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  1. Article ; Online: Radiation pneumonitis and chemotherapy in a patient with multiple myeloma.

    Cuchet, Pierre / Valette, Xavier

    Lancet (London, England)

    2021  Volume 397, Issue 10283, Page(s) 1484

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Aged ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bortezomib/therapeutic use ; Combined Modality Therapy ; Dyspnea/etiology ; Fever/etiology ; Humans ; Male ; Multiple Myeloma/complications ; Multiple Myeloma/drug therapy ; Radiation Pneumonitis/diagnosis ; Radiation Pneumonitis/drug therapy ; Tomography, X-Ray Computed
    Chemical Substances Adrenal Cortex Hormones ; Antineoplastic Agents ; Bortezomib (69G8BD63PP)
    Language English
    Publishing date 2021-04-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)00315-9
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  2. Article ; Online: Disease patterns and specific trajectories of anti-MDA5-related disease: a multicentre retrospective study of 70 adult patients.

    de Boysson, Hubert / Cuchet, Marie / Cassius, Charles / Cuchet, Pierre / Agard, Christian / Audemard-Verger, Alexandra / Marchand-Adam, Sylvain / Cohen-Sors, Raphaëlla / Gallay, Laure / Graveleau, Julie / Lesort, Cécile / Ly, Kim / Meyer, Alain / Monseau, Grégoire / Néel, Antoine / Bonnotte, Bernard / Pérard, Laurent / Schleinitz, Nicolas / Mariotte, Delphine /
    Le Mauff, Brigitte / Bourdenet, Gwladys / Masmoudi, Wafa / Deshayes, Samuel / Dumont, Anaël / Dompmartin, Anne / Kottler, Diane / Aouba, Achille

    Frontiers in immunology

    2024  Volume 14, Page(s) 1319957

    Abstract: Introduction: This study aimed to provide an updated analysis of the different prognostic trajectories of patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibodies.: Methods: Among a cohort of 70 patients, baseline ... ...

    Abstract Introduction: This study aimed to provide an updated analysis of the different prognostic trajectories of patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibodies.
    Methods: Among a cohort of 70 patients, baseline characteristics and phenotypes, treatments and outcomes were analyzed. A Cox proportional hazards model was used to identify factors associated with poor outcomes, i.e., death or progressive disease at the last follow-up.
    Results: Among the 70 patients, 45 were women, and 54 were Caucasian. A dermatologic involvement was observed in 58 (83%) patients, including 40 with MDA5 vasculopathy-related skin lesions. Muscular involvement was observed in 39 (56%) patients. Interstitial lung disease (ILD) was observed at baseline in 52 (74%) patients, including 23 (44%) who developed rapidly progressive (RP) ILD. Seven (10%) patients showed thromboembolic complications within the first weeks of diagnosis, and eight (11%) other patients developed a malignancy (4 before the diagnosis of anti-MDA5 disease). Poor outcomes were observed in 28 (40%) patients, including 13 (19%) deaths. Among the 23 patients with RP-ILD, 19 (79%) showed poor outcomes, including 12 (63%) who died. In multivariate analyses, RP-ILD (hazard ratio (HR), 95% CI: 8.24 [3.21-22], p<0.0001), the occurrence of thromboembolic events (HR: 5.22 [1.61-14.77], p=0.008) and the presence of any malignancy (HR: 19.73 [6.67-60], p<0.0001) were the three factors independently associated with poor outcomes.
    Discussion: This new independent cohort confirms the presence of different clinical phenotypes of anti-MDA5 diseases at baseline and the poor prognosis associated with RP-ILD. Thromboembolic events and malignancies were also identified as prognostic factors.
    MeSH term(s) Adult ; Humans ; Female ; Male ; Retrospective Studies ; Multivariate Analysis ; Thromboembolism ; Lung Diseases, Interstitial/etiology ; Neoplasms
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Multicenter Study ; Journal Article ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1319957
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  3. Article ; Online: Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study.

    Rouzé, Anahita / Martin-Loeches, Ignacio / Povoa, Pedro / Makris, Demosthenes / Artigas, Antonio / Bouchereau, Mathilde / Lambiotte, Fabien / Metzelard, Matthieu / Cuchet, Pierre / Boulle Geronimi, Claire / Labruyere, Marie / Tamion, Fabienne / Nyunga, Martine / Luyt, Charles-Edouard / Labreuche, Julien / Pouly, Olivier / Bardin, Justine / Saade, Anastasia / Asfar, Pierre /
    Baudel, Jean-Luc / Beurton, Alexandra / Garot, Denis / Ioannidou, Iliana / Kreitmann, Louis / Llitjos, Jean-François / Magira, Eleni / Mégarbane, Bruno / Meguerditchian, David / Moglia, Edgar / Mekontso-Dessap, Armand / Reignier, Jean / Turpin, Matthieu / Pierre, Alexandre / Plantefeve, Gaetan / Vinsonneau, Christophe / Floch, Pierre-Edouard / Weiss, Nicolas / Ceccato, Adrian / Torres, Antoni / Duhamel, Alain / Nseir, Saad

    Intensive care medicine

    2021  Volume 47, Issue 2, Page(s) 188–198

    Abstract: Purpose: Although patients with SARS-CoV-2 infection have several risk factors for ventilator-associated lower respiratory tract infections (VA-LRTI), the reported incidence of hospital-acquired infections is low. We aimed to determine the relationship ... ...

    Abstract Purpose: Although patients with SARS-CoV-2 infection have several risk factors for ventilator-associated lower respiratory tract infections (VA-LRTI), the reported incidence of hospital-acquired infections is low. We aimed to determine the relationship between SARS-CoV-2 pneumonia, as compared to influenza pneumonia or no viral infection, and the incidence of VA-LRTI.
    Methods: Multicenter retrospective European cohort performed in 36 ICUs. All adult patients receiving invasive mechanical ventilation > 48 h were eligible if they had: SARS-CoV-2 pneumonia, influenza pneumonia, or no viral infection at ICU admission. VA-LRTI, including ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP), were diagnosed using clinical, radiological and quantitative microbiological criteria. All VA-LRTI were prospectively identified, and chest-X rays were analyzed by at least two physicians. Cumulative incidence of first episodes of VA-LRTI was estimated using the Kalbfleisch and Prentice method, and compared using Fine-and Gray models.
    Results: 1576 patients were included (568 in SARS-CoV-2, 482 in influenza, and 526 in no viral infection groups). VA-LRTI incidence was significantly higher in SARS-CoV-2 patients (287, 50.5%), as compared to influenza patients (146, 30.3%, adjusted sub hazard ratio (sHR) 1.60 (95% confidence interval (CI) 1.26 to 2.04)) or patients with no viral infection (133, 25.3%, adjusted sHR 1.7 (95% CI 1.2 to 2.39)). Gram-negative bacilli were responsible for a large proportion (82% to 89.7%) of VA-LRTI, mainly Pseudomonas aeruginosa, Enterobacter spp., and Klebsiella spp.
    Conclusions: The incidence of VA-LRTI is significantly higher in patients with SARS-CoV-2 infection, as compared to patients with influenza pneumonia, or no viral infection after statistical adjustment, but residual confounding may still play a role in the effect estimates.
    MeSH term(s) Aged ; COVID-19/epidemiology ; Europe ; Female ; Humans ; Incidence ; Influenza, Human/epidemiology ; Male ; Middle Aged ; Pneumonia, Ventilator-Associated/epidemiology ; Respiratory Tract Infections/epidemiology ; Retrospective Studies ; Ventilators, Mechanical
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-06323-9
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  4. Article ; Online: Correction to: Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study.

    Rouzé, Anahita / Martin-Loeches, Ignacio / Povoa, Pedro / Makris, Demosthenes / Artigas, Antonio / Bouchereau, Mathilde / Lambiotte, Fabien / Metzelard, Matthieu / Cuchet, Pierre / Boulle Geronimi, Claire / Labruyere, Marie / Tamion, Fabienne / Nyunga, Martine / Luyt, Charles-Edouard / Labreuche, Julien / Pouly, Olivier / Bardin, Justine / Saade, Anastasia / Asfar, Pierre /
    Baudel, Jean-Luc / Beurton, Alexandra / Garot, Denis / Ioannidou, Iliana / Kreitmann, Louis / Llitjos, Jean-François / Magira, Eleni / Mégarbane, Bruno / Meguerditchian, David / Moglia, Edgar / Mekontso-Dessap, Armand / Reignier, Jean / Turpin, Matthieu / Pierre, Alexandre / Plantefeve, Gaetan / Vinsonneau, Christophe / Floch, Pierre-Edouard / Weiss, Nicolas / Ceccato, Adrian / Torres, Antoni / Duhamel, Alain / Nseir, Saad

    Intensive care medicine

    2021  Volume 48, Issue 4, Page(s) 514–515

    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-021-06588-8
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