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  1. Article: Oral status of a noble European couple from the 16

    Peracchia, Marianna / Meleti, Marco / Armocida, Emanuele / Toffoli, Andrea / Cucurachi, Nicola / Bussolati, Ovidio / Cecchi, Rossana

    Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur

    2021  Volume 79, Issue 1, Page(s) 69–81

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Dental Caries ; Humans ; Nutritional Status ; Spouses ; Tooth ; Tooth Loss ; Tooth Wear
    Language English
    Publishing date 2021-06-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 396-7
    ISSN 0003-5548
    ISSN 0003-5548
    DOI 10.1127/anthranz/2021/1423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Toxicological findings: A retrospective overview of medico-legal investigations in Parma (Italy).

    Anzillotti, Luca / Marezza, Francesca / Calò, Luca / Cucurachi, Nicola / Veronesi, Licia / Cecchi, Rossana

    Journal of forensic and legal medicine

    2019  Volume 62, Page(s) 92–96

    Abstract: The aim of this study was to collect all available data from 2009 to 2016 focusing on the epidemiological, clinical and pharmacological issues only related to acute intoxication fatalities in the Unit of Legal Medicine of the Department of Medicine and ... ...

    Abstract The aim of this study was to collect all available data from 2009 to 2016 focusing on the epidemiological, clinical and pharmacological issues only related to acute intoxication fatalities in the Unit of Legal Medicine of the Department of Medicine and Surgery at the University of Parma. All death certificates and autopsy reports were retrieved from the archives and evaluated to identify cases in which only acute intoxication from xenobiotics could be defined as the cause of death, however statistical and descriptive analyses were applied to all the data. A more comprehensive analysis on all causes of death showed that out of 1005 total cases the most common is haemorrhagic shock/traumatic shock (36.5%), followed by cardiogenic shock with 27.4%; asphyxia ranks as the third cause of death (11.8%); concerning encephalic injuries, our data show 10.9% of cases, while acute intoxication by xenobiotics accounts for 5.7%. Data show that the majority of subjects are poly-abuser (75.4%); people not enrolled within a preventive treatment (59.4%) were more likely to commit suicide (28.1%), whereas only 6.2% in the sub-population in treatment (40.6%) committed suicide: therefore, data strongly suggest the evidence that joining a preventive programme can decrease the probability of extreme action. Access to a full case history may indeed save considerable time and expense in carrying out tests, but also valuable targeted samplings. The investigating officer should, therefore, submit as much information as possible about the case, as this may influence the type and extent of analysis undertaken, as well as the interpretation of analytical results.
    MeSH term(s) Accidents/mortality ; Adult ; Age Distribution ; Aged ; Asphyxia/mortality ; Brain Injuries/mortality ; Cause of Death ; Central Nervous System Depressants/blood ; Drowning/mortality ; Ethanol/blood ; Female ; Forensic Medicine ; Homicide/statistics & numerical data ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Pharmaceutical Preparations/blood ; Poisoning/mortality ; Retrospective Studies ; Sex Distribution ; Shock/mortality ; Street Drugs/blood ; Substance-Related Disorders/mortality ; Suicide/statistics & numerical data ; Young Adult
    Chemical Substances Central Nervous System Depressants ; Pharmaceutical Preparations ; Street Drugs ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2019-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268721-X
    ISSN 1878-7487 ; 1752-928X
    ISSN (online) 1878-7487
    ISSN 1752-928X
    DOI 10.1016/j.jflm.2019.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Understanding the structural features of symptomatic calcific aortic valve stenosis: A broad-spectrum clinico-pathologic study in 236 consecutive surgical cases.

    Galli, Daniela / Manuguerra, Roberta / Monaco, Rodolfo / Manotti, Laura / Goldoni, Matteo / Becchi, Gabriella / Carubbi, Cecilia / Vignali, Giulia / Cucurachi, Nicola / Gherli, Tiziano / Nicolini, Francesco / Lorusso, Roberto / Vitale, Marco / Corradi, Domenico

    International journal of cardiology

    2017  Volume 228, Page(s) 364–374

    Abstract: Background: With age, aortic valve cusps undergo varying degrees of sclerosis which, sometimes, can progress to calcific aortic valve stenosis (AVS). To perform a retrospective clinico-pathologic investigation in patients with calcific AVS.: Methods: ...

    Abstract Background: With age, aortic valve cusps undergo varying degrees of sclerosis which, sometimes, can progress to calcific aortic valve stenosis (AVS). To perform a retrospective clinico-pathologic investigation in patients with calcific AVS.
    Methods: We characterized and graded the structural remodeling in 236 aortic valves (200 tricuspid and 36 bicuspid) from patients with calcific AVS (148 males; average 72years); possible relationships between general/clinical/echocardiographic characteristics and the histopathologic changes were explored. Twenty autopsy aortic valves served as controls. In 40 cases, we also tested the immunohistochemical expression of metalloproteinases and cytokines, and characterized the inflammatory infiltrate. In 5 cases, we cultured cusp stem cells and explored their potential to differentiate into osteoblasts/adipocytes.
    Results: AVS cusps showed structural remodeling as severe fibrosis (100%), calcific nodules (100%), neoangiogenesis (81%), inflammation (71%), bone metaplasia with or without hematopoiesis (6% and 53%, respectively), adipose metaplasia (16%), and cartilaginous metaplasia (7%). At multivariate analysis, AVS degree and interventricular septum thickness were the only predictors of remodeling (barring inflammation). All the tested metalloproteinases (except MMP-13) and cytokines were expressed in AVS cusps. Inflammation mainly consisted of B and T lymphocytes (CD4+/CD8+ cell ratio 3:1) and plasma cells. AVS changes were mostly different from typical atherosclerosis. Cultured mesenchymal cusp stem cells could differentiate into osteoblasts/adipocytes.
    Conclusions: Structural remodeling in AVS is peculiar and considerable, and is related to the severity of the disease. However, the different newly formed tissues-where "valvular interstitial cells" play a key role-and their well-known slow turnover suggest a reverse structural remodeling improbable.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Analysis of Variance ; Aortic Valve/diagnostic imaging ; Aortic Valve/pathology ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/pathology ; Aortic Valve Stenosis/surgery ; Autopsy ; Biopsy, Needle ; Calcinosis/diagnostic imaging ; Calcinosis/mortality ; Calcinosis/pathology ; Calcinosis/surgery ; Case-Control Studies ; Cause of Death ; Cohort Studies ; Echocardiography/methods ; Female ; Follow-Up Studies ; Heart Valve Prosthesis Implantation/methods ; Heart Valve Prosthesis Implantation/mortality ; Humans ; Immunohistochemistry ; Italy ; Male ; Middle Aged ; Multivariate Analysis ; Retrospective Studies ; Risk Assessment ; Sex Factors ; Statistics, Nonparametric ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2017-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2016.11.180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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