Artikel ; Online: Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections
medRxiv
Abstract: We report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals who do not seroconvert even weeks after infection. They are younger than ... ...
Abstract | We report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals who do not seroconvert even weeks after infection. They are younger than seroconverters who have increased co-morbidity and higher inflammatory markers such as C-Reactive Protein. Higher antibody responses are associated with non-white ethnicity. Antibody responses do not decline during follow up almost to 2 months. Serological assays increase understanding of disease severity. Their application in regular surveillance will clarify the duration and protective nature of humoral responses to SARS-CoV-2. |
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Schlagwörter | covid19 |
Sprache | Englisch |
Erscheinungsdatum | 2020-06-09 |
Verlag | Cold Spring Harbor Laboratory Press |
Dokumenttyp | Artikel ; Online |
DOI | 10.1101/2020.06.07.20124636 |
Datenquelle | COVID19 |
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