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  1. Article ; Online: PET/CT to diagnose and manage patients with infectious diseases: "¡vamos a brillar, mi amor! (Let's shine, my love!)".

    Cuervo, Guillermo

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2023  Volume 41, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Communicable Diseases ; Positron Emission Tomography Computed Tomography
    Language English
    Publishing date 2023-01-04
    Publishing country Spain
    Document type Editorial ; Comment
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2022.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Which trial do we need? Aminopenicillin-gentamicin versus aminopenicillin-ceftriaxone for Enterococcus faecalis endocarditis.

    Luque-Paz, David / Cuervo, Guillermo / Miró, José M / Tattevin, Pierre

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 6, Page(s) 676–678

    MeSH term(s) Humans ; Ceftriaxone/therapeutic use ; Gentamicins/therapeutic use ; Enterococcus faecalis ; Anti-Bacterial Agents/therapeutic use ; Penicillins/therapeutic use ; Endocarditis/drug therapy ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Drug Therapy, Combination ; Ampicillin/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology
    Chemical Substances Ceftriaxone (75J73V1629) ; Gentamicins ; Anti-Bacterial Agents ; Penicillins ; Ampicillin (7C782967RD)
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  3. Article ; Online: Native and prosthetic transcatheter aortic valve infective endocarditis due to Lactobacillus rhamnosus.

    Bergas, Alba / Rivera, Samuel / Torrecillas, Miriam / Cuervo, Guillermo

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 40, Issue 7, Page(s) 402–404

    MeSH term(s) Aortic Valve/surgery ; Endocarditis ; Endocarditis, Bacterial/complications ; Humans ; Lactobacillus rhamnosus
    Language English
    Publishing date 2022-07-29
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2021.05.018
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  4. Article ; Online: Native and prosthetic transcatheter aortic valve infective endocarditis due to Lactobacillus rhamnosus.

    Bergas, Alba / Rivera, Samuel / Torrecillas, Miriam / Cuervo, Guillermo

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  

    Language Spanish
    Publishing date 2021-07-02
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2021.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Clinical Challenge of Prosthetic Valve Endocarditis: JACC Focus Seminar 3/4.

    Cuervo, Guillermo / Quintana, Eduard / Regueiro, Ander / Perissinotti, Andrés / Vidal, Barbara / Miro, Jose M / Baddour, Larry M

    Journal of the American College of Cardiology

    2024  Volume 83, Issue 15, Page(s) 1418–1430

    Abstract: During the past 6 decades, there have been numerous changes in prosthetic valve endocarditis (PVE), currently affecting an older population and increasing in incidence in patients with transcatheter-implanted valves. Significant microbiologic (molecular ... ...

    Abstract During the past 6 decades, there have been numerous changes in prosthetic valve endocarditis (PVE), currently affecting an older population and increasing in incidence in patients with transcatheter-implanted valves. Significant microbiologic (molecular biology) and imaging diagnostic (fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography) advances have been incorporated into the 2023 Duke-International Society for Cardiovascular Infectious Diseases infective endocarditis diagnostic criteria, thus increasing the diagnostic sensitivity for PVE without sacrificing specificity in validation studies. PVE is a life-threatening disease requiring management by multidisciplinary endocarditis teams in cardiac centers to improve outcomes. Novel surgical options are now available, and an increasing set of patients may avoid surgical intervention despite indication. Selected patients may complete parenteral or oral antimicrobial treatment at home. Finally, patients with prosthetic valves implanted surgically or by the transcatheter approach are candidates for antibiotic prophylaxis before invasive dental procedures.
    MeSH term(s) Humans ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/therapy ; Endocarditis, Bacterial/complications ; Heart Valve Prosthesis/adverse effects ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/therapy ; Prosthesis-Related Infections/microbiology ; Endocarditis/diagnosis ; Endocarditis/etiology ; Positron Emission Tomography Computed Tomography/methods
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2024.01.037
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  6. Article: Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance.

    Gudiol, Carlota / Albasanz-Puig, Adaia / Cuervo, Guillermo / Carratalà, Jordi

    Frontiers in medicine

    2021  Volume 8, Page(s) 636547

    Abstract: Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern ... ...

    Abstract Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern in this population because any delay in starting adequate empirical antibiotic therapy can lead to poor outcomes. In this review, we aim to address: (1) the mechanisms involved in the development of sepsis and septic shock in these patients; (2) the risk factors associated with a worse prognosis; (3) the impact of adequate initial empirical antibiotic therapy given the current era of widespread antimicrobial resistance; and (4) the optimal management of sepsis, including adequate and early source control of infection, optimized antibiotic use based on the pharmacokinetic and pharmacodynamics changes in these patients, and the role of the new available antibiotics.
    Language English
    Publishing date 2021-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.636547
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  7. Article: Current Challenges in the Management of Infective Endocarditis.

    Cuervo, Guillermo / Escrihuela-Vidal, Francesc / Gudiol, Carlota / Carratalà, Jordi

    Frontiers in medicine

    2021  Volume 8, Page(s) 641243

    Abstract: Infective endocarditis is a relatively rare, but deadly cause of sepsis, with an overall mortality ranging from 20 to 25% in most series. Although the classic clinical classification into syndromes of acute or subacute endocarditis have not completely ... ...

    Abstract Infective endocarditis is a relatively rare, but deadly cause of sepsis, with an overall mortality ranging from 20 to 25% in most series. Although the classic clinical classification into syndromes of acute or subacute endocarditis have not completely lost their usefulness, current clinical forms have changed according to the profound epidemiological changes observed in developed countries. In this review, we aim to address the changing epidemiology of endocarditis, several recent advances in the understanding of the pathophysiology of endocarditis and endocarditis-triggered sepsis, new useful diagnostic tools as well as current concepts in the medical and surgical management of this disease. Given its complexity, the management of infective endocarditis requires the close collaboration of multidisciplinary endocarditis teams that must decide on the diagnostic approach; the appropriate initial treatment in the critical phase; the detection of patients needing surgery and the timing of this intervention; and finally the accurate selection of patients for out-of-hospital treatment, either at home hospitalization or with oral antibiotic treatment.
    Language English
    Publishing date 2021-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.641243
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  8. Article ; Online: Optimizing therapy of bloodstream infection due to extended-spectrum β-lactamase-producing Enterobacteriaceae.

    Gudiol, Carlota / Cuervo, Guillermo / Carratalà, Jordi

    Current opinion in critical care

    2019  Volume 25, Issue 5, Page(s) 438–448

    Abstract: Purpose of review: Infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are increasing worldwide. Carbapenems are usually regarded as the antibiotics of choice for the treatment of serious ESBL infections. However, ... ...

    Abstract Purpose of review: Infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are increasing worldwide. Carbapenems are usually regarded as the antibiotics of choice for the treatment of serious ESBL infections. However, because of the alarming emergence or carbapenem resistance, interest in effective alternatives has emerged. The present review summarizes the findings published on the antibiotics currently available for treatment of patients with an ESBL-E bloodstream infection (BSI).
    Recent findings: Meropenem and imipenem are the drugs recommended for treatment of ESBL BSIs in critically ill patients, and in infections with high bacterial loads or elevated β-lactam minimum inhibitory concentrations. Ertapenem should be reserved for patients with less severe presentations, and should be used at high doses. In milder presentations or BSIs from low-risk sources, other carbapenem-sparing alternatives could be considered: cephamycins, fluoroquinolones, and particularly a β-lactam/β-lactam inhibitor combination (particularly piperacillin/tazobactam). Optimized dosing of piperacillin/tazobactam is recommended (high doses and extended infusion). There are few data on the use of the promising newly available drugs (e.g. ceftolozane/tazobactam, ceftazidime/avibactam, cefiderocol, and plazomicin), and it seems reasonable to reserve them as last-resort drugs.
    Summary: Carbapenems should be used in patients with serious infections; alternatives could be used individually, particularly for definitive treatment of patients with milder presentations.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Critical Care ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/enzymology ; Enterobacteriaceae Infections/drug therapy ; Humans ; Microbial Sensitivity Tests ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2019-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000646
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    Zs.A 4999: Show issues Location:
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  9. Article ; Online: Role of the inflammatory response in community-acquired pneumonia: clinical implications.

    Rombauts, Alexander / Abelenda-Alonso, Gabriela / Cuervo, Guillermo / Gudiol, Carlota / Carratalà, Jordi

    Expert review of anti-infective therapy

    2021  Volume 20, Issue 10, Page(s) 1261–1274

    Abstract: Introduction: Despite adequate antibiotic coverage, community-acquired pneumonia (CAP) remains a leading cause of hospitalization and mortality worldwide. It induces both a local pulmonary and a systemic inflammatory response, particularly significant ... ...

    Abstract Introduction: Despite adequate antibiotic coverage, community-acquired pneumonia (CAP) remains a leading cause of hospitalization and mortality worldwide. It induces both a local pulmonary and a systemic inflammatory response, particularly significant in severe cases. The intensity of the dysregulated host response varies from patient to patient and has a negative impact on survival and other outcomes.
    Areas covered: This comprehensive review summarizes the pathophysiological aspects of the inflammatory response in CAP, briefly discusses the usefulness of biomarkers, and assesses the clinical evidence for modulating the inflammatory pathways. We searched PubMed for the most relevant studies, reviews, and meta-analysis until August 2020.
    Expert opinion: Notable efforts have been made to identify biomarkers that can accurately differentiate between viral and bacterial etiology, and indeed, to enhance risk stratification in CAP. However, none has proven ideal and no recommended biomarker-guided algorithms exist. Biomarker signatures from proteomic and metabolomic studies could be more useful for such assessments. To date, most studies have produced contradictory results concerning the role of immunomodulatory agents (e.g. corticosteroids, macrolides, and statins) in CAP. Adequately identifying the population who may benefit most from effective modulation of the inflammatory response remains a challenge.
    MeSH term(s) Adrenal Cortex Hormones ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Biomarkers ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Macrolides/pharmacology ; Pneumonia/diagnosis ; Pneumonia/drug therapy ; Pneumonia/epidemiology ; Proteomics
    Chemical Substances Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Biomarkers ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Macrolides
    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2021.1834848
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  10. Article ; Online: Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.

    Cuervo, Guillermo / Viasus, Diego / Carratalà, Jordi

    The New England journal of medicine

    2018  Volume 378, Issue 26, Page(s) 2540

    MeSH term(s) Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; Myocardial Infarction
    Keywords covid19
    Language English
    Publishing date 2018--28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1805679
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    Ua VI Zs.34: Show issues Location:
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