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Artikel ; Online: Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections

Staines, Henry M / Kirwan, Daniela E / Clark, David J / Adams, Emily R / Augustin, Yolanda / Byrne, Rachel L / Cocozza, Michael / Cubas-Atienza, Ana I / Cuevas, Luis E / Cusinato, Martina / Davies, Benedict M O / Davis, Mark / Davis, Paul / Duvoix, Annelyse / Eckersley, Nicholas M / Forton, Daniel / Fraser, Alice / Garrod, Gala / Hadcocks, Linda /
Hu, Qinxue / Johnson, Michael / Kay, Grant A / Klekotko, Kesja / Lewis, Zawditu / Mensah-Kane, Josephine / Menzies, Stefanie / Monahan, Irene / Moore, Catherine / Nebe-von-Caron, Gerhard / Owen, Sophie I / Sainter, Chris / Sall, Amadou A / Schouten, James / Williams, Chris / Wilkins, John / Woolston, Kevin / Fitchett, Joseph R A / Krishna, Sanjeev / Planche, Tim

medRxiv

Abstract: We report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals who do not seroconvert even weeks after infection. They are younger than ... ...

Abstract We report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals who do not seroconvert even weeks after infection. They are younger than seroconverters who have increased co-morbidity and higher inflammatory markers such as C-Reactive Protein. Higher antibody responses are associated with non-white ethnicity. Antibody responses do not decline during follow up almost to 2 months. Serological assays increase understanding of disease severity. Their application in regular surveillance will clarify the duration and protective nature of humoral responses to SARS-CoV-2.
Schlagwörter covid19
Sprache Englisch
Erscheinungsdatum 2020-06-09
Verlag Cold Spring Harbor Laboratory Press
Dokumenttyp Artikel ; Online
DOI 10.1101/2020.06.07.20124636
Datenquelle COVID19

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