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Article ; Online: The Sharp End of Pilonidal Disease.

Gosselink, Martijn P / Ctercteko, Grahame C

2018 Volume 61, Issue 2, Page(s) e12

MeSH term(s)	Humans ; Pilonidal Sinus ; Treatment Outcome
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000000989
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Article: Iatrogenic rectal injury associated with fleet enema administration masquerading as Fournier's Gangrene.

Liang, Yi / Di Re, Angelina / Ctercteko, Grahame

Journal of surgical case reports

2020 Volume 2020, Issue 2, Page(s) rjz414

Abstract: Rectal injuries secondary to fleet enemas are the result of a chemical irritation as well as mechanical trauma causing localized perforation and mucosal necrosis. These injuries can be managed expectantly. Fournier's Gangrene is a life-threatening, ... ...

Abstract	Rectal injuries secondary to fleet enemas are the result of a chemical irritation as well as mechanical trauma causing localized perforation and mucosal necrosis. These injuries can be managed expectantly. Fournier's Gangrene is a life-threatening, fulminant soft tissue infection of the genito-perineal region commonly secondary to a perianal infection, requiring extensive debridement of all affected tissue and judicious antibiotic therapy. This distinction is critical in the management of the current case, allowing for limited debridement and judicious observation without a resection of the injured rectum. A diverting colostomy allows for effective faecal management and minimizes contamination of the perineal wound.
Language	English
Publishing date	2020-02-24
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjz414
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Article ; Online: Acute Gastroenteritis in the Etiology of Inflammatory Bowel Disease: Systematic Review and Meta-analysis.

Di Re, Angelina / Liang, Yi / Gosselink, Martijn Pieter / Ctercteko, Grahame

Crohn's & colitis 360

2021 Volume 3, Issue 4, Page(s) otab065

Abstract: Background: Inflammatory bowel disease (IBD) consists of a spectrum of disorders including ulcerative colitis and Crohn's disease, with a rising incidence worldwide. However, despite this prevalence the etiology of IBD remains uncertain. It has been ... ...

Abstract	Background: Inflammatory bowel disease (IBD) consists of a spectrum of disorders including ulcerative colitis and Crohn's disease, with a rising incidence worldwide. However, despite this prevalence the etiology of IBD remains uncertain. It has been suggested that an episode of gastroenteritis may precipitate IBD. Methods: Studies were identified using a literature search of Pubmed/Medline and Embase/Ovid. This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The primary outcome was incidence of new-onset IBD after gastroenteritis. Secondary outcomes included incidence of IBD after bacterial, viral, and parasitic gastrointestinal infections. Results: Eleven studies ( Conclusions: In summary, our meta-analysis has shown that there is considerable heterogeneity in the literature regarding the role of gastroenteritis in the development of IBD. Further higher quality studies need to be performed to ascertain the true nature of this.
Language	English
Publishing date	2021-10-01
Publishing country	England
Document type	Journal Article
ISSN	2631-827X
ISSN (online)	2631-827X
DOI	10.1093/crocol/otab065
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Article ; Online: Chyme reinfusion nutritional management for enterocutaneous fistula: first international application of a novel pump technique.

Solis, Edgardo / Wright, Danette B / O'Grady, Greg / Ctercteko, Grahame

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 7, Page(s) 1924–1929

Abstract: Aim: High-output enterocutaneous fistulas (ECFs) are an established cause of intestinal failure. Parenteral nutrition (PN) remains the gold standard for nutritional management but is complex, expensive and associated with significant complications. ... ...

Abstract	Aim: High-output enterocutaneous fistulas (ECFs) are an established cause of intestinal failure. Parenteral nutrition (PN) remains the gold standard for nutritional management but is complex, expensive and associated with significant complications. Chyme reinfusion (CR) has been reported by multiple centres as a viable option for nutritional management that improves nutritional status, provides the capacity to cease PN and is cost-effective. The aim of this paper is to describe the first use of a novel pump device (The Insides System™) by an independent centre in Australia for the nutritional management of a patient with high-output ECF. Method: CR was performed on a 66-year-old woman with a high-output ECF. The device consists of two main components: a centrifugal pump that sits inside the stoma appliance and a battery-powered driver that is magnetically coupled externally onto the pump. The device allows for bolus CR at a rate of infusion that is manually controlled by the patient based on comfort, volume and effluent viscosity. Results: CR provided adequate nutritional support, with successful cessation of PN. Effective use of the device was learnt easily by the patient with minimal demands on nursing assistance. Side effects of CR (diarrhoea, abdominal cramping) were overcome by the patient's ability to manually adjust the reinfusion rate. Conclusion: Our experience with the novel Insides System™ device showed promising results in maintaining nutritional status as well as providing a minimally invasive, easy to use and low-cost system for CR. CR should be considered as a viable alternative for the nutritional management of patients with a high-output ECF.
MeSH term(s)	Aged ; Female ; Gastrointestinal Contents ; Humans ; Intestinal Fistula/therapy ; Intestines ; Nutritional Status ; Parenteral Nutrition
Language	English
Publishing date	2021-04-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15643
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Article: Metronidazole in the Management of Post-Open Haemorrhoidectomy Pain: Systematic Review.

Re, Angelina Di / Toh, James Wei Tatt / Iredell, Jonathan / Ctercteko, Grahame

Annals of coloproctology

2020 Volume 36, Issue 1, Page(s) 5–11

Abstract: Purpose: Open haemorrhoidectomy is associated with significant postoperative pain. Metronidazole is commonly prescribed in the postoperative period as an adjunct to analgesia in pain management.: Methods: In our systematic review, studies were ... ...

Abstract	Purpose: Open haemorrhoidectomy is associated with significant postoperative pain. Metronidazole is commonly prescribed in the postoperative period as an adjunct to analgesia in pain management. Methods: In our systematic review, studies were identified using PubMed/MEDLINE, Embase/Ovid and Cochrane Register of Controlled Trials databases. Studies were included if they were randomised controlled trials (RCTs) involving interventions with oral metronidazole at any dose over any time period. The primary outcome was pain score (visual analogue scale, VAS) after open haemorrhoidectomy. Secondary outcomes included time to return to normal daily activities, additional analgesia usage, and postoperative complications. Results: Of 14 RCTs reviewed, 4 met inclusion criteria and were selected. The studies comprised 336 study subjects and 169 subjects were randomised to metronidazole while 167 were in the control group. There was a significant reduction in VAS across all time points, with maximal reduction seen on day 5 posthaemorrhoidectomy (mean difference, -2.28; 95% confidence interval, -2.49 to -2.08; P < 0.001). There was no difference in incidence of complications (P = 0.13). The Cochrane Risk of Bias Tool showed 3 of 4 of the studies had a risk of bias. Conclusion: Metronidazole may be associated with decreased pain but there is insufficient evidence from RCTs to provide a strong grade of recommendation. Further RCTs are required.
Language	English
Publishing date	2020-02-29
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2711906-3
ISSN	2287-9722 ; 2287-9714
ISSN (online)	2287-9722
ISSN	2287-9714
DOI	10.3393/ac.2020.01.08
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Article ; Online: Dangers of delayed diagnosis of perianal abscess and undrained perianal sepsis in Fournier's gangrene: a case series.

Solis, Edgardo / Liang, Yi / Ctercteko, Grahame / Toh, James Wei Tatt

BMJ case reports

2020 Volume 13, Issue 10

Abstract: Fournier's gangrene (FG) is a rapidly progressing infective necrotising fasciitis of the perianal, perineal and genital region. It is characterised by its aggressive nature and high mortality rates of between 15% and 50%. While it has been commonly found ...

Abstract	Fournier's gangrene (FG) is a rapidly progressing infective necrotising fasciitis of the perianal, perineal and genital region. It is characterised by its aggressive nature and high mortality rates of between 15% and 50%. While it has been commonly found to primarily develop from urological sources, there have been increasing reports of the role of colorectal sources as the underlying aetiology of FG. Presented is a case series of four FG presentations at a single institution during a 12-month period as a result of underlying untreated perianal disease highlighting its dangers in progressing to a deadly infection, advocating for early and aggressive surgical debridement, and the role of adjunct scoring systems, such as Laboratory Risk Indicator for Necrotising Fasciitis, in guiding clinical diagnosis.
MeSH term(s)	Abscess/diagnosis ; Abscess/etiology ; Abscess/surgery ; Aged ; Anus Diseases/diagnosis ; Anus Diseases/etiology ; Anus Diseases/therapy ; Debridement/methods ; Delayed Diagnosis/adverse effects ; Fournier Gangrene/complications ; Fournier Gangrene/diagnosis ; Humans ; Male ; Middle Aged ; Sepsis/diagnosis ; Sepsis/etiology ; Sepsis/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-10-04
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-236503
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Article ; Online: Why is a haemorrhoid never infected?

Gosselink, Martijn Pieter / Harman, Andrew N / Ctercteko, Grahame

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2018 Volume 21, Issue 4, Page(s) 385–386

MeSH term(s)	Anal Canal/microbiology ; Hemorrhoids/microbiology ; Humans ; Infection Control ; Infections/microbiology ; Intestinal Mucosa/microbiology ; Wound Healing ; Wound Infection/microbiology
Language	English
Publishing date	2018-11-25
Publishing country	England
Document type	Editorial
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.14596
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Article ; Online: Attitudes towards Enhanced Recovery after Surgery (ERAS) interventions in colorectal surgery: nationwide survey of Australia and New Zealand colorectal surgeons.

Toh, James Wei Tatt / Collins, Geoffrey Peter / Pathma-Nathan, Nimalan / El-Khoury, Toufic / Engel, Alexander / Smith, Stephen / Richardson, Arthur / Ctercteko, Grahame

Langenbeck's archives of surgery

2022 Volume 407, Issue 4, Page(s) 1637–1646

Abstract: Background: Whilst Enhanced Recovery after Surgery (ERAS) has been widely accepted in the international colorectal surgery community, there remains significant variations in ERAS programme implementations, compliance rates and best practice ... ...

Abstract	Background: Whilst Enhanced Recovery after Surgery (ERAS) has been widely accepted in the international colorectal surgery community, there remains significant variations in ERAS programme implementations, compliance rates and best practice recommendations in international guidelines. Methods: A questionnaire was distributed to colorectal surgeons from Australia and New Zealand after ethics approval. It evaluated specialist attitudes towards the effectiveness of specific ERAS interventions in improving short term outcomes after colorectal surgery. The data were analysed using a rating scale and graded response model in item response theory (IRT) on Stata MP, version 15 (StataCorp LP, College Station, TX). Results: Of 300 colorectal surgeons, 95 (31.7%) participated in the survey. Of eighteen ERAS interventions, this study identified eight strategies as most effective in improving ERAS programmes alongside early oral feeding and mobilisation. These included pre-operative iron infusion for anaemic patients (IRT score = 7.82 [95% CI: 6.01-9.16]), minimally invasive surgery (IRT score = 7.77 [95% CI: 5.96-9.07]), early in-dwelling catheter removal (IRT score = 7.69 [95% CI: 5.83-9.01]), pre-operative smoking cessation (IRT score = 7.68 [95% CI: 5.49-9.18]), pre-operative counselling (IRT score = 7.44 [95% CI: 5.58-8.88]), avoiding drains in colon surgery (IRT score = 7.37 [95% CI: 5.17-8.95]), avoiding nasogastric tubes (IRT score = 7.29 [95% CI: 5.32-8.8]) and early drain removal in rectal surgery (IRT score = 5.64 [95% CI: 3.49-7.66]). Conclusions: This survey has demonstrated the current attitudes of colorectal surgeons from Australia and New Zealand regarding ERAS interventions. Eight of the interventions assessed in this study including pre-operative iron infusion for anaemic patients, minimally invasive surgery, early in-dwelling catheter removal, pre-operative smoking cessation, pre-operative counselling, avoidance of drains in colon surgery, avoiding nasogastric tubes and early drain removal in rectal surgery should be considered an important part of colorectal ERAS programmes.
MeSH term(s)	Attitude ; Colorectal Neoplasms/surgery ; Colorectal Surgery ; Enhanced Recovery After Surgery ; Humans ; Iron ; Length of Stay ; New Zealand ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Surgeons ; Surveys and Questionnaires
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2022-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-022-02488-7
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Article ; Online: OMIP 082: A 25-color phenotyping to define human innate lymphoid cells, natural killer cells, mucosal-associated invariant T cells, and γδ T cells from freshly isolated human intestinal tissue.

Doyle, Chloe M / Fewings, Nicole L / Ctercteko, Grahame / Byrne, Scott N / Harman, Andrew N / Bertram, Kirstie M

Cytometry. Part A : the journal of the International Society for Analytical Cytology

2022 Volume 101, Issue 3, Page(s) 196–202

Abstract: We developed a 25-color flow cytometry panel to comprehensively interrogate innate lymphoid cells (ILC), mucosal-associated invariant T (MAIT) cells, natural killer (NK) cells and γδ T cells in human tissues. The ability to isolate and interrogate these ... ...

Abstract	We developed a 25-color flow cytometry panel to comprehensively interrogate innate lymphoid cells (ILC), mucosal-associated invariant T (MAIT) cells, natural killer (NK) cells and γδ T cells in human tissues. The ability to isolate and interrogate these cells from fresh human tissue is crucial in understanding the role these cells play at immune-privileged mucosal surfaces like the intestine in health and disease settings. However, liberating these cells from tissue is extremely challenging as many key surface identification markers are susceptible to enzymatic cleavage. Choosing the correct enzyme-antibody clone combination within a high-parameter panel is, therefore, a critical consideration. Here, we present a comprehensive, in-depth analysis of the effect different common digestive enzyme blends have on key surface markers used to identify these cell types. In addition, we compared multiple antibody clones for surface markers that are highly susceptible to enzymatic cleavage, such as CD127 and NKp44, to achieve the most consistent and superior staining patterns among donors.
MeSH term(s)	Biomarkers ; Flow Cytometry ; Humans ; Immunity, Innate ; Intestines ; Killer Cells, Natural ; Mucosal-Associated Invariant T Cells
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099868-5
ISSN	1552-4930 ; 0196-4763 ; 1552-4922
ISSN (online)	1552-4930
ISSN	0196-4763 ; 1552-4922
DOI	10.1002/cyto.a.24529
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Zs.A 1688: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Management of intra-abdominal abscess in Crohn's disease.

Toh, James W T / Hammam, Elie / Cocco, Annelise / Albayati, Sinan / Ctercteko, Grahame

ANZ journal of surgery

2019 Volume 89, Issue 12, Page(s) E572–E573

MeSH term(s)	Abdominal Abscess/diagnosis ; Abdominal Abscess/etiology ; Abdominal Abscess/therapy ; Adolescent ; Anti-Bacterial Agents/administration & dosage ; Crohn Disease/complications ; Crohn Disease/diagnosis ; Drainage/methods ; Humans ; Injections, Intravenous ; Male ; Tomography, X-Ray Computed
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-01-24
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.14977
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