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  1. Article ; Online: Adult gonococcal conjunctivitis: Prevalence, clinical features and complications.

    Cuesta Chasco, Genoveva / Carreras-Castañer, Xavier / Zboromyrska, Yuliya / Pitart, Cristina / Palma-Carvajal, Francisco / Bosch, Jordi / Figueroa-Vercellino, Juan Pablo

    Journal of medical microbiology

    2021  Volume 70, Issue 9

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Adolescent ; Adult ; Aminoglycosides/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/therapeutic use ; Conjunctivitis, Bacterial/drug therapy ; Conjunctivitis, Bacterial/epidemiology ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Humans ; Middle Aged ; Neisseria gonorrhoeae/isolation & purification ; Ophthalmic Solutions/therapeutic use ; Prevalence ; Retrospective Studies ; Spain/epidemiology ; Young Adult
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; Ophthalmic Solutions ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001416
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: K-Means Clustering Identifies Diverse Clinical Phenotypes in COVID-19 Patients: Implications for Mortality Risks and Remdesivir Impact.

    Garcia-Vidal, Carolina / Teijón-Lumbreras, Christian / Aiello, Tommaso Francesco / Chumbita, Mariana / Menendez, Rosario / Mateu-Subirà, Aina / Peyrony, Olivier / Monzó, Patricia / Lopera, Carlos / Gallardo-Pizarro, Antonio / Méndez, Raúl / Calbo, Esther / Xercavins, Mariona / Cuesta-Chasco, Genoveva / Martínez, José A / Marcos, Ma Angeles / Mensa, Josep / Soriano, Alex

    Infectious diseases and therapy

    2024  Volume 13, Issue 4, Page(s) 715–726

    Abstract: Introduction: The impact of remdesivir on mortality in patients with COVID-19 is still controversial. We aimed to identify clinical phenotype clusters of COVID-19 hospitalized patients with highest benefit from remdesivir use and validate these findings ...

    Abstract Introduction: The impact of remdesivir on mortality in patients with COVID-19 is still controversial. We aimed to identify clinical phenotype clusters of COVID-19 hospitalized patients with highest benefit from remdesivir use and validate these findings in an external cohort.
    Methods: We included consecutive patients hospitalized between February 2020 and February 2021 for COVID-19. The derivation cohort comprised subjects admitted to Hospital Clinic of Barcelona. The validation cohort included patients from Hospital Universitari Mutua de Terrassa (Terrassa) and Hospital Universitari La Fe (Valencia), all tertiary centers in Spain. We employed K-means clustering to group patients according to reverse transcription polymerase chain reaction (rRT-PCR) cycle threshold (Ct) values and lymphocyte counts at diagnosis, and pre-test symptom duration. The impact of remdesivir on 60-day mortality in each cluster was assessed.
    Results: A total of 1160 patients (median age 66, interquartile range (IQR) 55-78) were included. We identified five clusters, with mortality rates ranging from 0 to 36.7%. Highest mortality rate was observed in the cluster including patients with shorter pre-test symptom duration, lower lymphocyte counts, and lower Ct values at diagnosis. The absence of remdesivir administration was associated with worse outcome in the high-mortality cluster (10.5% vs. 36.7%; p < 0.001), comprising subjects with higher viral loads. These results were validated in an external multicenter cohort of 981 patients.
    Conclusions: Patients with COVID-19 exhibit varying mortality rates across different clinical phenotypes. K-means clustering aids in identifying patients who derive the greatest mortality benefit from remdesivir use.
    Language English
    Publishing date 2024-03-15
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-024-00938-x
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  3. Article: Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication.

    Garcia-Vidal, Carolina / Iglesias-Caballero, María / Puerta-Alcalde, Pedro / Mas, Vicente / Cuesta-Chasco, Genoveva / Garcia-Pouton, Nicole / Varona, Sarai / Pozo, Francisco / Vázquez-Morón, Sonia / Marcos, Maria Angeles / Soriano, Alex / Casas, Inmaculada

    Frontiers in microbiology

    2022  Volume 13, Page(s) 826883

    Abstract: We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples ( ... ...

    Abstract We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed.
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.826883
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  4. Article ; Online: Chemosensory dysfunction in COVID-19 out-patients.

    Rojas-Lechuga, María Jesús / Izquierdo-Domínguez, Adriana / Chiesa-Estomba, Carlos / Calvo-Henríquez, Christian / Villarreal, Ithzel Maria / Cuesta-Chasco, Genoveva / Bernal-Sprekelsen, Manuel / Mullol, Joaquim / Alobid, Isam

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2020  Volume 278, Issue 3, Page(s) 695–702

    Abstract: Background: Since the outbreak in China due to coronavirus disease 2019 (COVID-19) various studies have been published describing olfactory and gustatory dysfunction (OGD).: Objective: The aim was to investigate the frequency and severity of OGD in ... ...

    Abstract Background: Since the outbreak in China due to coronavirus disease 2019 (COVID-19) various studies have been published describing olfactory and gustatory dysfunction (OGD).
    Objective: The aim was to investigate the frequency and severity of OGD in SARS-CoV-2 (+) out-patients compared to controls with common cold/flu like symptoms and two negative RT-PCR.
    Methods: A multicenter cross-sectional study on SARS-CoV-2-positive out-patients (n = 197) and controls (n = 107) from five Spanish Hospitals. Severity of OGD was categorized by visual analogue scale (VAS). Frequency and severity of the chemosensory impairment were analyzed.
    Results: The frequencies of smell (70.1%) and taste loss (65%) were significantly higher among COVID-19 subjects than in the controls (20.6% and 19.6%, respectively). Simultaneous OGD was more frequent in the COVID-19 group (61.9% vs 10.3%) and they scored higher in VAS for severity of OGD than controls. In the COVID-19 group, OGD was predominant in young subjects 46.5 ± 14.5 and females (63.5%). Subjects with severe loss of smell were younger (42.7 years old vs 45.5 years old), and recovered later (median = 7, IQR = 5.5 vs median = 4, IQR = 3) than those with mild loss of smell. Subjects with severe loss of taste, recovered later in days (median = 7, IQR = 6 vs median = 2, IQR = 2), compared to those with mild loss.
    Conclusion: OGD is a prevalent symptom in COVID-19 subjects with significant differences compared to controls. It was predominant in young and females subjects. Stratified analysis by the severity of OGD showed that more than 60% of COVID-19 subjects presented a severe OGD who took a longer time to recover compared to those with mild symptoms.
    MeSH term(s) Adult ; COVID-19 ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Outpatients ; SARS-CoV-2 ; Taste Disorders
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06266-3
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  5. Article ; Online: Prolonged viral replication in patients with hematologic malignancies hospitalized with COVID-19.

    Garcia-Vidal, Carolina / Puerta-Alcalde, Pedro / Mateu, Aina / Cuesta-Chasco, Genoveva / Meira, Fernanda / Lopera, Carlos / Monzo, Patricia / Santos-Bravo, Marta / Duenas, Gerard / Chumbita, Mariana / Garcia-Pouton, Nicole / Gaya, Anna / Bodro, Marta / Herrera, Sabina / Mosquera, Mar / Fernandez-Aviles, Francesc / Martinez, Jose Antonio / Mensa, Josep / Gine, Eva /
    Marcos, Maria Angeles / Soriano, Alex

    Haematologica

    2022  Volume 107, Issue 7, Page(s) 1731–1735

    MeSH term(s) COVID-19 ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/pathology ; Hospitalization ; Humans ; SARS-CoV-2 ; Virus Replication
    Language English
    Publishing date 2022-07-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.280407
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    Uh III Zs.76: Show issues Location:
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  6. Article: Chemosensory dysfunction in COVID-19 out-patients

    Rojas-Lechuga, María Jesús / Izquierdo-Domínguez, Adriana / Chiesa-Estomba, Carlos / Calvo-Henríquez, Christian / Villarreal, Ithzel Maria / Cuesta-Chasco, Genoveva / Bernal-Sprekelsen, Manuel / Mullol, Joaquim / Alobid, Isam

    Eur. arch. oto-rhino-laryngol

    Abstract: BACKGROUND: Since the outbreak in China due to coronavirus disease 2019 (COVID-19) various studies have been published describing olfactory and gustatory dysfunction (OGD). OBJECTIVE: The aim was to investigate the frequency and severity of OGD in SARS- ... ...

    Abstract BACKGROUND: Since the outbreak in China due to coronavirus disease 2019 (COVID-19) various studies have been published describing olfactory and gustatory dysfunction (OGD). OBJECTIVE: The aim was to investigate the frequency and severity of OGD in SARS-CoV-2 (+) out-patients compared to controls with common cold/flu like symptoms and two negative RT-PCR. METHODS: A multicenter cross-sectional study on SARS-CoV-2-positive out-patients (n = 197) and controls (n = 107) from five Spanish Hospitals. Severity of OGD was categorized by visual analogue scale (VAS). Frequency and severity of the chemosensory impairment were analyzed. RESULTS: The frequencies of smell (70.1%) and taste loss (65%) were significantly higher among COVID-19 subjects than in the controls (20.6% and 19.6%, respectively). Simultaneous OGD was more frequent in the COVID-19 group (61.9% vs 10.3%) and they scored higher in VAS for severity of OGD than controls. In the COVID-19 group, OGD was predominant in young subjects 46.5 ± 14.5 and females (63.5%). Subjects with severe loss of smell were younger (42.7 years old vs 45.5 years old), and recovered later (median = 7, IQR = 5.5 vs median = 4, IQR = 3) than those with mild loss of smell. Subjects with severe loss of taste, recovered later in days (median = 7, IQR = 6 vs median = 2, IQR = 2), compared to those with mild loss. CONCLUSION: OGD is a prevalent symptom in COVID-19 subjects with significant differences compared to controls. It was predominant in young and females subjects. Stratified analysis by the severity of OGD showed that more than 60% of COVID-19 subjects presented a severe OGD who took a longer time to recover compared to those with mild symptoms.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #730460
    Database COVID19

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  7. Article ; Online: Chemosensory dysfunction in COVID-19 out-patients

    Rojas-Lechuga, María Jesús / Izquierdo-Domínguez, Adriana / Chiesa-Estomba, Carlos / Calvo-Henríquez, Christian / Villarreal, Ithzel Maria / Cuesta-Chasco, Genoveva / Bernal-Sprekelsen, Manuel / Mullol, Joaquim / Alobid, Isam

    European Archives of Oto-Rhino-Laryngology ; ISSN 0937-4477 1434-4726

    2020  

    Keywords Otorhinolaryngology ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00405-020-06266-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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