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Article ; Online: Serratiomycins D1-D3, Antibacterial Cyclic Peptides from a

Du, Young Eun / Cui, Jinsheng / Cho, Eunji / Hwang, Sunghoon / Jang, Yong-Joon / Oh, Ki-Bong / Nam, Sang-Jip / Oh, Dong-Chan

Journal of natural products

2024

Abstract: Serratiomycin ( ...

Abstract	Serratiomycin (
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c00993
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Article ; Online: Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-β-Aggregation-Regulating Activity from a Marine Bacillus sp

Cui, Jinsheng / Ye, Suhyun / Shin, Daniel / Cho, Illhwan / Kim, Hye Yun / Kwon, Yun / Park, Keunwan / Nam, Sang-Jip / Kim, YoungSoo / Oh, Dong-Chan

Mar Drugs. 2023 Jan. 19, v. 21, no. 2

2023

Abstract: Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 ... ...

Abstract	Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 and 2 were proposed using mass spectrometric analysis and NMR spectroscopic data. The absolute configurations of 1 and 2 were determined by optical rotation, J-based configuration analysis, chemical derivatizations, including the modified Mosher’s method, and quantum-mechanics-based calculation. Biological evaluation of 1 and 2 revealed that succinyl glyco-oxydifficidin (1) inhibited/dissociated amyloid β (Aβ) aggregation, whereas succinyl macrolactin O (2) inhibited Aβ aggregation, indicating their therapeutic potential for disassembling and removing Aβ aggregation.
Keywords	Bacillus (bacteria) ; amyloid ; biological assessment ; glycosylation ; lactones ; littoral zone ; mass spectrometry ; spectral analysis ; therapeutics ; Korean Peninsula
Language	English
Dates of publication	2023-0119
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md21020067
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Article ; Online: The safety and efficacy of Sotn ureteroscopy for renal and upper ureteral calculi: a prospective multicenter randomized controlled trial.

Guo, Zhenlang / Wang, Zhichao / Weng, Xiangtao / Tang, Yanquan / Wu, Deneng / Cheng, Fan / Chen, Bin / Tang, Huilong / Cui, Jinsheng / Gu, Chiming / Zou, Qianming / Li, Yuan / Gan, Shu / Xiang, Songtao / Wang, Shusheng

Minerva urology and nephrology

2024 Volume 76, Issue 2, Page(s) 221–229

Abstract: Background: Sotn ureteroscopy is a new lithotripsy procedure developed on the basis of ureteroscopy and includes a rigid ureteral access sheath, standard mirror, lithotripsy mirror, and Sotn perfusion aspirator. Thus, we performed a prospective ... ...

Abstract	Background: Sotn ureteroscopy is a new lithotripsy procedure developed on the basis of ureteroscopy and includes a rigid ureteral access sheath, standard mirror, lithotripsy mirror, and Sotn perfusion aspirator. Thus, we performed a prospective multicenter randomized controlled trial comparing the safety and efficacy of Sotn ureteroscopy in the treatment of renal and upper ureteral calculi. Methods: In this study, 224 patients with renal and upper ureteral calculi were randomly divided equally into study and control groups from March 2018 to March 2022. All the patients were approved by the hospital ethics committee (proof number: ZF-2018-164-01 and ZF-2018-165-01) of the Second Affiliate Hospital of Guangzhou University of Chinese Medicine in China. The primary outcome was stone-free rate (SFR) assessed by computed tomography on the 1 Results: In total, for upper ureteral calculi, the SFR of 1 day after operation of the Sotn ureteroscopy group was significantly higher than the rigid ureteroscopy group (83.6% vs. 60%, P=0.006). Moreover, operative time (33.7±1.80 vs. 52.9±2.73 min, P<0.005) of the Sotn ureteroscopy group was significantly lower than the rigid ureteroscopy group. Additionally, the SFR of 1 day after operation and operative time for the study group (Sotn ureteroscopy combined with flexible ureteroscopy) and the control group (flexible ureteroscopy alone) were 63.2% and 36.8% (P=0.005), 65.6±4.06 and 80.3±4.91 (P=0.023), respectively. However, there were no significant differences in the SFR of 1 month after operation, success rate of ureteral access sheath placement, and postoperative complications between the two groups (P>0.05). In subgroups with stone diameters ≥1.5 cm and stone CT values ≥1000 Hounsfield units, Sotn ureteroscopy showed more advantages in terms of the SFR of 1 day after operation. Importantly, complications such as ureteral injury, sepsis, fever, and severe hematuria were not statistically different between the two groups (P>0.05). Conclusions: For renal and upper ureteral calculi, Sotn ureteroscopy has the advantage of a higher SFR of 1 day after the operation and a shorter operative time, suggesting that the Sotn ureteroscopy may have further potential applications in clinics.
MeSH term(s)	Humans ; Ureteroscopy/methods ; Ureteroscopy/adverse effects ; Ureteral Calculi/surgery ; Male ; Female ; Prospective Studies ; Middle Aged ; Kidney Calculi/surgery ; Kidney Calculi/diagnostic imaging ; Treatment Outcome ; Adult ; Lithotripsy/methods ; Lithotripsy/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
Language	English
Publishing date	2024-05-14
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial ; Multicenter Study ; Comparative Study
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.24.05595-2
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Article: Circ_101341 Deteriorates the Progression of Clear Cell Renal Cell Carcinoma Through the miR- 411/EGLN3 Axis.

Yue, Yongjun / Cui, Jinsheng / Zhao, Yu / Liu, Shangying / Niu, Weixing

Cancer management and research

2020 Volume 12, Page(s) 13513–13525

Abstract: Background: Clear cell renal cell carcinoma (ccRCC) is one of the main subtypes of renal cell carcinoma, with intense aggressiveness. The involvement of circular RNAs (circRNAs) in human cancers attracts much concern. The intention of this study was to ... ...

Abstract	Background: Clear cell renal cell carcinoma (ccRCC) is one of the main subtypes of renal cell carcinoma, with intense aggressiveness. The involvement of circular RNAs (circRNAs) in human cancers attracts much concern. The intention of this study was to investigate the expression of circ_101341 and explore its function in ccRCC. Materials and methods: The expression of circ_101341, miR-411 and Egl nine homolog 3 ( Results: The expression of circ_101341 was elevated in ccRCC tissues and cells. Functionally, circ_101341 knockdown depleted proliferation, migration and invasion of ccRCC cells in vitro and restricted tumor growth in vivo. Circ_101341 directly targeted miR-411, and miR-411 inhibition revised the inhibitory effects of circ_101341 knockdown on proliferation, migration and invasion in ccRCC cells. Moreover, miR-411 directly bound to EGLN3, and Conclusion: Circ_101341 functioned as a tumor promoter to strengthen proliferation, migration and invasion by regulating
Language	English
Publishing date	2020-12-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S272287
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Article ; Online: Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-β-Aggregation-Regulating Activity from a Marine

Cui, Jinsheng / Ye, Suhyun / Shin, Daniel / Cho, Illhwan / Kim, Hye Yun / Kwon, Yun / Park, Keunwan / Nam, Sang-Jip / Kim, YoungSoo / Oh, Dong-Chan

Marine drugs

2023 Volume 21, Issue 2

Abstract: Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin ( ...

Abstract	Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (
MeSH term(s)	Bacillus/chemistry ; Molecular Structure ; Amyloid beta-Peptides ; Lactones/pharmacology
Chemical Substances	oxydifficidin (95152-89-9) ; Amyloid beta-Peptides ; Lactones
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21020067
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Article: Antitumor Activity of Pulvomycin via Targeting Activated-STAT3 Signaling in Docetaxel-Resistant Triple-Negative Breast Cancer Cells.

Byun, Woong Sub / Bae, Eun Seo / Cui, Jinsheng / Park, Hyen Joo / Oh, Dong-Chan / Lee, Sang Kook

Biomedicines

2021 Volume 9, Issue 4

Abstract: Although docetaxel-based regimens are common and effective for early-stage triple-negative breast cancer (TNBC) treatment, acquired drug resistance frequently occurs. Therefore, a novel therapeutic strategy for docetaxel-resistant TNBC is urgently ... ...

Abstract	Although docetaxel-based regimens are common and effective for early-stage triple-negative breast cancer (TNBC) treatment, acquired drug resistance frequently occurs. Therefore, a novel therapeutic strategy for docetaxel-resistant TNBC is urgently required. Signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in the tumorigenesis and metastasis of numerous cancers, and STAT3 signaling is aberrantly activated in TNBC cells. In this study, a docetaxel-resistant TNBC cell line (MDA-MB-231-DTR) was established, and mechanisms for the antitumor activity of pulvomycin, a novel STAT3 inhibitor isolated from marine-derived actinomycete, were investigated. Levels of activated STAT3 (p-STAT3 (Y705)) increased in docetaxel-resistant cells, and knockdown of STAT3 recovered the sensitivity to docetaxel in MDA-MB-231-DTR cells. Pulvomycin effectively inhibited the proliferation of both cell lines. In addition, pulvomycin suppressed the activation of STAT3 and subsequently induced G
Language	English
Publishing date	2021-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9040436
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Article: Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp

An, Joon Soo / Kim, Myoun-Su / Han, Jaeho / Jang, Sung Chul / Im, Ji Hyeon / Cui, Jinsheng / Lee, Yeonjin / Nam, Sang-Jip / Shin, Jongheon / Lee, Sang Kook / Yoon, Yeo Joon / Oh, Dong-Chan

Journal of natural products. 2022 Mar. 16, v. 85, no. 4

2022

Abstract: A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of nyuzenamide C (1) revealed that 1 has a bicyclic backbone composed of six common amino ...

Abstract	A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of nyuzenamide C (1) revealed that 1 has a bicyclic backbone composed of six common amino acid residues (Asn, Leu, Pro, Gly, Val, and Thr) and four nonproteinogenic amino acid units, including hydroxyglycine, β-hydroxyphenylalanine, p-hydroxyphenylglycine, and 3,β-dihydroxytyrosine, along with 1,2-epoxypropyl cinnamic acid. The absolute configuration of 1 was proposed by J-based configuration analysis, the advanced Marfey’s method, quantum mechanics-based DP4 calculations, and bioinformatic analysis of its nonribosomal peptide synthetase biosynthetic gene cluster. Nyuzenamide C (1) displayed antiangiogenic activity in human umbilical vein endothelial cells and induced quinone reductase in murine Hepa-1c1c7 cells.
Keywords	NAD(P)H dehydrogenase (quinone) ; Streptomyces ; amino acids ; bioinformatics ; biosynthesis ; cinnamic acid ; epoxides ; mice ; multigene family ; nonribosomal peptides ; riparian areas ; spectral analysis
Language	English
Dates of publication	2022-0316
Size	p. 804-814.
Publishing place	American Chemical Society and American Society of Pharmacognosy
Document type	Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.1c00837
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 1144: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Ohmyungsamycin promotes M1-like inflammatory responses to enhance host defence against <i>Mycobacteroides abscessus</i> infections.

Jeon, Sang Min / Kim, Young Jae / Nguyen, Thanh Quang / Cui, Jinsheng / Thi Bich Hanh, Bui / Silwal, Prashanta / Kim, Jin Kyung / Kim, Jin-Man / Oh, Dong-Chan / Jang, Jichan / Jo, Eun-Kyeong

Virulence

2022 Volume 13, Issue 1, Page(s) 1966–1984

Abstract: Ohmyungsamycin A (OMS) is a newly identified cyclic peptide that exerts antimicrobial effects against ... Mycobacterium tuberculosis ... However, its role in nontuberculous mycobacteria (NTMs) infections has not been clarified. ... Mycobacteroides ... ...

Abstract	Ohmyungsamycin A (OMS) is a newly identified cyclic peptide that exerts antimicrobial effects against Mycobacterium tuberculosis. However, its role in nontuberculous mycobacteria (NTMs) infections has not been clarified. Mycobacteroides abscessus (Mabc) is a rapidly growing NTM that has emerged as a human pathogen in both immunocompetent and immunosuppressed individuals. In this study, we demonstrated that OMS had significant antimicrobial effects against Mabc infection in both immunocompetent and immunodeficient mice, and in macrophages. OMS treatment amplified Mabc-induced expression of M1-related proinflammatory cytokines and inducible nitric oxide synthase, and significantly downregulated arginase-1 expression in murine macrophages. In addition, OMS augmented Mabc-mediated production of mitochondrial reactive oxygen species (mtROS), which promoted M1-like proinflammatory responses in Mabc-infected macrophages. OMS-induced production of mtROS and nitric oxide was critical for OMS-mediated antimicrobial responses during Mabc infections. Notably, the combination of OMS and rifabutin had a synergistic effect on the antimicrobial responses against Mabc infections in vitro, in murine macrophages, and in zebrafish models in vivo. Collectively, these data strongly suggest that OMS may be an effective M1-like adjunctive therapeutic against Mabc infections, either alone or in combination with antibiotics.
MeSH term(s)	Humans ; Mice ; Animals ; Mycobacterium abscessus ; Zebrafish ; Mycobacterium Infections, Nontuberculous/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/metabolism ; Macrophages/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2657572-3
ISSN	2150-5608 ; 2150-5594
ISSN (online)	2150-5608
ISSN	2150-5594
DOI	10.1080/21505594.2022.2138009
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Article ; Online: Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine

An, Joon Soo / Kim, Myoun-Su / Han, Jaeho / Jang, Sung Chul / Im, Ji Hyeon / Cui, Jinsheng / Lee, Yeonjin / Nam, Sang-Jip / Shin, Jongheon / Lee, Sang Kook / Yoon, Yeo Joon / Oh, Dong-Chan

Journal of natural products

2022 Volume 85, Issue 4, Page(s) 804–814

Abstract: A new nonribosomal peptide, nyuzenamide C ( ...

Abstract	A new nonribosomal peptide, nyuzenamide C (
MeSH term(s)	Amino Acids/metabolism ; Angiogenesis Inhibitors/pharmacology ; Animals ; Cinnamates ; Endothelial Cells/metabolism ; Humans ; Mice ; Peptide Fragments ; Peptides/chemistry ; Streptomyces/chemistry
Chemical Substances	Amino Acids ; Angiogenesis Inhibitors ; Cinnamates ; Peptide Fragments ; Peptides ; cinnamic acid (140-10-3)
Language	English
Publishing date	2022-03-16
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.1c00837
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1144: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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ab Jg. 2022: Lesesaal (EG)

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Article: Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp

An, Joon Soo / Shin, Bora / Kim, Tae Ho / Hwang, Sunghoon / Shin, Yern-Hyerk / Cui, Jinsheng / Du, Young Eun / Yi, Jungwoo / Nam, Sang-Jip / Hong, Suckchang / Shin, Jongheon / Jang, Jichan / Yoon, Yeo Joon / Oh, Dong-Chan

Organic letters. 2021 Apr. 22, v. 23, no. 9

2021

Abstract: Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The ... ...

Abstract	Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher’s method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC₅₀ = 27.1 μM).
Keywords	Streptomyces ; biosynthesis ; genetic analysis ; macrolides ; multigene family ; riparian areas ; sediments ; spectral analysis ; stereochemistry
Language	English
Dates of publication	2021-0422
Size	p. 3359-3363.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c00847
Database	NAL-Catalogue (AGRICOLA)

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