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Article ; Online: Protective Role of Lycopene in Subjects with Liver Disease: NUTRIHEP Study.

Donghia, Rossella / Campanella, Angelo / Bonfiglio, Caterina / Cuccaro, Francesco / Tatoli, Rossella / Giannelli, Gianluigi

Nutrients

2024 Volume 16, Issue 4

Abstract: Background: Liver diseases are constantly increasing throughout the world and are often associated with other diseases, but above all they are caused by improper diet. Adherence to a diet with abundant vegetables has now been widely demonstrated to be ... ...

Abstract	Background: Liver diseases are constantly increasing throughout the world and are often associated with other diseases, but above all they are caused by improper diet. Adherence to a diet with abundant vegetables has now been widely demonstrated to be important in combating this pathological condition. The aim of this study was to explore the protective role of lycopene (LYC) extracts from cooked and fresh tomato. Methods: The study cohort included 969 participants assessed in the NUTRIHEP cohort (2005-2006) and the associated follow-up (2014-2016), divided into two groups, based on liver condition: NAFLD, or AFLD and FLD. Results: The results indicated a statistical significance of LYC consumption, showing a protective role against liver disease, the best concentration being 9.50 mg/die, with an RR value of 0.59, Conclusions: The protective role of LYC extracts from tomato has not been amply demonstrated in humans. We conclude that this is one of the few papers in the literature to evaluate the protective effect of LYC against liver disease, as well as how this molecule could be used in future possible treatments. Utilizing lycopene as a supplement alone or in combination with other foods could be useful for developing treatments with reduced contraindications.
MeSH term(s)	Humans ; Lycopene ; Carotenoids/therapeutic use ; Dietary Supplements ; Non-alcoholic Fatty Liver Disease/prevention & control ; Antioxidants/therapeutic use
Chemical Substances	Lycopene (SB0N2N0WV6) ; Carotenoids (36-88-4) ; Antioxidants
Language	English
Publishing date	2024-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16040562
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adding a Leafy Vegetable Fraction to Diets Decreases the Risk of Red Meat Mortality in MASLD Subjects: Results from the MICOL Cohort.

Donghia, Rossella / Tatoli, Rossella / Campanella, Angelo / Cuccaro, Francesco / Bonfiglio, Caterina / Giannelli, Gianluigi

Nutrients

2024 Volume 16, Issue 8

Abstract: Background: Dietary guidelines recommend limiting red meat intake because it has been amply associated with increased cancer mortality, particularly in patients with liver conditions, such as metabolic dysfunction-associated fatty liver disease (MASLD). ...

Abstract	Background: Dietary guidelines recommend limiting red meat intake because it has been amply associated with increased cancer mortality, particularly in patients with liver conditions, such as metabolic dysfunction-associated fatty liver disease (MASLD). MASLD is the leading cause of liver dysfunction in the world today, and no specific treatment other than lifestyle correction has yet been established. The aim of this study was to explore the protective role of leafy vegetables when associated with high red meat consumption. Methods: The study cohort included 1646 participants assessed during the fourth recall of the MICOL study, subdivided into two groups based on red meat intake (≤50 g/die vs. >50 g/die), in order to conduct a cancer mortality analysis. The prevalence of subjects that consumed >50 g/die was only 15.73%. Leafy vegetable intake was categorized based on median g/die consumption, and it was combined with red meat intake. Conclusions: This is the first study to demonstrate that the consumption of about 30 g/die of leafy vegetables reduces the risk of mortality. A strong association with mortality was observed in subjects with MASLD, and the protective role of vegetables was demonstrated.
MeSH term(s)	Humans ; Female ; Male ; Vegetables ; Middle Aged ; Red Meat ; Diet ; Cohort Studies ; Aged ; Non-alcoholic Fatty Liver Disease/mortality ; Risk Factors ; Adult
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081207
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Article ; Online: Effects of Egg Consumption on Subjects with SLD or Hypertension: A MICOL Study.

Tatoli, Rossella / Bonfiglio, Caterina / Cuccaro, Francesco / Campanella, Angelo / Coletta, Sergio / Pesole, Pasqua Letizia / Giannelli, Gianluigi / Donghia, Rossella

Nutrients

2024 Volume 16, Issue 3

Abstract: Background: Steatotic liver disease (SLD) is defined as a fat accumulation in more than 5% of hepatocytes; it can progress to non-alcoholic steatohepatitis (NASH), associated with an increased state of inflammation. The aim of this study was to explore ... ...

Abstract	Background: Steatotic liver disease (SLD) is defined as a fat accumulation in more than 5% of hepatocytes; it can progress to non-alcoholic steatohepatitis (NASH), associated with an increased state of inflammation. The aim of this study was to explore the protective effects of eating eggs and any association with SLD and hypertension (HTN). Methods: The study cohort included 908 participants assessed in the fourth recall of the MICOL study, grouped into four groups, based on NALFD and/or HTN. Results: The prevalence of HTN and SLD among participants was 31.61%. Overall, the results indicated a statistical significance of egg consumption, showing a protective role against the two disease conditions, in both the raw and adjusted models (RRR = 0.34, Conclusions: Many differences were found among the groups, and the protective role of eating eggs was amply demonstrated. We can conclude that it is unwise to demonize the intake of this food and its nutritional properties, in contrast with previous reports in the literature.
MeSH term(s)	Humans ; Diet ; Hypertension/epidemiology ; Eggs ; Fatty Liver ; Non-alcoholic Fatty Liver Disease/epidemiology
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16030430
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High Adherence to a Mediterranean Alcohol-Drinking Pattern and Mediterranean Diet Can Mitigate the Harmful Effect of Alcohol on Mortality Risk.

Campanella, Angelo / Bonfiglio, Caterina / Cuccaro, Francesco / Donghia, Rossella / Tatoli, Rossella / Giannelli, Gianluigi

Nutrients

2023 Volume 16, Issue 1

Abstract: Background: Alcohol is a psychoactive substance with deleterious effects on human health and mortality. This study aims to investigate the joint associations between the Mediterranean Diet (MedDiet), alcohol- consumption patterns and mortality from the ... ...

Abstract	Background: Alcohol is a psychoactive substance with deleterious effects on human health and mortality. This study aims to investigate the joint associations between the Mediterranean Diet (MedDiet), alcohol- consumption patterns and mortality from the following: all causes, cardiovascular, neoplastic, the digestive system, and other causes. Methods: A sample of 3411 alcohol consumers aged ≥18 years was selected from two prospective cohort studies: the MICOL and NUTRIHEP Study. Cohorts were enrolled in 2005-2006, and followed up until December 2022, capturing data on alcohol consumption, diet, and mortality. Adherence to the MedDiet was measured by the relative Mediterranean score (rMED), and alcohol consumption by the Mediterranean Alcohol-drinking Pattern index (MADP). Statistical analyses included flexible parametric survival models and subdistribution hazard ratios, to consider different causes of death. Results: a significant increase in digestive-system (SHR 2.77, 95% CI 1.16; 63) and cancer mortality risk (SHR 2.25, 95% CI 1.08; 4.70) was observed among individuals with low adherence to the MADP. Low adherence to the Mediterranean pattern of alcohol consumption, combined with low adherence to the MedDiet, was associated with higher overall mortality (HR 2.29, 95% CI 1.04, 5.04), and, in particular, with higher mortality from digestive system diseases (SHR 4.38, 95% CI 1.22, 15.8). Conclusions: This study suggests that deleterious effects of alcohol on mortality vary, depending on alcohol consumption patterns and dietary context. Higher adherence to the MedDiet appears to mitigate the adverse effects of moderate alcohol consumption, particularly for wine drinkers.
MeSH term(s)	Humans ; Adolescent ; Adult ; Diet, Mediterranean ; Prospective Studies ; Ethanol ; Alcohol Drinking/adverse effects ; Health Behavior
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-12-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16010059
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Article ; Online: Effect of Intake of Extra Virgin Olive Oil on Mortality in a South Italian Cohort with and without NAFLD.

Bonfiglio, Caterina / Cuccaro, Francesco / Campanella, Angelo / Rosso, Natalia / Tatoli, Rossella / Giannelli, Gianluigi / Donghia, Rossella

Nutrients

2023 Volume 15, Issue 21

Abstract: Background: Extra-virgin olive oil (EVOO) is the main source of seasoning fat in the Mediterranean diet and it is one of the components with known protective factors on chronic-degenerative disease. We aimed to evaluate the effect of a medium-high level ...

Abstract	Background: Extra-virgin olive oil (EVOO) is the main source of seasoning fat in the Mediterranean diet and it is one of the components with known protective factors on chronic-degenerative disease. We aimed to evaluate the effect of a medium-high level of oil consumption on mortality in a cohort with good adherence to the Mediterranean diet. Methods: A total of 2754 subjects who had completed the food questionnaire in the Multicenter Italian study on Cholelithiasis (MICOL) cohort were included in the study. EVOO consumption was categorized in four levels (<20 g/die, 21-30 g/die, 31-40 g/die, >40 g/die). We performed a flexible parametric survival model to assess mortality by EVOO consumption level adjusted for some covariates. We also performed the analysis on subjects with and without non-alcoholic fatty liver disease (NAFLD) to evaluate the effects of oil in this more fragile sub-cohort. Results: We found a statistically significant negative effect on mortality for the whole sample when EVOO consumption was used, both as a continuous variable and when categorized. The protective effect was stronger in the sub-cohort with NAFLD, especially for the highest levels of EVOO consumption (HR = 0.58 with Conclusions: Our study has shown a protective effect of EVOO consumption towards all causes of mortality. Despite the higher caloric intake, the protective power is greater for a consumption >40 g/day in both the overall cohort and the sub-cohorts with and without NAFLD.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/epidemiology ; Olive Oil/pharmacology ; Mortality ; Italy/epidemiology ; Multicenter Studies as Topic
Chemical Substances	Olive Oil
Language	English
Publishing date	2023-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15214593
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Article: Development and Internal Validation of a Model for Predicting Overall Survival in Subjects with MAFLD: A Cohort Study.

Bonfiglio, Caterina / Campanella, Angelo / Donghia, Rossella / Bianco, Antonella / Franco, Isabella / Curci, Ritanna / Bagnato, Claudia Beatrice / Tatoli, Rossella / Giannelli, Gianluigi / Cuccaro, Francesco

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: Background & ... ...

Abstract	Background & Aims
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13041181
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Article: 2022 revised European recommendations for the coding of the basis of diagnosis of cancer cases in population-based cancer registries.

Visser, Otto / Kościańska, Beata / Caetano Dos Santos, Florentino Luciano / Cuccaro, Francesco / Forjaz, Gonçalo / Michalek, Irmina Maria / Mousavi, Mohsen / Sulkowska, Urszula / Martos, Carmen / Giusti, Francesco

Frontiers in oncology

2023 Volume 13, Page(s) 1250549

Abstract: The basis of diagnosis recommendations for population-based cancer registries aim to provide a standardized coding tool that reflects the certainty of cancer diagnosis, especially when pathological confirmation is lacking. The proportion of clinical ... ...

Abstract	The basis of diagnosis recommendations for population-based cancer registries aim to provide a standardized coding tool that reflects the certainty of cancer diagnosis, especially when pathological confirmation is lacking. The proportion of clinical diagnoses serves as an indicator of data quality. Given the evolving nature of diagnostic techniques, regular revision of the basis of diagnosis rules is crucial. To address this, a working group comprising representatives from the steering committee and member registries of the European Network of Cancer Registries was established. The original 1999 recommendations were comprehensively reviewed, resulting in the publication of an updated version. These new recommendations came into effect for incident cancer cases starting from January 1, 2023. The updated recommendations comprise an adapted code list for the basis of diagnosis, optional codes for histology cases, revisions related to flow cytometry, liquid biopsy, and cytogenetic/molecular testing, consolidation of histology codes 6 and 7, introduction of a new code 8 for cytogenetic/molecular confirmation, and establishment of new criteria for registering specific morphology codes in cancers lacking pathological confirmation.
Language	English
Publishing date	2023-12-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1250549
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Article ; Online: Sudden Cardiac Death in Athletes in Italy during 2019: Internet-Based Epidemiological Research.

Sollazzo, Fabrizio / Palmieri, Vincenzo / Gervasi, Salvatore Francesco / Cuccaro, Francesco / Modica, Gloria / Narducci, Maria Lucia / Pelargonio, Gemma / Zeppilli, Paolo / Bianco, Massimiliano

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 1

MeSH term(s)	Athletes ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/prevention & control ; Female ; Humans ; Incidence ; Internet ; Italy/epidemiology ; Male ; Sports
Language	English
Publishing date	2021-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57010061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Peak oxygen uptake in sportsmen with spinal cord injury: importance of body composition.

Gervasi, Salvatore F / Orvieto, Sebastiano / Sollazzo, Fabrizio / Bianco, Massimiliano / Cuccaro, Francesco / Zeppilli, Paolo / Palmieri, Vincenzo

European journal of physical and rehabilitation medicine

2021 Volume 58, Issue 2, Page(s) 199–205

Abstract: Background: Although peak oxygen uptake (VO ... 2peak ... ) is considered the most useful index of functional capacity, it's difficult to interpret the results of cardiopulmonary exercise testing (CPET) in individuals with spinal cord injury (SCI). In ... ...

Abstract	Background: Although peak oxygen uptake (VO<inf>2peak</inf>) is considered the most useful index of functional capacity, it's difficult to interpret the results of cardiopulmonary exercise testing (CPET) in individuals with spinal cord injury (SCI). In fact, VO<inf>2peak</inf> is usually normalized for total body weight, but body composition in persons with SCI largely varies depending on physical activity and time since injury, with a progressive loss of fat-free mass (FFM). This can lead to a misinterpretation of the cardiopulmonary fitness in this population. Aim: Our study proposes a methodology of evaluation, based on bioelectrical impedance analysis (BIA), which could provide more individualized and accurate data in sportsmen with SCI. Design: Case-control study. Population: Ambulatory patients at the Sports Medicine Unit of the IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy. Methods: Comparison of data derived from BIA, echocardiography and CPET between 10 male sportsmen with complete, high SCI (group T) and 10 able-bodied controls (group C). Results: Mean VO<inf>2peak</inf>, weight-normalized VO<inf>2peak</inf>, fat-free mass (FFM)-normalized VO<inf>2peak</inf> and body cellular mass (BCM)-normalized values were significantly lower in group T. At the same heart rate (on average the 55% of the maximal theoretical for age), mean of absolute VO<inf>2</inf>, weight-normalized VO<inf>2</inf> and FFM-normalized VO<inf>2</inf> were still significantly lower in group T. Considering the BCM-normalized VO<inf>2</inf>, the group T showed greater values than controls, 39.4±7.8 vs. 31.1±8.5 mL/kg/min. Conclusions: Body composition is a crucial factor for properly interpreting a CPET in individuals with SCI. In particular, normalization of VO<inf>2peak</inf> values for the BCM seems the most reliable tool to assess the real functional capacity in this population. Clinical rehabilitation impact: A more accurate definition of the aerobic power and functional capacity of people with SCI can improve the monitoring of rehabilitations protocols and physical exercise in this population.
MeSH term(s)	Body Composition ; Case-Control Studies ; Exercise Test ; Female ; Humans ; Male ; Oxygen ; Oxygen Consumption ; Spinal Cord Injuries/rehabilitation
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-09-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2426908-6
ISSN	1973-9095 ; 1973-9087
ISSN (online)	1973-9095
ISSN	1973-9087
DOI	10.23736/S1973-9087.21.07028-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Response to: Influence and Reliability of Different Correction Formulas on QTc Calculation.

Gervasi, Salvatore F / Bianco, Massimiliano / Palmieri, Vincenzo / Cuccaro, Francesco / Zeppilli, Paolo

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

2019 Volume 30, Issue 1, Page(s) e25

MeSH term(s)	Electrocardiography ; Humans ; Long QT Syndrome ; Reproducibility of Results
Language	English
Publishing date	2019-12-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1062530-6
ISSN	1536-3724 ; 1050-642X
ISSN (online)	1536-3724
ISSN	1050-642X
DOI	10.1097/JSM.0000000000000564
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