ; Mangelkrankheit ; Hypo-alpha-1-Antitrypsinämie
    Subject Alpha-1-Antitrypsin-Mangel ; Alpha-1-PI-Mangel ; Laurell-Erikson-Syndrom ; Antitrypsinämie ; Alpha-1-Proteinasen-Inhibitor ; Mangelerscheinung ; Alpha-1-PI
    Language English
    Size XX, 449 S. : Ill., graph. Darst.
    Edition 1. print.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007304983
    ISBN 0-8247-8848-6 ; 978-0-8247-8848-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 5075 order for loan Magazin

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  9. Book: Lung injury

    Crystal, Ronald G.

    1992  

    Author's details ed.: Ronald G. Crystal
    Keywords Lung / injuries ; Lungenkrankheit ; Lungenverletzung
    Subject Lungenerkrankung ; Lungentrauma ; Lunge
    Size XV, 400 S. : Ill., graph. Darst.
    Publisher Raven Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT004156856
    ISBN 0-88167-848-1 ; 978-0-88167-848-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 A 1741 order for loan Magazin

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  10. Book: The lung / 1

    Crystal, Ronald G.

    scientific foundations

    1991  

    Author's details ed.-in-chief: Ronald G. Crystal
    Collection The lung
    Language English
    Size XXXIX, 1207, I-79 S. : Ill., graph. Darst.
    Publisher Raven Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003822384
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 3214 -1- order for loan Magazin

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