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  1. AU="Csont, Tamás"
  2. AU="Yusuf, Qamar Kassim"
  3. AU="Izquierdo-Vega, Judith"
  4. AU="Barc, Céline"
  5. AU="Herath, Tharuka"
  6. AU="Klontz, Erik H"
  7. AU=Lu Chen Chen
  8. AU="Shabsovich, David"
  9. AU="Foraker, Randi E"
  10. AU="Kolonko, Aureliusz"
  11. AU=Falagas M E
  12. AU="Dunstan, Melanie L"
  13. AU=Kacar Mark AU=Kacar Mark
  14. AU="Schaup, Rebecca Michaela"
  15. AU="Ye, Chaofu"
  16. AU="Tekin, Nur"
  17. AU="Martens, Dirk E"
  18. AU=Teos Leyla Y.
  19. AU="Sánchez-Garcia, Joaquín"
  20. AU="Schaller, Benoit"
  21. AU="Hernandez, A"
  22. AU="Nguyen, Thien H"
  23. AU="Park, Jung Wan"
  24. AU="Mahajan, Aman"
  25. AU="Hao, Yanling"
  26. AU="Eing, Lorenz"
  27. AU="Geoffroy, Pierre A"
  28. AU="Chapuis, J"
  29. AU="Berta, László"
  30. AU="Barzilay, Regina"
  31. AU="Schmidt, Michael Rahbek"
  32. AU=Tack J
  33. AU="Oh, Hye Min"
  34. AU=Gaffen Sarah L AU=Gaffen Sarah L
  35. AU="Schmitt, Christine"
  36. AU="McKay, Jackie"
  37. AU="Bellissimo, Catherine A"
  38. AU="Desai, Urja"
  39. AU="Chini, Maria Giovanna"
  40. AU="Xiao, Difei"
  41. AU="Ryan, Chris"
  42. AU="Omar Bazighifan"
  43. AU="Corominas Galbany, Jordi"
  44. AU=Fox Norma E
  45. AU="Hamilton, Shelia M"
  46. AU="Nichols, J Wylie"
  47. AU="Pesce R."
  48. AU="Gambitta, P"
  49. AU="Imran, Aqeel"
  50. AU="Sharma, Yashoda"
  51. AU="Kosai, Jordyn"
  52. AU="Aroca Ferri, María"
  53. AU="Laba, Stephanie"
  54. AU="Kim, Ye-Sel"

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  1. Artikel: The effect of electrical stimulation of skeletal muscle on cardioprotection and on muscle-derived myokine levels in rats: A pilot study.

    Szabó, Márton R / Csont, Tamás / Csonka, Csaba

    Physiology international

    2023  Band 110, Heft 2, Seite(n) 135–149

    Abstract: Electrical muscle stimulation (EMS) is a widely used method in sports and rehabilitation therapies to simulate physical exercise. EMS treatment via skeletal muscle activity improves the cardiovascular functions and the overall physical condition of the ... ...

    Abstract Electrical muscle stimulation (EMS) is a widely used method in sports and rehabilitation therapies to simulate physical exercise. EMS treatment via skeletal muscle activity improves the cardiovascular functions and the overall physical condition of the patients. However, the cardioprotective effect of EMS has not been proven so far, therefore, the aim of this study was to investigate the potential cardiac conditioning effect of EMS in an animal model. Low-frequency 35-min EMS was applied to the gastrocnemius muscle of male Wistar rats for three consecutive days. Their isolated hearts were then subjected to 30 min global ischemia and 120 min reperfusion. At the end of reperfusion cardiac specific creatine kinase (CK-MB) and lactate dehydrogenase (LDH) enzyme release and myocardial infarct size were determined. Additionally, skeletal muscle-driven myokine expression and release were also assessed. Phosphorylation of cardioprotective signaling pathway members AKT, ERK1/2, and STAT3 proteins were also measured. EMS significantly attenuated cardiac LDH and CK-MB enzyme activities in the coronary effluents at the end of the ex vivo reperfusion. EMS treatment considerably altered the myokine content of the stimulated gastrocnemius muscle without altering circulating myokine levels in the serum. Additionally, phosphorylation of cardiac AKT, ERK1/2, and STAT3 was not significantly different in the two groups. Despite the lack of significant infarct size reduction, the EMS treatment seems to influence the course of cellular damage due to ischemia/reperfusion and favorably modifies skeletal muscle myokine expressions. Our results suggest that EMS may have a protective effect on the myocardium, however, further optimization is required.
    Mesh-Begriff(e) Rats ; Male ; Animals ; Pilot Projects ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/prevention & control ; Rats, Wistar ; Apoptosis ; Myocardium/metabolism ; Muscle, Skeletal/metabolism
    Chemische Substanzen Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2023-05-05
    Erscheinungsland Hungary
    Dokumenttyp Journal Article
    ZDB-ID 2896288-6
    ISSN 2498-602X
    ISSN 2498-602X
    DOI 10.1556/2060.2023.00198
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity.

    Szűcs, Gergő / Pipicz, Márton / Szabó, Márton Richárd / Csont, Tamás / Török, László / Csonka, Csaba

    Sports medicine - open

    2023  Band 9, Heft 1, Seite(n) 91

    Abstract: There is a growing body of evidence showing the importance of physical activity against civilization-induced metabolic diseases, including type 2 diabetes (T2DM) and obesity. Eccentric contraction, when skeletal muscles generate force by lengthening, is ... ...

    Abstract There is a growing body of evidence showing the importance of physical activity against civilization-induced metabolic diseases, including type 2 diabetes (T2DM) and obesity. Eccentric contraction, when skeletal muscles generate force by lengthening, is a unique type of skeletal muscle activity. Eccentric contraction may lead to better power production characteristics of the muscle because eccentric contraction requires less energy and can result in higher tension. Therefore, it is an ideal tool in the rehabilitation program of patients. However, the complex metabolic effect (i.e., fat mass reduction, increased lipid oxidation, improvement in blood lipid profile, and increased insulin sensitivity) of the eccentric contraction alone has scarcely been investigated. This paper aims to review the current literature to provide information on whether eccentric contraction can influence metabolic health and body composition in T2DM or obesity. We also discussed the potential role of myokines in mediating the effects of eccentric exercise. A better understanding of the mechanism of eccentric training and particularly their participation in the regulation of metabolic diseases may widen their possible therapeutic use and, thereby, may support the fight against the leading global risks for mortality in the world.
    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2809942-4
    ISSN 2198-9761 ; 2199-1170
    ISSN (online) 2198-9761
    ISSN 2199-1170
    DOI 10.1186/s40798-023-00596-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Chemistry and Pharmacology of Modulators of Oxidative Stress.

    Saso, Luciano / Suzen, Sibel / Borges, Fernanda / Csont, Tamas

    Current medicinal chemistry

    2020  Band 27, Heft 13, Seite(n) 2038–2039

    Mesh-Begriff(e) Chemistry, Pharmaceutical ; Oxidative Stress/drug effects
    Sprache Englisch
    Erscheinungsdatum 2020-05-05
    Erscheinungsland United Arab Emirates
    Dokumenttyp Editorial
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986732713200425202016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4432: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Artikel ; Online: Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease.

    Gáspár, Renáta / Halmi, Dóra / Demján, Virág / Berkecz, Róbert / Pipicz, Márton / Csont, Tamás

    Frontiers in immunology

    2022  Band 12, Seite(n) 768560

    Abstract: Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc. contribute to the ... ...

    Abstract Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc. contribute to the development of coronary atherosclerosis and subsequent coronary artery disease. Inflammation plays an important role in coronary artery disease development and progression. Pro-inflammatory signals promote the degradation of tryptophan
    Mesh-Begriff(e) Biomarkers ; Coronary Artery Disease/diagnosis ; Humans ; Inflammation ; Kynurenine/metabolism ; Tryptophan/metabolism
    Chemische Substanzen Biomarkers ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX)
    Sprache Englisch
    Erscheinungsdatum 2022-02-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.768560
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Diet-Induced Hypercholesterolemia Leads to Cardiac Dysfunction and Alterations in the Myocardial Proteome.

    Szabó, Márton Richárd / Pipicz, Márton / Sárközy, Márta / Bruszel, Bella / Szabó, Zoltán / Csont, Tamás

    International journal of molecular sciences

    2022  Band 23, Heft 13

    Abstract: Elevated blood cholesterol is a major risk factor for coronary heart disease. Moreover, direct effects on the myocardium also contribute to the adverse effects of hypercholesterolemia. Here, we investigated the effect of hypercholesterolemia on the ... ...

    Abstract Elevated blood cholesterol is a major risk factor for coronary heart disease. Moreover, direct effects on the myocardium also contribute to the adverse effects of hypercholesterolemia. Here, we investigated the effect of hypercholesterolemia on the cardiac proteome. Male Wistar rats were fed with a laboratory rodent chow supplemented with 2% cholesterol for 8 weeks to induce hypercholesterolemia. The protein expression data obtained from the proteomic characterization of left ventricular samples from normo- and hypercholesterolemic animals were subjected to gene ontology (GO) and protein interaction analyses. Elevated circulating cholesterol levels were accompanied by diastolic dysfunction in cholesterol-fed rats. The proteomic characterization of left ventricular samples revealed altered expression of 45 proteins due to hypercholesterolemia. Based on the Gene Ontology analysis, hypercholesterolemia was associated with disturbed expression of cytoskeletal and contractile proteins. Beta-actin was downregulated in the hypercholesterolemic myocardium, and established a prominent hub of the protein interaction network. Analysis of the unfiltered dataset revealed concordant downregulated expression patterns in proteins associated with the arrangement of the contractile system (e.g., cardiac-specific troponins and myosin complex), and in subunits of the mitochondrial respiratory chain. We conclude that the observed changes in the cardiac proteome may contribute to the development of diastolic dysfunction in hypercholesterolemia.
    Mesh-Begriff(e) Animals ; Cholesterol/metabolism ; Diet ; Heart Diseases/metabolism ; Hypercholesterolemia/metabolism ; Male ; Myocardium/metabolism ; Proteome/metabolism ; Proteomics ; Rats ; Rats, Wistar
    Chemische Substanzen Proteome ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2022-07-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23137387
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Nitroglycerin-induced preconditioning: interaction with nitrate tolerance.

    Csont, Tamás

    American journal of physiology. Heart and circulatory physiology

    2009  Band 298, Heft 2, Seite(n) H308–9

    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Tolerance/physiology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Heme Oxygenase-1/metabolism ; Humans ; Ischemic Preconditioning/methods ; Nitrates/therapeutic use ; Nitroglycerin/therapeutic use ; Reperfusion Injury/metabolism ; Reperfusion Injury/physiopathology ; Reperfusion Injury/prevention & control ; Vasodilator Agents/therapeutic use
    Chemische Substanzen Antioxidants ; Nitrates ; Vasodilator Agents ; Heme Oxygenase-1 (EC 1.14.14.18) ; Nitroglycerin (G59M7S0WS3) ; Ascorbic Acid (PQ6CK8PD0R)
    Sprache Englisch
    Erscheinungsdatum 2009-12-11
    Erscheinungsland United States
    Dokumenttyp Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.01079.2009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Hefte anzeigen Standort:
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  7. Artikel ; Online: Modulatory Effect of Myokines on Reactive Oxygen Species in Ischemia/Reperfusion.

    Szabó, Márton Richárd / Pipicz, Márton / Csont, Tamás / Csonka, Csaba

    International journal of molecular sciences

    2020  Band 21, Heft 24

    Abstract: There is a growing body of evidence showing the importance of physical activity against acute ischemic events in various organs. Ischemia/reperfusion injury (I/R) is characterized by tissue damage as a result of restriction and subsequent restoration of ... ...

    Abstract There is a growing body of evidence showing the importance of physical activity against acute ischemic events in various organs. Ischemia/reperfusion injury (I/R) is characterized by tissue damage as a result of restriction and subsequent restoration of blood supply to an organ. Oxidative stress due to increased reactive oxygen species formation and/or insufficient antioxidant defense is considered to play an important role in I/R. Physical activity not only decreases the general risk factors for ischemia but also confers direct anti-ischemic protection via myokine production. Myokines are skeletal muscle-derived cytokines, representing multifunctional communication channels between the contracting skeletal muscle and other organs through an endocrine manner. In this review, we discuss the most prominent members of the myokines (i.e., brain-derived neurotrophic factor (BDNF), cathepsin B, decorin, fibroblast growth factors-2 and -21, follistatin, follistatin-like, insulin-like growth factor-1; interleukin-6, interleukin-7, interleukin-15, irisin, leukemia inhibitory factor, meteorin-like, myonectin, musclin, myostatin, and osteoglycin) with a particular interest in their potential influence on reactive oxygen and nitrogen species formation or antioxidant capacity. A better understanding of the mechanism of action of myokines and particularly their participation in the regulation of oxidative stress may widen their possible therapeutic use and, thereby, may support the fight against I/R.
    Mesh-Begriff(e) Animals ; Cytokines/metabolism ; Humans ; Muscle, Skeletal/metabolism ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/metabolism ; Signal Transduction
    Chemische Substanzen Cytokines ; Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2020-12-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21249382
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Effects of Cardiovascular Risk Factors on Cardiac STAT3.

    Pipicz, Márton / Demján, Virág / Sárközy, Márta / Csont, Tamás

    International journal of molecular sciences

    2018  Band 19, Heft 11

    Abstract: Nuclear, mitochondrial and cytoplasmic signal transducer and activator of transcription 3 (STAT3) regulates many cellular processes, e.g., the transcription or opening of mitochondrial permeability transition pore, and its activity depends on the ... ...

    Abstract Nuclear, mitochondrial and cytoplasmic signal transducer and activator of transcription 3 (STAT3) regulates many cellular processes, e.g., the transcription or opening of mitochondrial permeability transition pore, and its activity depends on the phosphorylation of Tyr705 and/or Ser727 sites. In the heterogeneous network of cardiac cells, STAT3 promotes cardiac muscle differentiation, vascular element formation and extracellular matrix homeostasis. Overwhelming evidence suggests that STAT3 is beneficial for the heart, plays a role in the prevention of age-related and postpartum heart failure, protects the heart against cardiotoxic doxorubicin or ischaemia/reperfusion injury, and is involved in many cardioprotective strategies (e.g., ischaemic preconditioning, perconditioning, postconditioning, remote or pharmacological conditioning). Ischaemic heart disease is still the leading cause of death worldwide, and many cardiovascular risk factors contribute to the development of the disease. This review focuses on the effects of various cardiovascular risk factors (diabetes, aging, obesity, smoking, alcohol, depression, gender, comedications) on cardiac STAT3 under non-ischaemic baseline conditions, and in settings of ischaemia/reperfusion injury with or without cardioprotective strategies.
    Mesh-Begriff(e) Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Humans ; Myocardium/metabolism ; Myocardium/pathology ; Risk Factors ; STAT3 Transcription Factor/chemistry ; STAT3 Transcription Factor/metabolism ; Signal Transduction
    Chemische Substanzen Cardiotonic Agents ; STAT3 Transcription Factor
    Sprache Englisch
    Erscheinungsdatum 2018-11-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19113572
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A myriad of roles of miR-25 in health and disease.

    Sárközy, Márta / Kahán, Zsuzsanna / Csont, Tamás

    Oncotarget

    2018  Band 9, Heft 30, Seite(n) 21580–21612

    Abstract: Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by ... ...

    Abstract Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in different predicted target mRNAs. In this review, we specifically focus on the role of miR-25 in healthy and diseased conditions. Many of miR-25 target mRNAs are involved in biological processes such as cell proliferation, differentiation, and migration, apoptosis, oxidative stress, inflammation, calcium handling, etc. Therefore, it is no surprise that miR-25 has been reported as a key regulator of common cancerous and non-cancerous diseases. MiR-25 plays an important role in the pathogenesis of acute myocardial infarction, left ventricular hypertrophy, heart failure, diabetes mellitus, diabetic nephropathy, tubulointerstitial nephropathy, asthma bronchiale, cerebral ischemia/reperfusion injury, neurodegenerative diseases, schizophrenia, multiple sclerosis, etc. MiR-25 is also a well-described oncogenic miRNA playing a crucial role in the development of many tumor types including brain tumors, lung, breast, ovarian, prostate, thyroid, oesophageal, gastric, colorectal, hepatocellular cancers, etc. In this review, our aim is to discuss the translational therapeutic role of miR-25 in common diseased conditions based on relevant basic research and clinical studies.
    Sprache Englisch
    Erscheinungsdatum 2018-04-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.24662
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Ambroxol Treatment Suppresses the Proliferation of Chlamydia pneumoniae in Murine Lungs

    Kókai, Dávid / Paróczai, Dóra / Virok, Dezső Peter / Endrész, Valéria / Gáspár, Renáta / Csont, Tamás / Bozó, Renáta / Burián, Katalin

    Microorganisms. 2021 Apr. 20, v. 9, no. 4

    2021  

    Abstract: Ambroxol (Ax) is used as a mucolytics in the treatment of respiratory tract infections. Ax, at a general dose for humans, does not alter Chlamydia pneumoniae growth in mice. Therefore, we aimed to investigate the potential anti-chlamydial effect of Ax at ...

    Abstract Ambroxol (Ax) is used as a mucolytics in the treatment of respiratory tract infections. Ax, at a general dose for humans, does not alter Chlamydia pneumoniae growth in mice. Therefore, we aimed to investigate the potential anti-chlamydial effect of Ax at a concentration four timed higher than that used in human medicine. Mice were infected with C. pneumoniae and 5-mg/kg Ax was administered orally. The number of recoverable C. pneumoniae inclusion-forming units (IFUs) in Ax-treated mice was significantly lower than that in untreated mice. mRNA expression levels of several cytokines, including interleukin 12 (IL-12), IL-23, IL-17F, interferon gamma (IFN-γ), and surfactant protein (SP)-A, increased in infected mice treated with Ax. The IFN-γ protein expression levels were also significantly higher in infected and Ax-treated mice. Furthermore, the in vitro results suggested that the ERK 1/2 activity was decreased, which is essential for the C. pneumoniae replication. SP-A and SP-D treatments significantly decreased the number of viable C. pneumoniae IFUs and significantly increased the attachment of C. pneumoniae to macrophage cells. Based on our results, a dose of 5 mg/kg of Ax exhibited an anti-chlamydial effect in mice, probably an immunomodulating effect, and may be used as supporting drug in respiratory infections caused by C. pneumoniae.
    Schlagwörter Chlamydophila pneumoniae ; expectorants ; gene expression ; interferon-gamma ; interleukin-12 ; interleukin-17 ; interleukin-23 ; macrophages ; medicine ; mice ; protein synthesis ; surfactant proteins
    Sprache Englisch
    Erscheinungsverlauf 2021-0420
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9040880
    Datenquelle NAL Katalog (AGRICOLA)

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